KEGG   ENZYME: 2.7.8.17Help
Entry
EC 2.7.8.17                 Enzyme                                 

Name
UDP-N-acetylglucosamine---lysosomal-enzyme N-acetylglucosaminephosphotransferase;
N-acetylglucosaminylphosphotransferase;
UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase;
UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase;
uridine diphosphoacetylglucosamine-lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase;
uridine diphosphoacetylglucosamine-glycoprotein acetylglucosamine-1-phosphotransferase;
lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase;
N-acetylglucosaminyl phosphotransferase;
UDP-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase;
UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase;
UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase;
UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose [RN:R04291]
Reaction(KEGG)
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
lysosomal-enzyme D-mannose [CPD:C03706]
Product
UMP [CPD:C00105];
lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose [CPD:C04789]
Comment
Some other glycoproteins with high-mannose can act as acceptors, but much more slowly than lysosomal enzymes.
History
EC 2.7.8.17 created 1984
Orthology
K08239  UDP-N-acetylglucosamine-lysosomal-enzyme
Genes
HSA: 79158(GNPTAB)
PTR: 452176(GNPTAB)
PPS: 100986324(GNPTAB)
GGO: 101124301(GNPTAB)
PON: 100441852(GNPTAB)
NLE: 100606002(GNPTAB)
MCC: 697307(GNPTAB)
MCF: 102121493(GNPTAB)
CSAB: 103238949(GNPTAB)
RRO: 104657408(GNPTAB)
RBB: 108543135(GNPTAB)
CJC: 100394765(GNPTAB) 100402714
SBQ: 101034734(GNPTAB)
MMU: 432486(Gnptab)
RNO: 362865(Gnptab)
CGE: 100774953(Gnptab)
NGI: 103733731(Gnptab)
HGL: 101710539(Gnptab)
CCAN: 109690295(Gnptab)
OCU: 100340567(GNPTAB)
TUP: 102486510(GNPTAB)
CFA: 475443(GNPTAB)
AML: 100483884(GNPTAB)
UMR: 103676570(GNPTAB)
ORO: 101376907(GNPTAB)
FCA: 101100231(GNPTAB)
PTG: 102962249(GNPTAB)
AJU: 106971899(GNPTAB)
BTA: 509610(GNPTAB)
BOM: 102269745(GNPTAB)
BIU: 109559441(GNPTAB)
PHD: 102342737(GNPTAB)
CHX: 102186936(GNPTAB)
OAS: 101122348(GNPTAB)
SSC: 100523554(GNPTAB)
CFR: 102511319(GNPTAB)
CDK: 105097459(GNPTAB)
BACU: 103017866(GNPTAB)
LVE: 103075123(GNPTAB) 103091430
OOR: 101271916(GNPTAB)
ECB: 100067011(GNPTAB)
EPZ: 103555699(GNPTAB)
EAI: 106827262(GNPTAB)
MYB: 102257362(GNPTAB)
MYD: 102766549(GNPTAB)
HAI: 109387783(GNPTAB)
RSS: 109447605(GNPTAB)
PALE: 102892520(GNPTAB)
LAV: 100668883(GNPTAB)
MDO: 100021000(GNPTAB)
SHR: 100917351(GNPTAB)
OAA: 100075585(GNPTAB)
GGA: 418096(GNPTAB)
MGP: 100546740(GNPTAB)
CJO: 107316196(GNPTAB)
APLA: 101792400(GNPTAB)
ACYG: 106031028(GNPTAB)
TGU: 100225345(GNPTAB)
GFR: 102032997(GNPTAB)
FAB: 101807127(GNPTAB)
PHI: 102114373(GNPTAB)
PMAJ: 107204412(GNPTAB)
CCW: 104696224(GNPTAB)
FPG: 101921963(GNPTAB)
FCH: 102059391(GNPTAB)
CLV: 102091116(GNPTAB)
EGZ: 104135578(GNPTAB)
AAM: 106488838(GNPTAB)
ASN: 102381964(GNPTAB)
AMJ: 102569913(GNPTAB)
PSS: 102458343(GNPTAB)
CMY: 102933760(GNPTAB)
CPIC: 101937487(GNPTAB)
ACS: 100561961(gnptab)
PVT: 110082687(GNPTAB)
PBI: 103063690(GNPTAB)
XLA: 108711016(gnptab.L) 108713209(gnptab.S)
XTR: 100036684(gnptab)
NPR: 108787158(GNPTAB)
DRE: 553365(gnptab)
IPU: 108274741(gnptab)
AMEX: 103033431(gnptab)
TRU: 101073922(gnptab)
LCO: 104926728(gnptab)
NCC: 104950103(gnptab)
MZE: 101475826(gnptab)
OLA: 101160613(gnptab)
XMA: 102234905(gnptab)
PRET: 103459179(gnptab)
NFU: 107386129(gnptab)
CSEM: 103382686(gnptab)
LCF: 108890213(gnptab)
BPEC: 110161776(gnptab)
ELS: 105030154(gnptab)
SFM: 108931544(gnptab)
LCM: 102357933(GNPTAB)
CMK: 103179873(gnptab)
CIN: 100175423(gnptab)
SPU: 100891240
APLC: 110975033
SKO: 102800521
ZNE: 110832957
TUT: 107361970
CRG: 105336164
MYI: 110450047
OBI: 106867695
EPA: 110243799
ADF: 107352997
HMG: 100199845
AQU: 100632364
BVG: 104885609
DDI: DDB_G0285815(gpt1)
DFA: DFA_06347(gpt1)
 » show all
Taxonomy
Reference
1  [PMID:6452459]
  Authors
Reitman ML, Kornfeld S.
  Title
UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes.
  Journal
J Biol Chem 256:4275-81 (1981)
Reference
2  [PMID:6457829]
  Authors
Reitman ML, Kornfeld S.
  Title
Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes.
  Journal
J Biol Chem 256:11977-80 (1981)
Reference
3  [PMID:6288715]
  Authors
Waheed A, Hasilik A, von Figura K.
  Title
UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme.
  Journal
J Biol Chem 257:12322-31 (1982)
Reference
4  [PMID:6260788]
  Authors
Waheed A, Pohlmann R, Hasilik A, von Figura K.
  Title
Subcellular location of two enzymes involved in the synthesis of phosphorylated recognition markers in lysosomal enzymes.
  Journal
J Biol Chem 256:4150-2 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.17
IUBMB Enzyme Nomenclature: 2.7.8.17
ExPASy - ENZYME nomenclature database: 2.7.8.17
BRENDA, the Enzyme Database: 2.7.8.17
CAS: 84012-69-1

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