KEGG   ENZYME: 3.1.2.22Help
Entry
EC 3.1.2.22                 Enzyme                                 

Name
palmitoyl[protein] hydrolase;
palmitoyl-protein thioesterase;
palmitoyl-(protein) hydrolase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
palmitoyl[protein] hydrolase
Reaction(IUBMB)
palmitoyl[protein] + H2O = palmitate + protein [RN:R01705]
Reaction(KEGG)
R01705 > R08602;
(other) R01274
Show
Substrate
palmitoyl[protein];
H2O [CPD:C00001]
Product
palmitate [CPD:C00249];
protein [CPD:C00017]
Comment
Specific for long-chain thioesters of fatty acids. Hydrolyses fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.
History
EC 3.1.2.22 created 1999
Pathway
ec00062  Fatty acid elongation
ec01100  Metabolic pathways
Orthology
K01074  palmitoyl-protein thioesterase
K01076  abhydrolase domain-containing protein 17
Genes
HSA: 51104(ABHD17B) 5538(PPT1) 58489(ABHD17C) 81926(ABHD17A) 9374(PPT2)
PTR: 107966263(ABHD17A) 455557 456789(PPT1) 462580(PPT2) 464524(ABHD17B) 467739(ABHD17C) 743474
PPS: 100969155(PPT1) 100972657(ABHD17C) 100974796(ABHD17A) 100989791(PPT2) 100993036(ABHD17B)
GGO: 101124587(ABHD17A) 101127127(PPT2) 101129649(ABHD17C) 101131377(ABHD17B) 101148324 101154001(PPT1) 109028905
PON: 100174770(PPT1) 100434271(PPT2) 100438683(ABHD17C) 100443044 100443228(ABHD17A) 112134998(ABHD17B)
NLE: 100581931(ABHD17B) 100592644 100599270(PPT2) 100601322(ABHD17C) 100604487(PPT1) 100607201(ABHD17A)
MCC: 693377(PPT1) 703828(ABHD17B) 709119(ABHD17A) 717212(PPT2) 717757(ABHD17C)
MCF: 102124313(PPT2) 102126191(PPT1) 102133497(ABHD17A) 102136912(ABHD17B)
CSAB: 103219574(ABHD17B) 103221712(PPT2) 103225040(PPT1) 103233626(ABHD17A) 103245220(ABHD17C)
RRO: 104654886(PPT1) 104671404(ABHD17A) 104672134(ABHD17B) 104674001(PPT2) 104678108(ABHD17C)
RBB: 108519890(PPT2) 108522875(ABHD17B) 108530241(ABHD17A) 108530410(PPT1) 108538654(ABHD17C)
CJC: 100401597(ABHD17A) 100403808(PPT1) 100407074(ABHD17C) 100409669(ABHD17B) 100413646(PPT2)
SBQ: 101035630(ABHD17C) 101038156(PPT1) 101039406(ABHD17B) 101043430(PPT2) 101052136
MMU: 19063(Ppt1) 216169(Abhd17a) 226016(Abhd17b) 54397(Ppt2) 70178(Abhd17c)
RNO: 29411(Ppt1) 299617(Abhd17a) 309399(Abhd17b) 361601(Abhd17c) 54398(Ppt2)
CGE: 100750408(Ppt1) 100758494(Ppt2) 100759841(Abhd17c) 100769196(Abhd17a) 100773175(Abhd17b)
NGI: 103724411(Ppt2) 103735139(Ppt1) 103737311(Abhd17a) 103741841(Abhd17b) 103750347(Abhd17c)
HGL: 101711471(Abhd17b) 101713926(Ppt2) 101714881(Abhd17c) 101718692(Ppt1) 101721456(Abhd17a)
CCAN: 109675563 109690406(Ppt2) 109691574(Ppt1) 109692225(Abhd17b) 109698868(Abhd17a)
