KEGG ENZYME: 2.7.7.71

ENZYME: 2.7.7.71

Entry

EC 2.7.7.71                 Enzyme

Name

D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase;
hddC (gene name);
gmhD (gene name)

Class

Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases

Sysname

GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase

Reaction(IUBMB)

D-glycero-alpha-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-alpha-D-manno-heptose + diphosphate [RN:R09772]

Reaction(KEGG)

R09772

Substrate

D-glycero-alpha-D-manno-heptose 1-phosphate [CPD:C19880];
GTP [CPD:C00044]

Product

GDP-D-glycero-alpha-D-manno-heptose [CPD:C19881];
diphosphate [CPD:C00013]

Comment

The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria.

History

EC 2.7.7.71 created 2010

Pathway

ec00540

Lipopolysaccharide biosynthesis

ec01100

Metabolic pathways

Orthology

K15669

D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase

Genes

YPB:

YPTS_1057

YPQ:

DJ40_1346

YPU:

BZ21_256

YPR:

BZ20_1033

YPC:

BZ23_532

YAS:	N0H69_17355

PLU:	plu4824(wblY)

PLUM:

A4R40_23995

LSOL:

GOY17_03460

LHX:	LYSHEL_08780(hddC)

LCAS:

LYSCAS_08780(hddC)

THES:

FHQ07_06195

TCN:	H9L16_07625

TBV:	H9L17_06855

VAF:	D1115_23000

VSR:	Vspart_00205(rfbF_2)

VZI:	G5S32_14895

VJP:	NP165_18360

VRU:	RND59_05065

PGB:	H744_2c2396

PGH:	FH974_09830

PPB:	PPUBIRD1_1474

PEN:

PSEEN2466

PALL:

UYA_23035

PBZ:	GN234_10455

PKH:	JLK41_16275

PMUY:

KSS95_17175

PORY:

EJA05_20070

PWZ:	J7655_08605

PSIH:

LOY51_19415

PASI:

LG197_25605

PAGR:

E2H98_17305

SBB:	Sbal175_1479

PSHO:

KQ246_01930

AMAG:

I533_13330

CEB:	B0D95_15710

ASIP:

AQUSIP_18120(hddC_2)

METL:

U737_03410

MMOB:

F6R98_01285

MEIN:

methR_P2383

MESL:

KKZ03_15205

HTR:	EPV75_08905

TVI:	Thivi_4047

HCH:

HCH_06180

HAHE:

ENC22_26650

HAHH:

O5O45_29345

TOL:

TOL_2195

TOR:	R615_06680

ENW:	MJO57_17215

REU:	Reut_A0722

CUP:	BKK80_17030

CUU:	BKK79_15325

BMA:	BMA2294(hddC)

BMV:	BMASAVP1_A0534(hddC)

BML:	BMA10229_A1066(wcbM)

BMN:	BMA10247_2172(wcbM)

BMAL:

DM55_1490

BMAE:

DM78_2664

BMAQ:

DM76_1468

BMAI:

DM57_1069

BMAF:

DM51_1935

BMAZ:

BM44_1069

BMAB:

BM45_2460

BPS:	BPSL2794(wcbM)

BPM:	BURPS1710b_3290(wcbM)

BPL:	BURPS1106A_3276(wcbM)

BPD:	BURPS668_3241(wcbM)

BPR:	GBP346_A3419

BPSE:

BDL_2651

BPSM:

BBQ_515

BPSU:

BBN_643

BPSD:

BBX_1049

BPZ:	BP1026B_I0516(wcbM)

BPQ:	BPC006_I3324

BPK:

BBK_2136

BPSH:

DR55_1724

BPSA:

BBU_2768

BPSO:

X996_1364

BUT:

X994_3362

BTD:

BTI_922

BTHA:

DR62_527

BCEW:

DM40_4221

BLAT:

WK25_23470

BSTL:

BBJ41_08330

BARI:

NLX30_31955

BAEN:

L3V59_19735

BPLA:

bpln_1g18360

BUZ:	AYM40_03130 AYM40_03410

BCAI:

K788_0007829

PHS:	C2L64_13955

PMEG:

FNZ07_18190

PACS:

FAZ98_02535

PCOS:

C2747_01705

TVL:	FAZ95_17365

TCAR:

U0034_03655

RSB:	RS694_17780

ATER:

MW290_21690

HSE:	Hsero_4416

HSZ:	ACP92_22055

HFR:	G5S34_23460

MASS:

CR152_19315

AON:	DEH84_17470

NET:

Neut_0159

MEH:

M301_2250

MBAT:

BN1208_0915

MEU:	ACJ67_08020

ARES:

IWH25_01540

REN:	EF513_03800

BRN:	D1F64_11925

CSE:

Cseg_1878

CMB:	CSW64_13085

BND:	KWG56_04320

AZS:	E6C72_17750

MAGX:

XM1_1801

MAGN:

WV31_16780

FER:	FNB15_03140

MAG:

amb0798

APB:	SAR116_0975

HWI:	A0Z60_06595

HPUL:

NCTC13154_01557(rmlA1)

