KEGG   ENZYME: 2.7.7.64Help
Entry
EC 2.7.7.64                 Enzyme                                 

Name
UTP-monosaccharide-1-phosphate uridylyltransferase;
UDP-sugar pyrophosphorylase;
PsUSP
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Reaction(IUBMB)
UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide [RN:R08845]
Reaction(KEGG)
Substrate
UTP [CPD:C00075];
monosaccharide 1-phosphate [CPD:C00991]
Product
diphosphate [CPD:C00013];
UDP-monosaccharide [CPD:C05227]
Comment
Requires Mg2+ or Mn2+ for maximal activity. The reaction can occur in either direction and it has been postulated that MgUTP and Mg-diphosphate are the actual substrates [1,2]. The enzyme catalyses the formation of UDP-Glc, UDP-Gal, UDP-GlcA, UDP-L-Ara and UDP-Xyl, showing broad substrate specificity towards monosaccharide 1-phosphates. Mannose 1-phosphate, L-Fucose 1-phosphate and glucose 6-phosphate are not substrates and UTP cannot be replaced by other nucleotide triphosphates [1].
History
EC 2.7.7.64 created 2006
Pathway
ec00040  Pentose and glucuronate interconversions
ec00052  Galactose metabolism
ec00053  Ascorbate and aldarate metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K12447  UDP-sugar pyrophosphorylase
Genes
RSS: 109440828
ATH: AT5G52560(USP)
ALY: ARALYDRAFT_495327
CRB: 17875462
CSAT: 104725768 104727645 104761268
EUS: EUTSA_v10000457mg
BRP: 103842186
BNA: 106368564 106415929
BOE: 106307311
THJ: 104808371
CIT: 102628031
TCC: 18592423
EGR: 104450548
VRA: 106762599
VAR: 108332148
CCAJ: 109796895
CAM: 101505137
LJA: Lj0g3v0214629.1(Lj0g3v0214629.1) Lj0g3v0214629.2(Lj0g3v0214629.2)
ADU: 107460668
AIP: 107606001
LANG: 109344323
FVE: 101297604
PPER: 18790905
PMUM: 103319759
PAVI: 110766413
MDM: 103456258
ZJU: 107421126
CSV: 101202798
CMO: 103485690(UGGPase)
MCHA: 111011819
CMAX: 111487149
CMOS: 111462581
CPEP: 111802306
RCU: 8270969
JCU: 105639006
POP: 7467856
VVI: 100259254
SLY: 101247010
SOT: 102596087
CANN: 107852493
NSY: 104232978
NTO: 104119089
INI: 109170461
SIND: 105180105
LSV: 111901456
DCR: 108204601
BVG: 104894442
SOE: 110782013
NNU: 104606683
OSA: 4341967
DOSA: Os06t0701200-01(Os06g0701200)
OBR: 102704348
BDI: 100845164
ATS: 109751835(LOC109751835)
SBI: 8065566
PDA: 103713110
EGU: 105049301
DCT: 110114106
AOF: 109850719
ATR: 18424675
CRE: CHLREDRAFT_32796(UAP2)
MNG: MNEG_4914
APRO: F751_3978
PYO: PY17X_1235700(PY05379)
PCB: PCHAS_123290(PC301053.00.0)
CPV: cgd7_1830
SMIN: v1.2.004770.t1(symbB.v1.2.004770.t1) v1.2.004770.t2(symbB.v1.2.004770.t2) v1.2.011414.t1(symbB.v1.2.011414.t1)
LMA: LMJF_17_1160(USP)
LIF: LINJ_17_1260(USP)
LBZ: LBRM_17_1270(USP)
CAA: Caka_1908
 » show all
Taxonomy
Reference
1  [PMID:15326166]
  Authors
Kotake T, Yamaguchi D, Ohzono H, Hojo S, Kaneko S, Ishida HK, Tsumuraya Y.
  Title
UDP-sugar pyrophosphorylase with broad substrate specificity toward various monosaccharide 1-phosphates from pea sprouts.
  Journal
J Biol Chem 279:45728-36 (2004)
DOI:10.1074/jbc.M408716200
  Sequence
Reference
2  [PMID:4430676]
  Authors
Rudick VL, Weisman RA.
  Title
Uridine diphosphate glucose pyrophosphorylase of Acanthamoeba castellanii. Purification, kinetic, and developmental studies.
  Journal
J Biol Chem 249:7832-40 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.64
IUBMB Enzyme Nomenclature: 2.7.7.64
ExPASy - ENZYME nomenclature database: 2.7.7.64
BRENDA, the Enzyme Database: 2.7.7.64

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