KEGG   ENZYME: 2.9.1.2Help
Entry
EC 2.9.1.2                  Enzyme                                 

Name
O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase;
MMPSepSecS;
SepSecS;
SLA/LP;
O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase;
O-phospho-L-seryl-tRNA:L-selenocysteinyl-tRNA synthase
Class
Transferases;
Transferring selenium-containing groups;
Selenotransferases
BRITE hierarchy
Sysname
selenophosphate:O-phospho-L-seryl-tRNASec selenium transferase
Reaction(IUBMB)
O-phospho-L-seryl-tRNASec + selenophosphate + H2O = L-selenocysteinyl-tRNASec + 2 phosphate [RN:R08224]
Reaction(KEGG)
Substrate
O-phospho-L-seryl-tRNASec;
selenophosphate [CPD:C05172];
H2O [CPD:C00001]
Product
L-selenocysteinyl-tRNA(Sec) [CPD:C06482];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein [4]. In archaea and eukarya selenocysteine formation is achieved by a two-step process: EC 2.7.1.164 (O-phosphoseryl-tRNASec kinase) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase.
History
EC 2.9.1.2 created 2009, modified 2014
Pathway
ec00450  Selenocompound metabolism
ec00970  Aminoacyl-tRNA biosynthesis
Orthology
K03341  O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase
Genes
HSA: 51091(SEPSECS)
PTR: 461145(SEPSECS)
PPS: 100992368(SEPSECS)
GGO: 101136598(SEPSECS)
PON: 100172631(SEPSECS)
NLE: 100591591(SEPSECS)
MCC: 693433(SEPSECS)
MCF: 102132029(SEPSECS)
CSAB: 103246272(SEPSECS)
RRO: 104662083(SEPSECS)
RBB: 108526004(SEPSECS)
CJC: 100409581(SEPSECS)
SBQ: 101048101(SEPSECS)
MMU: 211006(Sepsecs)
RNO: 679383(Sepsecs)
CGE: 100768289(Sepsecs)
NGI: 103737508(Sepsecs)
HGL: 101700995(Sepsecs)
CCAN: 109700381(Sepsecs)
OCU: 100349983(SEPSECS)
TUP: 102475263(SEPSECS)
CFA: 488852(SEPSECS)
AML: 100472220(SEPSECS)
UMR: 103658375(SEPSECS)
ORO: 101365917(SEPSECS)
FCA: 101081043(SEPSECS)
PTG: 102960465(SEPSECS)
AJU: 106975108(SEPSECS)
BTA: 518874(SEPSECS)
BOM: 102277118(SEPSECS)
BIU: 109560372(SEPSECS)
PHD: 102344893(SEPSECS)
CHX: 102170038(SEPSECS)
OAS: 101105573(SEPSECS)
SSC: 100622027(SEPSECS)
CFR: 102508284(SEPSECS)
CDK: 105098366(SEPSECS)
BACU: 103004348(SEPSECS)
LVE: 103075038(SEPSECS)
OOR: 101271241(SEPSECS)
ECB: 100067546(SEPSECS)
EPZ: 103556046(SEPSECS)
EAI: 106840428(SEPSECS)
MYB: 102249462(SEPSECS)
MYD: 102770020(SEPSECS)
HAI: 109382715(SEPSECS)
RSS: 109453845(SEPSECS)
PALE: 102878761(SEPSECS)
LAV: 100655833(SEPSECS)
TMU: 101361256
MDO: 100011061(SEPSECS)
SHR: 100929347(SEPSECS)
OAA: 100083170(SEPSECS)
GGA: 422808(SEPSECS)
MGP: 100541247(SEPSECS)
CJO: 107313946(SEPSECS)
APLA: 101805269(SEPSECS)
ACYG: 106035860(SEPSECS)
TGU: 100229507(SEPSECS)
GFR: 102035661(SEPSECS)
FAB: 101807497(SEPSECS)
PHI: 102111984(SEPSECS)
PMAJ: 107202971(SEPSECS)
CCAE: 111928137(SEPSECS)
CCW: 104690699(SEPSECS)
FPG: 101923091(SEPSECS)
FCH: 102046928(SEPSECS)
CLV: 102084644(SEPSECS)
EGZ: 104134470(SEPSECS)
AAM: 106498743(SEPSECS)
ASN: 102371649(SEPSECS)
AMJ: 102573860(SEPSECS)
PSS: 102445712(SEPSECS)
CMY: 102944820(SEPSECS)
CPIC: 101948154(SEPSECS)
ACS: 100565997(sepsecs)
PVT: 110072255(SEPSECS)
PBI: 103065916(SEPSECS)
GJA: 107115130(SEPSECS)
XLA: 100101304(sepsecs.L) 108704214
