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Entry
EC 2.8.2.5                  Enzyme                                 

Name
chondroitin 4-sulfotransferase;
chondroitin sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate [RN:R02180]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
chondroitin [CPD:C00401]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
chondroitin 4'-sulfate [CPD:C00634]
Comment
The sulfation takes place at the 4-position of N-acetyl-galactosamine residues of chondroitin. Not identical with EC 2.8.2.17 chondroitin 6-sulfotransferase.
History
EC 2.8.2.5 created 1965, modified 1986
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Orthology
K01017  chondroitin 4-sulfotransferase 11
K04742  chondroitin 4-sulfotransferase 12
K07779  chondroitin 4-sulfotransferase 13
Genes
HSA: 166012(CHST13) 50515(CHST11) 55501(CHST12)
PTR: 467113(CHST11) 471065(CHST13) 472270(CHST12)
PPS: 100971795(CHST13) 100975988(CHST11) 100977359(CHST12)
GGO: 101133837 101139277(CHST13) 101144960(CHST12) 109029234(CHST11)
PON: 100456373(CHST12) 100457862(CHST11) 103890079(CHST13)
NLE: 100589808(CHST12) 100594174(CHST13) 100602866(CHST11)
MCC: 700690(CHST11) 713591(CHST12) 716548(CHST13)
MCF: 102121463(CHST12) 102142576(CHST13) 102145281(CHST11)
CSAB: 103228121(CHST13) 103238996(CHST11) 103246866(CHST12)
RRO: 104657479(CHST11) 104664960(CHST12) 104675913(CHST13)
RBB: 108528199(CHST13) 108543796(CHST12) 108544272(CHST11)
CJC: 100389849(CHST13) 100399023(CHST12) 100402381(CHST11)
SBQ: 101041861(CHST11) 101050645(CHST13) 101051059(CHST12)
MMU: 58250(Chst11) 59031(Chst12) 71797(Chst13)
RNO: 304322(Chst12) 314694(Chst11) 500257(Chst13)
CGE: 100762689(Chst12) 100771243(Chst13) 100771304(Chst11)
NGI: 103730362(Chst13) 103742136(Chst11) 103748676(Chst12)
HGL: 101699086(Chst11) 101700717(Chst12) 101703999(Chst13)
CCAN: 109675795(Chst11) 109694295(Chst12) 109700988(Chst13)
OCU: 100340729(CHST12) 100343641(CHST11) 100357997(CHST13)
TUP: 102472415(CHST12) 102500906(CHST11)
CFA: 481299(CHST11) 484618(CHST13) 609635(CHST12)
AML: 100475790(CHST11) 100478956(CHST12) 105239284(CHST13)
ORO: 101369477(CHST12) 101375725(CHST13) 101381523(CHST11)
FCA: 101085731(CHST11) 101086274(CHST12) 101093089(CHST13)
PTG: 102956639(CHST11) 102962488(CHST12)
AJU: 106971879(CHST11) 106984521(CHST12)
BTA: 513030(CHST12) 523460(CHST13) 528860(CHST11)
BOM: 102266002(CHST11) 102284925(CHST12)
BIU: 109556624(CHST13) 109559464(CHST11) 109578774(CHST12)
PHD: 102324187(CHST12) 102343636(CHST11)
CHX: 102168320(CHST12) 102184407(CHST11) 108633379(CHST13)
OAS: 101113667(CHST11) 101118845(CHST12)
SSC: 100157186(CHST11) 100519444(CHST13) 100524793(CHST12)
CFR: 102505142(CHST12) 102520253(CHST11) 106730843
CDK: 105097485(CHST11) 105105772(CHST12)
BACU: 103001272(CHST12) 103007407(CHST11) 103018950(CHST13)
LVE: 103068836(CHST13) 103088503(CHST11) 103089407(CHST12)
OOR: 101282560(CHST12) 101286427(CHST13) 101287126(CHST11)
ECB: 100059762(CHST12) 100067989(CHST11) 111768279(CHST13)
EPZ: 103551754(CHST12) 103554080(CHST11)
EAI: 106834774(CHST12) 106846795(CHST11)
MYB: 102256866(CHST11) 102261451(CHST12)
MYD: 102763992(CHST11) 102765213(CHST12)
HAI: 109376608(CHST13) 109380237(CHST12) 109387746(CHST11)
RSS: 109439260(CHST13) 109445796(CHST11) 109461373(CHST12)
PALE: 102887006(CHST11) 102893899(CHST13) 102897939(CHST12)
LAV: 100669843(CHST13) 100672295(CHST11) 100675592(CHST12)
MDO: 100010103(CHST12) 100015110(CHST11) 100026788(CHST13)
SHR: 100914185(CHST12) 100921711(CHST11) 100922364(CHST13)
OAA: 100076609(CHST11) 100082901(CHST12) 100088952
GGA: 416032(CHST13) 416469(CHST12) 418081(CHST11)
MGP: 100540137(CHST13) 100543037(CHST11) 100548662(CHST12)
CJO: 107314821(CHST11) 107319851(CHST13) 107320779(CHST12)
APLA: 101793228(CHST13) 101796810(CHST12) 101802330(CHST11)
