KEGG   ENZYME: 2.7.7.78Help
Entry
EC 2.7.7.78                 Enzyme                                 

Name
GDP-D-glucose phosphorylase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
GDP:alpha-D-glucose 1-phosphate guanylyltransferase
Reaction(IUBMB)
GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP [RN:R09752]
Reaction(KEGG)
Substrate
GDP-alpha-D-glucose [CPD:C00394];
phosphate [CPD:C00009]
Product
alpha-D-glucose 1-phosphate [CPD:C00103];
GDP [CPD:C00035]
Comment
The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-alpha-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose.
History
EC 2.7.7.78 created 2011
Orthology
K15630  GDP-D-glucose phosphorylase
Genes
HSA: 390637(GDPGP1)
PTR: 745569(GDPGP1)
PPS: 100982804(GDPGP1)
GGO: 101152503(GDPGP1)
PON: 100444173(GDPGP1)
NLE: 100594834(GDPGP1)
MCC: 701954(GDPGP1)
MCF: 102121174(GDPGP1)
CSAB: 103231172(GDPGP1)
RRO: 104674333(GDPGP1)
RBB: 108521402(GDPGP1)
CJC: 100392315(GDPGP1)
SBQ: 101035205(GDPGP1)
MMU: 269952(Gdpgp1)
RNO: 308763(Gdpgp1)
CGE: 100772319(Gdpgp1)
NGI: 103749895(Gdpgp1)
HGL: 106010011(Gdpgp1)
CCAN: 109695080(Gdpgp1)
OCU: 100340539(GDPGP1)
TUP: 102501837(GDPGP1)
CFA: 479045(GDPGP1)
AML: 100473017(GDPGP1)
UMR: 103660194(GDPGP1)
ORO: 101375354(GDPGP1)
FCA: 101082062(GDPGP1)
PTG: 102960896(GDPGP1)
AJU: 106965881(GDPGP1)
BTA: 522909(GDPGP1)
BOM: 102288281(GDPGP1)
BIU: 109575519(GDPGP1)
PHD: 102334089(GDPGP1)
CHX: 102169222(GDPGP1)
OAS: 101105361(GDPGP1)
SSC: 100156697(GDPGP1)
CFR: 102510192(GDPGP1)
CDK: 105094688(GDPGP1)
BACU: 102999980(GDPGP1)
LVE: 103071553(GDPGP1)
OOR: 101269491(GDPGP1)
ECB: 100069039(GDPGP1)
EPZ: 103558648(GDPGP1)
EAI: 106832038(GDPGP1)
MYB: 102240979(GDPGP1)
MYD: 102759603(GDPGP1)
HAI: 109381493(GDPGP1)
RSS: 109438260(GDPGP1)
PALE: 102885796(GDPGP1)
LAV: 100673104(GDPGP1)
TMU: 101351913
MDO: 100015004(GDPGP1)
SHR: 100923815(GDPGP1)
OAA: 100081924(GDPGP1)
GGA: 100858151(GDPGP1)
MGP: 104912902(GDPGP1)
CJO: 107318942(GDPGP1)
PHI: 102109647(GDPGP1)
PMAJ: 107209304(GDPGP1)
AAM: 106491439(GDPGP1)
ASN: 102383638(GDPGP1)
AMJ: 102563294(GDPGP1)
PSS: 102450889(GDPGP1)
CMY: 102940662(GDPGP1)
CPIC: 101931318(GDPGP1)
PVT: 110091453(GDPGP1)
PBI: 103057762(GDPGP1)
GJA: 107125346(GDPGP1)
XLA: 100126619(gdpgp1.S)
XTR: 779852(gdpgp1)
NPR: 108799851(GDPGP1)
DRE: 560896(zgc:153343)
SANH: 107673239(gdpgp1)
CCAR: 109051094(gdpgp1)
IPU: 108274456(gdpgp1)
AMEX: 103039909(gdpgp1)
LCO: 104925271(gdpgp1)
NCC: 104944010(gdpgp1)
MZE: 101485114(gdpgp1)
OLA: 101157128(gdpgp1)
XMA: 102218616(gdpgp1)
PRET: 103466114(gdpgp1)
NFU: 107388974(gdpgp1)
KMR: 108239930(gdpgp1)
CSEM: 103380517(gdpgp1)
LCF: 108875359(gdpgp1)
SDU: 111228367(gdpgp1)
HCQ: 109530305(gdpgp1)
BPEC: 110165957(gdpgp1)
MALB: 109968722(gdpgp1)
SASA: 106573338(gdpgp1)
ELS: 105018388(gdpgp1)
SFM: 108942052(gdpgp1)
LCM: 102348470(GDPGP1)
CMK: 103188517(gdpgp1)
CIN: 100175149
SPU: 581869
APLC: 110981940
SKO: 100367014
MDE: 101897755
AAG: 5574728
AME: 102655796
BIM: 100741522
BTER: 100645275
SOC: 105198366
AEC: 105143464
ACEP: 105617424
PBAR: 105431382
HST: 105186148
DQU: 106749279
CFO: 105254250
PGC: 109863787
PCF: 106793017
NVI: 100678972
MDL: 103570636
BMOR: 101737046
PMAC: 106711096
PRAP: 110997303
HAW: 110376713
API: 100165161
DNX: 107161738
CLEC: 106666055
ZNE: 110834328
FCD: 110859191
TUT: 107365411
CEL: CELE_C10F3.4(mcp-1)
CBR: CBG09277
BMY: Bm1_24620
MYI: 110459831
OBI: 106880321
LAK: 106169828
SHX: MS3_04850
ADF: 107331927
HMG: 100211520
AQU: 109582674
 » show all
Taxonomy
Reference
1  [PMID:21507950]
  Authors
Adler LN, Gomez TA, Clarke SG, Linster CL
  Title
A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.
  Journal
J Biol Chem 286:21511-23 (2011)
DOI:10.1074/jbc.M111.238774
  Sequence
[cel:CELE_C10F3.4] [hsa:390637] [mmu:269952]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.78
IUBMB Enzyme Nomenclature: 2.7.7.78
ExPASy - ENZYME nomenclature database: 2.7.7.78
BRENDA, the Enzyme Database: 2.7.7.78

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