KEGG   ENZYME: 2.7.7.48
Entry
EC 2.7.7.48                 Enzyme                                 
Name
RNA-directed RNA polymerase;
RNA nucleotidyltransferase (RNA-directed);
RNA nucleotidyltransferase (RNA-directed);
RNA-dependent ribonucleate nucleotidyltransferase;
3D polymerase;
PB1 proteins;
PB2 proteins;
phage f2 replicase;
polymerase L;
Q-beta replicase;
phage f2 replicase;
ribonucleic acid replicase;
ribonucleic acid-dependent ribonucleate nucleotidyltransferase;
ribonucleic acid-dependent ribonucleic acid polymerase;
ribonucleic replicase;
ribonucleic synthetase;
RNA replicase;
RNA synthetase;
RNA transcriptase;
RNA-dependent ribonucleate nucleotidyltransferase;
RDRP;
RNA-dependent RNA polymerase;
RNA-dependent RNA replicase;
transcriptase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Reaction(IUBMB)
nucleoside triphosphate + RNAn = diphosphate + RNAn+1 [RN:R00444]
Reaction(KEGG)
Substrate
nucleoside triphosphate [CPD:C00201];
RNAn [CPD:C00046]
Product
diphosphate [CPD:C00013];
RNAn+1 [CPD:C00046]
Comment
Catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase.
History
EC 2.7.7.48 created 1981, modified 1982
Orthology
K00985  Enterovirus RNA-directed RNA polymerase
K11699  RNA-dependent RNA polymerase
K19376  Morbillivirus RNA-directed RNA polymerase L
K19389  Influenza virus RNA-directed RNA polymerase catalytic subunit
K21316  Rhabdoviridae RNA-directed RNA polymerase L
K21924  Orthobornavirus RNA-directed RNA polymerase L
K22472  HCV RNA-dependent RNA polymerase
K25021  Coronaviridae RNA-directed RNA polymerase
K25303  Mammarenavirus RNA-dependent RNA polymerase L
K25309  Rotavirus RNA-directed RNA polymerase
K25311  Coltivirus RNA-directed RNA polymerase
K25323  Norovirus RNA-directed RNA polymerase
K25332  Flavivirus RNA-directed RNA polymerase NS5
K25333  Ebolavirus RNA-dependent RNA polymerase L
K25336  Marburgvirus RNA-dependent RNA polymerase L
K25345  Orthobunyavirus RNA-dependent RNA polymerase L
K25347  Orthonairovirus RNA-dependent RNA polymerase L
K25521  Respirovirus RNA-directed RNA polymerase L
K26131  Henipavirus RNA-directed RNA polymerase L
K26132  Orthorubulavirus RNA-directed RNA polymerase L
K26133  Pneumoviridae RNA-directed RNA polymerase L
K26134  Hantaviridae RNA-directed RNA polymerase L
K26140  Alphavirus RNA-directed RNA polymerase nsP4
Genes
BFO118420943 118427356 118428502 118428503 118429714
BBEL109481876 109482478 109482591 109483270 109486421
SKO100373859
EAF111701756
ISCIscW_ISCW001005 IscW_ISCW002744 IscW_ISCW004502 IscW_ISCW008904 IscW_ISCW008905 IscW_ISCW009270 IscW_ISCW018089
DSV119432954 119433454 119433620 119433862 119435580 119437001 119439287 119439367 119439416 119439527 119444391 119463244
RSAN119372084 119392810 119398745 119399513 119404543 119404960 119405282 119405482
RMP119177102 119177164 119179084 119179556 119181112 119181122 119181398 119185871 119187896
VDE111244709 111249053 111252784
VJA111259205 111262788 111263600 111267812
TUT107371323 107371324
DPTE113791671 113794713 113796940 113797127
DFR124496566 124496574 124497247 124499850
