EC                  Enzyme                                 

acetate CoA-transferase;
acetate coenzyme A-transferase;
butyryl CoA:acetate CoA transferase;
butyryl coenzyme A transferase;
succinyl-CoA:acetate CoA transferase
Transferring sulfur-containing groups;
BRITE hierarchy
acyl-CoA:acetate CoA-transferase
acyl-CoA + acetate = a fatty acid anion + acetyl-CoA [RN:R00393]
acyl-CoA [CPD:C00040];
acetate [CPD:C00033]
fatty acid anion [CPD:C02403];
acetyl-CoA [CPD:C00024]
The enzyme belongs to family I of CoA-transferases, which operate with a ping-pong kinetic mechanism. The reaction takes place in two half-reactions and involves the formation of a CoA thioester intermediate with a glutamate residue. Unlike EC, butyrate---acetoacetate CoA-transferase, this enzyme exhibits maximal activity using acetate as the CoA acceptor. Substrate range depends on the specific enzyme. Typical substrates include butanoyl-CoA and pentanoyl-CoA.
EC created 1972
ec00627  Aminobenzoate degradation
ec00640  Propanoate metabolism
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
K01034  acetate CoA/acetoacetate CoA-transferase alpha subunit
K01035  acetate CoA/acetoacetate CoA-transferase beta subunit
K19709  acetate CoA-transferase
ECO: b1694(ydiF) b2221(atoD) b2222(atoA)
ECJ: JW1684(ydiF) JW2215(atoD) JW2216(atoA)
ECD: ECDH10B_2379(atoD) ECDH10B_2380(atoA)
EBW: BWG_1508(ydiF) BWG_1995(atoD) BWG_1996(atoA)
ECOK: ECMDS42_1367(ydiF) ECMDS42_1789(atoD) ECMDS42_1790(atoA)
ECE: Z2722(ydiF)
ECS: ECs2401
ECF: ECH74115_2410(pct)
ETW: ECSP_2261(ydiF)
ELX: CDCO157_2235
EOH: ECO103_1837(ydiF)
ECG: E2348C_1779(ydiF) E2348C_2366(atoD) E2348C_2367(atoA)
EOK: G2583_2091(ydiF)
ECC: c2089(ydiF) c2764(atoD) c2765(atoA)
ECI: UTI89_C1886(ydiF) UTI89_C2503(atoD) UTI89_C2504(atoA)
ECV: APECO1_4337(atoA) APECO1_4338(atoD) APECO1_770(ydiF)
ECY: ECSE_1817
ECR: ECIAI1_1747(ydiF)
ECQ: ECED1_1893(ydiF) ECED1_2687(atoD) ECED1_2688(atoA)
ECK: EC55989_1861(ydiF)
ECT: ECIAI39_1364(ydiF) ECIAI39_2359(atoD) ECIAI39_2360(atoA)
EOC: CE10_1968(ydiF) CE10_2596(atoD) CE10_2597(atoA)
EUM: ECUMN_1983(ydiF) ECUMN_2559(atoD) ECUMN_2560(atoA)
ECZ: ECS88_1744(ydiF) ECS88_2370(atoD) ECS88_2371(atoA)
ELO: EC042_1861 EC042_2462(atoD) EC042_2463(atoA)
ESO: O3O_13870
ESM: O3M_11730
ESL: O3K_11765
