KEGG   ENZYME: 2.8.3.18Help
Entry
EC 2.8.3.18                 Enzyme                                 

Name
succinyl-CoA:acetate CoA-transferase;
aarC (gene name);
SCACT
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
BRITE hierarchy
Sysname
succinyl-CoA:acetate CoA-transferase
Reaction(IUBMB)
succinyl-CoA + acetate = acetyl-CoA + succinate [RN:R10343]
Reaction(KEGG)
Substrate
succinyl-CoA [CPD:C00091];
acetate [CPD:C00033]
Product
acetyl-CoA [CPD:C00024];
succinate [CPD:C00042]
Comment
In acetic acid bacteria the enzyme, which is highly specific, catalyses the conversion of toxic acetate to acetyl-CoA [2,3]. In the hydrogenosomes of some trichomonads the enzyme catalyses the production of acetate [1].
History
EC 2.8.3.18 created 2013
Pathway
ec00020  Citrate cycle (TCA cycle)
ec00620  Pyruvate metabolism
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
ec01130  Biosynthesis of antibiotics
Orthology
K18118  succinyl-CoA:acetate CoA-transferase
Genes
LVE: 103069380
XCC: XCC3588
XCB: XC_0550
XCA: xcc-b100_0566(ach)
XCP: XCR_3969
XSA: SB85_10825
XTN: FD63_17565
XFR: BER92_17475
XGA: BI317_20985
XVE: BJD12_15350
SML: Smlt0471
SMT: Smal_0350
SMZ: SMD_0398
PAE: PA5445
PAEV: N297_5633
PAEI: N296_5633
PAU: PA14_71890(psecoA)
PNC: NCGM2_6222(psecoA)
PAEB: NCGM1900_6300(psecoA)
PAEP: PA1S_29415
PAEM: U769_29920
PAEL: T223_29880
PAEG: AI22_04570
PAEC: M802_5631
PAEO: M801_5498
PCQ: PcP3B5_01650(cat1)
PPU: PP_0154(scpC)
PPF: Pput_0172
PPT: PPS_0120
PPI: YSA_05271
PPX: T1E_0574(cat1)
PPUH: B479_01105
PPUT: L483_00420
PPUN: PP4_01470
PPUD: DW66_0131
PMON: X969_26830
PMOT: X970_26445
PSB: Psyr_5019
PSYR: N018_25345
PSP: PSPPH_5101(psecoA)
PFL: PFL_0112
PPRC: PFLCHA0_c01130(cat1)
PPRO: PPC_0118
PFS: PFLU_0110
PFB: VO64_3158
PMAN: OU5_3335
PEN: PSEEN0113
PSA: PST_2797
PSTT: CH92_07195
PPUU: PputUW4_00103(cat1)
PKC: PKB_0064(cat1)
PSES: PSCI_1875
PSEM: TO66_00560
PSEC: CCOS191_5158(cat1)
PSOS: POS17_0119
PANR: A7J50_0112
PSET: THL1_101
PSIL: PMA3_00250
PAR: Psyc_1175
PSYC: DABAL43B_1591(cat1)
ACB: A1S_3231
ABM: ABSDF0248
ABY: ABAYE0257
ABN: AB57_3679
ABX: ABK1_3477
ABH: M3Q_3664
ABAD: ABD1_31110
ABAZ: P795_1265
ABAU: IX87_13020
ABAA: IX88_00920
ACC: BDGL_002696(cat1)
ACI: ACIAD3390
MCT: MCR_0670(ach1)
MCS: DR90_1263
MCAT: MC25239_00653(scpC)
PHA: PSHAa2002(ygfH)
PAT: Patl_3791