CSCU111615506 111615508 111615791 111619721 111620431 111625043 111627519 111628944 111629905 111635993 111638442
PTEP107437196 107439500 107441293 107442665 107443305 107448215 107457022
SDM118186841 118186842 118190586 118193877 118197259 118198167 118201431
LOALOAG_18837
NAINECAME_11510
TSPTsp_01517
CRG105327250 105327251 105343412 105343415 117689449
MYI110450676 110455096 110455102 110455104
PMAX117326693 117326802
LAK106181258
NVE116616211 116619673 5504594 5511133
EPA110231370 110234736 110252328 110252333 110252386 110252393
ATEN116288436 116288452 116288463 116288465 116291599 116292984
ADF107330332 107333406 107333407 107333443 107333465 107341164 107347032 107347042 107347247
AMIL114956239 114963256 114963261 114963262 114963263 114966049 114966061 114966062 114966064 114975959
PDAM113670596 113670610 113670612 113670620 113670621 113670622 113670624 113676949 113676950 113678531 113685027
SPIS111319571 111325017 111332042 111332043 111332045 111332061 111332062 111332063 111332090 111332098 111334347 111334362 111342587 111346331 111346816
DGT114515528 114521695 114521699
HMG105846434
ATHAT1G14790(RDR1) AT2G19910 AT2G19920 AT2G19930 AT3G49500(RDR6) AT4G11130(RDR2)
ALY9304548 9308620 9313749 9320032 9322080 9322081 9326139
CRB17882313 17886790 17890788 17893836 17900295
CSAT104702425 104707406 104711463 104719267 104737110 104743310 104747902 104747905 104755786 104766851 104766852 104767479 104773593 104780770 104791175 109133249
EUSEUTSA_v10001896mg EUTSA_v10001897mg EUTSA_v10006629mg EUTSA_v10010107mg EUTSA_v10028370mg
BRP103828268 103833901 103842618 103845422 103849572 103872274 103875370 117126499
BNA106346610 106357580 106360573 106368929 106374093 106376417 106376419 106400784 106412393 106422376 106424065 106436049 106436060 106439671 111198138
BOE106294140 106304791 106304792 106311438 106312177 106315087 106318727 106321534 106338572 106344377
RSZ108809592 108822350 108822351 108828213 108832396 108832413 108833825 108833826 108837663 108842298 108863141 108863590
THJ104805089 104807524 104807527 104808318 104818229
CPAP110809349 110809668 110823608 110823660
CIT102606638 102608479 102608769 102610690 102611197 102611878 102619723 102621864
CICCICLE_v10007331mg
PVY116105456 116105466 116105469 116108518 116114492 116115375 116115387 116118052 116127304 116132351 116133492 116133493 116135951 116142001 116146188 116146209
MINC123194546 123194547 123194714 123197382 123201499 123201500 123201501 123207306 123207413 123212223 123213656 123213657 123213658 123213659 123213660 123214681 123225543
TCC18587800 18591983 18603867 18610049 18610050
GRA105765743 105767380 105780729 105783092 105789401
GHI107906882 107913503 107920197 107932268 107939293 107939800 107940156 107958956 121216009 121216010 121228308
GAB108464563 108472273 108474016 108476570 108481748
DZI111282464 111285794 111285924 111286545 111291044 111303171 111317556 111317557 111318164 111318165
EGR104426281 104430467 104433045 104433047 104433049 104437676 104437677 104438229 104453649 104453651 104455625 104455627
