KEGG   ENZYME: 2.8.1.9Help
Entry
EC 2.8.1.9                  Enzyme                                 

Name
molybdenum cofactor sulfurtransferase;
molybdenum cofactor sulfurase;
ABA3;
HMCS;
MoCo sulfurase;
MoCo sulfurtransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
BRITE hierarchy
Sysname
L-cysteine:molybdenum cofactor sulfurtransferase
Reaction(IUBMB)
molybdenum cofactor + L-cysteine + reduced acceptor + 2 H+ = thio-molybdenum cofactor + L-alanine + H2O + oxidized acceptor [RN:R11583]
Reaction(KEGG)
Substrate
molybdenum cofactor [CPD:C18237];
L-cysteine [CPD:C00097];
reduced acceptor [CPD:C00030];
H+ [CPD:C00080]
Product
thio-molybdenum cofactor [CPD:C21486];
L-alanine [CPD:C00041];
H2O [CPD:C00001];
oxidized acceptor
Comment
Contains pyridoxal phosphate. Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide. The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes. In prokaryotes the reaction is catalysed by two enzymes: cysteine desulfurase (EC 2.8.1.7), which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein.
History
EC 2.8.1.9 created 2011, modified 2015
Pathway
ec00790  Folate biosynthesis
Orthology
K15631  molybdenum cofactor sulfurtransferase
Genes
HSA: 55034(MOCOS)
PTR: 455379(MOCOS)
PPS: 100980622(MOCOS)
GGO: 101144098(MOCOS)
PON: 100437474(MOCOS)
NLE: 100603055(MOCOS)
MCC: 715633(MOCOS)
MCF: 102120844(MOCOS)
CSAB: 103222528(MOCOS)
RRO: 104661881(MOCOS)
RBB: 108530893(MOCOS)
CJC: 100394299(MOCOS)
SBQ: 101048496(MOCOS)
MMU: 68591(Mocos)
RNO: 361300(Mocos)
CGE: 103158571(Mocos)
NGI: 103733624(Mocos)
HGL: 101714313(Mocos)
OCU: 100353426(MOCOS)
TUP: 102477563(MOCOS)
CFA: 490482(MOCOS)
AML: 100471952(MOCOS)
UMR: 103665067(MOCOS)
ORO: 101376236(MOCOS)
FCA: 101098093(MOCOS)
PTG: 102960562(MOCOS)
AJU: 106984131(MOCOS)
BTA: 281226(MOCOS)
BOM: 102271668(MOCOS)
BIU: 109577802(MOCOS)
PHD: 102325177(MOCOS)
CHX: 102184109(MOCOS)
OAS: 101115591(MOCOS)
SSC: 100621611(MOCOS)
CFR: 102519803(MOCOS)
CDK: 105086901(MOCOS)
BACU: 103013287(MOCOS)
LVE: 103077536(MOCOS)
OOR: 101270096(MOCOS)
ECB: 100067480(MOCOS)
EPZ: 103557043(MOCOS)
EAI: 106823547(MOCOS)
MYB: 102247364(MOCOS)
MYD: 102753138(MOCOS)
HAI: 109380405(MOCOS)
RSS: 109452115(MOCOS)
PALE: 102880788(MOCOS)
LAV: 100677256(MOCOS)
TMU: 101346589
MDO: 100013356(MOCOS)
SHR: 100930485(MOCOS)
OAA: 100075210(MOCOS)
GGA: 420964(MOCOS)
MGP: 100545875(MOCOS)
CJO: 107309449(MOCOS)
APLA: 101790101(MOCOS)
ACYG: 106045026(MOCOS)
TGU: 100221503(MOCOS)
GFR: 102035844(MOCOS)
FAB: 101818369(MOCOS)
PHI: 102107851(MOCOS)
PMAJ: 107200520(MOCOS)
CCAE: 111925340(MOCOS)
CCW: 104685912(MOCOS)
FPG: 101916617(MOCOS)
FCH: 102048214(MOCOS)
CLV: 102094081(MOCOS)
EGZ: 104127290(MOCOS)
AAM: 106492843(MOCOS)
ASN: 102371402(MOCOS)
AMJ: 102570986(MOCOS)
PSS: 102456094(MOCOS)
CMY: 102946540
CPIC: 101945849(MOCOS)
ACS: 100552531(mocos) 103281780
PVT: 110075377(MOCOS)
GJA: 107118425(MOCOS)
XLA: 108720028
XTR: 100490959(mocos)
NPR: 108790410(MOCOS)
DRE: 100331902(mocos)
SRX: 107708374 107721213(mocos)
SGH: 107582499
IPU: 108263722(mocos)
AMEX: 103041534(mocos)
TRU: 101076796(mocos)
LCO: 104921895(mocos)
NCC: 104941688(mocos)
MZE: 101482613(mocos)
OLA: 101157481(mocos)
XMA: 102225677(mocos)
PRET: 103477143(mocos)
NFU: 107375543(mocos)
KMR: 108247154(mocos)
CSEM: 103387498(mocos)
LCF: 108886273(mocos)
