KEGG   ENZYME: 2.8.2.30Help
Entry
EC 2.8.2.30                 Enzyme                                 

Name
[heparan sulfate]-glucosamine 3-sulfotransferase 3
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate [RN:R05798]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
[heparan sulfate]-glucosamine [CPD:C17141]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
[heparan sulfate]-glucosamine 3-sulfate [CPD:C11553]
Comment
Two major substrates contain the tetrasaccharides: -> undetermined 2-sulfo-uronic acid-> GlcN2S-> IdoA2S-> GlcN*-> and -> undetermined 2-sulfo-uronic acid-> GlcN2S-> IdoA2S-> GlcN6S*-> (symbols as in 2-Carb-38) with modification of the N-unsubstituted glucosamine residue (shown with an asterisk) [1,4]. Modification of selected sequences containing N-sulfo-glucosamine residues cannot yet be excluded. The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex virus type 1 as an entry receptor to infect the target cells [2]. There are two isozymes, known as 3-OST-3A and 3-OST-3B, which have identical catalytic domains but are encoded by different mammalian genes [3]. The specificity of this enzyme differs from that of the other [heparan sulfate]-glucosamine 3-sulfotransferases. It is inefficient at modifying precursors of the antithrombin binding site [in contrast to EC 2.8.2.23 ([heparan sulfate]-glucosamine 3-sulfotransferase 1)] and it does not modify glucosamine preceded by GlcA2S [unlike EC 2.8.2.29 ([heparan sulfate]-glucosamine 3-sulfotransferase 2)].
History
EC 2.8.2.30 created 2001
Pathway
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Orthology
K07809  [heparan sulfate]-glucosamine 3-sulfotransferase 3
Genes
HSA: 9953(HS3ST3B1) 9955(HS3ST3A1)
PTR: 455061(HS3ST3A1) 468393(HS3ST3B1)
PPS: 100974193(HS3ST3A1) 100988267(HS3ST3B1)
GGO: 101145926(HS3ST3A1) 101151182(HS3ST3B1)
PON: 100441136(HS3ST3A1) 100442248
NLE: 100586137(HS3ST3A1) 100589938(HS3ST3B1)
MCC: 718232(HS3ST3A1)
MCF: 102131170(HS3ST3A1) 102135242(HS3ST3B1)
CSAB: 103242411(HS3ST3A1) 103242418(HS3ST3B1)
RRO: 104667951(HS3ST3A1) 104667957(HS3ST3B1)
RBB: 108525424
CJC: 100413776(HS3ST3B1) 100414502(HS3ST3A1)
SBQ: 101037911 101038227(HS3ST3B1)
MMU: 15478(Hs3st3a1) 54710(Hs3st3b1)
RNO: 303218(Hs3st3b1) 363618(Hs3st3a1)
NGI: 103752044(Hs3st3b1) 103752048(Hs3st3a1)
HGL: 101696746(Hs3st3b1)
CCAN: 109680480 109684974(Hs3st3b1)
OCU: 100352865(HS3ST3B1) 100355575(HS3ST3A1)
TUP: 102487594(HS3ST3A1) 102489387(HS3ST3B1)
CFA: 489512(HS3ST3A1) 489516
ORO: 101366769(HS3ST3A1) 101375153(HS3ST3B1)
FCA: 101087432(HS3ST3A1) 101091978
PTG: 102967959(HS3ST3A1) 102968545
AJU: 106989807(HS3ST3A1)
BTA: 521959(HS3ST3A1) 617069(HS3ST3B1)
BOM: 102264332(HS3ST3A1) 102264905(HS3ST3B1)
BIU: 109574448(HS3ST3B1) 109574478(HS3ST3A1)
PHD: 102326770(HS3ST3B1) 102334005(HS3ST3A1)
CHX: 102176640(HS3ST3A1) 102184089(HS3ST3B1)
OAS: 101105173(HS3ST3A1) 101115554(HS3ST3B1)
SSC: 100625836(HS3ST3A1) 100737777(HS3ST3B1)