GMX100789458 100795178 100801632(RDR3) 100805477 100807347 100808274 100811587
GSJ114384657 114392165 114407766 114408968 114411945 114414987 114419295
PVUPHAVU_003G016600g PHAVU_003G016800g PHAVU_003G198500g PHAVU_004G1764001 PHAVU_009G093700g
VRA106762333 106769296 106773122 106776843 106777533 106777534
VAR108319587 108331726 108335362 108335810 108335849 108345787
VUN114173223 114173255 114173336 114178500 114182675 114192384
CCAJ109790276 109808203 109812971 109812985 109817661
APRC113847054 113864777 113865950 113867379 113868710 113869241
MTR11407970 11431963 25482560 25482562 25482564 25482568 25496960
CAM101489233 101494491 101504917 101509076 101511942
LJALj0g3v0080799.1(Lj0g3v0080799.1) Lj1g3v1911730.1(Lj1g3v1911730.1) Lj2g3v0855300.1(Lj2g3v0855300.1) Lj2g3v0855300.2(Lj2g3v0855300.2) Lj2g3v0855300.3(Lj2g3v0855300.3) Lj2g3v1069050.1(Lj2g3v1069050.1) Lj2g3v1069050.2(Lj2g3v1069050.2) Lj4g3v1535110.1(Lj4g3v1535110.1)
ADU107463019 107463218 107466044 107468620 107490207 107492239
AIP107613197 107618033 107622585 107632394 107644422
AHF112695656 112707821 112707887 112711119 112714769 112722371 112751257 112772172 112772191 112775469 112783143 112802089
LANG109327001 109343732 109357377 109358499 109360794
FVE101291816 101292403 101296862 101296932 101302698 101302983 101303220 101311644
RCN112171683 112176776 112186259 112187799 112187801 112189880 112191540 112197020 112197021 112197120 112197951 112197953 112203092
PPER18771238 18776512 18780505 18789671 18791346 18793205 18793924
PMUM103319696 103320955 103320956 103321444 103323062 103325107 103325194 103338320 103340827 103344344
PAVI110748697 110750174 110751032 110762769 110762817 110762820 110763776 110766881 110773993 110774039
PDUL117614246 117614251 117615156 117626790 117626791 117627079 117633946 117634020 117634456 117635135
MDM103400767 103400768 103430640 103444585 103451530 103452960 103455234 103456206
PXB103943088 103943091 103943900 103944027 103946696 103947128 103947129
ZJU107405543 107405545 107406415 107406416 107406732 107408448 107418475 107421211 107429223 107429227 107429229 107429230
MNT112091389 21385159 21385698 21388985 21390198 21394175 21394878
CSV101205704 101206705 101206946(RDR1) 101209921 101213473 101214455 101217108
CMO103483034 103483036 103488305 103492255 103493922 103502906(RDR1a)
BHJ120067969 120070159 120071010 120071550 120075756 120080903
MCHA111004698 111007004 111014566 111015673 111015912 111015923
CMAX111485606 111487656 111489826 111490498 111490531 111491746 111499362
CMOS111429858 111430971 111436744 111444909 111447985 111447986 111462552
CPEP111780221 111788091 111791825 111793930 111800381 111805227 111808151
RCU8259458 8289038
JCU105633469 105634133 105634134 105637645 105637857 105640411
HBR110636355 110640470 110644682 110653668 110653703 110653704 110653710 110657879 110658863 110660470
MESC110599598 110601454 110603620 110603720 110604758 122722179
POP18100462 18100983 18109877 7457721 7457809 7459099 7462987 7468633 7471427
PEU105113913 105123745 105125519 105126434 105127046 105128224 105128568 105136162
