KEGG   ENZYME: 2.7.8.14Help
Entry
EC 2.7.8.14                 Enzyme                                 

Name
CDP-ribitol ribitolphosphotransferase;
teichoic-acid synthase (ambiguous);
polyribitol phosphate synthetase (ambiguous);
teichoate synthetase (ambiguous);
poly(ribitol phosphate) synthetase (ambiguous);
polyribitol phosphate polymerase (ambiguous);
teichoate synthase (ambiguous);
CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
CDP-ribitol:4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol ribitolphosphotransferase
Reaction(IUBMB)
n CDP-ribitol + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n CMP + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11621]
Reaction(KEGG)
Substrate
CDP-ribitol [CPD:C00789];
4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21502]
Product
CMP [CPD:C00055];
4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21508]
Comment
Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds around 40 ribitol units to the linker molecule.
History
EC 2.7.8.14 created 1972 as EC 2.4.1.55, transferred 1982 to EC 2.7.8.14, modified 2017
Orthology
K18704  CDP-ribitol ribitolphosphotransferase / teichoic acid ribitol-phosphate polymerase
Genes
CSK: ES15_3332
CKE: B5M06_15315
HAD: CDV25_02490
CJQ: UC78_1376(tagB)
ABL: A7H1H_2198
BSL: A7A1_1140
BSY: I653_17460
BSS: BSUW23_17580(tarL)
BST: GYO_3936(tarL)
BSX: C663_3471(tarL)
BJS: MY9_3633
BACY: QF06_16305
SAX: USA300HOU_0264(tagB1) USA300HOU_0268(tagB2)
SUW: SATW20_02550(tarK) SATW20_02590(tarL)
SEP: SE0321
SER: SERP0198
SEPS: DP17_1631
SSP: SSP0356
SSCH: LH95_01800
LMOG: BN389_11100(tarL)
LMP: MUO_05655
LMOX: AX24_02805
LMQ: LMM7_1109
LMOK: CQ02_05615
LIN: lin1068
LWE: lwe1060
LIV: LIV_1026
ESI: Exig_0188
EAN: Eab7_0180(tarL)
LLT: CVCAS_0892(tagB)
LLS: lilo_0876(tagB)
LLM: llmg_1603(tagB)
LLR: llh_8010
LLI: uc509_0962(tagB)
LLW: kw2_0921(tagB)
LLJ: LG36_1397(tagB)
LGR: LCGT_1233
LGV: LCGL_1254
LPL: lp_1819(tarL)
LPJ: JDM1_1532(tagB2)
LPT: zj316_1807(tarL)
LPS: LPST_C1461(tagB2)
LPZ: Lp16_1408
PCE: PECL_1837
WCE: WS08_0699
WCT: WS74_0701
CBV: U729_1133
RIX: RO1_35060
RIM: ROI_04730
HSD: SD1D_2042
JDE: Jden_1795
XCE: Xcel_2590
MGG: MPLG2_2612(tagB)
BBP: BBPR_0698 BBPR_0699(tagB)
BBF: BBB_0690(tarK) BBB_0691
AEQ: AEQU_0651
MEB: Abm4_1699
MCUB: MCBB_1531(tarL)
NDV: NDEV_0136
 » show all
Taxonomy
Reference
1  [PMID:5908130]
  Authors
Ishimoto N, Strominger JL.
  Title
Polyribitol phosphate synthetase of Staphylococcus aureus.
  Journal
J Biol Chem 241:639-50 (1966)
Reference
2  [PMID:18215769]
  Authors
Brown S, Zhang YH, Walker S
  Title
A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.
  Journal
Chem Biol 15:12-21 (2008)
DOI:10.1016/j.chembiol.2007.11.011
  Sequence
Reference
3  [PMID:18556787]
  Authors
Pereira MP, D'Elia MA, Troczynska J, Brown ED
  Title
Duplication of teichoic acid biosynthetic genes in Staphylococcus aureus leads to functionally redundant poly(ribitol phosphate) polymerases.
  Journal
J Bacteriol 190:5642-9 (2008)
DOI:10.1128/JB.00526-08
Reference
4  [PMID:21035733]
  Authors
Brown S, Meredith T, Swoboda J, Walker S
  Title
Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.
  Journal
Chem Biol 17:1101-10 (2010)
DOI:10.1016/j.chembiol.2010.07.017
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.14
IUBMB Enzyme Nomenclature: 2.7.8.14
ExPASy - ENZYME nomenclature database: 2.7.8.14
BRENDA, the Enzyme Database: 2.7.8.14
CAS: 9076-71-5

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