EBR: ECB_01663(ydiF) ECB_02148(atoD) ECB_02149(atoA)
EKF: KO11_14275(ydiF)
EAB: ECABU_c19480(ydiF) ECABU_c25570(atoD) ECABU_c25580(atoA)
EIH: ECOK1_1814(pct) ECOK1_2456(pcaI)
ENA: ECNA114_1741(ydiF) ECNA114_2314(atoD) ECNA114_2315(atoA)
ELW: ECW_m1863(ydiF)
ELL: WFL_09120(ydiF)
ELC: i14_1911(ydiF) i14_2562(atoD) i14_2563(atoA)
ELD: i02_1911(ydiF) i02_2562(atoD) i02_2563(atoA)
ELP: P12B_c1389 P12B_c2313(atoD) P12B_c2314(atoA)
EBL: ECD_01663(ydiF) ECD_02148(atoD) ECD_02149(atoA)
EBE: B21_01652(ydiF) B21_02107(atoD) B21_02108(atoA)
ELF: LF82_0185(atoA) LF82_0188(atoD) LF82_2872(ydiF)
ECOI: ECOPMV1_01793(atoD_1) ECOPMV1_02383(atoD_2) ECOPMV1_02384(atoA)
ECOO: ECRM13514_2189(ydiF)
ECOH: ECRM13516_2094(ydiF)
ECOS: EC958_1914(ydiF) EC958_2558(atoD) EC958_2559(atoA)
EFE: EFER_0937(atoA) EFER_0938(atoD)
SEO: STM14_1648(ydiF)
SEY: SL1344_1291(ydiF)
SEJ: STMUK_1324(ydiF)
SEB: STM474_1362(ydiF)
SENI: CY43_06910
SEI: SPC_2373(ydiF)
SEC: SCH_1376(ydiF)
SHB: SU5_01975
SENS: Q786_08465
SED: SeD_A1986
SEG: SG1759(ydiF)
SEL: SPUL_1175(ydiF)
SEGA: SPUCDC_1175(ydiF)
SET: SEN1687(ydiF)
SENA: AU38_08735
SENO: AU37_08740
SENV: AU39_08745
SENQ: AU40_09745
SENL: IY59_08930
SEEP: I137_05410
SENE: IA1_06695
SSN: SSON_2280(atoD) SSON_2281(atoA)
SBC: SbBS512_E1897(pct)
ENF: AKI40_1898(ydiF)
KPT: VK055_4879(atoA) VK055_4880(ctfA)
YIN: CH53_2126(atoA) CH53_2127(atoD)
ECA: ECA1283(atoA) ECA1284(atoD)
PATO: GZ59_13090(atoA) GZ59_13100(atoD)
PLU: plu3799(atoD) plu3800(atoA)
PAY: PAU_01019(atoA) PAU_01020(atoD)
ETR: ETAE_2012(atoD) ETAE_2013(atoA1) ETAE_2119(pcaI)
ETE: ETEE_4071(atoD) ETEE_4072(atoA)
HIN: HI0773(atoA) HI0774
HIT: NTHI0934(atoA) NTHI0935(atoD)
HIZ: R2866_1620(atoD) R2866_1621(atoA)
HIK: HifGL_000448(atoA) HifGL_000449(atoD)
HIW: NTHI477_00932(atoD) NTHI477_00933(atoA)
HIX: NTHI723_00836(atoD) NTHI723_00837(atoA)
VNI: VIBNI_B0463(ctfB) VIBNI_B0464(ctfA)
HCO: LOKO_02616(atoD)
HBE: BEI_2296(atoD)
RPI: Rpic_4029
BCEN: DM39_3658
BUB: BW23_3843
PBH: AAW51_0375 AAW51_0877(atoD) AAW51_0878(atoA)
AZA: AZKH_p0587(atoA) AZKH_p0588(atoD)
SFU: Sfum_2291
BJA: bll3461(pcaJ) bll3462(pcaI)
BID: Bind_3273
FIL: BN1229_v1_3823(atoD) BN1229_v1_3824(atoA)
FIY: BN1229_v1_3813(atoD) BN1229_v1_3814(atoA)
AZL: AZL_d00130(atoD) AZL_d00140(scoB)
ALI: AZOLI_p40132(scoA) AZOLI_p40133(scoB)