PSM: PSM_A1168(ygfH)
PTN: PTRA_a2445(aarC)
PART: PARC_a1272(aarC)
PNG: PNIG_a2661(aarC)
PTD: PTET_a1322(aarC)
NWE: SAMEA3174300_0876(scpC)
KKI: KKKWG1_1610(cat)
LHK: LHK_02849
PSE: NH8B_3318(ach)
RPI: Rpic_1335
REH: H16_A1358(h16_A1358)
CNC: CNE_1c13820(cat)
RME: Rmet_4895(ygfH)
CTI: RALTA_A1278(ygfH)
BMA: BMAA1763
BMAL: DM55_4019
BMAQ: DM76_4715
BMAI: DM57_07190
BMAF: DM51_3456
BMAZ: BM44_3979
BMAB: BM45_4756
BPS: BPSS0514
BPM: BURPS1710b_A2071(aarC)
BPSE: BDL_3740
BPSM: BBQ_5682
BPSU: BBN_3914
BPSD: BBX_5577
BPK: BBK_5719
BPSH: DR55_4838
BPSA: BBU_5533
BPSO: X996_4588
BUT: X994_4106
BTQ: BTQ_5185
BTJ: BTJ_3815
BTZ: BTL_4671
BTD: BTI_5343
BTV: BTHA_5558
BTHE: BTN_4310
BTHM: BTRA_4575
BTHA: DR62_4359
BTHL: BG87_4642
BOK: DM82_4616
BOC: BG90_5975
BVE: AK36_4227
BCN: Bcen_4240
BCJ: BCAM1250
BCEN: DM39_3748
BCEW: DM40_4168
BCEO: I35_5099
BAM: Bamb_3540
BMU: Bmul_4466
BMK: DM80_3627
BMUL: NP80_4153
BCT: GEM_4490
BCED: DM42_3841
BDL: AK34_4225
BCON: NL30_06345
BUB: BW23_4924
BLAT: WK25_23180
BTEI: WS51_03945
BSEM: WJ12_26110
BPSL: WS57_07765
BMEC: WJ16_24735
BSTG: WT74_25040
BGU: KS03_4914
BGO: BM43_5363
BUK: MYA_4536
BUL: BW21_5023
BPH: Bphy_5077
BFN: OI25_4317
PPNO: DA70_00945
PPNM: LV28_05380
PPUL: RO07_24410
PSPU: NA29_12265
PAPI: SG18_23755
PLG: NCTC10937_05170(scpC)
HYF: DTO96_100904(cat1)
BPE: BP2031
BPC: BPTD_2002
BPER: BN118_1043
BPET: B1917_1806
BPEU: Q425_15880
BPA: BPP2411
BPAR: BN117_1564
BBR: BB1861
BAV: BAV2501
BHO: D560_0798
BHM: D558_0784
BHZ: ACR54_03535(cat1_1)
BTRM: SAMEA390648700004(scpC_1) SAMEA390648704214(scpC_2)
AXX: ERS451415_04718(scpC)
TEG: KUK_1431
TAS: TASI_1415
TAT: KUM_1211
BPSI: IX83_06565
AFQ: AFA_14710
ODI: ODI_R1777
RFR: Rfer_1216
PNA: Pnap_0073
AAV: Aave_0100
AJS: Ajs_0046
AAA: Acav_0130
ACRA: BSY15_1567
DAC: Daci_0085
OFO: BRW83_0203(cat1)
RGE: RGE_11660
PBH: AAW51_3529(aarC)
DSU: Dsui_0799
DAR: Daro_2807
AZO: azo3307(cat1)
AZA: AZKH_4172(cat1)
AOA: dqs_3445
CGRA: CGRAC_2147
CHYO: CHH_0817
CLX: CLAN_0745
DML: Dmul_38090(cat1)
ADE: Adeh_1288
BBAT: Bdt_1329
BBAC: EP01_04310
ATU: Atu0396
AVI: Avi_0516
RHT: NT26_3773(cat)
BME: BMEI0928
BMEL: DK63_494
BMEE: DK62_366
BMF: BAB1_1077
BABO: DK55_1061
BABR: DO74_828
BABT: DK49_818
BABB: DK48_1058
BABU: DK53_1044
BABS: DK51_413
BABC: DO78_967
BMS: BR1058
BSZ: DK67_1953
BOV: BOV_1023
BCAR: DK60_1110
