KEGG   ENZYME: 2.7.8.27Help
Entry
EC 2.7.8.27                 Enzyme                                 

Name
sphingomyelin synthase;
SM synthase;
SMS1;
SMS2
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
ceramide:phosphatidylcholine cholinephosphotransferase
Reaction(IUBMB)
a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol [RN:R08969]
Reaction(KEGG)
Substrate
ceramide [CPD:C00195];
phosphatidylcholine [CPD:C00157]
Product
sphingomyelin [CPD:C00550];
1,2-diacyl-sn-glycerol [CPD:C00641]
Comment
The reaction can occur in both directions [3]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [4]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [4]. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [2].
History
EC 2.7.8.27 created 2006
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K04714  shingomyelin synthase
Genes
HSA: 166929(SGMS2) 259230(SGMS1)
PTR: 100613097(SGMS2) 450460(SGMS1)
PPS: 100983907(SGMS1) 100993903(SGMS2)
GGO: 101138449(SGMS2) 101138874(SGMS1)
PON: 100444992(SGMS1) 100446194(SGMS2)
NLE: 100593842(SGMS2) 100601656(SGMS1)
MCC: 695947(SGMS2) 704027(SGMS1)
MCF: 101867034(SGMS2) 102126212(SGMS1)
CSAB: 103216200(SGMS1) 103236087(SGMS2)
RRO: 104670047(SGMS2) 104675166(SGMS1)
RBB: 108515885(SGMS2) 108523223 108527547(SGMS1)
CJC: 100391389(SGMS1) 100400486(SGMS2)
SBQ: 101041388(SGMS1) 101049165(SGMS2)
MMU: 208449(Sgms1) 74442(Sgms2)
RNO: 310849(Sgms2) 353229(Sgms1)
CGE: 100760913(Sgms2) 100766719(Sgms1) 103161496
NGI: 103738051(Sgms1) 103742560(Sgms2)
HGL: 101710267(Sgms1) 101712715(Sgms2)
CCAN: 109681828(Sgms1) 109684300(Sgms2)
OCU: 100354454(SGMS2) 100357932(SGMS1)
TUP: 102484900(SGMS2) 102485341(SGMS1)
CFA: 477582(SGMS1) 478505(SGMS2)
AML: 100466473(SGMS2) 100468555(SGMS1)
UMR: 103661724(SGMS2) 103661995(SGMS1)
ORO: 101368457(SGMS1) 101371231(SGMS2)
FCA: 101088574(SGMS2) 101090897(SGMS1)
PTG: 102957023(SGMS1) 102970893(SGMS2)
AJU: 106980950(SGMS1) 106988439(SGMS2)
BTA: 520954(SGMS2) 533538(SGMS1)
BOM: 102268543(SGMS2) 102269418(SGMS1)
BIU: 109553156 109560269(SGMS2) 109579164(SGMS1)
PHD: 102315273(SGMS1) 102342407(SGMS2)
CHX: 102184583(SGMS1) 102187660(SGMS2)
OAS: 101118575(SGMS1) 101123121(SGMS2)
SSC: 100037303(SGMS1) 100518796(SGMS2)
CFR: 102508365(SGMS1) 102509917(SGMS2)
CDK: 105088962(SGMS1) 105105285(SGMS2)
BACU: 103014494(SGMS1) 103016480(SGMS2)
LVE: 103070270(SGMS2) 103073289(SGMS1)
OOR: 101278460(SGMS1) 101288900(SGMS2)
ECB: 100062484(SGMS1) 100072971(SGMS2)
EPZ: 103546319(SGMS2) 103549843(SGMS1)
EAI: 106829816(SGMS2) 106845892(SGMS1)
MYB: 102255621(SGMS1) 102257109(SGMS2)
MYD: 102752902(SGMS1) 102771993(SGMS2)
HAI: 109379483(SGMS2) 109387531(SGMS1)
RSS: 109450920(SGMS1) 109452741(SGMS2)
PALE: 102883450(SGMS1) 102886439(SGMS2)
LAV: 100662186(SGMS1) 100666455(SGMS2)
MDO: 100011020(SGMS2) 100013212(SGMS1)
SHR: 100928230(SGMS1) 100933601(SGMS2)
GGA: 378907(SGMS1) 422529(SGMS2)
MGP: 100540329(SGMS1) 100541752(SGMS2)
CJO: 107313258(SGMS2) 107315618(SGMS1)
APLA: 101791169(SGMS2) 101798673(SGMS1)
ACYG: 106030221(SGMS1) 106038651(SGMS2)
TGU: 100218763(SGMS2) 100229900(SGMS1)
GFR: 102035610(SGMS2) 102040343(SGMS1)
FAB: 101816191(SGMS1) 101821395(SGMS2)
PHI: 102106139(SGMS1) 102109103(SGMS2)
PMAJ: 107203429(SGMS2) 107206882(SGMS1)
CCAE: 111927765(SGMS2) 111931636(SGMS1)
CCW: 104695075(SGMS1) 104697118(SGMS2)
FPG: 101912331(SGMS2) 101914270(SGMS1)
FCH: 102046789(SGMS2) 102050714(SGMS1)
CLV: 102093540(SGMS2) 102093853(SGMS1)