ACYG: 106033547(CHST12) 106035913(CHST11) 106045054(CHST13)
TGU: 100222220(CHST12) 100225306(CHST11) 100228818(CHST13)
GFR: 102034597(CHST11) 102042843(CHST13) 102042953(CHST12)
FAB: 101806996(CHST11) 101808164(CHST13) 101816778(CHST12)
PHI: 102103855(CHST12) 102109237(CHST13) 102110718(CHST11)
PMAJ: 107205092(CHST11) 107210495(CHST13) 107210929(CHST12)
CCW: 104683299(CHST13) 104684815(CHST12) 104696241(CHST11)
FPG: 101910612(CHST12) 101914956(CHST13) 101924047(CHST11)
FCH: 102046810(CHST11) 102058463(CHST13) 102058489(CHST12)
CLV: 102088065(CHST13) 102089116(CHST12) 102095894(CHST11)
EGZ: 104126707(CHST13) 104132591(CHST12) 104132737(CHST11)
AAM: 106488448(CHST11) 106498985(CHST13) 106499955(CHST12)
ASN: 102379722(CHST12) 102383336(CHST13) 102384031(CHST11)
AMJ: 102564297(CHST11) 102565939(CHST12) 102574132(CHST13)
PSS: 102449023(CHST11) 102459582(CHST13) 102463513(CHST12)
CMY: 102932531(CHST12) 102941104 102942919(CHST11)
CPIC: 101937092(CHST11) 101944705(CHST13) 101953300(CHST12)
ACS: 100551540(chst11) 100560568(chst13) 100566390(chst12)
PVT: 110084788(CHST11) 110091163 110091687(CHST12)
PBI: 103048906(CHST11) 103049785(CHST12) 103049881
GJA: 107112011(CHST12) 107124190(CHST11) 107125909(CHST13)
XLA: 108703125(chst12.S) 108711031 108713201 380581(chst13.L) 496355(chst12.L) 734260(chst13.S)
XTR: 100125190(chst11) 493458(chst13) 548703(chst12)
NPR: 108784926(CHST11) 108786200(CHST12) 108802185
DRE: 404232(chst11) 407076(chst12a) 565671(si:ch211-236h17.3)
XMA: 102224428(chst12) 102229515 102235302 102236173(chst11)
BPEC: 110157995 110159100(chst11) 110162319(chst12) 110165816
SFM: 108918170 108920743(chst11) 108922503(chst12) 108939113
LCM: 102347601(CHST12) 102350815(CHST11) 102354698(CHST13) 102365200
CMK: 103175681 103176680(chst13) 103179823(chst11) 103186616 103186826(chst12)
SPU: 591353
DME: Dmel_CG31743(CG31743)
DSI: Dsimw501_GD24092(Dsim_GD24092)
MDE: 101899240
AAG: 5565900
PBAR: 105427651
NVI: 100119726
TCA: 663404
DPA: 109546811
NVL: 108561330
API: 100160220
DNX: 107168413
FCD: 110841711
HMG: 100204866
AQU: 105313833
 » show all
Taxonomy
Reference
1  [PMID:6957247]
  Authors
Habuchi O, Miyashita N.
  Title
Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage.
  Journal
Biochim Biophys Acta 717:414-21 (1982)
DOI:10.1016/0304-4165(82)90282-3
Reference
2  [PMID:6130977]
  Authors
Nakanishi Y, Otsu K, Suzuki S.
  Title
Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine.
  Journal
FEBS Lett 151:15-8 (1983)
DOI:10.1016/0014-5793(83)80332-9
Reference
3  [PMID:6787041]
  Authors
Nakanishi Y, Shimizu M, Otsu K, Kato S, Tsuji M, Suzuki S.
  Title
A terminal 6-sulfotransferase catalyzing a synthesis of N-acetylgalactosamine 4,6-bissulfate residue at the nonreducing terminal position of chondroitin sulfate.
  Journal
J Biol Chem 256:5443-9 (1981)
Reference
4  [PMID:13835879]
  Authors
SUZUKI S, STROMINGER JL.
  Title
Enzymatic sulfation of mucopolysaccharides in hen oviduct. I. Transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to mucopolysaccharides.
  Journal
J Biol Chem 235:257-66 (1960)
Reference
5  [PMID:13835880]
  Authors
SUZUKI S, STROMINGER JL.
  Title
Enzymatic sulfation of mucopolysaccharides in hen oviduct. II. Mechanism of the reaction studied with oligosaccharides and monosaccharides as acceptors.
  Journal
J Biol Chem 235:267-73 (1960)
Reference
6  [PMID:13835881]
  Authors
SUZUKI S, STROMINGER JL.
  Title
Enzymatic sulfation of mucopolysaccharides in hen oviduct. III. Mechanism of sulfation of chondrotin and chondrotin sulfate A.
  Journal
J Biol Chem 235:274-6 (1960)
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.5
IUBMB Enzyme Nomenclature: 2.8.2.5
ExPASy - ENZYME nomenclature database: 2.8.2.5
BRENDA, the Enzyme Database: 2.8.2.5
CAS: 83589-04-2

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