KEGG   ENZYME: 3.1.1.79
Entry
EC 3.1.1.79                 Enzyme                                 
Name
hormone-sensitive lipase;
HSL
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
diacylglycerol acylhydrolase
Reaction(IUBMB)
(1) diacylglycerol + H2O = monoacylglycerol + a carboxylate [RN:R05209];
(2) triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369];
(3) monoacylglycerol + H2O = glycerol + a carboxylate [RN:R07293]
Reaction(KEGG)
Substrate
diacylglycerol [CPD:C00165];
H2O [CPD:C00001];
triacylglycerol [CPD:C00422];
monoacylglycerol [CPD:C01885]
Product
monoacylglycerol [CPD:C01885];
carboxylate [CPD:C00060];
diacylglycerol [CPD:C00165];
glycerol [CPD:C00116]
Comment
This enzyme is a serine hydrolase. Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity. It hydrolyses all acylglycerols (triacylglycerol, diacylglycerol and monoacylglycerol) [2,3,4] as well as cholesteryl esters [2,4], steroid fatty acid esters [5], retinyl esters [6] and p-nitrophenyl esters [4,7]. It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond [8]. The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length. The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP.
History
EC 3.1.1.79 created 2004
Orthology
K07188  hormone-sensitive lipase
Genes
HSA3991(LIPE)
PTR456076(LIPE)
PPS100975071(LIPE)
GGO101145804(LIPE)
PON100445800(LIPE)
NLE100603864(LIPE)
MCC707997(LIPE)
MCF102143368(LIPE)
CSAB103234777(LIPE)
CATY105598066(LIPE)
PANU101023266(LIPE)
TGE112612101(LIPE)
RRO104658678(LIPE)
RBB108513895(LIPE)
TFN117075239(LIPE)
PTEH111530380
CJC100387953(LIPE)
SBQ101052652(LIPE)
CSYR103264729(LIPE)
MMUR105868011(LIPE)
LCAT123624035(LIPE)
OGA100952035(LIPE)
MMU16890(Lipe)
MCAL110298158(Lipe)
MPAH110336545(Lipe)
RNO25330(Lipe)
MCOC116101848(Lipe)
MUN110563910(Lipe)
CGE100755300(Lipe)
MAUA101825806(Lipe)
PLEU114685349(Lipe)
MORG121450098(Lipe)
AAMP119820308(Lipe)
NGI103744591(Lipe)
HGL101709284(Lipe)
CPOC100734974(Lipe)
CCAN109691865(Lipe)
DORD105997968(Lipe)
DSP122097600(Lipe)
NCAR124966648
OCU100339941(LIPE)
OPI101528437(LIPE)
TUP102477502(LIPE)
CFA403607(LIPE)
CLUD112645376(LIPE)
VVP112931218(LIPE)
VLG121484344(LIPE)
AML100479605(LIPE)
UMR103680155(LIPE)
UAH113243521(LIPE)
UAR123780404(LIPE)
ELK111161566
LLV125088629
MPUF101683381(LIPE)
ORO101384261(LIPE)
EJU114197074(LIPE)
ZCA113935476(LIPE)
MLX117998053(LIPE)
FCA751818(LIPE)
PYU121018485(LIPE)
PBG122493988(LIPE)
PTG102952452(LIPE)
PPAD109257948(LIPE)
AJU106987707(LIPE)
HHV120243020(LIPE)
BTA286879(LIPE)
BOM102266815(LIPE)
BIU109572731(LIPE)
BBUB102389675(LIPE)
CHX100860801(LIPE)
OAS100169699(LIPE)
ODA120872376(LIPE)
CCAD122420167(LIPE)
SSC397583(LIPE)
CFR102520149
CBAI105062447(LIPE)
CDK105090211(LIPE)
VPC102531302(LIPE)
BACU103006716(LIPE)
LVE103074607(LIPE)
OOR101277193(LIPE)
DLE111180817(LIPE)
PCAD102989235(LIPE)
PSIU116743963(LIPE)
ECB100069598(LIPE)
EPZ103558823(LIPE) 103563985
EAI106847941(LIPE)
MYB102247234(LIPE)
MYD102764534(LIPE)
MMYO118674384(LIPE)
