KEGG   ENZYME: 3.1.1.25Help
Entry
EC 3.1.1.25                 Enzyme                                 

Name
1,4-lactonase;
gamma-lactonase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
1,4-lactone hydroxyacylhydrolase
Reaction(IUBMB)
a 1,4-lactone + H2O = a 4-hydroxyacid [RN:R03708]
Reaction(KEGG)
Substrate
1,4-lactone [CPD:C01770];
H2O [CPD:C00001]
Product
4-hydroxyacid [CPD:C01991]
Comment
The enzyme is specific for 1,4-lactones with 4-8 carbon atoms. It does not hydrolyse simple aliphatic esters, acetylcholine, sugar lactones or substituted aliphatic lactones, e.g. 3-hydroxy-4-butyrolactone; requires Ca2+.
History
EC 3.1.1.25 created 1972, modified 1981
Pathway
ec00052  Galactose metabolism
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:4958984]
  Authors
Fishbein WN, Bessman SP.
  Title
Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. I. Tissue localization, stoichiometry, specificity, distinction from esterase.
  Journal
J Biol Chem 241:4835-41 (1966)
Reference
2  [PMID:4958985]
  Authors
Fishbein WN, Bessman SP.
  Title
Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. II. Metal ion effects, kinetics, and equilibra.
  Journal
J Biol Chem 241:4842-7 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.25
IUBMB Enzyme Nomenclature: 3.1.1.25
ExPASy - ENZYME nomenclature database: 3.1.1.25
BRENDA, the Enzyme Database: 3.1.1.25
CAS: 37278-38-9

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