KEGG   ENZYME: 3.1.1.34Help
Entry
EC 3.1.1.34                 Enzyme                                 

Name
lipoprotein lipase;
clearing factor lipase;
diglyceride lipase;
diacylglycerol lipase;
postheparin esterase;
diglyceride lipase;
postheparin lipase;
diacylglycerol hydrolase;
lipemia-clearing factor
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
triacylglycero-protein acylhydrolase
Reaction(IUBMB)
triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]
Reaction(KEGG)
R01369;
(other) R01350
Show
Substrate
triacylglycerol [CPD:C00422];
H2O [CPD:C00001]
Product
diacylglycerol [CPD:C00165];
carboxylate [CPD:C00060]
Comment
Hydrolyses triacylglycerols in chylomicrons and low-density lipoproteins. Also hydrolyses diacylglycerol.
History
EC 3.1.1.34 created 1972, modified 1976
Pathway
ec00561  Glycerolipid metabolism
Orthology
K01059  lipoprotein lipase
Genes
HSA: 4023(LPL)
PTR: 464031(LPL)
PPS: 100986925(LPL)
GGO: 101124245(LPL)
PON: 100443394(LPL)
NLE: 100584438(LPL)
MCC: 712887(LPL)
MCF: 102129758(LPL)
CSAB: 103215415(LPL)
RRO: 104662456(LPL)
RBB: 108526485(LPL)
CJC: 100409187(LPL)
SBQ: 101050033(LPL)
MMU: 16956(Lpl)
RNO: 24539(Lpl)
CGE: 100689191(Lpl)
NGI: 103747648(Lpl)
HGL: 101703016(Lpl)
CCAN: 109695316 109695324(Lpl)
OCU: 100340171(LPL)
TUP: 102492328(LPL)
CFA: 403626(LPL)
AML: 100482804(LPL)
UMR: 103676703(LPL)
ORO: 101380450(LPL)
FCA: 727696(LPL)
PTG: 102967736(LPL)
AJU: 106971857(LPL)
BTA: 280843(LPL)
BOM: 102266770(LPL)
BIU: 109563092(LPL)
PHD: 102341297(LPL)
CHX: 100860750(LPL)
OAS: 443408(LPL)
SSC: 397537(LPL)
CFR: 102520179(LPL)
CDK: 105094532(LPL)
BACU: 103005101
LVE: 103083746(LPL)
OOR: 101284828(LPL)
ECB: 100055358(LPL)
EPZ: 103559571(LPL)
EAI: 106831205(LPL)
MYB: 102247387(LPL)
MYD: 102759852(LPL)
HAI: 109382488(LPL)
RSS: 109450058(LPL)
PALE: 102892638(LPL)
LAV: 100667686(LPL)
TMU: 101345905
MDO: 100033067(LPL)
SHR: 100933361(LPL)
OAA: 100077350(LPL)
GGA: 396219(LPL)
MGP: 100544844(LPL)
CJO: 107306443(LPL)
APLA: 101796218(LPL)
ACYG: 106040417(LPL)
TGU: 100223817(LPL)
GFR: 102041807(LPL)
FAB: 101814126(LPL)
PHI: 102111905(LPL)
PMAJ: 107216453(LPL)
CCAE: 111941733(LPL)
CCW: 104689737(LPL)
FPG: 101913413(LPL)
FCH: 102046454(LPL)
CLV: 102097018(LPL)
EGZ: 104123360(LPL)
ASN: 102368909(LPL)
AMJ: 102573889(LPL)
PSS: 102456906(LPL)
CMY: 102941095
CPIC: 101932991(LPL)
ACS: 100556298(lpl)
PVT: 110083190(LPL)
PBI: 103057093(LPL)
GJA: 107118995(LPL)
XLA: 108706825(lpl.S) 108712233(lpl.L)
XTR: 100127862(lpl)
NPR: 108804916(LPL)
IPU: 108271131(LPL) 108280930
TRU: 101062428(lpl) 101068642(LPL2)
OLA: 101160309(lpl) 101160547
PRET: 103463532 103463534(lpl)
NFU: 107393172 107393174(lpl)
KMR: 108230795(lpl) 108230848
CSEM: 103397050 103397060(lpl)
LCF: 108881396 108881397(lpl)
SDU: 111232066(lpl) 111232091
BPEC: 110160148
MALB: 109967464
SFM: 108919920 108919924(lpl)
LCM: 102349247(LPL) 102362907
CMK: 103183498(lpl) 103183499
PMAC: 106717696
 » show all
Taxonomy
Reference
1  [PMID:4703566]
  Authors
Egelrud T, Olivecrona T.
  Title
Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors.
  Journal
Biochim Biophys Acta 306:115-27 (1973)
DOI:10.1016/0005-2760(73)90215-4
Reference
2  [PMID:5441398]
  Authors
Fielding CJ.
  Title
Human lipoprotein lipase. I. Purification and substrate specificity.
  Journal
Biochim Biophys Acta 206:109-17 (1970)
DOI:10.1016/0005-2744(70)90087-2
Reference
3  [PMID:5466051]
  Authors
Greten H, Levy RI, Fales H, Fredrickson DS.
  Title
Hydrolysis of diglyceride and glyceryl monoester diethers with "lipoprotein lipase".
  Journal
Biochim Biophys Acta 210:39-45 (1970)
DOI:10.1016/0005-2760(70)90059-7
Reference
4  [PMID:5076762]
  Authors
Morley N, Kuksis A.
  Title
Positional specificity of lipoprotein lipase.
  Journal
J Biol Chem 247:6389-93 (1972)
Reference
5  [PMID:5168777]
  Authors
Nilsson-Ehle P, Belfrage P, Borgstrom B.
  Title
Purified human lipoprotein lipase: positional specificity.
  Journal
Biochim Biophys Acta 248:114-20 (1971)
DOI:10.1016/0005-2760(71)90081-6
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.34
IUBMB Enzyme Nomenclature: 3.1.1.34
ExPASy - ENZYME nomenclature database: 3.1.1.34
BRENDA, the Enzyme Database: 3.1.1.34
CAS: 9004-02-8

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