KEGG   ENZYME: 3.1.1.89Help
Entry
EC 3.1.1.89                 Enzyme                                 

Name
protein phosphatase methylesterase-1;
PME-1;
PPME1
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
[phosphatase 2A protein]-leucine ester acylhydrolase
Reaction(IUBMB)
[phosphatase 2A protein]-leucine methyl ester + H2O = [phosphatase 2A protein]-leucine + methanol
Substrate
[phosphatase 2A protein]-leucine methyl ester;
H2O [CPD:C00001]
Product
[phosphatase 2A protein]-leucine;
methanol [CPD:C00132]
Comment
A key regulator of protein phosphatase 2A. The methyl ester is formed by EC 2.1.1.233 (leucine carboxy methyltransferase-1). Occurs mainly in the nucleus.
History
EC 3.1.1.89 created 2011
Orthology
K13617  protein phosphatase methylesterase 1
Genes
HSA: 51400(PPME1)
PTR: 451419(PPME1)
PPS: 100976774(PPME1)
GGO: 101140575(PPME1)
PON: 100173996(PPME1)
NLE: 100592354(PPME1)
MCC: 718858(PPME1)
MCF: 101865123(PPME1)
CSAB: 103248028(PPME1)
RRO: 104665123(PPME1)
RBB: 108537618(PPME1)
CJC: 100398273(PPME1)
SBQ: 101040531(PPME1)
MMU: 72590(Ppme1)
RNO: 361613(Ppme1)
CGE: 100753403(Ppme1)
NGI: 103749826(Ppme1)
HGL: 101711871(Ppme1)
CCAN: 109691557(Ppme1)
OCU: 100358403(PPME1)
TUP: 102481322(PPME1)
CFA: 612812(PPME1)
AML: 100472410(PPME1)
UMR: 103678118(PPME1)
ORO: 101378001(PPME1)
FCA: 101094949(PPME1)
PTG: 102958634(PPME1)
AJU: 106977985(PPME1)
BTA: 535390(PPME1)
BOM: 102280327(PPME1)
BIU: 109569024(PPME1)
PHD: 102334485(PPME1)
CHX: 102185484(PPME1)
OAS: 101105849(PPME1)
SSC: 100624455(PPME1)
CFR: 102522134(PPME1)
CDK: 105097011(PPME1)
BACU: 103012189(PPME1)
LVE: 103071698(PPME1)
OOR: 101277369(PPME1)
ECB: 100065317(PPME1)
EPZ: 103564584(PPME1)
EAI: 106831685(PPME1)
MYB: 102243633(PPME1)
MYD: 102759562(PPME1)
HAI: 109386306(PPME1)
RSS: 109454060(PPME1)
PALE: 102893967(PPME1)
LAV: 100668583(PPME1)
TMU: 101357572
MDO: 100011602(PPME1)
SHR: 100921513(PPME1)
OAA: 100087028(PPME1)
GGA: 419058(PPME1)
MGP: 100550791(PPME1)
CJO: 107308632(PPME1)
APLA: 101798216(PPME1)
ACYG: 106042399(PPME1)
TGU: 100228154(PPME1)
GFR: 102038533(PPME1)
FAB: 101820109(PPME1)
PHI: 102108695(PPME1)
PMAJ: 107214792(PPME1)
CCW: 104698111(PPME1)
FPG: 101913352(PPME1)
FCH: 102052338(PPME1)
CLV: 102092524(PPME1)
EGZ: 104133053(PPME1)
AAM: 106495805(PPME1)
ASN: 102370897(PPME1)
AMJ: 102569517(PPME1)
PSS: 102444844(PPME1)
CMY: 102935651(PPME1)
CPIC: 101952993(PPME1)
PVT: 110078116(PPME1)
PBI: 103065992(PPME1)
GJA: 107124136(PPME1)
XLA: 444718 446717(ppme1.S)
XTR: 100495664(ppme1)
NPR: 108803473(PPME1)
DRE: 335124(ppme1)
IPU: 108275807(rnf150) 108279251(ppme1)
AMEX: 103024383 103026835(ppme1)
TRU: 101067569(ppme1)
LCO: 104919713(ppme1) 104932261
MZE: 101480187(ppme1)
OLA: 101161182(ppme1)
XMA: 102227617(ppme1)
PRET: 103475729(ppme1)
NFU: 107386549(ppme1)
CSEM: 103395319(ppme1)
LCF: 108886844 108894034(ppme1)
HCQ: 109512517(ppme1) 109516492
BPEC: 110168160(ppme1) 110174692
SASA: 100195184(ppme1) 106567820(ppme1) 106578192(PPME1)
ELS: 105006233(ppme1)
SFM: 108921181(ppme1) 108938266
LCM: 102360160(PPME1) 102362562
CMK: 103177144(ppme1)
CIN: 100176026
SPU: 578324
APLC: 110977215
DME: Dmel_CG5068(CG5068)
DSI: Dsimw501_GD14146(Dsim_GD14146)
