KEGG   ENZYME: 2.7.7.66Help
Entry
EC 2.7.7.66                 Enzyme                                 

Name
malonate decarboxylase holo-[acyl-carrier protein] synthase;
holo ACP synthase (ambiguous);
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo ACP 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA transferase;
MdcG;
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-malonate-decarboxylase adenylyltransferase;
holo-malonate-decarboxylase synthase (incorrect)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-malonate-decarboxylase 2'-(5-phosphoribosyl)-3'-dephospho-CoA-transferase
Reaction(IUBMB)
2'-(5-triphosphoribosyl)-3'-dephospho-CoA + malonate decarboxylase apo-[acyl-carrier protein] = malonate decarboxylase holo-[acyl-carrier protein] + diphosphate [RN:R10706]
Reaction(KEGG)
Substrate
2'-(5-triphosphoribosyl)-3'-dephospho-CoA [CPD:C19771];
malonate decarboxylase apo-[acyl-carrier protein]
Product
malonate decarboxylase holo-[acyl-carrier protein];
diphosphate [CPD:C00013]
Comment
The delta subunit of malonate decarboxylase serves as an an acyl-carrier protein (ACP) and contains the prosthetic group 2-(5-triphosphoribosyl)-3-dephospho-CoA. Two reactions are involved in the production of the holo-ACP form of this enzyme. The first reaction is catalysed by EC 2.4.2.52, triphosphoribosyl-dephospho-CoA synthase. The resulting prosthetic group is then attached to the ACP subunit via a phosphodiester linkage to a serine residue, thus forming the holo form of the enzyme, in a manner analogous to that of EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase.
History
EC 2.7.7.66 created 2008
Orthology
K13934  phosphoribosyl-dephospho-CoA transferase
Genes
EFE: EFER_3133
SES: SARI_04163
ENT: Ent638_3773
ENC: ECL_04721
ENO: ECENHK_20495
ECLO: ENC_25560
EEC: EcWSU1_04145(mdcG)
ENL: A3UG_20980
ECLG: EC036_40920
ECLE: ECNIH2_21510
ECLX: LI66_20765
ECLY: LI62_22750
ECLZ: LI64_19850
ENF: AKI40_0445(mdcG)
CTU: CTU_35010
KPN: KPN_01559
KPU: KP1_2574
KPP: A79E_2681
KPT: VK055_0945(mdcG)
KPE: KPK_2900(mdcG)
KPR: KPR_2752(mdcG)
KPJ: N559_2768
KPX: PMK1_03876(mdcG)
KPNU: LI86_13810
KPNK: BN49_2669(mdcG)
KVA: Kvar_2801
KOX: KOX_21670
KOE: A225_3207
EAE: EAE_18260
EAR: CCG30239
CKO: CKO_04763
CRO: ROD_44631(mdcG)
CAMA: F384_01120
EBT: EBL_c35250(mdcG)
EBF: D782_0357
SMAF: D781_3738
RAA: Q7S_01175
DDQ: DDI_1353
PVA: Pvag_2974(mdcG)
PSI: S70_04115
PSX: DR96_1(mdcG)
PRG: RB151_030980(mdcG)
PHEI: NCTC12003_01197(mdcG)
XCC: XCC3613(mdcE)
XCB: XC_0576
XCA: xcc-b100_0593(mdcG)
XCP: XCR_3940
XCV: XCV0598(mdcG)
