KEGG   ENZYME: 2.7.8.2Help
Entry
EC 2.7.8.2                  Enzyme                                 

Name
diacylglycerol cholinephosphotransferase;
phosphorylcholine-glyceride transferase;
alkylacylglycerol cholinephosphotransferase;
1-alkyl-2-acetylglycerol cholinephosphotransferase;
cholinephosphotransferase;
CPT;
alkylacylglycerol choline phosphotransferase;
diacylglycerol choline phosphotransferase;
1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase;
CDP-choline diglyceride phosphotransferase;
cytidine diphosphocholine glyceride transferase;
cytidine diphosphorylcholine diglyceride transferase;
phosphocholine diacylglyceroltransferase;
sn-1,2-diacylglycerol cholinephosphotransferase;
1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase;
CDP choline:1,2-diacylglycerol cholinephosphotransferase;
CDP-choline:1,2-diacylglycerol cholinephosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
CDP-choline:1,2-diacyl-sn-glycerol cholinephosphotransferase
Reaction(IUBMB)
CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine [RN:R01321]
Reaction(KEGG)
Substrate
CDP-choline [CPD:C00307];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
CMP [CPD:C00055];
phosphatidylcholine [CPD:C00157]
Comment
1-Alkyl-2-acylglycerol can act as acceptor; this activity was previously listed separately.
History
EC 2.7.8.2 created 1961, modified 1986 (EC 2.7.8.16 created 1983, incorporated 1986)
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec00564  Glycerophospholipid metabolism
ec00565  Ether lipid metabolism
ec01100  Metabolic pathways
Orthology
K00994  diacylglycerol cholinephosphotransferase
K13644  choline/ethanolamine phosphotransferase
Genes
HSA: 10390(CEPT1) 56994(CHPT1)
PTR: 457116(CEPT1) 467109(CHPT1)
PPS: 100975614(CEPT1) 100986998(CHPT1)
GGO: 101146100(CEPT1) 101151506(CHPT1)
PON: 100439046(CEPT1) 100440613(CHPT1)
NLE: 100599371(CEPT1) 100605676(CHPT1)
MCC: 696056(CHPT1) 702700(CEPT1)
MCF: 101926162(CEPT1) 102122766(CHPT1)
CSAB: 103224236(CEPT1) 103238948(CHPT1)
RRO: 104657409(CHPT1) 104658945(CEPT1)
RBB: 108528075(CEPT1) 108538927(CHPT1)
CJC: 100388578(CEPT1) 100401644 100408188(CHPT1) 103787260(CHPT1)
SBQ: 101043338(CEPT1) 101052362(CHPT1)
MMU: 212862(Chpt1) 99712(Cept1)
RNO: 310773(Cept1) 362866(Chpt1)
CGE: 100750762(Chpt1) 100773070(Cept1)
NGI: 103733732(Chpt1) 103747803(Cept1)
HGL: 101711138(Chpt1) 101721378(Cept1)
CCAN: 109690293(Chpt1) 109699595(Cept1)
OCU: 100353363(CEPT1) 100353669(CHPT1)
TUP: 102485648(CHPT1) 102499314(CEPT1)
CFA: 610214(CHPT1) 612948(CEPT1)
AML: 100473311(CEPT1) 100484386(CHPT1)
UMR: 103675028(CEPT1) 103676503(CHPT1)
ORO: 101377488(CHPT1) 101385081(CEPT1)
FCA: 101093451(CEPT1) 101099986(CHPT1)
PTG: 102961960(CHPT1) 102967463(CEPT1)
AJU: 106971875(CHPT1) 106978009(CEPT1)
BTA: 504650(CEPT1) 511291(CHPT1)
BOM: 102269460(CHPT1) 102273094(CEPT1)
BIU: 109555949(CEPT1) 109558502(CHPT1)
PHD: 102319771(CEPT1) 102339059(CHPT1)
CHX: 102175100(CHPT1) 102182086(CEPT1)
OAS: 101108821(CHPT1) 101112775(CEPT1)
SSC: 100154792(CEPT1) 100523738(CHPT1)
CFR: 102508627(CHPT1) 102513980(CEPT1)
CDK: 105097458(CHPT1) 105100462(CEPT1)
BACU: 102998184(CEPT1) 103018700(CHPT1)
LVE: 103072539(CEPT1) 103085556(CHPT1)
OOR: 101272174(CHPT1) 101285127(CEPT1)
ECB: 100062845(CEPT1) 106782693(CHPT1)
EPZ: 103547790(CEPT1) 103555701(CHPT1)
EAI: 106827266(CHPT1) 106828607(CEPT1)
MYB: 102249628 102257668(CHPT1) 102263162(CEPT1)
MYD: 102755578(CHPT1) 102763884(CEPT1)
HAI: 109371576(CEPT1) 109387759(CHPT1)
RSS: 109446739(CEPT1) 109447598(CHPT1)
PALE: 102892767(CHPT1) 102898529(CEPT1)