BSR: I33_2216
BSL: A7A1_2844
BSH: BSU6051_19730(yodS)
BSUT: BSUB_02125(yodS)
BSUL: BSUA_02125(yodS)
BSUS: Q433_11745
BSS: BSUW23_10555(yodS)
BST: GYO_2381
BSO: BSNT_08546(yodS)
BSQ: B657_19730(yodS)
BSX: C663_2031(atoD)
BLI: BL01426(yodS)
BLD: BLi02298(yodS)
BLH: BaLi_c23830(yodS)
BAY: RBAM_019560(yodS)
BAQ: BACAU_1957(yodS)
BYA: BANAU_2080(yodS)
BAMP: B938_10135
BAML: BAM5036_1888(yodS)
BAMA: RBAU_1925(yodS)
BAMN: BASU_1905(yodS)
BAMB: BAPNAU_1789(yodS)
BAMT: AJ82_11100
BAMY: V529_21790(yodS)
BMP: NG74_02035(atoD)
BAO: BAMF_2052(yodS)
BAZ: BAMTA208_07245(yodS)
BQL: LL3_02155(yodS)
BXH: BAXH7_01473(yodS)
BQY: MUS_2334(yodS)
BAMI: KSO_009565
BAMC: U471_20190
BAMF: U722_10665
BATR: TD68_07755
BHA: BH2259
BAN: BA_2295(atoD)
BAR: GBAA_2295(atoD)
BAT: BAS2140
BAH: BAMEG_2299(atoD)
BAI: BAA_2359(atoD)
BANT: A16_23330
BANR: A16R_23590
BANV: DJ46_1092(atoD)
BCE: BC2246
BCA: BCE_2329(atoD)
BCZ: BCE33L2074(atoD) BCE33L2075(atoA)
BCR: BCAH187_A2403(atoD)
BCB: BCB4264_A2276(atoD)
BCU: BCAH820_2320(atoD)
BCG: BCG9842_B3047(atoD)
BCQ: BCQ_2229(atoD) BCQ_2230(atoA)
BCX: BCA_2376(atoD)
BAL: BACI_c22560(atoD) BACI_c22570(atoA)
BCF: bcf_11495
BCER: BCK_23365
BTK: BT9727_2078(atoD) BT9727_2079(atoA)
BTB: BMB171_C2024(atoD)
BTT: HD73_2535
BTHI: BTK_12570
BTC: CT43_CH2212(atoD)
BTM: MC28_1465
BTG: BTB_c23280(yodS)
BTI: BTG_08645
BTW: BF38_3496(atoD)
BWW: bwei_2749(atoA) bwei_2750(atoD)
BPF: BpOF4_18595(atoA) BpOF4_18600(atoD)
BMQ: BMQ_4044
BMD: BMD_4029
BJS: MY9_2161
BMET: BMMGA3_10155(yodS)
BACP: SB24_18920
BACB: OY17_12905
BACO: OXB_2770
BACY: QF06_09000
BALM: BsLM_2099
BGY: BGLY_2551(yodS)
BKW: BkAM31D_12405(scoB_1) BkAM31D_12410(atoD)
HHD: HBHAL_4175(atoA) HBHAL_4176(atoD)
PPM: PPSC2_06045(atoA) PPSC2_06050(atoD)
PPO: PPM_1143(atoA) PPM_1144(atoD)
PPQ: PPSQR21_012330(atoA) PPSQR21_012340(atoD)
PRI: PRIO_0483(ctfB1) PRIO_0484 PRIO_1096(atoD) PRIO_1097(ctfB3)
SPY: SPy_0141(atoD.2) SPy_0142 SPy_1638(atoD.1) SPy_1639(atoA)
SPYA: A20_0169(atoD) A20_0170(ctfB) A20_1388(atoD) A20_1389(atoA)
SPG: SpyM3_0109(atoD.2) SpyM3_0110 SpyM3_1379(atoD.1) SpyM3_1380(atoA)
SPF: SpyM50115(atoD1) SpyM50116(atoA1) SpyM50446(atoD2)
SPB: M28_Spy0118(atoD.2) M28_Spy0119 M28_Spy1386(atoD.1) M28_Spy1387(atoA)
STG: MGAS15252_0156(atoD.1) MGAS15252_0157(atoA.1) MGAS15252_1241(atoD.2) MGAS15252_1242(atoA.2)