PALZ118030227 118043606 118046450 118050284 118051216 118051998 118053858 118054358
JRE108983627 108986463 108987250 108992217 108999241 109007791 109007793 109009256 109011160 109018908 109018917
QSU111994326 111998328 111999320 112027217 112029785 112038837 112040507 112040590 112040640 112040662 112040663 112040670
QLO115963412 115971074 115971769 115972027 115972075 115974958 115975644 115979273 115979509 115980826 115980829 115981607
TWL119981034 119987816 119997213 120007613 120012982 120013455
VVI100260325 100260997 100262771 100262811 100268011
VRI117904459 117912535 117918933 117918943 117924514
SLY101055593 101250389 101252013 101257834 101263417 544124(RdRP)
SPEN107005181 107015037 107017736 107020639 107021779 107029057
SOT102578633 102578970 102579148 102590975 102602961 102603611
SSTN125841595 125856892 125860885 125861978 125866562 125866775 125874389
CANN107840980 107847444 107862408 107870116 107877592 107879082
NTA107773126 107774542 107778920 107788900 107796049 107798716(NtRDR6) 107814202 107815430 107827981 107828996
NSY104210787 104212718 104229185 104230071 104243134
NTO104089287 104098354 104109005 104114537 104114603
NAU109219850 109223750 109238504 109240225
INI109169571 109171882 109171889 109184805 109186425 109191160
ITR116003996 116007310 116012225 116019534 116025343 116025500 116025786
SIND105157186 105160121 105162051 105164250 105164582 105173547
OEU111367001 111368183 111376641 111376642 111396340 111399118 111407880
EGT105952205 105954547 105965523 105967512 105977177
SSPL121751294 121762034 121766325 121782538 121783934 121794903 121794905 121798025
HAN110872826 110872827 110872865 110915203 110917788 110917789 110918210 110930657
ECAD122582152 122585750 122586427 122586812 122589981 122594200 122597702 122604033
LSV111883367 111888043 111902636 111904376 111905283 111911903
CCAV112504627 112504877 112504970 112509884 112512332 112516794 112516800 112520213 112520462 112526324
DCR108192216 108192567 108196319 108202618 108204482 108214317 108219690 108219962
CSIN114257247 114262331 114268885 114272835 114289082 114289083 114292290 114318901
BVG104887440 104894239 104902283 104902284 104908673
SOE110779092 110779950 110786770 110788257 110788258 110788260 110788261 110788679 110790148
CQI110690952 110691085 110700419 110704409 110704985 110707697 110707698 110733596 110735246
NNU104592065 104592435 104595382 104607426 104607911 104610409
MING122061027 122061122 122061556 122067216 122074115 122074877 122078598 122079766 122079799 122080020 122081888 122081923 122093456 122093722 122094219
TSS122646145 122646634 122646635 122654284 122654286 122667048 122667049 122667050 122670062 122671028 122671755
PSOM113297929 113298335 113316527 113318239 113318814 113334689 113340976 113348172 113349194
NCOL116249516 116258401 116258796 116260444 116267407
OSA4323938 4327335 4327336 4330655 4336092
DOSAOs01t0197900-01(Os01g0197900) Os01t0198000-01(Os01g0198000) Os01t0527600-01(Os01g0527600) Os04t0465700-01(Os04g0465700)
OBR102699682 102701962 102702237 102710170 102714535
BDI100821561 100829667 100830376 100844989 104582839