MLF102426455(LIPE)
MNA107534157(LIPE)
PKL118702302(LIPE)
HAI109374451(LIPE)
DRO112320229(LIPE)
SHON119000496(LIPE)
AJM119060132(LIPE)
PDIC114511611(LIPE)
PHAS123818235(LIPE)
MMF118639408(LIPE)
RFQ117035485(LIPE)
PALE102889858(LIPE)
PVP105307364(LIPE)
RAY107502572(LIPE)
MJV108393430(LIPE)
TOD119249387(LIPE)
SARA101540265(LIPE)
LAV100670874(LIPE)
TMU101361564
DNM101434958(LIPE)
MDO103104890(LIPE)
SHR100926393(LIPE)
PCW110219706(LIPE)
OAA103167455(LIPE)
AAM106487870(LIPE)
AROW112971701(LIPE)
ASN102386893(LIPE)
AMJ102571969(LIPE)
CPIC101953217(LIPE)
TST117888400(LIPE)
CABI116818657(LIPE)
MRV120390744(LIPE)
PVT110086763(LIPE)
SUND121915645(LIPE)
PBI103054092(LIPE)
PMUR107289716(LIPE)
PGUT117677674(LIPE)
VKO123025874(LIPE)
PMUA114603349(LIPE)
ZVI118087523(LIPE)
GJA107106853(LIPE) 107117837
STOW125435512(LIPE)
XLA100174796(lipe.L) 108697769(lipe.S)
XTR733899(lipe)
NPR108799329(LIPE)
RTEM120916360(LIPE)
BBUF120990803(LIPE)
BGAR122926911(LIPE)
DRE557893(lipeb) 568368(lipea)
SRX107706458 107723485 107739528 107748718
SANH107656618 107657706 107693390 107699484
SGH107565586 107593665 107595727 107599546
CCAR109105935 109111854
CAUA113059067 113062343 113116658 113120143
PPRM120483517(lipea) 120484659(lipeb)
MAMB125242790(lipeb) 125275320(lipea)
IPU108256376(lipeb) 108272659(lipea)
PHYP113532968(lipe) 113535092
SMEO124375514(lipeb) 124382218(lipea)
TFD113641262(lipea) 113659674(lipeb)
AMEX103030794(lipe) 103036112
EEE113571934(lipe) 113578376
TRU101067661(lipe) 101070911
TNGGSTEN00005445G001 GSTEN00015593G001
LCO104927333(lipe) 104928056
NCC104955347 104963766
CGOB115015627 115021198(lipe)
ELY117263762(lipea) 117265772(lipeb)
EFO125892771(lipeb) 125904660(lipea)
PLEP121945131(lipeb) 121958297(lipea)
SLUC116042460(lipeb) 116047175(lipea)
ECRA117945621(lipeb) 117957028(lipea)
PFLV114556966(lipe) 114567920
GAT120811071(lipeb) 120826336(lipea)
PPUG119197023(lipeb) 119218887(lipea)
MSAM119897337(lipeb) 119907925(lipea)
CUD121513730(lipeb) 121524390(lipea)
ALAT119005801(lipeb) 119016736(lipea)
MZE101473301 101485272(lipe)
ONL100534456(lipe) 100708083
OAU116309493(lipeb) 116318878(lipea)
OLA101157970(lipe) 101160745
OML112143493(lipeb) 112160867(lipea)
XMA102217205 102234893(lipe)
XCO114138258(lipe) 114156439
XHE116716805(lipe) 116731753
PRET103473021 103477914(lipe)
PFOR103139235(lipe) 103143485
PLAI106946893 106960167(lipe)
PMEI106916842(lipe) 106923653
GAF122830737(lipeb) 122843462(lipea)
CVG107083574(lipe)
CTUL119771906(lipeb) 119781167(lipea)
GMU124865649(lipeb) 124879454(lipea)
NFU107379673(lipe) 107394884
KMR108229521(lipea) 108235517(lipeb)
ALIM106523738(lipe) 106530086
NWH119409953(lipeb) 119425963(lipea)
AOCE111564221(lipe) 111580224
MCEP125016201(lipeb) 125020043(lipea)
CSEM103388799(lipe) 103393953
POV109633466(lipe) 109640422
SSEN122774381(lipeb) 122786205(lipea)
HHIP117770234(lipea) 117777502(lipeb)
HSP118113590(lipeb) 118125101(lipea)
LCF108880754(lipe) 108899366
SDU111230513 111236037(lipe)
SLAL111657262(lipe) 111661080