SDU: 111220745(mocos)
HCQ: 109523029(mocos)
BPEC: 110173521(mocos)
MALB: 109960038
ELS: 105026557(mocos)
SFM: 108923697(mocos)
LCM: 102345152(MOCOS)
CMK: 103181183(mocos)
CIN: 100182548
SPU: 583644
APLC: 110975000
SKO: 102802829
DME: Dmel_CG1692(mal)
DER: 6549751
DPE: 6599378
DSI: Dsimw501_GD19688(Dsim_GD19688)
DWI: 6644650
MDE: 101890540
AGA: AgaP_AGAP000555(MOCOS_ANOGA)
AME: 411261
BIM: 100747497
BTER: 100647735
SOC: 105193848
PBAR: 105432349
HST: 105192250
DQU: 106752064
CFO: 105259179
LHU: 105672589
PGC: 109856555
PCF: 106784086
NVI: 100122104(mal)
MDL: 103570737
TCA: 655996
DPA: 109532846
NVL: 108569660
BMOR: 100134930(mal)
PRAP: 110996467
HAW: 110374298
PXY: 105390609
DNX: 107168202
CLEC: 106669371
ZNE: 110840571
FCD: 110849036
CEL: CELE_R03A10.3(mocs-1)
CBR: CBG07703
TSP: Tsp_00269
MYI: 110445086
EPA: 110238345
ADF: 107334248
AQU: 100632714
ATH: AT1G16540(ABA3)
CRB: 17900233
BRP: 103872446
BOE: 106295608
THJ: 104812356
CPAP: 110813185
CIT: 102577967
TCC: 18594558
GRA: 105775773
EGR: 104448676
GMX: 100787334
VRA: 106756103
VAR: 108340378
CCAJ: 109817449
CAM: 101491274
LJA: Lj3g3v0461990.1(Lj3g3v0461990.1) Lj3g3v0462260.1(Lj3g3v0462260.1)
ADU: 107470927
AIP: 107622615
LANG: 109325633
FVE: 101310007
PPER: 18780634
PMUM: 103325694
PAVI: 110769002
PXB: 103952011
ZJU: 107417969
CSV: 101220625
CMO: 103496300
MCHA: 111017992
CMAX: 111469677
CMOS: 111451282
CPEP: 111795061
RCU: 8272616
JCU: 105646197
HBR: 110662033
POP: 7483072
JRE: 108998007
VVI: 100247369
SLY: 543832(FLACCA)
SPEN: 107026467
SOT: 102580056
CANN: 107878893
NTO: 104115990
SIND: 105175074
OEU: 111385378
HAN: 110890120
LSV: 111904522
CCAV: 112506408
DCR: 108214967
BVG: 104904512
SOE: 110784245
NNU: 104608087
OSA: 4341801
DOSA: Os06t0670000-01(Os06g0670000)
OBR: 102708066
BDI: 100833860
ATS: 109764490(LOC109764490)
SBI: 8061592
SITA: 101770290
MUS: 103993636
PEQ: 110038799
ATR: 18443110
NCR: NCU02777
NTE: NEUTE1DRAFT106582(NEUTE1DRAFT_106582)
SSCK: SPSK_05938
MAW: MAC_05269
MAJ: MAA_03960
CMT: CCM_07073
ANG: ANI_1_1786184(An04g03890)
ABE: ARB_00349
TVE: TRV_04189
DDI: DDB_G0272935(mocos)
DFA: DFA_00843(mocos)
SMIN: v1.2.020005.t1(symbB.v1.2.020005.t1) v1.2.036207.t1(symbB.v1.2.036207.t1)
SPAR: SPRG_02564
 » show all
Taxonomy
Reference
1  [PMID:11553608]
  Authors
Bittner F, Oreb M, Mendel RR
  Title
ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana.
  Journal
J Biol Chem 276:40381-4 (2001)
DOI:10.1074/jbc.C100472200
  Sequence
[ath:AT1G16540]
Reference
2  [PMID:15561708]
  Authors
Heidenreich T, Wollers S, Mendel RR, Bittner F
  Title
Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.
  Journal
J Biol Chem 280:4213-8 (2005)
DOI:10.1074/jbc.M411195200
  Sequence
[ath:AT1G16540]
Reference
3  [PMID:18258600]
  Authors
Wollers S, Heidenreich T, Zarepour M, Zachmann D, Kraft C, Zhao Y, Mendel RR, Bittner F
  Title
Binding of sulfurated molybdenum cofactor to the C-terminal domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.
  Journal
J Biol Chem 283:9642-50 (2008)
DOI:10.1074/jbc.M708549200
  Sequence
[ath:AT1G16540]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.1.9
IUBMB Enzyme Nomenclature: 2.8.1.9
ExPASy - ENZYME nomenclature database: 2.8.1.9
BRENDA, the Enzyme Database: 2.8.1.9

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