OCU: 100339827(PPT1) 100343527(ABHD17B) 100357617(ABHD17C) 100358167(PPT2)
TUP: 102484501(PPT2) 102490310(PPT1) 102491512(ABHD17C) 102492049(ABHD17A) 102499893(ABHD17B)
CFA: 474856(PPT2) 475316(PPT1) 484170(ABHD17B) 485076(ABHD17A)
AML: 100463540(ABHD17B) 100475095(PPT1) 100476267(PPT2) 100483876(ABHD17A)
UMR: 103660292(ABHD17C) 103663259(ABHD17B) 103681794(ABHD17A) 103682279(PPT2) 103682394(PPT1)
ORO: 101362292(PPT2) 101368745 101370088(ABHD17A) 101377189(ABHD17B) 101382443(ABHD17C) 101386758(PPT1)
FCA: 101086952(ABHD17A) 101089403(ABHD17B) 101093939(ABHD17C) 101095578(PPT2) 101097408(PPT1)
PTG: 102952614(ABHD17C) 102963070(PPT1) 102971153(PPT2) 102972142(ABHD17B)
AJU: 106983473(PPT2) 106983701(ABHD17A) 106985809(ABHD17B) 106988413(PPT1)
BTA: 281421(PPT1) 516797(PPT2) 520956(ABHD17C) 614425(ABHD17A) 781153(ABHD17B)
BOM: 102264883(PPT2) 102272816(ABHD17A) 102276889(ABHD17C) 102278938(ABHD17B) 102280715(PPT1)
BIU: 109556456(PPT1) 109562000(ABHD17A) 109562952(ABHD17B) 109575175 109576851(PPT2)
PHD: 102317063(ABHD17C) 102324734(ABHD17A) 102327456(ABHD17B) 102334148(PPT2) 102338079(PPT1)
CHX: 102169669(ABHD17B) 102173897(PPT2) 102179941(ABHD17A) 102180803(ABHD17C) 102188105(PPT1)
OAS: 101102206(ABHD17B) 101109488(ABHD17C) 101112855(PPT2) 101117506(ABHD17A) 101121049(PPT1)
SSC: 100144537(PPT2) 100155547(ABHD17B) 100517533(PPT1) 100522555(ABHD17C) 100524666(ABHD17A)
CFR: 102503937(ABHD17A) 102505919(ABHD17C) 102507761(ABHD17B) 102512385(PPT1) 102522115(PPT2)
CDK: 105090849(PPT2) 105094742(ABHD17C) 105103370(PPT1) 105106054(ABHD17B) 105106534(ABHD17A)
BACU: 103006799(PPT1) 103008066(ABHD17B) 103009775(ABHD17C) 103011720(ABHD17A) 103014067(PPT2)
LVE: 103071245 103075316 103079376(ABHD17C) 103083488(ABHD17B) 103084525(ABHD17A) 103084593(PPT1) 103091119(PPT2)
OOR: 101272615(ABHD17B) 101275083 101277496(PPT2) 101278305(ABHD17A) 101283521(ABHD17C) 101283893(PPT1)
ECB: 100050162(ABHD17B) 100051483 100067399(ABHD17C) 100068301(PPT1) 100146322(ABHD17A)
EPZ: 103544201(ABHD17A) 103546744(ABHD17B) 103552973(ABHD17C) 103553563(PPT1) 103566642(PPT2)
EAI: 106823113(PPT1) 106831016(PPT2) 106831993(ABHD17C) 106834174(ABHD17A) 106836155(ABHD17B)
MYB: 102242959(PPT1) 102248230(ABHD17A) 102253197(ABHD17B) 102253546(PPT2) 106723897(ABHD17C)
MYD: 102768095(PPT2) 102770643(PPT1) 102770678(ABHD17B) 102772590(ABHD17A)
HAI: 109373111(PPT2) 109381466 109383389(PPT1) 109387015(ABHD17B) 109390627(ABHD17A)
RSS: 109436773(PPT2) 109442022 109442396 109449930(ABHD17B) 109450130(PPT1) 109453640(ABHD17C) 109453887(ABHD17A)
PALE: 102882258(ABHD17A) 102893847(ABHD17B) 102897388(PPT2) 102898049(PPT1)