XAX: XACM_0555(mdcG)
XAC: XAC0564(mdcE)
XCI: XCAW_00978(mdcE)
XFU: XFF4834R_chr05600(mdcG)
XPH: XppCFBP6546_08910(XppCFBP6546P_08910)
XVA: C7V42_02950(mdcG)
SML: Smlt1228
SMT: Smal_1077
SMZ: SMD_1149
STEN: CCR98_05730(mdcG)
STEM: CLM74_05740(mdcG)
PAE: PA0213
PAEV: N297_219(mdcG)
PAEI: N296_219(mdcG)
PAU: PA14_02610(mdcG)
PAP: PSPA7_0297(mdcG)
PNC: NCGM2_0218(mdcG)
PAEB: NCGM1900_0203(mdcG)
PAEP: PA1S_01100
PAEM: U769_01060
PAEL: T223_01050
PAEG: AI22_02845
PAEC: M802_218(mdcG)
PAEO: M801_219(mdcG)
PMK: MDS_0239
PRE: PCA10_01860(mdcG)
PPT: PPS_2970
PPUH: B479_14765
PPUT: L483_18310
PPUN: PP4_23670(mdcG)
PPUD: DW66_3233
PMON: X969_14220
PMOT: X970_13865
PSB: Psyr_0447
PSYR: N018_02140
PFL: PFL_5815(mdcG)
PPRC: PFLCHA0_c57700(mdcG)
PPRO: PPC_5762
PFS: PFLU_5738
PFE: PSF113_5516(mdcG)
PFC: PflA506_5037(mdcG)
PFW: PF1751_v1c51600(mdcG)
PFB: VO64_2621
PMAN: OU5_3879(mdcG)
PSA: PST_4115
PSTT: CH92_21545
PPUU: PputUW4_05094(mdcG)
PSES: PSCI_2026
PSEM: TO66_29415
PSOS: POS17_5752
PANR: A7J50_5468
PSET: THL1_150
PSIL: PMA3_28325
AVN: Avin_10330(mdcG)
AVL: AvCA_10330(mdcG)
AVD: AvCA6_10330(mdcG)
ACX: Achr_31780(mdcG)
PAR: Psyc_1142(mdcE)
PALI: A3K91_1688
ACB: A1S_1426
ABY: ABAYE2228(mdcG)
ABN: AB57_1659
ABB: ABBFA_002061(mdcG)
ABX: ABK1_1919
ABH: M3Q_1821
ABAD: ABD1_14270(mdcG)
ABAZ: P795_10070
ABAU: IX87_03100
ABAA: IX88_09095
ACC: BDGL_000811(mdcG)
ACI: ACIAD1758(mdcG)
PIN: Ping_3655
LPN: lpg2429(mdcG)
LPH: LPV_2750(mdcG)
LPO: LPO_2619(mdcG)
LPM: LP6_2457(mdcG)
LPP: lpp2496
LPC: LPC_2047(mdcG)
LPA: lpa_03542
LPE: lp12_2421
LLO: LLO_2544
LFA: LFA_0135
LOK: Loa_02048
LSH: CAB17_18030(mdcG)
TMC: LMI_1330
SALN: SALB1_2481
PSE: NH8B_2985(mdcG)
RPI: Rpic_4946
RIN: ACS15_5437(mdcG)
CNC: CNE_1c16500(mdcG)
BMA: BMA3033(mdcG)
BMV: BMASAVP1_A1260(mdcG)
BML: BMA10229_A0610(mdcG)
BMN: BMA10247_0543(mdcG)
BMAL: DM55_2722(mdcG)
BMAE: DM78_2262(mdcG)
BMAQ: DM76_2706(mdcG)
BMAI: DM57_2819
BMAF: DM51_2637(mdcG)
BMAZ: BM44_2487(mdcG)
BMAB: BM45_2052(mdcG)
BPS: BPSL1333
BPM: BURPS1710b_1587(mdcG)
BPL: BURPS1106A_1486(mdcG)
BPD: BURPS668_1456(mdcG)
BPR: GBP346_A1489(mdcG)
BPSE: BDL_683(mdcG)
BPSM: BBQ_2110(mdcG)
BPSU: BBN_2236(mdcG)
BPSD: BBX_2624(mdcG)
BPK: BBK_187(mdcG)
BPSH: DR55_3265(mdcG)
BPSA: BBU_860(mdcG)
BPSO: X996_2872(mdcG)
BUT: X994_1332(mdcG)
BTE: BTH_I2799
BTQ: BTQ_1220(mdcG)
BTJ: BTJ_1213(mdcG)
BTZ: BTL_2448(mdcG)
BTD: BTI_2497(mdcG)
BTV: BTHA_2634(mdcG)
BTHE: BTN_2210(mdcG)
BTHM: BTRA_2805(mdcG)
BTHA: DR62_2445
BTHL: BG87_2696(mdcG)
BOK: DM82_775(mdcG)
BOC: BG90_242(mdcG)
BVE: AK36_2675(mdcG)
BCN: Bcen_0792
