KEGG   ENZYME: 2.8.2.11Help
Entry
EC 2.8.2.11                 Enzyme                                 

Name
galactosylceramide sulfotransferase;
GSase;
3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase;
galactocerebroside sulfotransferase;
galactolipid sulfotransferase;
glycolipid sulfotransferase;
glycosphingolipid sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate [RN:R04017 R06279]
Reaction(KEGG)
R04017 R06279(G);
(other) R05105 R06122(G) R10805
Show
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
galactosylceramide [CPD:C02686]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
galactosylceramide sulfate [CPD:C06125]
Comment
Also acts on lactosylceramide.
History
EC 2.8.2.11 created 1972, modified 1976
Pathway
ec00565  Ether lipid metabolism
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K01019  galactosylceramide sulfotransferase
Genes
HSA: 9514(GAL3ST1)
PTR: 458758(GAL3ST1)
PPS: 100977095(GAL3ST1)
GGO: 101145588(GAL3ST1)
PON: 100452559(GAL3ST1)
NLE: 100607890(GAL3ST1)
MCC: 715998(GAL3ST1)
MCF: 102117816(GAL3ST1)
CSAB: 103223169(GAL3ST1)
RRO: 104668179(GAL3ST1)
RBB: 108527632(GAL3ST1)
CJC: 100392008(GAL3ST1)
SBQ: 101040941(GAL3ST1)
MMU: 53897(Gal3st1)
RNO: 683713(Gal3st1)
CGE: 100756367(Gal3st1)
NGI: 103740443(Gal3st1) 103740444
HGL: 101706903(Gal3st1)
CCAN: 109696785(Gal3st1)
OCU: 103351708(GAL3ST1)
TUP: 102467729(GAL3ST1)
CFA: 611960(GAL3ST1)
AML: 100481232(GAL3ST1)
UMR: 103681122(GAL3ST1)
ORO: 101371578(GAL3ST1)
FCA: 101092797(GAL3ST1)
PTG: 102972364(GAL3ST1)
AJU: 106983278(GAL3ST1)
BTA: 513295(GAL3ST1)
BOM: 102276313(GAL3ST1)
PHD: 102319785(GAL3ST1)
CHX: 102169694(GAL3ST1)
OAS: 101112599(GAL3ST1)
SSC: 100155265(GAL3ST1)
CDK: 105099440(GAL3ST1)
BACU: 102998748(GAL3ST1)
LVE: 103089977(GAL3ST1)
OOR: 101277883(GAL3ST1)
ECB: 100063781(GAL3ST1)
EPZ: 103548105(GAL3ST1)
EAI: 106827087(GAL3ST1)
MYB: 102254410(GAL3ST1)
MYD: 102768622(GAL3ST1)
HAI: 109383083(GAL3ST1)
RSS: 109453397(GAL3ST1)
PALE: 102891895(GAL3ST1)
TMU: 101340828
MDO: 100031088(GAL3ST1)
OAA: 100088700(GAL3ST1)
GGA: 417006(GAL3ST1)
MGP: 100538663(GAL3ST1)
CJO: 107321503(GAL3ST1)
APLA: 101805029(GAL3ST1)
ACYG: 106049052(GAL3ST1)
TGU: 100218664(GAL3ST1)
GFR: 102039149(GAL3ST1)
FAB: 101815086(GAL3ST1)
PHI: 102111822(GAL3ST1)
PMAJ: 107211434(GAL3ST1)
CCAE: 111936675(GAL3ST1)
CCW: 104694982(GAL3ST1)
FPG: 101914565(GAL3ST1)
FCH: 102049840(GAL3ST1)
CLV: 102095258(GAL3ST1)
EGZ: 104129879(GAL3ST1)
AAM: 106494522(GAL3ST1)
ASN: 102371784(GAL3ST1)
AMJ: 102564060(GAL3ST1)
PSS: 102464092
CMY: 102935410(GAL3ST1) 102940064
CPIC: 101936200(GAL3ST1) 101940487
ACS: 100551827(gal3st1) 100563379
PVT: 110077998 110082861(GAL3ST1)
PBI: 103053254(GAL3ST1)
GJA: 107105972(GAL3ST1) 107119337
XLA: 108707055(gal3st1.S) 108715331(gal3st1.L)
XTR: 100495120(gal3st1)
NPR: 108786252(GAL3ST1)
DRE: 793735(gal3st1a)
IPU: 108255842(gal3st1) 108277024
AMEX: 103033194 103042075(gal3st1) 103043086
TRU: 101078195(gal3st1) 101078688
MZE: 101476500(gal3st1) 101486819
XMA: 102229419(gal3st1)
PRET: 103470350(gal3st1) 103473755
NFU: 107373629 107393955(gal3st1)
KMR: 108232652 108234457(gal3st1)
CSEM: 103384136 103390132 103397303(gal3st1)
HCQ: 109514250(gal3st1) 109526053
BPEC: 110156702(gal3st1) 110160534 110166260
MALB: 109956870(gal3st1) 109970811
ELS: 105014430(gal3st1) 105027060
LCM: 102353453(GAL3ST1) 102367311
CMK: 103184338(gal3st1)
SPU: 577607
TUT: 107364531
CRG: 105341335
MYI: 110460715
 » show all
Taxonomy
Reference
1  [PMID:5850675]
  Authors
McKhann GM, Levy R, Ho W.
  Title
Metabolism of sulfatides. I. The effect of galactocerebrosides on the synthesis of sulfatides.
  Journal
Biochem Biophys Res Commun 20:109-13 (1965)
DOI:10.1016/0006-291X(65)90331-1
Reference
2  [PMID:2562926]
  Authors
Sakakibara N, Gasa S, Kamio K, Makita A, Koyanagi T.
  Title
Association of elevated sulfatides and sulfotransferase activities with human renal cell carcinoma.
  Journal
Cancer Res 49:335-9 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.11
IUBMB Enzyme Nomenclature: 2.8.2.11
ExPASy - ENZYME nomenclature database: 2.8.2.11
BRENDA, the Enzyme Database: 2.8.2.11
CAS: 9081-06-5

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