CJE:	Cj1423c(hddC)

CJB:	BN148_1423c(hddC)

CJJ:	CJJ81176_1422

CJN:	ICDCCJ07001_1353

CJS:

CJS3_1516

CJEJ:

N564_02350

CJEU:

N565_02430

CJEN:

N755_02485

CJEI:

N135_01513

CJER:

H730_08135

CJY:	QZ67_01562(hddC_2)

CJQ:	UC78_1364(hddC_2)

CJW:	PJ18_07290

CJR:

CJE1608

CJD:	JJD26997_1755

CJZ:	M635_02840

CJX:	BN867_14000

CLR:	UPTC16701_0318

CLM:	UPTC16712_0316

CLN:	UPTC3659_0328

CCF:

YSQ_01745

CIS:

CINS_0294

CAMR:

CAQ16704_0317

CSM:	CSUB8521_0329

CHV:	CHELV3228_0219

CCUN:

CCUN_1150

CLX:

CLAN_0154

CHW:	A2J15_004895

CAMZ:

CVIC12175_0186

COJ:

CORN_0315

CUX:	CUP3940_1431

CARM:

CARM_0283

CNV:	CNZW441b_0370

CVU:	CVULP_1505

ANT:	Arnit_2924

ALK:

ALEK_0997

AMYT:

AMYT_0705

HMR:	Hipma_1691

GLO:

Glov_0792

DMA:	DMR_p1_00350

DOV:	DSCO28_03320

TCM:	HL41_06280

APAU:

AMPC_02940(hddC)

PPSC:

EHS13_28190

PRZ:	GZH47_12300

ASOC:

CB4_00634(hddC)

ACUR:

JZ785_20285

CAC:

CA_C3056

CAE:

SMB_G3092

CAY:

CEA_G3062

CFER:

D4Z93_01725

CRW:	CROST_039040(hddC)

CFB:	CLFE_008780(hddC)

CAUN:

CLAUR_036220(hddC)

HHJ:	NQ487_27320

DEC:	DCF50_p1136

CSH:	Closa_3799

LXA:	OW255_03125

CASP:

NQ535_04230

PBIF:

KXZ80_16775

AOC:	Aocu_04610(hddC)

SYZ:	MYO_122470

SYY:	SYNGTS_2223(slr0007)

SYT:	SYNGTI_2222(slr0007)

SYS:	SYNPCCN_2221(slr0007)

SYQ:	SYNPCCP_2221(slr0007)

SYJ:	D082_33180

SYO:	C7I86_11615

PMH:	P9215_14341

GEN:

GM3709_95

GEE:	GM3708_2173

CAN:	Cyan10605_0114

MAR:

MAE_55660

MPK:

VL20_391

MIQ:	B5D77_10620

MVZ:	myaer102_27900

CYU:	UCYN_11560

CYT:

cce_0965

CWA:	CwatDRAFT_2259

CYP:	PCC8801_1636

CYH:	Cyan8802_1663

CEO:

ETSB_0017

CER:	RGRSB_1051

CEEC:

P3F56_10000

SNG:	SNE_A16750(mpg1)

ULI:	ETAA1_11120(hddC)

KST:	KSMBR1_2292

BPIT:

BPIT_11880 BPIT_20160

MSIL:

METEAL_02450(hddC)

FVA:	FV113G1_09570(hddC)

HABY:

HLVA_19740(hddC)

ACO:	Amico_1360

TLI:

Tlie_1237

AMO:	Anamo_1480

BTH:

BT_0476

BTHO:

Btheta7330_02886(hddC_2)

BFG:	BF638R_1446

PCLR:

PC1C4_23770

ALD:	GFH31_01605

AIT:	AI2BBH_01750

AIU:	NQ491_03840

CPI:

Cpin_3113

CHIH:

GWR21_07435

COY:	HF329_02880

CFIL:

MYF79_22185

CHF:	KTO58_06615

CSAC:

SIO70_23820

NKO:	Niako_2549

NSO:	NIASO_09040

NIA:	A8C56_12860

NYN:	U0035_05275

FLA:	SY85_01480

ARK:	D6B99_15400

FLN:

FLA_2279

PSEG:

D3H65_10795

PGIN:

FRZ67_05020

PGO:	FSB84_23210

FLS:	GLV81_14345

FEI:	K9M53_08230

FLP:	LK994_12850

THEO:

IMW88_11155

CHRW:

KA713_13915

PAA:

Paes_1744

NDE:

NIDE3423

NALL:

PP769_09065

NNEO:

PQG83_20300

LFI:	LFML04_1776

NVA:	G3M78_07675

MPI:

Mpet_1391

» show all

Reference

1 [PMID:11279237]

Authors

Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P

Title

Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose.

Journal

J Biol Chem 276:20935-44 (2001)
DOI:10.1074/jbc.M100378200

Sequence

[ag:AAK27852]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.7.71

IUBMB Enzyme Nomenclature:

2.7.7.71

ExPASy - ENZYME nomenclature database:

2.7.7.71

BRENDA, the Enzyme Database:

2.7.7.71

DBGET integrated database retrieval system