KEGG   ENZYME: 2.8.2.35Help
Entry
EC 2.8.2.35                 Enzyme                                 

Name
dermatan 4-sulfotransferase;
dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase;
dermatan-4-sulfotransferase-1;
dermatan-4-sulfotransferase 1;
D4ST-1;
dermatan N-acetylgalactosamine 4-O-sulfotransferase;
CHST14 protein;
CHST14
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phospho-5'-adenylyl sulfate:[dermatan]-N-acetyl-D-galactosamine 4-sulfotransferase
Reaction(IUBMB)
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine [RN:R10873]
Reaction(KEGG)
Substrate
3'-phospho-5'-adenylyl sulfate [CPD:C00053];
[dermatan]-N-acetyl-D-galactosamine
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
[dermatan]-4-O-sulfo-N-acetyl-D-galactosamine
Comment
The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAalpha(1,3)GalNAcbeta(1,4) that is flanked by GlcUAbeta(1,3)GalNAcbeta(1,4) as compared with IdoUAalpha(1,3)GalNAcbeta(1,4) flanked by IdoUAalpha(1,3)GalNAcbeta(1,4) [1].
History
EC 2.8.2.35 created 2010
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Orthology
K08105  dermatan 4-sulfotransferase 1
Genes
HSA: 113189(CHST14)
PTR: 453336(CHST14)
PPS: 100974168(CHST14)
GGO: 101144190(CHST14)
PON: 100460562(CHST14)
NLE: 100582723(CHST14)
MCC: 703115(CHST14)
MCF: 102144190(CHST14)
CSAB: 103245830(CHST14)
RRO: 104659660(CHST14)
RBB: 108523421(CHST14)
CJC: 100414908(CHST14)
SBQ: 101050993(CHST14)
MMU: 72136(Chst14)
RNO: 691394(Chst14)
CGE: 100753239(Chst14)
NGI: 103744909(Chst14)
HGL: 101712567(Chst14)
CCAN: 109700142(Chst14)
OCU: 100347170(CHST14)
TUP: 102491092(CHST14)
CFA: 608435(CHST14)
AML: 100474523(CHST14)
UMR: 103673547(CHST14)
ORO: 101371480(CHST14)
FCA: 101089445(CHST14)
PTG: 102960344(CHST14)
AJU: 106968540(CHST14)
BTA: 511245(CHST14)
BOM: 102276696(CHST14)
BIU: 109564936(CHST14)
PHD: 102321309(CHST14)
CHX: 102171342(CHST14)
OAS: 101108574(CHST14)
SSC: 100520059(CHST14)
CFR: 102522609(CHST14)
CDK: 105096881(CHST14)
BACU: 103015208(CHST14)
LVE: 103077004(CHST14)
OOR: 101279989(CHST14)
ECB: 100146378(CHST14)
EPZ: 103564234(CHST14)
EAI: 106830884(CHST14)
MYB: 102255542(CHST14)
MYD: 102756367(CHST14)
HAI: 109384001(CHST14)
RSS: 109444230(CHST14)
PALE: 102895029(CHST14)
LAV: 100669698(CHST14)
TMU: 101348444
MDO: 100027325(CHST14)
SHR: 100925127(CHST14)
GGA: 770193(CHST14)
MGP: 104910967(CHST14)
CJO: 107314214(CHST14)
APLA: 101789722(CHST14)
ACYG: 106047026(CHST14)
GFR: 102033127(CHST14)
FAB: 101817927(CHST14)
PHI: 102102390(CHST14)
PMAJ: 107205280(CHST14)
CCAE: 111930367(CHST14)
CCW: 104693010(CHST14)
FPG: 101924189(CHST14)
FCH: 102048313(CHST14)
CLV: 102086987(CHST14)
EGZ: 104130085(CHST14)
AAM: 106486718(CHST14)
ASN: 102382545(CHST14)
AMJ: 102567038(CHST14)
PSS: 102462445(CHST14)
CMY: 102945000(CHST14)
CPIC: 101933563(CHST14)
ACS: 100563611(chst14)
PVT: 110091558(CHST14)
PBI: 103049955(CHST14)
GJA: 107113505(CHST14)
XLA: 108699261(chst14.L)
XTR: 100496179(chst14)
NPR: 108799094(CHST14)
DRE: 404732(chst14)
IPU: 108257907(chst14)
AMEX: 103039455(chst14)
TRU: 101073313(chst14)
LCO: 104919098(chst14)
NCC: 104947083(chst14)
MZE: 101475363(chst14)
OLA: 101163891(chst14)
XMA: 102234472(chst14)
PRET: 103463827(chst14)
NFU: 107393406(chst14)
KMR: 108243380(chst14)
CSEM: 103376694(chst14)
LCF: 108879115(chst14)
SDU: 111226386(chst14)
HCQ: 109509816(chst14) 109531938
BPEC: 110154819(chst14)
MALB: 109962092(chst14)
SASA: 106584126
ELS: 105011847(chst14)
SFM: 108922740(chst14)
LCM: 102352110(CHST14)
CMK: 103178176(chst14)
SPU: 594830
EPA: 110238992
ADF: 107332762
AQU: 100635685
 » show all
Taxonomy
Reference
1  [PMID:11470797]
  Authors
Evers MR, Xia G, Kang HG, Schachner M, Baenziger JU
  Title
Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.
  Journal
J Biol Chem 276:36344-53 (2001)
DOI:10.1074/jbc.M105848200
  Sequence
[hsa:113189]
Reference
2  [PMID:12847091]
  Authors
Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K
  Title
Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine  4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis.
  Journal
J Biol Chem 278:36115-27 (2003)
DOI:10.1074/jbc.M306044200
  Sequence
[hsa:113189]
Reference
3  [PMID:19661164]
  Authors
Pacheco B, Maccarana M, Malmstrom A
  Title
Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate.
  Journal
Glycobiology 19:1197-203 (2009)
DOI:10.1093/glycob/cwp110
  Sequence
[hsa:113189]
Reference
4  [PMID:16702220]
  Authors
Mitsunaga C, Mikami T, Mizumoto S, Fukuda J, Sugahara K
  Title
Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases.
  Journal
J Biol Chem 281:18942-52 (2006)
DOI:10.1074/jbc.M510870200
  Sequence
[mmu:72136]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.35
IUBMB Enzyme Nomenclature: 2.8.2.35
ExPASy - ENZYME nomenclature database: 2.8.2.35
BRENDA, the Enzyme Database: 2.8.2.35

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