LAV: 100653658(ABHD17C) 100657111(ABHD17A) 100663399(ABHD17B) 100665656 100671106(PPT1)
MDO: 100011300(ABHD17C) 100015026(ABHD17B) 100018272(ABHD17A) 100024015(PPT2) 100032080(PPT1) 103093344
SHR: 100917850(PPT1) 100918673(ABHD17C) 100921051(ABHD17B) 100931986(ABHD17A) 100933490(PPT2)
OAA: 100073758(ABHD17B) 100077897(PPT1) 100078347(PPT2) 100081062
GGA: 415479(ABHD17C) 419681(PPT1) 427252(ABHD17B) 769919(ABHD17A)
MGP: 100540149(PPT1) 100542042(ABHD17B) 100547449(ABHD17A) 100547486(ABHD17C) 104915837(PPT2)
CJO: 107306195(ABHD17B) 107307852(PPT2) 107318817(ABHD17C) 107323936(PPT1) 107325622(ABHD17A)
APLA: 101789761(PPT1) 101791420(ABHD17A) 101791527(ABHD17B) 101801797(ABHD17C)
ACYG: 106037878(PPT1) 106043341(ABHD17C) 106044481(ABHD17B) 106045708(ABHD17A)
TGU: 100190233(PPT1) 100225524(ABHD17C) 100227266(ABHD17B)
GFR: 102032495(ABHD17C) 102037741(ABHD17A) 102042422(PPT1) 102044467(ABHD17B)
FAB: 101806828(ABHD17C) 101810323(PPT1) 101810334(ABHD17B) 101821764(ABHD17A)
PHI: 102101923(ABHD17A) 102102523(ABHD17B) 102111198(ABHD17C) 102113700(PPT1) 102114091(PPT2)
PMAJ: 107198280(ABHD17B) 107209490(ABHD17C) 107214159(PPT1) 107215335(ABHD17A)
CCAE: 111934058(ABHD17C) 111939127(PPT1) 111941652(ABHD17B) 111944054(ABHD17A)
CCW: 104684094(ABHD17C) 104685246(ABHD17B) 104694666(PPT1) 104696947(ABHD17A)
FPG: 101911174(ABHD17B) 101911350(ABHD17C) 101918408(ABHD17A) 101924773(PPT1)
FCH: 102047783(ABHD17B) 102051741(ABHD17A) 102053964(PPT1) 102055762(ABHD17C)
CLV: 102085710(PPT1) 102087579(ABHD17C) 102089556(ABHD17A) 102092465(ABHD17B) 102094639(PPT2)
EGZ: 104123844(ABHD17B) 104127749(ABHD17A) 104130947(ABHD17C) 104134971(PPT1)
AAM: 106493355(PPT1) 106495580 106498513 106498569(ABHD17B)
ASN: 102373732(ABHD17A) 102374012(ABHD17C) 102376287(ABHD17B) 102377936(PPT2) 102384268(PPT1)
AMJ: 102560507(ABHD17C) 102565657(ABHD17A) 102566224(PPT1) 102570797(PPT2) 102575994(ABHD17B)
PSS: 102450927(PPT1) 102452979(ABHD17C) 102454777(ABHD17B) 102459254(ABHD17A)
CMY: 102940334(ABHD17A) 102943077(ABHD17C) 102944318(ABHD17B) 102945976(PPT1)
CPIC: 101935277(ABHD17B) 101938303(ABHD17C) 101942757(PPT1) 101942779(ABHD17A) 101949778(PPT2)
ACS: 100553077(abhd17c) 100556763(ppt2) 100560557(abhd17a) 100563048(ppt1) 100567053(abhd17b)
PVT: 110070972 110071327 110072469(ABHD17A) 110077247(ABHD17C) 110081698(ABHD17B) 110082514(PPT1)
PBI: 103048105(PPT2) 103055229(ABHD17B) 103059749(ABHD17C) 103065485(PPT1) 103066789(ABHD17A)
GJA: 107105434(ABHD17C) 107106782(ABHD17B) 107112540(PPT1) 107116815(ABHD17A) 107118454(PPT2)