ATS109740747 109755585 109755586 109759488 109769276 109770706 109774018 109781451
TDC119267448 119267449 119267450 119270496 119278640 119279439 119285524 119317801 119325472 119325595 119341251 119355419 119364541 119364543
TAES123045701 123045704 123053573 123053576 123060582 123060583 123069192 123069194 123072503 123076182 123077715 123080716 123085656 123098132 123128326 123128327 123138175 123138176 123145431 123156924 123189475
TUA125528004 125531168 125538641 125538643 125543113 125543114 125551921
SBI8058444 8066011 8072152 8073554 8075421 8075746 8084336
ZMA100274261 100384503 100502460 100502529 103638848 103640184
SITA101767540 101769532 101769940 101770455 101775178 101778059 101778544 101786991
SVS117837237 117857969 117859987 117860364 117863962 117864070
PVIR120639761 120641083 120642357 120657167 120657169 120672833 120676794 120677917 120679097 120679337 120681587 120681702 120681788 120682917 120684039 120694008 120707067 120709424 120713243
PHAI112887224 112893464 112898051 112898726 112899380
PDA103698619 103700847 103708395 103723736 120111660
EGU105039189 105041461 105042112 105045403
MUS103969591 103969723 103972704 103973036 103976045
DCT110094757 110100676 110100972 110113272
PEQ110018923 110027480 110028517 110030584
AOF109826065 109840313 109842359 109844456
ATR18427525 18431895 18431896 18439576 18443413
SMOSELMODRAFT_126929 SELMODRAFT_150191 SELMODRAFT_235652 SELMODRAFT_413790 SELMODRAFT_431698 SELMODRAFT_448382
PPP112276617 112282733 112283568 112296087
MNGMNEG_1492
CSLCOCSUDRAFT_20637
NCRNCU02178(sad-1)
NTENEUTE1DRAFT149305(NEUTE1DRAFT_149305)
SMPSMAC_05269
PANPODANSg4487
TTTTHITE_2048877
MTMMYCTH_2297939
CTHRCTHT_0012940
MGRMGG_02748
PPEIPpBr36_09682
TMNUCRPA7_2815
SSCKSPSK_02932
FGRFGSG_08716
FPUFPSE_07701
FVRFVEG_01945 FVEG_15719
FOXFOXG_03081
NHENECHADRAFT_91974(RDR2103)
TRETRIREDRAFT_103470
TRRM419DRAFT_90611
MAWMAC_00872
MAJMAA_07362
CMTCCM_03262
PLJVFPFJ_00358
VALVDBG_02071
VDAVDAG_02528
CFJCFIO01_12459
CLUPCLUP02_08815
CHIGCH63R_07506
SAPOSAPIO_CDS7473
ELAUCREL1_5479
PFYPFICI_02795
SSLSS1G_13161
BFUBCIN_01g01810
MBEMBM_00675
PSCOLY89DRAFT_361884
GLZGLAREA_08123
ANIAN4790.2
AFMAFUA_3G06790
ACTACLA_034760
NFINFIA_070460
AORAO090020000318
ANGANI_1_2480094(An11g09540)
AFVAFLA_010349
ALUCAKAW2_80811S
ACHEACHE_70399S
APUUAPUU_31102S
PCSPc20g02950
PDPPDIP_09310
TMFPMAA_003080
TRGTRUGW13939_11082
CIMCIMG_00395
CPWCPC735_058150
UREUREG_00448
PBLPAAG_03813
PBNPADG_11586
ABEARB_07328
TVETRV_04770
AJEHCAG_07234
BGHBDBG_00773
PNOSNOG_00237
PTEPTT_17559
BZECOCCADRAFT_10243 COCCADRAFT_82125
BSCCOCSADRAFT_354694
BORCOCMIDRAFT_24397
AALTCC77DRAFT_7868
ZTRMYCGRDRAFT_51407(RDR2402)
PFJMYCFIDRAFT_202751
FFUCLAFUR5_14313
BCOMBAUCODRAFT_67567
NPAUCRNP2_9253
TMLGSTUM_00008250001
SPOSPAC6F12.09(rdp1)
CNECNG01230
CNBCNBG3560
CNGCNAG_03466
CGICGB_G5150C
TMSTREMEDRAFT_74213
TASAA1Q1_01210 A1Q1_01432 A1Q1_05020
PPLPOSPLDRAFT_103190 POSPLDRAFT_104078 POSPLDRAFT_90441 POSPLDRAFT_91083 POSPLDRAFT_97976
TVSTRAVEDRAFT_116047 TRAVEDRAFT_120043 TRAVEDRAFT_139911 TRAVEDRAFT_59189