BCAS: DA85_05050
BMR: BMI_I1063
BPP: BPI_I1101
BPV: DK65_319
OAN: Oant_2146
OAH: DR92_1641
BRA: BRADO2714
BBT: BBta_3051
BRS: S23_04740
AOL: S58_49060
RPA: RPA0537
RPB: RPB_0503
RPC: RPC_0254
RPD: RPD_0322
RPE: RPE_0804
RPT: Rpal_0538
XAU: Xaut_1730
AZC: AZC_3728
SNO: Snov_1616
MSL: Msil_3000
RVA: Rvan_0941
BVR: BVIR_1907
HDI: HDIA_2399(cat1)
CCR: CC_3724
CAK: Caul_5056
CSE: Cseg_4264
RSP: RSP_0029
PDE: Pden_4309
CID: P73_1301
RSU: NHU_01035
RHC: RGUI_1050
SPHK: SKP52_22425(cat1)
SPHM: G432_03675
SPKC: KC8_01440
SINB: SIDU_13960
AAY: WYH_00538(cat1)
ACR: Acry_1436
GDI: GDI1836
GDJ: Gdia_0063
GXY: GLX_06800
GXL: H845_1800
KEU: S101446_01070(aarC)
APK: APA386B_2589(aarC)
ASZ: ASN_3794(aarC)
RRU: Rru_A1927
RRF: F11_09905
RCE: RC1_0310
MAG: amb1383
TMO: TMO_a0434
BAN: BA_1862
BAR: GBAA_1862
BAT: BAS1726
BAI: BAA_1931
BANT: A16_19000
BANR: A16R_19210
BANS: BAPAT_1777
BANV: DJ46_672
BCE: BC1790
BCA: BCE_1948
BCQ: BCQ_1863
BCX: BCA_1870
BNC: BCN_1790
BCF: bcf_09130
BCER: BCK_25275
BTL: BALH_1640
BTT: HD73_2039
BTHI: BTK_10315
BTG: BTB_c18410(cat1)
BTI: BTG_11470
BTW: BF38_3022
BMQ: BMQ_2719
BMD: BMD_2706
BMEG: BG04_5186
BACO: OXB_0828
OIH: OB3115
GTN: GTNG_2784
VPN: A21D_01773(cat1)
ASOC: CB4_00369(cat1_1) CB4_02095(cat1_2)
CKL: CKL_3016(cat1)
CKR: CKR_2664
AOE: Clos_0435
CDF: CD630_23430(cat1)
PDC: CDIF630_02582(cat1)
CDC: CD196_2186(cat1)
CDL: CDR20291_2232(cat1)
PDF: CD630DERM_23430(cat1)
TOC: Toce_1836
TTM: Tthe_1655
VPR: Vpar_1249
VRM: 44547418_01331(scpC)
MHG: MHY_07490
CGL: NCgl2480(Cgl2569)
CGB: cg2840(actA)
CGU: WA5_2480(ActA)
CGT: cgR_2472
CGM: cgp_0592 cgp_2840(actA)
CEF: CE2460
CDI: DIP1902(cat1)
CDP: CD241_1814(cat1)
CDH: CDB402_1772(cat1)
CDT: CDHC01_1816(cat1)
CDE: CDHC02_1807(cat1)
CDR: CDHC03_1785(cat1)
CDA: CDHC04_1791(cat1)
CDZ: CD31A_1902(cat1)
CDB: CDBH8_1878(cat1)
CDS: CDC7B_1876(cat1)
CDD: CDCE8392_1794(cat1)
CDW: CDPW8_1873(cat1)
CDV: CDVA01_1749(cat1)
CDIP: ERS451417_01927(cat1)
CJK: jk0384(cat1)
CUR: cu1605(cat1)
CUA: CU7111_1546(cat)
CAR: cauri_2148(cat1)
CKP: ckrop_0406(cat1)
CPU: cpfrc_01706(cat1)
CPL: Cp3995_1755(cat1)
CPG: Cp316_1759(cat1)
CPP: CpP54B96_1736(cat1)
CPK: Cp1002_1707(cat1)
CPQ: CpC231_1699(cat1)
CPX: CpI19_1715(cat1)
CPZ: CpPAT10_1707(cat1)
COR: Cp267_1776(cat1)
COP: Cp31_1698(cat1)
COD: Cp106_1664(cat1)
COS: Cp4202_1696(cat1)
