KEGG   ENZYME: 2.8.2.21Help
Entry
EC 2.8.2.21                 Enzyme                                 

Name
keratan sulfotransferase;
3'-phosphoadenylyl keratan sulfotransferase;
keratan sulfate sulfotransferase;
3'-phosphoadenylylsulfate:keratan sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate [RN:R03553]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
keratan [CPD:C00573]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
keratan 6'-sulfate [CPD:C00573]
Comment
Sulfation takes place at the 6-position of galactosyl and N-acetylglucosaminyl residues in keratan, a proteoglycan. Not identical with EC 2.8.2.5 (chondroitin 4-sulfotransferase), EC 2.8.2.6 (choline sulfotransferase) or EC 2.8.2.17 (chondroitin 6-sulfotransferase).
History
EC 2.8.2.21 created 1989
Pathway
ec00533  Glycosaminoglycan biosynthesis - keratan sulfate
Orthology
K01022  keratan sulfate 6-sulfotransferase 1
Genes
HSA: 8534(CHST1)
PTR: 466500(CHST1)
PPS: 100979080(CHST1)
GGO: 101136055(CHST1)
PON: 100936783(CHST1)
NLE: 100607513(CHST1)
MCC: 715176(CHST1)
MCF: 102121159(CHST1)
CSAB: 103236789(CHST1)
RRO: 104668375(CHST1)
RBB: 108519267(CHST1)
CJC: 100403467(CHST1)
SBQ: 101041677(CHST1)
MMU: 76969(Chst1)
RNO: 295934(Chst1)
CGE: 100774066(Chst1)
NGI: 103751543(Chst1)
HGL: 101709273(Chst1)
CCAN: 109692002(Chst1) 109696439
OCU: 100348291(CHST1)
TUP: 102494285(CHST1)
CFA: 483642(CHST1)
AML: 100472620(CHST1)
UMR: 103672398(CHST1)
ORO: 101363802(CHST1)
FCA: 101085495(CHST1)
PTG: 102972740(CHST1)
AJU: 106978039(CHST1)
BTA: 506932(CHST1)
BOM: 102269216(CHST1)
BIU: 109569674(CHST1)
PHD: 102326729(CHST1)
CHX: 102182814(CHST1)
OAS: 101112159(CHST1)
SSC: 100519885(CHST1)
CFR: 102507446(CHST1)
CDK: 105106847(CHST1)
BACU: 103002842(CHST1)
LVE: 103089266(CHST1)
OOR: 101282618(CHST1)
EPZ: 103554341(CHST1)
EAI: 106843980(CHST1)
MYB: 102242164(CHST1) 102254023
MYD: 102766961(CHST1)
HAI: 109390240(CHST1)
RSS: 109455096(CHST1)
PALE: 102892829(CHST1)
LAV: 100654881(CHST1)
TMU: 101342127
MDO: 100011264(CHST1)
OAA: 100074919(CHST1)
GGA: 428866(CHST1)
MGP: 100550392(CHST1)
CJO: 107314790(CHST1)
APLA: 101796672(CHST1)
ACYG: 106043347(CHST1)
TGU: 100218131(CHST1)
GFR: 102031769(CHST1)
FAB: 101821527(CHST1)
PHI: 102102314(CHST1)
PMAJ: 107206472(CHST1)
CCAE: 111930194(CHST1)
CCW: 104698272(CHST1)
FPG: 101914171(CHST1)
FCH: 102059692(CHST1)
CLV: 102090832(CHST1)
EGZ: 104134086(CHST1)
AAM: 106498277(CHST1)
ASN: 102377269(CHST1)
AMJ: 102576487(CHST1)
PSS: 102450260(CHST1)
CMY: 102947896(CHST1)
CPIC: 101951161(CHST1)
ACS: 100556876(chst1)
PVT: 110082498(CHST1)
PBI: 103058223(CHST1)
GJA: 107113395(CHST1)
XLA: 108710801 108713774(chst1.L) 108715239(chst1.S)
XTR: 100485856 100492654(chst1)
NPR: 108785449(CHST1) 108788171
DRE: 445124(chst1)
TRU: 101070681(chst1) 101077034
NCC: 104951776 104967808(chst1)
XMA: 102227014 102236602(chst1)
PRET: 103462734(chst1) 103466195
NFU: 107381806(chst1) 107389055
KMR: 108234746(chst1) 108237443
HCQ: 109525715(chst1) 109530398
LCM: 102346083 102366374(CHST1)
CIN: 100185779
SPU: 100893412
HMG: 100213095
 » show all
Taxonomy
Reference
1  [PMID:6592165]
  Authors
Ruter ER, Kresse H.
  Title
Partial purification and characterization of 3'-phosphoadenylylsulfate:keratan sulfate sulfotransferases.
  Journal
J Biol Chem 259:11771-6 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.21
IUBMB Enzyme Nomenclature: 2.8.2.21
ExPASy - ENZYME nomenclature database: 2.8.2.21
BRENDA, the Enzyme Database: 2.8.2.21
CAS: 62168-79-0

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