XTR: 448354(sepsecs)
NPR: 108801339(SEPSECS)
DRE: 393123(sepsecs)
SRX: 107709093(sepsecs) 107728650
CCAR: 109070758(sepsecs) 109087236 109106035
IPU: 108267743(sepsecs)
AMEX: 103040362(sepsecs)
TRU: 101064634(sepsecs)
NCC: 104966101(sepsecs)
MZE: 101474696(sepsecs)
OLA: 101167574(sepsecs)
XMA: 102216650(sepsecs)
PRET: 103480697(sepsecs)
NFU: 107377078(sepsecs)
KMR: 108234877(sepsecs)
CSEM: 103390481(sepsecs)
LCF: 108892801(sepsecs)
SDU: 111231632(sepsecs)
HCQ: 109507047(sepsecs)
BPEC: 110159356(sepsecs)
MALB: 109974271(sepsecs)
SASA: 106609074(sepsecs)
OTW: 112214484(sepsecs)
ELS: 105030660(sepsecs)
SFM: 108938692(sepsecs)
LCM: 102364035(SEPSECS)
CMK: 103175827(sepsecs)
CIN: 100178161
SPU: 575747(sepsecs)
APLC: 110975396
SKO: 100373943
DME: Dmel_CG1427(CG1427)
DSI: Dsimw501_GD29559(Dsim_GD29559)
MDE: 101888931
AAG: 5564663
AME: 552745
BIM: 100746242
BTER: 100642620
SOC: 105201120
AEC: 105151672
ACEP: 105621156
PBAR: 105428247
HST: 105189511
DQU: 106743002
CFO: 105249069
LHU: 105674749
PGC: 109853538
PCF: 106788873
MDL: 103573793
NVL: 108565896
API: 100160680
DNX: 107161826
CLEC: 106664722
ZNE: 110828214
FCD: 110856771
TUT: 112539241
CEL: CELE_D1054.13(secs-1)
CBR: CBG09712(Cbr-secs-1)
BMY: Bm1_27840
TSP: Tsp_04124
CRG: 105326081
MYI: 110462366
OBI: 106882424
SHX: MS3_04318
EGL: EGR_06833
EPA: 110235899
ADF: 107338739
HMG: 100210985
AQU: 100641076
CRE: CHLREDRAFT_117639(SPCS)
MNG: MNEG_0856
MIS: MICPUN_56124(SEPSECS)
DDI: DDB_G0280197(sepsecs)
DFA: DFA_01728(sepsecs)
PYO: PY17X_0606400(PY05385)
PCB: PCHAS_060560(PC001287.02.0)
SMIN: v1.2.006611.t1(symbB.v1.2.006611.t1)
SPAR: SPRG_03891
MJA: MJ_0610
MMP: MMP0595
MMD: GYY_03500
MAE: Maeo_0553
MVO: Mvol_0257
MKA: MK0672
LOKI: Lokiarch_10080(spcS)
 » show all
Taxonomy
Reference
1  [PMID:19608919]
  Authors
Palioura S, Sherrer RL, Steitz TA, Soll D, Simonovic M
  Title
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation.
  Journal
Science 325:321-5 (2009)
DOI:10.1126/science.1173755
  Sequence
[hsa:51091]
Reference
2  [PMID:18158303]
  Authors
Araiso Y, Palioura S, Ishitani R, Sherrer RL, O'Donoghue P, Yuan J, Oshikane H, Domae N, Defranco J, Soll D, Nureki O
  Title
Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation.
  Journal
Nucleic Acids Res 36:1187-99 (2008)
DOI:10.1093/nar/gkm1122
  Sequence
[mmp:MMP0595]
Reference
3  [PMID:19279205]
  Authors
Aeby E, Palioura S, Pusnik M, Marazzi J, Lieberman A, Ullu E, Soll D, Schneider A
  Title
The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes.
  Journal
Proc Natl Acad Sci U S A 106:5088-92 (2009)
DOI:10.1073/pnas.0901575106
Reference
4  [PMID:17142313]
  Authors
Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Soll D
  Title
RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and  archaea.
  Journal
Proc Natl Acad Sci U S A 103:18923-7 (2006)
DOI:10.1073/pnas.0609703104
  Sequence
[hsa:51091] [mmp:MMP0595] [mja:MJ_0610]
Other DBs
ExplorEnz - The Enzyme Database: 2.9.1.2
IUBMB Enzyme Nomenclature: 2.9.1.2
ExPASy - ENZYME nomenclature database: 2.9.1.2
BRENDA, the Enzyme Database: 2.9.1.2

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