KEGG   ENZYME: 2.8.2.14Help
Entry
EC 2.8.2.14                 Enzyme                                 

Name
bile-salt sulfotransferase;
BAST I;
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase;
bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase;
bile acid sulfotransferase I;
glycolithocholate sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase
Reaction(IUBMB)
(1) 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate [RN:R07287];
(2) 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate [RN:R03987]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
glycolithocholate [CPD:C15557];
taurolithocholate [CPD:C02592]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
glycolithocholate 3-sulfate [CPD:C11301];
taurolithocholate sulfate [CPD:C03642]
Comment
The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species [3]. This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5beta-bile acid glycolithocholate, deoxycholate, 3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2 [3].
History
EC 2.8.2.14 created 1978, modified 2005
Pathway
ec00980  Metabolism of xenobiotics by cytochrome P450
Orthology
K11822  bile-salt sulfotransferase
Genes
HSA: 6822(SULT2A1)
PTR: 456409(SULT2A1)
PPS: 100971784(SULT2A1)
GGO: 101137965(SULT2A1)
PON: 100431471(SULT2A1)
NLE: 100603984(SULT2A1)
MCC: 717600(SULT2A1)
MCF: 102130325(SULT2A1)
CSAB: 103234953(SULT2A1)
RRO: 104673376(SULT2A1)
RBB: 108539899(SULT2A1)
CJC: 100401107 100413663(SULT2A1)
MMU: 20859(Sult2a1) 629203(Sult2a3)
RNO: 24912(Sult2a1)
CCAN: 109675537
OCU: 100008598(SULT2A1)
BTA: 514658 533560(SULT2A1)
SSC: 641359(SULT2A1)
CFR: 102518264(SULT2A1)
CDK: 105098927(SULT2A1)
BACU: 103005028(SULT2A1)
OOR: 105747730
MYD: 102762349 102762941(SULT2A1)
HAI: 109390976(SULT2A1)
RSS: 109439242 109458702(SULT2A1)
PALE: 102890032(SULT2A1)
MDO: 100018596
 » show all
Taxonomy
Reference
1  [PMID:831833]
  Authors
Chen LJ, Bolt RJ, Admirand WH.
  Title
Enzymatic sulfation of bile salts. Partial purification and characterization of an enzyme from rat liver that catalyzes the sulfation of bile salts.
  Journal
Biochim Biophys Acta 480:219-27 (1977)
DOI:10.1016/0005-2744(77)90335-7
Reference
2  [PMID:3470420]
  Authors
Barnes S, Waldrop R, Crenshaw J, King RJ, Taylor KB.
  Title
Evidence for an ordered reaction mechanism for bile salt: 3'phosphoadenosine-5'-phosphosulfate: sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholate.
  Journal
J Lipid Res 27:1111-23 (1986)
Reference
3  [PMID:2754334]
  Authors
Barnes S, Buchina ES, King RJ, McBurnett T, Taylor KB.
  Title
Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: purification, N-terminal amino acid sequence, and kinetic properties.
  Journal
J Lipid Res 30:529-40 (1989)
Reference
4  [PMID:12543708]
  Authors
Russell DW.
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.14
IUBMB Enzyme Nomenclature: 2.8.2.14
ExPASy - ENZYME nomenclature database: 2.8.2.14
BRENDA, the Enzyme Database: 2.8.2.14
CAS: 65802-92-8

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