KEGG   ENZYME: 2.7.7.82Help
Entry
EC 2.7.7.82                 Enzyme                                 

Name
CMP-N,N'-diacetyllegionaminic acid synthase;
CMP-N,N'-diacetyllegionaminic acid synthetase;
neuA (gene name);
legF (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:N,N'-diacetyllegionaminate cytidylyltransferase
Reaction(IUBMB)
CTP + N,N'-diacetyllegionaminate = CMP-N,N'-diacetyllegionaminate + diphosphate [RN:R10182]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
N,N'-diacetyllegionaminate [CPD:C20418]
Product
CMP-N,N'-diacetyllegionaminate [CPD:C20419];
diphosphate [CPD:C00013]
Comment
Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni. Involved in biosynthesis of legionaminic acid, a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates which may include lipopolysaccharide (LPS), capsular polysaccharide, pili and flagella.
History
EC 2.7.7.82 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K18431  CMP-N,N'-diacetyllegionaminic acid synthase
Genes
LPN: lpg0751(neuA)
LPH: LPV_0877(neuA)
LPO: LPO_0832(neuA)
LPU: LPE509_02460
LPM: LP6_0731(neuA)
LPF: lpl0788(neuA)
LPP: lpp0817(neuA)
LPC: LPC_2541(neuA)
LPA: lpa_01159(neuA)
LPE: lp12_0761
FPH: Fphi_1170
FPI: BF30_1414
FPX: KU46_144
HCP: HCN_1208
SULR: B649_08520
CJE: Cj1331(ptmB)
CJB: BN148_1331(ptmB)
CJI: CJSA_1267(ptmB)
CJS: CJS3_1425
CJEJ: N564_02275
CJEU: N565_02365
CJEN: N755_02425
CJEI: N135_01419
CJER: H730_07610
CJY: QZ67_01467(legF_2)
CJQ: UC78_1274(legF_2)
CJR: CJE1520(ptmB)
CJD: JJD26997_0378(ptmB)
CCO: CCC13826_2299(legF)
CLA: Cla_1229(ptmB)
CCQ: N149_1294
CCF: YSQ_02195
CCY: YSS_07220
CCOI: YSU_02230
CCOF: VC76_06680(legF_2)
CIS: CINS_1190(legF)
CVO: CVOL_1210(legF)
CSM: CSUB8521_1413(legF)
CSF: CSUB8523_1513(legF)
ABT: ABED_0623
ARC: ABLL_0815
PPY: PPE_04402
EFU: HMPREF0351_10922(neuA)
CBL: CLK_2102
CBB: CLD_1850
CBN: CbC4_0995
CKL: CKL_2466(neuA)
CKR: CKR_2180
CTH: Cthe_2639
BPB: bpr_I0432(neuA1)
CST: CLOST_0369(neuA)
AWO: Awo_c24820(neuA)
TIT: Thit_0484
TSH: Tsac_2665
LIL: LA_1605(neuA)
LIE: LIF_A1292(neuA)
LIC: LIC_12177(neuA)
 » show all
Taxonomy
Reference
1  [PMID:18275154]
  Authors
Glaze PA, Watson DC, Young NM, Tanner ME
  Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
  Journal
Biochemistry 47:3272-82 (2008)
DOI:10.1021/bi702364s
  Sequence
[lpn:lpg0751]
Reference
2  [PMID:19282391]
  Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
  Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel  GDP-linked precursors.
  Journal
Glycobiology 19:715-25 (2009)
DOI:10.1093/glycob/cwp039
  Sequence
[cje:Cj1331]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.82
IUBMB Enzyme Nomenclature: 2.7.7.82
ExPASy - ENZYME nomenclature database: 2.7.7.82
BRENDA, the Enzyme Database: 2.7.7.82

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