KEGG   ENZYME: 2.8.2.29Help
Entry
EC 2.8.2.29                 Enzyme                                 

Name
[heparan sulfate]-glucosamine 3-sulfotransferase 2;
glucosaminyl 3-O-sulfotransferase;
heparan sulfate D-glucosaminyl 3-O-sulfotransferase;
isoform/isozyme 2 (3-OST-2, HS3ST2)
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate [RN:R05798]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
[heparan sulfate]-glucosamine [CPD:C17141]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
[heparan sulfate]-glucosamine 3-sulfate [CPD:C11553]
Comment
This enzyme sulfates the residues marked with an asterisk in sequences containing at least -> IdoA2S-> GlcN*-> or -> GlcA2S-> GlcN*-> (symbols as in {iupac/2carb/38::2-Carb-38}). Preference for GlcN2S vs. unmodified GlcN has not yet been established. Additional structural features are presumably required for substrate recognition, since the 3-O-sulfated residue is of low abundance, whereas the above IdoA-containing sequence is quite abundant. This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases by modifying selected glucosamine residues preceded by GlcA2S; EC 2.8.2.23 ([heparan sulfate]-glucosamine 3-sulfotransferase 1) prefers GlcA or IdoA, whereas EC 2.8.2.30 ([heparan sulfate]-glucosamine 3-sulfotransferase 3) prefers IdoA2S.
History
EC 2.8.2.29 created 2001
Pathway
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Orthology
K07808  [heparan sulfate]-glucosamine 3-sulfotransferase 2
Genes
HSA: 9956(HS3ST2)
PTR: 467924(HS3ST2)
PPS: 100969271(HS3ST2)
GGO: 101138321(HS3ST2)
PON: 100459958(HS3ST2)
NLE: 100590606(HS3ST2)
MCC: 699722(HS3ST2)
MCF: 102143244(HS3ST2)
CSAB: 103229688(HS3ST2)
RRO: 104658241(HS3ST2)
RBB: 108513770 108538879(HS3ST2)
CJC: 100405177(HS3ST2)
SBQ: 101034115(HS3ST2)
MMU: 195646(Hs3st2)
RNO: 293451(Hs3st2)
CGE: 100765580(Hs3st2)
NGI: 103742741(Hs3st2)
HGL: 101715838(Hs3st2)
CCAN: 109678012(Hs3st2)
OCU: 100349071(HS3ST2)
TUP: 102470961(HS3ST2)
CFA: 489975(HS3ST2)
AML: 100475753(HS3ST2)
UMR: 103668867(HS3ST2)
ORO: 101384501(HS3ST2)
FCA: 101090732(HS3ST2)
PTG: 102955706(HS3ST2)
AJU: 106970459(HS3ST2)
BTA: 532099(HS3ST2)
BOM: 102266030(HS3ST2)
BIU: 109578864(HS3ST2)
PHD: 102339420(HS3ST2)
CHX: 102183286(HS3ST2)
OAS: 101116370(HS3ST2)
SSC: 100522426(HS3ST2)
CFR: 102517676(HS3ST2)
CDK: 105094820(HS3ST2)
BACU: 103004974(HS3ST2)
LVE: 103086879(HS3ST2)
OOR: 101273003(HS3ST2)
ECB: 100068342(HS3ST2)
EPZ: 103544564(HS3ST2)
EAI: 106846156(HS3ST2)
MYB: 102257576(HS3ST2)
MYD: 102760096(HS3ST2)
HAI: 109386564(HS3ST2)
RSS: 109458205(HS3ST2)
PALE: 102883217(HS3ST2)
LAV: 100670647(HS3ST2)
TMU: 101354165
MDO: 100019945(HS3ST2)
SHR: 100914793(HS3ST2)
OAA: 100083841
GGA: 416581(HS3ST2)
MGP: 100540809(HS3ST2)
CJO: 107320809(HS3ST2)
APLA: 101800694(HS3ST2)
ACYG: 106046022
TGU: 100222527
GFR: 102037521 102044079(HS3ST2)
FAB: 101808999(HS3ST2)
PHI: 102113866(HS3ST2)
PMAJ: 107210993(HS3ST2)
CCW: 104684726
FPG: 101913235(HS3ST2)
FCH: 102054410(HS3ST2)
CLV: 102088439(HS3ST2)
EGZ: 104134551(HS3ST2)
AAM: 106487617(HS3ST2)
ASN: 102371657
AMJ: 102563033(HS3ST2)
PSS: 102445195
CMY: 102932960(HS3ST2)
CPIC: 101942810(HS3ST2)
ACS: 100560689
PVT: 110085030
PBI: 103064628
GJA: 107126204(HS3ST2)
XLA: 108701605(hs3st2.L) 108703165(hs3st2.S)
XTR: 100492586(hs3st2)
NPR: 108783720
DRE: 571246(hs3st2)
IPU: 108256804
AMEX: 103021790
NCC: 104964195(hs3st2) 104965376
CSEM: 103392778(hs3st2) 103399474
SFM: 108923900(hs3st2)
LCM: 102347024(HS3ST2)
SKO: 102805062
AQU: 105313345
 » show all
Taxonomy
Reference
1  [PMID:9988767]
  Authors
Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD.
  Title
Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.
  Journal
J Biol Chem 274:5170-84 (1999)
DOI:10.1074/jbc.274.8.5170
  Sequence
[hsa:9956]
Reference
2  [PMID:9988768]
  Authors
Liu J, Shworak NW, Sinay P, Schwartz JJ, Zhang L, Fritze LM, Rosenberg RD.
  Title
Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities.
  Journal
J Biol Chem 274:5185-92 (1999)
DOI:10.1074/jbc.274.8.5185
  Sequence
[hsa:9956]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.29
IUBMB Enzyme Nomenclature: 2.8.2.29
ExPASy - ENZYME nomenclature database: 2.8.2.29
BRENDA, the Enzyme Database: 2.8.2.29

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