XLA: 100036952(ppt1.S) 100037210(ppt1.L) 100127338 108711453 379689(ppt2.L) 444228(ppt2l.L) 446585(abhd17b.S) 446755(abhd17c.S) 447065(abhd17b) 734783(abhd17a.S)
XTR: 100101696(ppt2) 448170(abhd17c) 448619(abhd17b) 448650(ppt1) 496639(abhd17a)
NPR: 108786546(PPT2) 108791713(ABHD17B) 108793538(PPT1) 108799608(ABHD17C) 108801544
DRE: 100003419(abhd17ab) 100126133(ppt2) 322121(abhd17aa) 393126(abhd17c) 393135(zgc:55621) 393657 405845(zgc:77118) 406648(ppt1) 437017(abhd17b)
IPU: 108255672(abhd17b) 108257031(ppt1) 108265288 108271310(abhd17c) 108274839(ppt2) 108277463 108280794
LCO: 104918431 104921533(ppt1) 104922538(ppt2) 104929639 104931139(abhd17b) 104935034 104938801(abhd17c)
MZE: 101468085 101472327 101474457(abhd17c) 101475534(ppt2) 101475909(abhd17b) 101476191 101479416(ppt1)
KMR: 108230834 108236449(abhd17b) 108237780(ppt2) 108239535 108249591(ppt1) 108249862 108251360(abhd17c)
CSEM: 103378920(abhd17c) 103394015(ppt1) 103394071(ppt2) 103395921 103398222(abhd17b) 103399962
LCF: 108877370(abhd17a) 108878676(abhd17b) 108883618 108890321 108894299(abhd17c) 108899552 108903130(ppt1)
SDU: 111222249(abhd17c) 111222602 111223008(ppt1) 111223511(ppt2) 111228784 111231602(abhd17b) 111232137
BPEC: 110155804 110157950 110159233(ppt1) 110162600(abhd17c) 110169927(abhd17b) 110173282(ppt2) 110174041
ELS: 105011616(abhd17a) 105014490(abhd17b) 105014568(abhd17c) 105020419 105027908(ppt1) 105028023 105031354
SFM: 108919929 108921772 108927395 108931813(ppt1) 108935599(ppt2) 108938997(abhd17b) 108941982(abhd17c)
LCM: 102348057(ABHD17A) 102348251(ABHD17B) 102353105(PPT1) 102355870(PPT2) 102366926(ABHD17C)
CMK: 103187197(abhd17b) 103187620(abhd17c) 103188689(ppt1) 103189680(abhd17a)
DME: Dmel_CG12108(Ppt1) Dmel_CG33096(CG33096) Dmel_CG4851(Ppt2)
DER: 6555489
DPE: 6591784
DSI: Dsimw501_GD16099(Dsim_GD16099) Dsimw501_GD23774(Dsim_GD23774) Dsimw501_GD26850(Dsim_GD26850)
CEL: CELE_F44C4.5(ppt-1) CELE_K04G2.2(aho-3)
CBR: CBG08215 CBG18981(Cbr-ppt-1)
LJA: Lj0g3v0159509.1(Lj0g3v0159509.1) Lj0g3v0328109.1(Lj0g3v0328109.1) Lj0g3v0335789.1(Lj0g3v0335789.1) Lj0g3v0345669.1(Lj0g3v0345669.1) Lj1g3v3702640.1(Lj1g3v3702640.1) Lj1g3v3702640.2(Lj1g3v3702640.2) Lj2g3v1106430.1(Lj2g3v1106430.1) Lj2g3v1129580.1(Lj2g3v1129580.1) Lj2g3v1129580.2(Lj2g3v1129580.2) Lj2g3v1129580.3(Lj2g3v1129580.3) Lj2g3v1510570.1(Lj2g3v1510570.1) Lj2g3v1989240.1(Lj2g3v1989240.1) Lj4g3v1400000.1(Lj4g3v1400000.1)
DOSA: Os01t0689800-01(Os01g0689800) Os02t0190800-01(Os02g0190800) Os02t0796600-01(Os02g0796600) Os03t0101100-01(Os03g0101100) Os08t0161500-01(Os08g0161500) Os08t0487900-01(Os08g0487900) Os10t0563000-01(Os10g0563000) Os12t0286600-01(Os12g0286600)
