KEGG   ENZYME: 3.1.2.25Help
Entry
EC 3.1.2.25                 Enzyme                                 

Name
phenylacetyl-CoA hydrolase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
phenylglyoxylyl-CoA hydrolase
Reaction(IUBMB)
phenylglyoxylyl-CoA + H2O = phenylglyoxylate + CoA [RN:R07294]
Reaction(KEGG)
Substrate
phenylglyoxylyl-CoA [CPD:C15524];
H2O [CPD:C00001]
Product
phenylglyoxylate [CPD:C02137];
CoA [CPD:C00010]
Comment
This is the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1, phenylacetyl-CoA dehydrogenase.
History
EC 3.1.2.25 created 2004
Pathway
ec00360  Phenylalanine metabolism
Orthology
K18361  phenylacetyl-CoA:acceptor oxidoreductase
Genes
EBA: ebA5393(padB)
AZO: azo1946(padB)
AZA: AZKH_2904(padB)
TMZ: Tmz1t_0199 Tmz1t_2959
RPD: RPD_1507
MAG: amb1241 amb2015
Taxonomy
Reference
1  [PMID:10336636]
  Authors
Rhee SK, Fuchs G.
  Title
Phenylacetyl-CoA:acceptor oxidoreductase, a membrane-bound molybdenum-iron-sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica.
  Journal
Eur J Biochem 262:507-15 (1999)
DOI:10.1046/j.1432-1327.1999.00399.x
Reference
2  [PMID:9575237]
  Authors
Schneider S, Fuchs G.
  Title
Phenylacetyl-CoA:acceptor oxidoreductase, a new alpha-oxidizing enzyme that produces phenylglyoxylate. Assay, membrane localization, and differential production in Thauera aromatica.
  Journal
Arch Microbiol 169:509-16 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.25
IUBMB Enzyme Nomenclature: 3.1.2.25
ExPASy - ENZYME nomenclature database: 3.1.2.25
BRENDA, the Enzyme Database: 3.1.2.25
CAS: 57219-72-4

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