LAV: 100674609(CEPT1) 104846858(CHPT1)
MDO: 100020969(CHPT1) 100030357(CEPT1)
SHR: 100933929(CEPT1)
OAA: 100075425(CHPT1) 100081592(CEPT1)
GGA: 418098(CHPT1) 421152(CEPT1)
MGP: 100546891 100550822(CEPT1)
CJO: 107316205(CHPT1) 107324694(CEPT1)
APLA: 101791878(CHPT1) 101801996(CEPT1)
ACYG: 106031029(CHPT1) 106046152(CEPT1)
TGU: 100219217(CEPT1) 100219586(CHPT1)
GFR: 102039926(CHPT1) 102042695(CEPT1)
FAB: 101806735(CHPT1) 101813197(CEPT1)
PHI: 102104902(CEPT1) 102108343(CHPT1)
PMAJ: 107204414(CHPT1) 107214859(CEPT1)
CCAE: 111936201(CHPT1) 111939633(CEPT1)
CCW: 104692467(CEPT1) 104696223(CHPT1)
FPG: 101911330(CHPT1) 101917473(CEPT1)
FCH: 102046063(CEPT1) 102048528(CHPT1)
CLV: 102084659 102086581(CHPT1)
EGZ: 104121991(CEPT1) 104135594(CHPT1)
AAM: 106485642(CEPT1) 106488652(CHPT1)
ASN: 102368380(CEPT1) 102382218(CHPT1)
AMJ: 102560772(CEPT1) 102570848(CHPT1)
PSS: 102458739(CHPT1) 102461379(CEPT1)
CMY: 102933991(CHPT1) 102946218(CEPT1)
CPIC: 101937224(CHPT1) 101940701(CEPT1)
ACS: 100561765(chpt1) 100567654(cept1)
PVT: 110073385(CEPT1) 110082685(CHPT1)
PBI: 103064252(CHPT1) 103064689(CEPT1)
GJA: 107114824(CEPT1) 107119583(CHPT1)
XLA: 108713210(chpt1.S) 379805(cept1.S) 734631(chpt1.L)
XTR: 100216268(chpt1) 549188(cept1)
NPR: 108787169(CHPT1) 108804882(CEPT1)
DRE: 322605(chpt1) 570720(cept1b)
IPU: 100305100(cept1) 108265319 108274771(chpt1)
AMEX: 103025726(cept1) 103031285(chpt1) 103046724
TRU: 101078788(cept1)
LCO: 104926726(chpt1) 104927824(cept1)
NCC: 104950095(chpt1) 104961372(cept1)
MZE: 101474280(cept1) 101476120(chpt1)
OLA: 101173516(chpt1)
XMA: 102225565(cept1) 102235171(chpt1)
PRET: 103459173(chpt1) 103464802
NFU: 107384952(cept1) 107386145(chpt1)
KMR: 108233186(chpt1) 108244951(cept1)
CSEM: 103382702(chpt1) 103386450(cept1)
LCF: 108889793(cept1) 108890214(chpt1)
SDU: 111219428(cept1) 111225032(chpt1)
HCQ: 109510326(cept1) 109523684
BPEC: 110161596(chpt1) 110162476(cept1)
MALB: 109959927(chpt1) 109966394(cept1)
LCM: 102361623(CHPT1) 102364240(CEPT1)
CMK: 103179874(chpt1) 103190121(cept1)
CIN: 100176633
SPU: 763773
AME: 552795
TUT: 107363409
TSP: Tsp_04639
CRG: 105326860
MYI: 110453160
OBI: 106867824
EPA: 110249485
ADF: 107349498
AQU: 100638347
SCE: YNL130C(CPT1)
ERC: Ecym_8190
KMX: KLMA_60263(CPT1)
NCS: NCAS_0G02370(NCAS0G02370)
NDI: NDAI_0B04390(NDAI0B04390) NDAI_0F02920(NDAI0F02920)
TPF: TPHA_0I01400(TPHA0I01400)
TBL: TBLA_0B01190(TBLA0B01190) TBLA_0D00380(TBLA0D00380)
TDL: TDEL_0B05000(TDEL0B05000)
KAF: KAFR_0F00670(KAFR0F00670) KAFR_0J02190(KAFR0J02190)
 » show all
Taxonomy
Reference
1  [PMID:192727]
  Authors
Coleman R, Bell RM.
  Title
Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities.
  Journal
J Biol Chem 252:3050-6 (1977)
Reference
2  [PMID:6295501]
  Authors
Lee TC, Blank ML, Fitzgerald V, Snyder F.
  Title
Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver.
  Journal
Biochim Biophys Acta 713:479-83 (1982)
DOI:10.1016/0005-2760(82)90269-7
Reference
3  [PMID:204847]
  Authors
Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ.
  Title
Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate.
  Journal
Lipids 13:161-4 (1978)
DOI:10.1007/BF02533260
Reference
4  [PMID:6260215]
  Authors
Renooij W, Snyder F.
  Title
Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues.
  Journal
Biochim Biophys Acta 663:545-56 (1981)
DOI:10.1016/0005-2760(81)90182-X
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.2
IUBMB Enzyme Nomenclature: 2.7.8.2
ExPASy - ENZYME nomenclature database: 2.7.8.2
BRENDA, the Enzyme Database: 2.7.8.2
CAS: 9026-13-5

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