ATS: 109734694(LOC109734694) 109739826(LOC109739826) 109745060(LOC109745060) 109749825(LOC109749825) 109758352(LOC109758352) 109759958(LOC109759958) 109770631(LOC109770631) 109772768(LOC109772768) 109780247(LOC109780247) 109786319(LOC109786319)
MNG: MNEG_5752
CAL: CAALFM_CR04490CA(CaO19.540)
CAUR: QG37_05293
NCR: NCU06530
NTE: NEUTE1DRAFT145000(NEUTE1DRAFT_145000)
MGR: MGG_04920
SSCK: SPSK_03444
MAW: MAC_00241
MAJ: MAA_08177
CMT: CCM_08776
MBE: MBM_01578
ANI: AN2497.2
ANG: ANI_1_1416084(An09g04580)
PBL: PAAG_12104(PAAG_05837)
ABE: ARB_05715
TVE: TRV_03000
PTE: PTT_08509
SPO: SPBC530.12c(pdf1)
CNE: CNA00890
CNB: CNBA0860
ABP: AGABI1DRAFT112549(AGABI1DRAFT_112549)
ABV: AGABI2DRAFT192516(AGABI2DRAFT_192516)
MGL: MGL_1417
DDI: DDB_G0285533(ppt1) DDB_G0288807(ppt2) DDB_G0292862(ppt3)
DFA: DFA_01175(ppt3) DFA_01247(ppt1) DFA_08205(ppt2)
PCB: PCHAS_100240(PC100147.00.0) PCHAS_122620
TAN: TA04130
TPV: TP03_0361
SMIN: v1.2.002128.t1(symbB.v1.2.002128.t1) v1.2.002930.t1(symbB.v1.2.002930.t1) v1.2.004002.t1(symbB.v1.2.004002.t1) v1.2.012083.t1(symbB.v1.2.012083.t1) v1.2.016070.t1(symbB.v1.2.016070.t1) v1.2.018092.t1(symbB.v1.2.018092.t1) v1.2.021245.t1(symbB.v1.2.021245.t1) v1.2.021338.t1(symbB.v1.2.021338.t1) v1.2.026088.t1(symbB.v1.2.026088.t1) v1.2.026424.t1(symbB.v1.2.026424.t1) v1.2.032242.t1(symbB.v1.2.032242.t1) v1.2.032242.t3(symbB.v1.2.032242.t3) v1.2.033029.t1(symbB.v1.2.033029.t1) v1.2.033367.t1(symbB.v1.2.033367.t1) v1.2.039019.t1(symbB.v1.2.039019.t1) v1.2.039427.t1(symbB.v1.2.039427.t1)
HHG: XM38_001320(rtxA)
 » show all
Taxonomy
Reference
1  [PMID:7651163]
  Authors
Camp LA, Hofmann SL.
  Title
Assay and isolation of palmitoyl-protein thioesterase from bovine brain using palmitoylated H-Ras as substrate.
  Journal
Methods Enzymol 250:336-47 (1995)
DOI:10.1016/0076-6879(95)50083-9
Reference
2  [PMID:8786130]
  Authors
Schriner JE, Yi W, Hofmann SL.
  Title
cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis.
  Journal
Genomics 34:317-22 (1996)
DOI:10.1006/geno.1996.0292
  Sequence
[hsa:5538]
Reference
3  [PMID:8663305]
  Authors
Verkruyse LA, Hofmann SL.
  Title
Lysosomal targeting of palmitoyl-protein thioesterase.
  Journal
J Biol Chem 271:15831-6 (1996)
DOI:10.1074/jbc.271.26.15831
  Sequence
[bta:281421]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.22
IUBMB Enzyme Nomenclature: 3.1.2.22
ExPASy - ENZYME nomenclature database: 3.1.2.22
BRENDA, the Enzyme Database: 3.1.2.22
CAS: 150605-49-5

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