STX: MGAS1882_0156(atoD.1) MGAS1882_0157(atoA.1) MGAS1882_1302(atoD.2) MGAS1882_1303(atoA.2)
SOZ: Spy49_0124(atoD.2) Spy49_0125 Spy49_1269(atoD1) Spy49_1270(atoA)
SEZO: SeseC_01932(scoB) SeseC_01933(atoD)
SUB: SUB1395(atoD2) SUB1396(atoA2)
SDS: SDEG_1701(atoD.1) SDEG_1702(atoA)
SDA: GGS_1534(atoD.1) GGS_1535(atoA)
SDC: SDSE_1796(atoD) SDSE_1797(atoA)
SDQ: SDSE167_1761(atoD.1) SDSE167_1762(atoA)
SANG: SAIN_0966(cftB) SAIN_0967(ctfA)
SANC: SANR_1042(cftB) SANR_1043(ctfA)
SCG: SCI_0953(cftB) SCI_0954(ctfA)
SCON: SCRE_0881(cftB) SCRE_0882(ctfA)
SCOS: SCR2_0881(cftB) SCR2_0882(ctfA)
JDA: BW727_101419(atoD)
CAC: CA_P0163(ctfa) CA_P0164(ctfb)
CAE: SMB_P161(ctfa) SMB_P162(ctfb)
CAY: CEA_P0161(ctfa) CEA_P0162(ctfb)
CBO: CBO2847(ctfA) CBO2848(ctfB)
CBL: CLK_2238
CBI: CLJ_B3081
CBT: CLH_1917
CSR: Cspa_c21000(atoD1) Cspa_c21010(ctfB1) Cspa_c22630(atoD2) Cspa_c22640(ctfB2) Cspa_c50190 Cspa_c56890(ctfA) Cspa_c56900(ctfB3)
CPAT: CLPA_c08840(ctfB1) CLPA_c08850(atoD) CLPA_c15170(ctfA) CLPA_c15180(ctfB2)
CPAE: CPAST_c08840(ctfB1) CPAST_c08850(atoD) CPAST_c15170(ctfA) CPAST_c15180(ctfB2)
CSB: CLSA_c33620(ctfB) CLSA_c33630(ctfA)
CACE: CACET_c04240(ctfA) CACET_c04250(ctfB)
BPRL: CL2_15490
CDF: CD630_26770(scoA) CD630_26780(scoB)
PDC: CDIF630_02931(ctfA) CDIF630_02932(ctfB)
CDC: CD196_2518(ctfA) CD196_2519(ctfB)
CDL: CDR20291_2565(ctfA) CDR20291_2566(ctfB)
CST: CLOST_1123(atoD) CLOST_1124(atoA)
AWO: Awo_c10970(ctfA)
OVA: OBV_33430
TTE: TTE0720(AtoD) TTE0721(AtoA)
MBJ: KQ51_00858(ctfA) KQ51_00859(ctfB)
BACC: BRDCF_p1066(ctfB) BRDCF_p1076(ctfA)
PGI: PG_1066(ctfA) PG_1075
CACI: CLOAM0042(atoD) CLOAM0043(atoA)
 » show all
1  [PMID:4884054]
Vanderwinkel E, Furmanski P, Reeves HC, Ajl SJ.
Growth of Escherichia coli on fatty acids: requirement for coenzyme A transferase activity.
Biochem Biophys Res Commun 33:902-8 (1968)
2  [PMID:16253988]
Rangarajan ES, Li Y, Ajamian E, Iannuzzi P, Kernaghan SD, Fraser ME, Cygler M, Matte A
Crystallographic trapping of the glutamyl-CoA thioester intermediate of family I  CoA transferases.
J Biol Chem 280:42919-28 (2005)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
UM-BBD (Biocatalysis/Biodegradation Database):
BRENDA, the Enzyme Database:
CAS: 37278-35-6

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