KEGG   ENZYME: 2.7.7.71Help
Entry
EC 2.7.7.71                 Enzyme                                 

Name
D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase;
hddC (gene name);
gmhD (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Reaction(IUBMB)
D-glycero-alpha-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-alpha-D-manno-heptose + diphosphate [RN:R09772]
Reaction(KEGG)
Substrate
D-glycero-alpha-D-manno-heptose 1-phosphate [CPD:C19880];
GTP [CPD:C00044]
Product
GDP-D-glycero-alpha-D-manno-heptose [CPD:C19881];
diphosphate [CPD:C00013]
Comment
The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria.
History
EC 2.7.7.71 created 2010
Pathway
ec00540  Lipopolysaccharide biosynthesis
Orthology
K15669  D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Genes
YPB: YPTS_1057
YPQ: DJ40_1346
YPU: BZ21_256
YPR: BZ20_1033
YPC: BZ23_532
PLU: plu4824(wblY)
PLUM: A4R40_23995
PGB: H744_2c2396
PPB: PPUBIRD1_1474
SBB: Sbal175_1479
AMAG: I533_13330
HCH: HCH_06180
TOL: TOL_2195
BMA: BMA2294(hddC)
BMV: BMASAVP1_A0534(hddC)
BML: BMA10229_A1066(wcbM)
BMN: BMA10247_2172(wcbM)
BMAL: DM55_1490
BMAE: DM78_2664
BMAQ: DM76_1468
BMAI: DM57_1069
BMAF: DM51_1935
BMAZ: BM44_1069
BMAB: BM45_2460
BPS: BPSL2794(wcbM)
BPM: BURPS1710b_3290(wcbM)
BPL: BURPS1106A_3276(wcbM)
BPD: BURPS668_3241(wcbM)
BPSE: BDL_2651
BPSM: BBQ_515
BPSU: BBN_643
BPSD: BBX_1049
BPZ: BP1026B_I0516(wcbM)
BPK: BBK_2136
BPSH: DR55_1724
BPSA: BBU_2768
BPSO: X996_1364
BUT: X994_3362
BTD: BTI_922
BTHA: DR62_527
BCEW: DM40_4221
BLAT: WK25_23470
NET: Neut_0159
MEH: M301_2250
CJE: Cj1423c(hddC)
CJB: BN148_1423c(hddC)
CJS: CJS3_1516
CJEJ: N564_02350
CJEU: N565_02430
CJEN: N755_02485
CJEI: N135_01513
CJER: H730_08135
CJY: QZ67_01562(hddC_2)
CJQ: UC78_1364(hddC_2)
CJR: CJE1608
CCF: YSQ_01745
CIS: CINS_0294
CCUN: CCUN_1150
CLX: CLAN_0154
GLO: Glov_0792
CSE: Cseg_1878
MAGX: XM1_1801
ASOC: CB4_00634(hddC)
CAC: CA_C3056
CAE: SMB_G3092
CAY: CEA_G3062
AOC: Aocu_04610(hddC)
EYY: EGYY_07220(GCD1)
SYY: SYNGTS_2223(slr0007)
SYT: SYNGTI_2222(slr0007)
SYS: SYNPCCN_2221(slr0007)
SYQ: SYNPCCP_2221(slr0007)
MAR: MAE_55660
MPK: VL20_391
GEN: GM3709_95
SNG: SNE_A16750(mpg1)
FVA: FV113G1_09570(hddC)
TLI: Tlie_1237
BTH: BT_0476
BTHO: Btheta7330_02886(hddC_2)
CPI: Cpin_3113
FLN: FLA_2279
PAA: Paes_1744
NDE: NIDE3423
 » show all
Taxonomy
Reference
1  [PMID:11279237]
  Authors
Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P
  Title
Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose.
  Journal
J Biol Chem 276:20935-44 (2001)
DOI:10.1074/jbc.M100378200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.71
IUBMB Enzyme Nomenclature: 2.7.7.71
ExPASy - ENZYME nomenclature database: 2.7.7.71
BRENDA, the Enzyme Database: 2.7.7.71

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