XGL120784156(lipeb) 120786574(lipea)
HCQ109513537 109531659(lipe)
BPEC110168856 110174235(lipe)
MALB109954692(lipe) 109958776
BSPL114842682(lipeb) 114865425(lipea)
SASA100380378(lips) 106570130 106577399 106605704
OTW112226531(lipeb) 112230020(lipea) 112235274 112257644
OMY100505413(lipe1) 100505414(lipea) 110510088 110537667
OGO123998047 124018384 124038460 124043704(lipea)
ONE115112988 115120676 115131807
SALP111955344 111958912 111978396
SNH120027276(lipea) 120046687 120048653 120048772
CCLU121575665 121586170
ELS105024275(lipe) 105027558 105028269
SFM108922191(lipe)
PKI111854848(tmem145)
AANG118229831(lipeb)
PSPA121299176(lipeb) 121304208
ARUT117434050(lipeb) 117969359
LCM102346636(LIPE)
BFO118424806
BBEL109479227
CIN100181083
SCLV120335513
SPU115928003 585712
APLC110988815
SKO100376662
DMEDmel_CG11055(Hsl)
DER6547758
DSE6610042
DSIDsimw501_GD11499(Dsim_GD11499)
DYADyak_GE12096
DAN6494614
DSR110179545
DPO4804498
DPE6593171
DMN108160005
DWI6640914
DGR6568727
DMODmoj_GI21105
DAZ108616685
DNV108654876
DHE111593545
DVI6625071
CCAT101462188
BOD106621184
MDE101899540
SCAC106083183
LCQ111687523
LSQ119606515
HIS119654893
AGAAgaP_AGAP002567
ACOZ120948401
AARA120908555
ASTE118508269
AAG5566934
AALB109399347 109433364
CQUCpipJ_CPIJ015981
CPII120417328
CNS116339615
BCOO119075947
AME413702
ACER107994522
ALAB122710375
BIM100748813
BBIF117209615
BVK117234575
BVAN117158600
BTER100646474
BPYO122571728
CCAL108623011
OBB114874463
MGEN117220220
NMEA116426143
CGIG122402372
SOC105198580
MPHA105835099
AEC105143573
ACEP105620501
PBAR105428403
VEM105562337
HST105188918
DQU106743086
CFO105248955 105258252
FEX115237774
LHU105676433
PGC109856830
OBO105286291
PCF106788649
PFUC122514241
VPS122634879
NVI100120573
CSOL105364358
TPRE106648819
MDL103568258
CGLO123274188
FAS105270162
DAM107041986
AGIF122853192
LHT122500678
CCIN107264147
TCA664547
DPA109543096
SOY115875835
ATD109602787
CSET123309196
AGB108911225
LDC111506685
NVL108569775
APLN108745144
PPYR116182824
OTU111423682
BMOR101737209
BMAN114239644
MSEX115452516
DPLKGM_206593
BANY112051309
PMAC106708647
PPOT106104345
PXU106121800
PRAP110998313
ZCE119832926
HAW110384566
HZE124636292
TNL113495550
SLIU111356413
OFU114365414
PXY105392962
API100159927
DNX107171212
AGS114124269
RMD113549469
BTAB109032262
CLEC106668997
HHAL106688498
NLU111053191
PHUPhum_PHUM288260
FOC113207942
TPAL117644556
ZNE110826823
CSEC111861999
FCD110844206
DPXDAPPUDRAFT_30662
DMK116918167
PVM113810962 113818201
PJA122256419
PCHN125025900
HAME121857466
PCLA123764980
PTRU123518859
HAZT108668222
PPOI119107877
ISCIscW_ISCW018728 IscW_ISCW018730
DSV119455920 119455921
RSAN119378685 119390381 119394211
RMP119172409 119172410
VDE111243951
VJA111271304
TUT107359099 107361343 107362310 107362816 107368307 107370828 107371243
DPTE113797455
DFR124498193
CSCU111613708
PTEP107442104
SDM118189220
CELCELE_C46C11.1(hosl-1)
CBRCBG_14512
NAINECAME_04548
TSPTsp_02264
HROHELRODRAFT_111475 HELRODRAFT_161006
LGILOTGIDRAFT_113239