DSQDICSQDRAFT_132296 DICSQDRAFT_164456 DICSQDRAFT_55194 DICSQDRAFT_63701 DICSQDRAFT_80852 DICSQDRAFT_95170
PCOPHACADRAFT_118286 PHACADRAFT_161565 PHACADRAFT_168316 PHACADRAFT_173398 PHACADRAFT_173705 PHACADRAFT_173707 PHACADRAFT_201955
SHSSTEHIDRAFT_101865 STEHIDRAFT_117647 STEHIDRAFT_119644 STEHIDRAFT_124929 STEHIDRAFT_137322 STEHIDRAFT_139256 STEHIDRAFT_170031 STEHIDRAFT_73750 STEHIDRAFT_96893
HIRHETIRDRAFT_309978 HETIRDRAFT_318296 HETIRDRAFT_443820
PSQPUNSTDRAFT_122140 PUNSTDRAFT_139475 PUNSTDRAFT_144738
ADLAURDEDRAFT_109701 AURDEDRAFT_111135 AURDEDRAFT_114369 AURDEDRAFT_179816 AURDEDRAFT_181733 AURDEDRAFT_79747 AURDEDRAFT_83259
GTRGLOTRDRAFT_135659 GLOTRDRAFT_136725 GLOTRDRAFT_36051
LBCLACBIDRAFT_311867 LACBIDRAFT_315790(RDR16201)
CCICC1G_00360 CC1G_03668 CC1G_05505 CC1G_12290
ABPAGABI1DRAFT127795(AGABI1DRAFT_127795) AGABI1DRAFT56570(AGABI1DRAFT_56570) AGABI1DRAFT56593(AGABI1DRAFT_56593) AGABI1DRAFT66661(AGABI1DRAFT_66661) AGABI1DRAFT72859(AGABI1DRAFT_72859)
ABVAGABI2DRAFT117230(AGABI2DRAFT_117230) AGABI2DRAFT205003(AGABI2DRAFT_205003) AGABI2DRAFT205025(AGABI2DRAFT_205025) AGABI2DRAFT214572(AGABI2DRAFT_214572) AGABI2DRAFT220313(AGABI2DRAFT_220313)
MRRMoror_112 Moror_2579 Moror_3929 Moror_7426 Moror_8374 Moror_9807
MOREE1B28_008320 E1B28_008326
SCMSCHCO_01153940(SCHCODRAFT_01153940) SCHCO_02483397(SCHCODRAFT_02483397) SCHCO_02506699(SCHCODRAFT_02506699)
CPUTCONPUDRAFT_114545 CONPUDRAFT_115565 CONPUDRAFT_162201 CONPUDRAFT_64357 CONPUDRAFT_68887
SLASERLADRAFT_417518 SERLADRAFT_432597
PFPPFL1_06447
PGRPGTG_02834 PGTG_05092 PGTG_09533 PGTG_17766 PGTG_20838
MLRMELLADRAFT_103030 MELLADRAFT_114044 MELLADRAFT_64236
DFADFA_00541(rrpB)
EHIEHI_139420(171.t00022)
EDIEDI_284080
EIVEIN_150930
TETTTHERM_00853150
PTMGSPATT00018564001 GSPATT00024768001 GSPATT00036857001
SMINv1.2.028223.t1(symbB.v1.2.028223.t1)
PIFPITG_10457
PSOJPHYSODRAFT_558487
SPARSPRG_00698 SPRG_15273 SPRG_15276 SPRG_17963 SPRG_22099
EHXEMIHUDRAFT_205162 EMIHUDRAFT_99932
NGRNAEGRDRAFT_1269 NAEGRDRAFT_47340 NAEGRDRAFT_53874 NAEGRDRAFT_57625 NAEGRDRAFT_64904 NAEGRDRAFT_67488 NAEGRDRAFT_67961 NAEGRDRAFT_72038 NAEGRDRAFT_81763
GLAGL50803_00102515
 » show all
Reference
1
  Authors
August, J.T., Cooper, S., Shapiro, L. and Zinder, N.D.
  Title
RNA phage induced RNA polymerase.
  Journal
Cold Spring Harbour Symp Quant Biol 28:95-97 (1963)
Reference
2  [PMID:14082356]
  Authors
HARUNA I, NOZU K, OHTAKA Y, SPIEGELMAN S
  Title
AN RNA "REPLICASE" INDUCED BY AND SELECTIVE FOR A VIRAL RNA: ISOLATION AND PROPERTIES.
  Journal
Proc Natl Acad Sci U S A 50:905-11 (1963)
DOI:10.1073/pnas.50.5.905
Reference
3  [PMID:13999778]
  Authors
WEISSMANN C, SIMON L, OCHOA S
  Title
Induction by an RNA phage of an enzyme catalyzing incorporation of ribonucleotides into ribonucleic acid.
  Journal
Proc Natl Acad Sci U S A 49:407-14 (1963)
DOI:10.1073/pnas.49.3.407
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.48
IUBMB Enzyme Nomenclature: 2.7.7.48
ExPASy - ENZYME nomenclature database: 2.7.7.48
BRENDA, the Enzyme Database: 2.7.7.48
CAS: 9026-28-2

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