KEGG   ENZYME: 2.7.8.34Help
Entry
EC 2.7.8.34                 Enzyme                                 

Name
CDP-L-myo-inositol myo-inositolphosphotransferase;
CDP-inositol:inositol-1-phosphate transferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
DIPPS (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS))
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
CDP-1L-myo-inositol:1L-myo-inositol 1-phosphate myo-inositolphosphotransferase
Reaction(IUBMB)
CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate = CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate [RN:R09670]
Reaction(KEGG)
Substrate
CDP-1L-myo-inositol [CPD:C19794];
1L-myo-inositol 1-phosphate [CPD:C04006]
Product
CMP [CPD:C00055];
bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
Comment
In many organisms this activity is catalysed by a bifunctional enzyme. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-1L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3-phosphate, a widespread organic solute in microorganisms adapted to hot environments.
History
EC 2.7.8.34 created 2011
Pathway
ec00562  Inositol phosphate metabolism
Orthology
K07291  CDP-L-myo-inositol myo-inositolphosphotransferase
Genes
MTHD: A3224_07290
ENM: EBS_0412
STAX: MC45_17790
NTR: B0W44_00905
TMR: Tmar_0126
TPZ: Tph_c20790
RXY: Rxyl_1212
TTR: Tter_0472
AAE: aq_1367(spsI)
PMX: PERMA_1921
TTK: TST_0884
TPT: Tpet_1375
TRQ: TRQ2_1311
TNA: CTN_1075
TNP: Tnap_1393
AFU: AF_0263
FPL: Ferp_0148
GAC: GACE_2065
GAH: GAH_01161
PHO: PH1219(PH1219)
PAB: PAB2433
PFU: PF1058
PFI: PFC_04525
PYN: PNA2_1704
PYS: Py04_1010
TKO: TK2279
TON: TON_1248
TGA: TGAM_1853
TSI: TSIB_1010
THE: GQS_09430
THA: TAM4_5
THM: CL1_1475
TLT: OCC_08385
THS: TES1_1181
TNU: BD01_1626
TEU: TEU_00190
PPAC: PAP_05835
ACJ: ACAM_0952
IAG: Igag_0487
HBU: Hbut_0151
KCR: Kcr_0184
BARC: AOA65_0707
 » show all
Taxonomy
Reference
1  [PMID:17526717]
  Authors
Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H
  Title
Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.
  Journal
J Bacteriol 189:5405-12 (2007)
DOI:10.1128/JB.00465-07
  Sequence
[aae:aq_1367] [afu:AF_0263] [pfu:PF1058] [rxy:Rxyl_1212] [tko:TK2279]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.34
IUBMB Enzyme Nomenclature: 2.7.8.34
ExPASy - ENZYME nomenclature database: 2.7.8.34
BRENDA, the Enzyme Database: 2.7.8.34

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