MDE: 101894178
AAG: 5568805
AME: 550901
BIM: 100746942
BTER: 100643963
SOC: 105194297
AEC: 105150051
ACEP: 105620642
PBAR: 105426948
HST: 105182758
CFO: 105251621
LHU: 105678140
PGC: 109852690
NVI: 100121028
TCA: 661489
DPA: 109537187
NVL: 108558927
BMOR: 101735326
PRAP: 111000426
API: 100161823
ZNE: 110832548
FCD: 110858216
TUT: 107363315
CEL: CELE_B0464.9(B0464.9)
CBR: CBG10085
BMY: Bm1_23540
TSP: Tsp_01169
CRG: 105318323
MYI: 110449521
OBI: 106874864
LAK: 106150520
SHX: MS3_01618
EGL: EGR_06738
EPA: 110245071
ADF: 107349478
HMG: 100205631
AQU: 100640410
ATH: AT4G10050
CRB: 17881128
BRP: 103858551
BOE: 106331585
THJ: 104815846
CPAP: 110818748
CIT: 102618805
TCC: 18592887
GRA: 105769978
DZI: 111287206
EGR: 104449824
VRA: 106778089
VAR: 108320903
CCAJ: 109810865
CAM: 101492485
LJA: Lj2g3v2124220.1(Lj2g3v2124220.1)
ADU: 107488370
AIP: 107643156
LANG: 109331752
FVE: 101309637
PPER: 18792262
PMUM: 103319362
PAVI: 110755985
MDM: 103441794
PXB: 103928189
ZJU: 107421438
CSV: 101204951
CMO: 103498681
MCHA: 111012093
CMAX: 111472065
CMOS: 111432673
CPEP: 111796923
RCU: 8277186
JCU: 105638066
JRE: 109001417
VVI: 100248151
SLY: 101265196
SPEN: 107003053
SOT: 102584754
CANN: 107847559
NTO: 104111701
INI: 109148528
SIND: 105175018
OEU: 111402022
HAN: 110904512
LSV: 111886257
DCR: 108223539
BVG: 104898059
NNU: 104589189
OSA: 4335946
DOSA: Os04t0443500-01(Os04g0443500)
OBR: 102706468
BDI: 100829971
ATS: 109737664(LOC109737664) 109756603(LOC109756603)
SBI: 110436356
ZMA: 100283464(AI714808)
SITA: 101754005
EGU: 105051665
MUS: 103979411
AOF: 109824366
ATR: 18427713
PPP: 112283126
MNG: MNEG_7024
APRO: F751_1201
SCE: YHR075C(PPE1)
ERC: Ecym_8174
KMX: KLMA_50348(PPE1)
NDI: NDAI_0C01940(NDAI0C01940)
TPF: TPHA_0E01080(TPHA0E01080)
TBL: TBLA_0A03160(TBLA0A03160)
TDL: TDEL_0E02690(TDEL0E02690)
KAF: KAFR_0D04700(KAFR0D04700)
CAL: CAALFM_C201520WA(PPE1)
CDU: CD36_16370(PPE1)
CAUR: QG37_00724
SLB: AWJ20_2892(PPE1)
NCR: NCU00954
NTE: NEUTE1DRAFT90214(NEUTE1DRAFT_90214)
MGR: MGG_15748
SSCK: SPSK_03334
MAW: MAC_03049
MAJ: MAA_11223
CMT: CCM_09540
BFU: BCIN_01g05340(Bcppe1)
MBE: MBM_01393
ANI: AN0293.2
ANG: ANI_1_2536014(An01g05310)
ABE: ARB_04505
TVE: TRV_03650
PTE: PTT_07281
CNE: CNI02890
CNB: CNBH2760
ABP: AGABI1DRAFT42433(AGABI1DRAFT_42433)
ABV: AGABI2DRAFT115941(AGABI2DRAFT_115941)
MGL: MGL_3324
DDI: DDB_G0281651(ppme1)
DFA: DFA_02740(ppme1)
SMIN: v1.2.031501.t1(symbB.v1.2.031501.t1)
SPAR: SPRG_10013
 » show all
Taxonomy
Reference
1  [PMID:10318862]
  Authors
Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC
  Title
A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A.
  Journal
J Biol Chem 274:14382-91 (1999)
DOI:10.1074/jbc.274.20.14382
  Sequence
[hsa:51400] [mmu:72590]
Reference
2  [PMID:18394995]
  Authors
Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y
  Title
Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
  Journal
Cell 133:154-63 (2008)
DOI:10.1016/j.cell.2008.02.041
  Sequence
[hsa:51400]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.89
IUBMB Enzyme Nomenclature: 3.1.1.89
ExPASy - ENZYME nomenclature database: 3.1.1.89
BRENDA, the Enzyme Database: 3.1.1.89

DBGET integrated database retrieval system