KEGG   ENZYME: 2.8.3.15Help
Entry
EC 2.8.3.15                 Enzyme                                 

Name
succinyl-CoA:(R)-benzylsuccinate CoA-transferase;
benzylsuccinate CoA-transferase
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
BRITE hierarchy
Sysname
succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase
Reaction(IUBMB)
succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA [RN:R05588]
Reaction(KEGG)
Substrate
succinyl-CoA [CPD:C00091];
(R)-2-benzylsuccinate [CPD:C09816]
Product
succinate [CPD:C00042];
(R)-2-benzylsuccinyl-CoA [CPD:C09817]
Comment
Involved in anaerobic catabolism of toluene and is a strictly toluene-induced enzyme that catalyses the reversible regio- and enantio-selective synthesis of (R)-2-benzylsuccinyl-CoA. The enzyme from Thauera aromatica is inactive when (R)-benzylsuccinate is replaced by (S)-benzylsuccinate.
History
EC 2.8.3.15 created 2003
Pathway
ec00623  Toluene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07543  benzylsuccinate CoA-transferase BbsE subunit
K07544  benzylsuccinate CoA-transferase BbsF subunit
Genes
BYI: BYI23_C006080 BYI23_C006090(bbsE)
BUE: BRPE67_CCDS05370(bbsE) BRPE67_CCDS05380
BCAI: K788_0001720 K788_0001721
BBR: BB4333(bbsE) BB4334(bbsF)
BBX: BBS798_4110(bbsE) BBS798_4111(bbsF)
BFZ: BAU07_03770 BAU07_03775
BGM: CAL15_20530 CAL15_20535
BOZ: DBV39_02105 DBV39_02110
AXY: AXYL_00933 AXYL_00934
VEI: Veis_4269 Veis_4270
EBA: c2A311(bbsF) c2A312(bbsE)
GME: Gmet_1521(bbsE) Gmet_1522(bbsF)
GEO: Geob_2420(bbsE) Geob_2421(bbsF)
DTO: TOL2_C01510(bbsE) TOL2_C01520(bbsF) TOL2_C04940(bhsE) TOL2_C04950(bhsF)
 » show all
Taxonomy
Reference
1  [PMID:11418570]
  Authors
Leutwein C, Heider J.
  Title
Succinyl-CoA:(R)-benzylsuccinate CoA-transferase: an enzyme of the anaerobic toluene catabolic pathway in denitrifying bacteria.
  Journal
J Bacteriol 183:4288-95 (2001)
DOI:10.1128/JB.183.14.4288-4295.2001
  Sequence
Reference
2  [PMID:10589736]
  Authors
Leutwein C, Heider J.
  Title
Anaerobic toluene-catabolic pathway in denitrifying Thauera aromatica: activation and beta-oxidation of the first intermediate, (R)-(+)-benzylsuccinate.
  Journal
Microbiology 145 ( Pt 11):3265-71 (1999)
DOI:10.1099/00221287-145-11-3265
Reference
3  [PMID:10629170]
  Authors
Leuthner B, Heider J.
  Title
Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate.
  Journal
J Bacteriol 182:272-7 (2000)
DOI:10.1128/JB.182.2.272-277.2000
  Sequence
Reference
4  [PMID:11749953]
  Authors
Heider J.
  Title
A new family of CoA-transferases.
  Journal
FEBS Lett 509:345-9 (2001)
DOI:10.1016/S0014-5793(01)03178-7
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.15
IUBMB Enzyme Nomenclature: 2.8.3.15
ExPASy - ENZYME nomenclature database: 2.8.3.15
UM-BBD (Biocatalysis/Biodegradation Database): 2.8.3.15
BRENDA, the Enzyme Database: 2.8.3.15
CAS: 260966-56-1

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