KEGG   ENZYME: 2.7.7.67Help
Entry
EC 2.7.7.67                 Enzyme                                 

Name
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase;
carS (gene name);
CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase;
CTP:2,3-GG-GP ether cytidylyltransferase;
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase;
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase;
CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase;
CDP-unsaturated archaeol synthase;
CDP-archaeol synthase (incorrect)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol [RN:R08966]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
Product
diphosphate [CPD:C00013];
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
Comment
This enzyme catalyses one of the steps in the biosynthesis of polar lipids in archaea, which are characterized by having an sn-glycerol 1-phosphate backbone rather than an sn-glycerol 3-phosphate backbone as is found in bacteria and eukaryotes [1]. The enzyme requires Mg2+ and K+ for maximal activity [1].
History
EC 2.7.7.67 created 2009, modified 2014
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K19664  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
Genes
MHC: MARHY3241
MAD: HP15_3131
MSR: AU15_17460
MARI: ACP86_06245
MLQ: ASQ50_07895
MSQ: BKP64_17980
MARA: D0851_09735
NWA: Nwat_2678
TVI: Thivi_0225
TMB: Thimo_1259
HCH: HCH_02040(cdsA)
SVA: SVA_0598
BRS: S23_36500
MCG: GL4_0229
MJA: MJ_1600
MMP: MMP1698
MMD: GYY_09365
MAE: Maeo_1211
MVO: Mvol_1258
MTH: MTH_832
METC: MTCT_0746
MWO: MWSIV6_1209(carS)
METE: tca_00799
MST: Msp_0385
MSI: Msm_0850
MRU: mru_1693
MEB: Abm4_0509
MMIL: sm9_1776
MEYE: TL18_07940
MOL: YLM1_1161
METH: MBMB1_0693
MFC: BRM9_1502
MCUB: MCBB_0704(carS)
MFV: Mfer_0208
MKA: MK1073(cdsA)
AFU: AF_1740
FPL: Ferp_2014
GAC: GACE_1587
GAH: GAH_00166
TAC: Ta0107
TVO: TVG0192666(TVG0192666)
PTO: PTO1104
FAI: FAD_0022
CDIV: CPM_1888
MARC: AR505_1616
ABI: Aboo_1071
PHO: PH0343(PH0343)
PAB: PAB1285
PFU: PF0398
PFI: PFC_01075
PYN: PNA2_0955
PYS: Py04_0654
TKO: TK2119
TON: TON_1624
TGA: TGAM_2129
TSI: TSIB_1853
THE: GQS_07300
THA: TAM4_297
THM: CL1_1098
TLT: OCC_07371
THS: TES1_1802
TNU: BD01_1847
TEU: TEU_02180
PPAC: PAP_07885
MAC: MA_3306
MBAR: MSBR2_0091
MBAK: MSBR3_0103
MMA: MM_0141
MMAC: MSMAC_2529
METM: MSMTP_1153
MTHE: MSTHC_0619
MTHR: MSTHT_0110
MHOR: MSHOH_1382
MBU: Mbur_1051
MMET: MCMEM_1528
MMH: Mmah_0606
MPY: Mpsy_1082
MTP: Mthe_1386
MCJ: MCON_1076
MHI: Mhar_2089
MHU: Mhun_1107
MLA: Mlab_0318
MEMA: MMAB1_2497
MPI: Mpet_1312
MBN: Mboo_0842
MPL: Mpal_2361
MEZ: Mtc_0822
RCI: RCIX520
HAL: VNG_2119C
HSL: OE_3954R
HHB: Hhub_3406
HALH: HTSR_0279
HHSR: HSR6_0265
HMA: rrnAC3084
HHI: HAH_0338
NPH: NP_0990A(carS)
NMO: Nmlp_1221
HUT: Huta_0926
HTI: HTIA_0779
HMU: Hmuk_1106
HWA: HQ_3230A(carS)
HWC: Hqrw_3793(carS)
HVO: HVO_0332(carS)
HME: HFX_0317(cdsA)
HLA: Hlac_0350
HTU: Htur_2944
NMG: Nmag_0950(carS)
NAT: NJ7G_2173
SALI: L593_07400
APE: APE_0433
ACJ: ACAM_0313
SMR: Smar_0617
IHO: Igni_0763
IIS: EYM_07025
DKA: DKAM_0148
TAG: Tagg_1160
IAG: Igag_1133
HBU: Hbut_1639
STO: STK_04650
SSO: SSO0776
SOL: Ssol_1837
SSOA: SULA_1867
SSOL: SULB_1868
SSOF: SULC_1866
SAI: Saci_0897
SID: M164_1356
SII: LD85_1487
SIH: SiH_1309
SIR: SiRe_1225
SIC: SiL_1222
MSE: Msed_2040
MCN: Mcup_0242
AHO: Ahos_0527
PAI: PAE0660
PIS: Pisl_0708
PCL: Pcal_2086
PAS: Pars_2316
PYR: P186_2173
POG: Pogu_2549
TNE: Tneu_1958
CMA: Cmaq_0732
TUZ: TUZN_1828
TTN: TTX_1683
VDI: Vdis_0355
VMO: VMUT_1277
TPE: Tpen_0433
ASC: ASAC_1228
ACIA: SE86_07310
MARH: Mia14_0125
KCR: Kcr_1437
BARC: AOA65_2317
 » show all
Taxonomy
Reference
1  [PMID:10960477]
  Authors
Morii H, Nishihara M, Koga Y
  Title
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.
  Journal
J Biol Chem 275:36568-74 (2000)
DOI:10.1074/jbc.M005925200
Reference
2  [PMID:12562787]
  Authors
Morii H, Koga Y
  Title
CDP-2,3-Di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus.
  Journal
J Bacteriol 185:1181-9 (2003)
DOI:10.1128/JB.185.4.1181-1189.2003
Reference
3  [PMID:25219966]
  Authors
Jain S, Caforio A, Fodran P, Lolkema JS, Minnaard AJ, Driessen AJ
  Title
Identification of CDP-archaeol synthase, a missing link of ether lipid biosynthesis in Archaea.
  Journal
Chem Biol 21:1392-401 (2014)
DOI:10.1016/j.chembiol.2014.07.022
  Sequence
[afu:AF_1740]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.67
IUBMB Enzyme Nomenclature: 2.7.7.67
ExPASy - ENZYME nomenclature database: 2.7.7.67
BRENDA, the Enzyme Database: 2.7.7.67
CAS: 329791-09-5

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