KEGG   ENZYME: 2.8.2.34Help
Entry
EC 2.8.2.34                 Enzyme                                 

Name
glycochenodeoxycholate sulfotransferase;
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase;
bile acid:PAPS:sulfotransferase;
BAST
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate [RN:R07289]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
glycochenodeoxycholate [CPD:C05466]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
glycochenodeoxycholate 7-sulfate [CPD:C15559]
Comment
The enzyme specifically sulfates glycochenodeoxycholate at the 7alpha-position (see also EC 2.8.2.14 bile-salt sulfotransferase). The monohydroxy bile acids glycolithocholate, chenodeoxycholate and ursodeoxycholate act as inhibitors.
History
EC 2.8.2.34 created 2005
Reference
1  [PMID:533830]
  Authors
Barnes S, Burhol PG, Zander R, Haggstrom G, Settine RL, Hirschowitz BI.
  Title
Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters.
  Journal
J Lipid Res 20:952-9 (1979)
Reference
2  [PMID:12543708]
  Authors
Russell DW.
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.34
IUBMB Enzyme Nomenclature: 2.8.2.34
ExPASy - ENZYME nomenclature database: 2.8.2.34
BRENDA, the Enzyme Database: 2.8.2.34
CAS: 72668-90-7

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