CFR: 102512802(HS3ST3A1)
CDK: 105085069 105085097(HS3ST3A1)
BACU: 103016406(HS3ST3A1)
LVE: 103071775(HS3ST3A1) 103072323(HS3ST3B1) 103080038
OOR: 101269529(HS3ST3A1) 101290366(HS3ST3B1)
ECB: 100063069(HS3ST3B1) 100073112(HS3ST3A1)
EAI: 106845777(HS3ST3A1) 106845781(HS3ST3B1)
MYB: 102261026(HS3ST3B1) 102261616(HS3ST3A1)
MYD: 102768025
HAI: 109382157(HS3ST3B1) 109382182
RSS: 109435010 109460146(HS3ST3A1)
PALE: 102889218(HS3ST3A1) 102889972(HS3ST3B1)
LAV: 100667730 100668015(HS3ST3B1)
OAA: 100078354
GGA: 769421(HS3ST3B1L) 769490(HS3ST3B1)
MGP: 100547284(HS3ST3B1)
CJO: 107322099 107322259(HS3ST3A1)
ACYG: 106029692 106046700(HS3ST3A1)
TGU: 100232358 100232659(HS3ST3B1)
PHI: 102104421(HS3ST3B1) 102112304(HS3ST3A1)
CPIC: 101934697(HS3ST3A1) 101934991(HS3ST3B1)
ACS: 100555056 100555456(hs3st3a1)
PVT: 110075060 110084026(HS3ST3B1)
XLA: 100037135(hs3st3a1.L) 108701173 108702850
XTR: 100380167(hs3st3a1)
DRE: 100329339(si:ch211-216b21.2) 558084(hs3st3b1b)
IPU: 108260710(Hs3st3b1) 108273439 108273751 108274355(HS3ST3B1)
LCM: 102359925(HS3ST3B1) 102360615(HS3ST3A1)
DME: Dmel_CG7890(Hs3st-B)
DSI: Dsimw501_GD24871(Dsim_GD24871)
MDE: 101892345
AAG: 5577441
AME: 413133
BIM: 100746082
BTER: 100642292
SOC: 105195630
AEC: 105144583
ACEP: 105618373
PBAR: 105431729
HST: 105185983
CFO: 105259454
LHU: 105678665
PGC: 109854140
NVI: 100120076
TCA: 662715
DPA: 109539423
NVL: 108562372
BMOR: 101745633
PMAC: 106717481
PRAP: 110996735
PXY: 105384979
ZNE: 110837600
CEL: CELE_F52B10.2(hst-3.2)
CBR: CBG02023
MYI: 110443208
LAK: 106168414
AQU: 109586843
 » show all
Taxonomy
Reference
1  [PMID:10608887]
  Authors
Liu J, Shriver Z, Blaiklock P, Yoshida K, Sasisekharan R, Rosenberg RD.
  Title
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N-unsubstituted glucosamine residues.
  Journal
J Biol Chem 274:38155-62 (1999)
DOI:10.1074/jbc.274.53.38155
  Sequence
[hsa:9955]
Reference
2  [PMID:10520990]
  Authors
Shukla D, Liu J, Blaiklock P, Shworak NW, Bai X, Esko JD, Cohen GH, Eisenberg RJ, Rosenberg RD, Spear PG.
  Title
A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry.
  Journal
Cell 99:13-22 (1999)
DOI:10.1016/S0092-8674(00)80058-6
  Sequence
[hsa:9955 9953][mmu:54710]
Reference
3  [PMID:9988767]
  Authors
Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD.
  Title
Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.
  Journal
J Biol Chem 274:5170-84 (1999)
DOI:10.1074/jbc.274.8.5170
  Sequence
[hsa:9955 9953]
Reference
4  [PMID:9988768]
  Authors
Liu J, Shworak NW, Sinay P, Schwartz JJ, Zhang L, Fritze LM, Rosenberg RD.
  Title
Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities.
  Journal
J Biol Chem 274:5185-92 (1999)
DOI:10.1074/jbc.274.8.5185
  Sequence
[hsa:9955 9953]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.30
IUBMB Enzyme Nomenclature: 2.8.2.30
ExPASy - ENZYME nomenclature database: 2.8.2.30
BRENDA, the Enzyme Database: 2.8.2.30

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