PCAN112567841
BGT106058325
GAE121386894
HRF124150184 124150187
HRJ124286910
CRG105345018
MYI110445915
PMAX117320218 117341288
OBI106878881
OSN115211786
LAK106161696 106177073
SMMSmp_000130.1
OVIT265_02504
EGLEGR_02179
NVE5511001
EPA110241065
ATEN116303467
ADF107330377 107352460
AMIL114951856
PDAM113675352
SPIS111332161
DGT114524710
XEN124446480
HMG100210426
TADTRIADDRAFT_55258
AQU105314138
CMECYME_CMF053C
GSLGasu_23200
MBRMONBRDRAFT_25836 MONBRDRAFT_34791
SREPTSG_06139 PTSG_08491
TETTTHERM_00185900 TTHERM_00689920 TTHERM_00827140
PTMGSPATT00000473001 GSPATT00006124001 GSPATT00010470001 GSPATT00014607001 GSPATT00014951001 GSPATT00015462001 GSPATT00015563001 GSPATT00020740001 GSPATT00023970001 GSPATT00027668001 GSPATT00031398001 GSPATT00032768001 GSPATT00034492001 PTMB.72
PIFPITG_10850
PSOJPHYSODRAFT_322905
SPARSPRG_01501
GTTGUITHDRAFT_134743
NGRNAEGRDRAFT_57147
 » show all
Reference
1  [PMID:10940339]
  Authors
Holm C, Osterlund T, Laurell H, Contreras JA.
  Title
Molecular mechanisms regulating hormone-sensitive lipase and lipolysis.
  Journal
Annu Rev Nutr 20:365-93 (2000)
DOI:10.1146/annurev.nutr.20.1.365
Reference
2  [PMID:7240206]
  Authors
Fredrikson G, Stralfors P, Nilsson NO, Belfrage P.
  Title
Hormone-sensitive lipase of rat adipose tissue. Purification and some properties.
  Journal
J Biol Chem 256:6311-20 (1981)
Reference
3  [PMID:14169138]
  Authors
VAUGHAN M, BERGER JE, STEINBERG D.
  Title
HORMONE-SENSITIVE LIPASE AND MONOGLYCERIDE LIPASE  ACTIVITIES IN ADIPOSE TISSUE.
  Journal
J Biol Chem 239:401-9 (1964)
Reference
4  [PMID:8912675]
  Authors
Osterlund T, Danielsson B, Degerman E, Contreras JA, Edgren G, Davis RC, Schotz MC, Holm C.
  Title
Domain-structure analysis of recombinant rat hormone-sensitive lipase.
  Journal
Biochem J 319 ( Pt 2):411-20 (1996)
DOI:10.1042/bj3190411
Reference
5  [PMID:3196730]
  Authors
Lee FT, Adams JB, Garton AJ, Yeaman SJ.
  Title
Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones.
  Journal
Biochim Biophys Acta 963:258-64 (1988)
DOI:10.1016/0005-2760(88)90289-5
Reference
6  [PMID:9162045]
  Authors
Wei S, Lai K, Patel S, Piantedosi R, Shen H, Colantuoni V, Kraemer FB, Blaner WS.
  Title
Retinyl ester hydrolysis and retinol efflux from BFC-1beta adipocytes.
  Journal
J Biol Chem 272:14159-65 (1997)
DOI:10.1074/jbc.272.22.14159
Reference
7  [PMID:2794798]
  Authors
Tsujita T, Ninomiya H, Okuda H.
  Title
p-nitrophenyl butyrate hydrolyzing activity of hormone-sensitive lipase from bovine adipose tissue.
  Journal
J Lipid Res 30:997-1004 (1989)
Reference
8  [PMID:14725507]
  Authors
Yeaman SJ.
  Title
Hormone-sensitive lipase--new roles for an old enzyme.
  Journal
Biochem J 379:11-22 (2004)
DOI:10.1042/BJ20031811
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.79
IUBMB Enzyme Nomenclature: 3.1.1.79
ExPASy - ENZYME nomenclature database: 3.1.1.79
BRENDA, the Enzyme Database: 3.1.1.79

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