KEGG   ENZYME: 3.1.1.57Help
Entry
EC 3.1.1.57                 Enzyme                                 

Name
2-pyrone-4,6-dicarboxylate lactonase;
2-pyrone-4,6-dicarboxylate hydrolase;
2-pyrone-4,6-dicarboxylate lactonohydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
2-oxo-2H-pyran-4,6-dicarboxylate lactonohydrolase
Reaction(IUBMB)
2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate [RN:R04277]
Reaction(KEGG)
Substrate
2-oxo-2H-pyran-4,6-dicarboxylate;
H2O [CPD:C00001]
Product
(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate [CPD:C04434]
Comment
The product is most likely the keto-form of 4-oxalomesaconate (as shown in the reaction) [1,2]. It can be converted to the enol-form, 4-hydroxybuta-1,3-diene-1,2,4-trioate, either spontaneously or by EC 5.3.2.8, 4-oxalomesaconate tautomerase [3].
History
EC 3.1.1.57 created 1986, modified 2010
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K10221  2-pyrone-4,6-dicarboxylate lactonase
Genes
SOD: Sant_P0178
SRH: BAY15_1814
SLM: BIZ42_18450
VNA: PN96_18540
VEJ: VEJY3_18106
VFL: AL536_10305
PPUH: B479_13055
PCG: AXG94_02720
PAT: Patl_3887
AAW: AVL56_08870
SALN: SALB1_0063
BPH: Bphy_3206
HYF: DTO96_100891(ligI)
AFQ: AFA_05525
RFR: Rfer_0332
POL: Bpro_4322
PNA: Pnap_2029
ACRA: BSY15_1205
VEI: Veis_0169
DAC: Daci_4447
CTES: O987_16270
RTA: Rta_24780
LIM: L103DPR2_01496(ligI)
LIH: L63ED372_01143(ligI_1)
HYB: Q5W_10750
CBAA: SRAA_1352
CBAB: SMCB_0793
LCH: Lcho_3635
AZO: azo2539(ligI)
AOA: dqs_2696
TCL: Tchl_1060
ARA: Arad_8733
RLE: pRL120277(ligI)
BRA: BRADO2340(ligI)
BBT: BBta_2700(ligI)
AOL: S58_52590
BRO: BRAD285_4997(ligI)
RPA: RPA4700(ligI)
RPB: RPB_0874
RPD: RPD_0984
RPE: RPE_0749
RPT: Rpal_5181
MALG: MALG_02281
AHT: ANTHELSMS3_03529(ligI)
NAR: Saro_2819
SMAZ: LH19_17725
SPHI: TS85_18485
SSAN: NX02_17535
SSY: SLG_12570(ligI)
SPHB: EP837_03485(ligI)
SPHR: BSY17_3453(ligI)
SFLA: SPHFLASMR4Y_02981(ligI)
BLAS: BSY18_3517(ligI)
AAY: WYH_01902(ligI)
ADO: A6F68_01086(ligI)
MAG: amb0254
MAGX: XM1_1090(ligI)
MAGN: WV31_13610
ABS: AZOBR_p310190(ligI)
MAGQ: MGMAQ_2663(ligI)
SALB: XNR_3393
SFA: Sfla_0533
STRP: F750_6349
STRD: NI25_00230
SMAL: SMALA_3249
SLAU: SLA_7097
KSK: KSE_75150(pcmC)
AMIN: AUMI_19400
AUW: AURUGA1_00418(ligI)
ART: Arth_4374
ACH: Achl_3359
AMQ: AMETH_3608(ligI)
 » show all
Taxonomy
Reference
1  [PMID:7142106]
  Authors
Kersten PJ, Dagley S, Whittaker JW, Arciero DM, Lipscomb JD.
  Title
2-pyrone-4,6-dicarboxylic acid, a catabolite of gallic acids in Pseudomonas species.
  Journal
J Bacteriol 152:1154-62 (1982)
Reference
2  [PMID:6841353]
  Authors
Maruyama K.
  Title
Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase.
  Journal
J Biochem (Tokyo) 93:557-65 (1983)
Reference
3  [PMID:21219457]
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.57
IUBMB Enzyme Nomenclature: 3.1.1.57
ExPASy - ENZYME nomenclature database: 3.1.1.57
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.1.57
BRENDA, the Enzyme Database: 3.1.1.57
CAS: 84177-55-9

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