KEGG   ENZYME: 2.8.4.2Help
Entry
EC 2.8.4.2                  Enzyme                                 

Name
arsenate-mycothiol transferase;
ArsC1;
ArsC2;
mycothiol:arsenate transferase
Class
Transferases;
Transferring sulfur-containing groups;
Transferring alkylthio groups
BRITE hierarchy
Sysname
mycothiol:arsenate S-arsenotransferase
Reaction(IUBMB)
arsenate + mycothiol = arseno-mycothiol + H2O
Substrate
arsenate [CPD:C11215];
mycothiol [CPD:C06717]
Product
arseno-mycothiol;
H2O [CPD:C00001]
Comment
Reduction of arsenate is part of a defence mechanism of the cell against toxic arsenate. The product arseno-mycothiol is reduced by EC 1.20.4.3 (mycoredoxin) to arsenite and mycothiol-mycoredoxin disulfide. Finally, a second mycothiol recycles mycoredoxin and forms mycothione.
History
EC 2.8.4.2 created 2010
Orthology
K18701  arsenate-mycothiol transferase
Genes
MAV: MAV_1497
MJL: Mjls_1444
MDX: BTO20_20570
MVA: Mvan_3220
MGI: Mflv_1656
MSP: Mspyr1_53720
MCB: Mycch_4038 Mycch_5680
MFT: XA26_02280
MRH: MycrhN_2862 MycrhN_4470
MAB: MAB_4864
MCHE: BB28_04970
CGL: NCgl0259(Cgl0263) NCgl1454(Cgl1511)
CGB: cg0319(arsX) cg1706
CGU: WA5_0259(ArsX) WA5_1454
CGT: cgR_1571
CGM: cgp_0319(arsX) cgp_1706
CEF: CE0876
CDE: CDHC02_0082(arsC1)
CDZ: CD31A_0079(arsC1)
CDB: CDBH8_0082(arsC1)
CJK: jk2004(arsC)
CUR: cu0032
CUA: CU7111_0033(arsC)
CAR: cauri_1082(arsX)
CRD: CRES_1295(arsC)
CVA: CVAR_2931(arsC)
CTER: A606_00525
CGY: CGLY_11930(arsC)
CSX: CSING_05920(arsX)
CMQ: B840_09910(arsC1)
CDX: CDES_00615 CDES_00620(arsC1) CDES_01420(arsC2)
CSP: WM42_0272
CPHO: CPHO_07460
CGV: CGLAU_09665(arsC1)
CMIN: NCTC10288_01454(arsX)
NFA: PNF2_260
NFR: ERS450000_05859(arsC_5)
RER: RER_pREL1-01620(arsC)
REY: O5Y_29285
ROP: ROP_00190
RHB: NY08_3233
RFA: A3L23_01427(arsC1)
RHS: A3Q41_01930(arsC1_1)
RHU: A3Q40_02951(arsC1_1) A3Q40_03063(arsC1_3) A3Q40_03401(arsC1_5)
RRT: 4535765_02655(arsC_3)
GBR: Gbro_0790
TPR: Tpau_2232
CMI: CMM_1218
CMS: CMS1869
CMC: CMN_01192
ART: Arth_0216
ARR: ARUE_c37620(arsC1)
ARM: ART_1218
AAU: AAur_pTC20062(arsC)
JDE: Jden_2256
BLIN: BLSMQ_3134
GOB: Gobs_4719
MMAR: MODMU_1928
KRA: Krad_0500
 » show all
Taxonomy
Reference
1  [PMID:19286650]
  Authors
Ordonez E, Van Belle K, Roos G, De Galan S, Letek M, Gil JA, Wyns L, Mateos LM, Messens J
  Title
Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange.
  Journal
J Biol Chem 284:15107-16 (2009)
DOI:10.1074/jbc.M900877200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.4.2
IUBMB Enzyme Nomenclature: 2.8.4.2
ExPASy - ENZYME nomenclature database: 2.8.4.2
BRENDA, the Enzyme Database: 2.8.4.2

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