BCJ: BCAL1244
BCEN: DM39_1151(mdcG)
BCEW: DM40_1927(mdcG)
BCEO: I35_1157
BAM: Bamb_1151
BMU: Bmul_2046
BMJ: BMULJ_01198(mdcG)
BMK: DM80_379(mdcG)
BMUL: NP80_1361(mdcG)
BCT: GEM_2182
BCED: DM42_447(mdcG)
BDL: AK34_1894(mdcG)
BCON: NL30_09295
BUB: BW23_466(mdcG)
BLAT: WK25_06360
BTEI: WS51_16705
BSEM: WJ12_06255
BPSL: WS57_24085
BMEC: WJ16_06030
BSTG: WT74_06550
BGP: BGL_1c12110(mdcG)
BGU: KS03_2054(mdcG)
BGO: BM43_2653(mdcG)
BUK: MYA_1151
BUL: BW21_2513(mdcG)
BXE: Bxe_B1849
BXB: DR64_7156(mdcG)
BPH: Bphy_5082
BFN: OI25_4301(mdcG)
PLG: NCTC10937_05018(mdcG)
AMIM: MIM_c07940
AFQ: AFA_04480(mdcG)
ODI: ODI_R0984
RFR: Rfer_1847
PNA: Pnap_0951
VEI: Veis_2892
DAC: Daci_1764
MPT: Mpe_A0790
HAR: HEAR1473
MMS: mma_0108(mdcG1) mma_2559(mdcG2)
JAG: GJA_2730(mdcG)
HSE: Hsero_2680(mdcG)
HRB: Hrubri_2766(mdcG)
HEE: hmeg3_12670(mdcG)
CFU: CFU_1712(mdcE)
CARE: LT85_3017
CPRA: CPter91_2203(mdcG)
MASS: CR152_24345(mdcG)
MTIM: DIR46_04285(mdcG)
OFO: BRW83_1383(mdcG)
LCH: Lcho_0075
DAR: Daro_4016
AZA: AZKH_1586(mdcG)
ATW: C0099_10795(mdcG)
CCX: COCOR_05849(mdcG)
CCRO: CMC5_081270(mdcG)
BJA: bll0266(mdcG) bll1273(mdcG)
BRS: S23_13510(mdcG)
RPB: RPB_3293
OCA: OCAR_6868(mdcG)
OCG: OCA5_c12110(mdcG)
OCO: OCA4_c12110(mdcG)
SNO: Snov_1211
MEX: Mext_0028
MDI: METDI0028
MCH: Mchl_0029
MPO: Mpop_0050
MET: M446_6853
MNO: Mnod_3155
MOR: MOC_0178(mdcG)
META: Y590_00180
MEE: DA075_34105(mdcG)
METD: C0214_00185(mdcG)
MSL: Msil_3188
HDI: HDIA_0495
RCP: RCAP_rcp00125(mdcG)
SWI: Swit_4290
STAX: MC45_04610
ROS: CTJ15_14410(mdcG)
RRU: Rru_A1327
RRF: F11_06865
NAO: Y958_23545(mdcG)
BPF: BpOF4_11990(mdcG)
BMQ: BMQ_0800(mdcG)
BMD: BMD_0801(mdcG)
BMEG: BG04_3095(mdcG)
BEO: BEH_05670
BKW: BkAM31D_07980(mdcG)
PPOL: X809_35655
SIV: SSIL_3613
EFU: HMPREF0351_10356(mdcG)
EFM: M7W_527
ECAS: ECBG_00930
EDU: LIU_13395
PFT: JBW_01395
MSM: MSMEG_6631(mdcG)
 » show all
Taxonomy
Reference
1  [PMID:11052675]
  Authors
Hoenke S, Wild MR, Dimroth P.
  Title
Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase.
  Journal
Biochemistry 39:13223-32 (2000)
DOI:10.1021/bi0011532
  Sequence
[kpn:KPN_01559]
Reference
2  [PMID:11052676]
  Authors
Hoenke S, Schmid M, Dimroth P.
  Title
Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases.
  Journal
Biochemistry 39:13233-40 (2000)
DOI:10.1021/bi001154u
  Sequence
[kpn:KPN_01559]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.66
IUBMB Enzyme Nomenclature: 2.7.7.66
ExPASy - ENZYME nomenclature database: 2.7.7.66
BRENDA, the Enzyme Database: 2.7.7.66

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