EGZ: 104125134(SGMS1) 104135526(SGMS2)
AAM: 106489083(SGMS1) 106491991(SGMS2)
ASN: 102384963(SGMS2) 102386662(SGMS1)
AMJ: 102560347(SGMS1) 102561422(SGMS2)
PSS: 102457944(SGMS2) 102458830(SGMS1)
CMY: 102929744(SGMS2) 102942050(SGMS1)
CPIC: 101931755(SGMS1) 101952554(SGMS2)
ACS: 100553259(sgms1) 100556412(sgms2)
PVT: 110080466(SGMS2) 110083115(SGMS1)
PBI: 103054795 103063562(SGMS1)
GJA: 107108743(SGMS1) 107123168(SGMS2)
XLA: 108696069(sgms1.L) 108706723(sgms2.S) 108710613(sgms2.L) 414566(sgms1.S)
XTR: 493559(sgms1) 496853(sgms2)
NPR: 108785425(SGMS2) 108794033(SGMS1)
DRE: 556193(sgms2a) 566563(sgms1)
IPU: 108262964(sgms2) 108269687(SGMS1) 108274297(sgms1) 108275722
AMEX: 103022236(sgms1) 103032666(sgms2) 103044873 103044881
TRU: 101061029(sgms1) 101062959 101064260(sgms2)
LCO: 104927264(sgms2) 104927467(sgms1) 104939615
NCC: 104953568(sgms2) 104961480(sgms1)
MZE: 101466244(sgms1) 101466523(sgms2) 101471562
OLA: 101170793 101172470(sgms2) 101173002(sgms1)
PRET: 103472709(sgms2) 103476797(sgms1) 103480961
NFU: 107375265(sgms2) 107376030(sgms1) 107396478
KMR: 108245812(sgms1) 108248702(sgms2) 108249825
CSEM: 103383517(sgms2) 103387683(sgms1) 103389486
LCF: 108874529 108888244(sgms2) 108897294(sgms1)
SDU: 111233129 111235272(sgms1) 111236643(sgms2)
HCQ: 109508334 109511073(sgms2) 109528787(sgms1)
BPEC: 110157080(sgms1) 110165258(sgms2) 110170302
MALB: 109955488(sgms2) 109960328(sgms1) 109972936
CMK: 103180856(sgms1) 103187947(sgms2)
CIN: 100178736
AAG: 5565303
AME: 408766
BIM: 100743987
BTER: 100646584
SOC: 105198487
AEC: 105151108
ACEP: 105619855
PBAR: 105424399
HST: 105186991
DQU: 106743028
CFO: 105253937
LHU: 105675772
PGC: 109859235
PCF: 106793971
NVI: 100120614
MDL: 103575346
TCA: 657306
DPA: 109546370
NVL: 108559553
BMOR: 101746851
PMAC: 106709597
PRAP: 110998350
HAW: 110375208
API: 100162696
DNX: 107173732
CLEC: 106669485
ZNE: 110838759
TUT: 107361649
CEL: CELE_F53H8.4(sms-2) CELE_H21P03.3(sms-1) CELE_Y22D7AL.8(sms-3)
CBR: CBG06147(Cbr-sms-1) CBG08086(Cbr-sms-2) CBG11695(Cbr-sms-3)
CSAT: 104753419
BOE: 106321612
CPAP: 110810058
PAVI: 110762375
RCU: 8279797
NSY: 104220339
NTO: 104106746
 » show all
Taxonomy
Reference
1  [PMID:4817756]
  Authors
Ullman MD, Radin NS.
  Title
The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver.
  Journal
J Biol Chem 249:1506-12 (1974)
Reference
2  [PMID:7093220]
  Authors
Voelker DR, Kennedy EP.
  Title
Cellular and enzymic synthesis of sphingomyelin.
  Journal
Biochemistry 21:2753-9 (1982)
Reference
3  [PMID:14685263]
  Authors
Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC.
  Title
Identification of a family of animal sphingomyelin synthases.
  Journal
EMBO J 23:33-44 (2004)
DOI:10.1038/sj.emboj.7600034
  Sequence
Reference
4  [PMID:16905542]
  Authors
Tafesse FG, Ternes P, Holthuis JC.
  Title
The multigenic sphingomyelin synthase family.
  Journal
J Biol Chem 281:29421-5 (2006)
DOI:10.1074/jbc.R600021200
Reference
5  [PMID:14976195]
  Authors
Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T.
  Title
Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells.
  Journal
J Biol Chem 279:18688-93 (2004)
DOI:10.1074/jbc.M401205200
  Sequence
[hsa:259230]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.27
IUBMB Enzyme Nomenclature: 2.7.8.27
ExPASy - ENZYME nomenclature database: 2.7.8.27
BRENDA, the Enzyme Database: 2.7.8.27
CAS: 58703-97-2

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