COI: CpCIP5297_1724(cat1)
COE: Cp258_1723(cat1)
COU: Cp162_1684(cat1)
CPSE: CPTA_00084
CPSU: CPTB_01443
CPSF: CPTC_01113
CRD: CRES_0103(cat1)
CUL: CULC22_01882(cat)
CUC: CULC809_01780(cat)
CUE: CULC0102_1923(cat)
CUN: Cul210932_1897(cat)
CUS: CulFRC11_1793(cat)
CUQ: Cul210931_1790(cat)
CUZ: Cul05146_1888(cat)
CUJ: CUL131002_1815c(cat)
CVA: CVAR_0586(cat1) CVAR_0587(cat2)
CGY: CGLY_13000(cat1)
CSX: CSING_11110(cat1)
CMQ: B840_10510(cat1)
CKU: UL82_02895(cat1)
CCJ: UL81_09605(cat1)
CMV: CMUST_12890(cat1)
CEI: CEPID_10335(cat1)
CTED: CTEST_11140(cat1)
CUT: CUTER_09160(cat1)
CDX: CDES_11675(cat1)
CSP: WM42_1869
CPHO: CPHO_02535
CGV: CGLAU_10415(cat1)
CAQU: CAQU_10345
CAMG: CAMM_10815
CMIN: NCTC10288_00420(cat1_1) NCTC10288_00672(cat1_2)
RER: RER_55980
REY: O5Y_26725
REQ: REQ_45490
RRT: 4535765_01877(scpC)
ARM: ART_3835
AAI: AARI_33970(cat1)
BLIN: BLSMQ_1446
DCO: SAMEA4475696_1802(scpC)
PAC: PPA2053
PAW: PAZ_c21400(cat2)
PACC: PAC1_10470
PACH: PAGK_1965
CACN: RN83_10565
CGRN: 4412665_00653(scpC_1)
PFR: PFREUD_03110(cat)
PFRE: RM25_0280
SEN: SACE_5861(aarC)
TAI: Taci_0301
TLI: Tlie_1893
FSC: FSU_2081
FLN: FLA_2108
SMIZ: 4412673_03150(scpC)
MPW: MPR_1568
CHZ: CHSO_1208(ygfH)
CLI: Clim_1025
PPH: Ppha_2304
HAL: VNG_2291G(cat)
HSL: OE_4211F(cat)
HLA: Hlac_2589
ACJ: ACAM_0233
 » show all
Taxonomy
Reference
1  [PMID:3090435]
  Authors
Steinbuchel A, Muller M
  Title
Anaerobic pyruvate metabolism of Tritrichomonas foetus and Trichomonas vaginalis  hydrogenosomes.
  Journal
Mol Biochem Parasitol 20:57-65 (1986)
DOI:10.1016/0166-6851(86)90142-8
Reference
2  [PMID:18502856]
  Authors
Mullins EA, Francois JA, Kappock TJ
  Title
A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti.
  Journal
J Bacteriol 190:4933-40 (2008)
DOI:10.1128/JB.00405-08
  Sequence
Reference
3  [PMID:23030530]
  Authors
Mullins EA, Kappock TJ
  Title
Crystal structures of Acetobacter aceti succinyl-coenzyme A (CoA):acetate CoA-transferase reveal specificity determinants and illustrate the mechanism used by class I CoA-transferases.
  Journal
Biochemistry 51:8422-34 (2012)
DOI:10.1021/bi300957f
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.18
IUBMB Enzyme Nomenclature: 2.8.3.18
ExPASy - ENZYME nomenclature database: 2.8.3.18
BRENDA, the Enzyme Database: 2.8.3.18

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