KEGG   ENZYME: 3.1.2.27Help
Entry
EC 3.1.2.27                 Enzyme                                 

Name
choloyl-CoA hydrolase;
PTE-2 (ambiguous);
choloyl-coenzyme A thioesterase;
chenodeoxycholoyl-coenzyme A thioesterase;
peroxisomal acyl-CoA thioesterase 2
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
choloyl-CoA hydrolase
Reaction(IUBMB)
choloyl-CoA + H2O = cholate + CoA [RN:R07296]
Reaction(KEGG)
R07296;
(other) R03974
Show
Substrate
choloyl-CoA [CPD:C01794];
H2O [CPD:C00001]
Product
cholate [CPD:C00695];
CoA [CPD:C00010]
Comment
Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoAs, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoAs, all of which are present in peroxisomes. The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome [1].
History
EC 3.1.2.27 created 2005
Pathway
ec00120  Primary bile acid biosynthesis
ec01100  Metabolic pathways
Orthology
K11992  acyl-CoA thioesterase 8
Genes
HSA: 10005(ACOT8)
PTR: 458288(ACOT8)
PPS: 100968654(ACOT8)
GGO: 101153013(ACOT8)
PON: 100173249(ACOT8)
NLE: 100583641(ACOT8)
MCC: 717238(ACOT8)
MCF: 102141803(ACOT8)
CSAB: 103245242(ACOT8)
RRO: 104678827(ACOT8)
RBB: 108533338(ACOT8)
CJC: 100412346(ACOT8)
SBQ: 101031716(ACOT8)
MMU: 170789(Acot8)
RNO: 170588(Acot8)
CGE: 100761464
NGI: 103737941(Acot8)
HGL: 101723404(Acot8)
CCAN: 109689267(Acot8)
OCU: 100338853(ACOT8)
TUP: 102482443(ACOT8)
CFA: 477247(ACOT8)
AML: 100473659(ACOT8)
UMR: 103669711(ACOT8)
ORO: 101377976(ACOT8)
FCA: 101086550(ACOT8)
PTG: 102970206(ACOT8)
AJU: 106968968(ACOT8)
BTA: 504360(ACOT8)
BOM: 102271157(ACOT8)
BIU: 109567496(ACOT8)
PHD: 102324309(ACOT8)
CHX: 102180774(ACOT8)
OAS: 101115474(ACOT8)
SSC: 100157173(ACOT8)
CFR: 102506493(ACOT8)
CDK: 105087835(ACOT8)
BACU: 103019412(ACOT8)
LVE: 103089157(ACOT8)
OOR: 101275178(ACOT8)
ECB: 100056378(ACOT8)
EPZ: 103551928(ACOT8)
EAI: 106843034(ACOT8)
MYB: 102256663(ACOT8)
MYD: 102767910(ACOT8)
HAI: 109379967(ACOT8)
RSS: 109457067(ACOT8)
PALE: 102886033(ACOT8)
LAV: 100662846(ACOT8)
TMU: 101348063
MDO: 100021873(ACOT8)
SHR: 100932746(ACOT8)
GGA: 419303(ACOT8)
MGP: 104914099(ACOT8)
CJO: 107323042(ACOT8)
APLA: 101799658(ACOT8)
ACYG: 106047186(ACOT8)
TGU: 100226822(ACOT8)
GFR: 102041910(ACOT8)
FAB: 101812723(ACOT8)
PHI: 102113815(ACOT8)
PMAJ: 107213229(ACOT8)
CCW: 104687856(ACOT8)
FPG: 101912113(ACOT8)
FCH: 102046223(ACOT8)
CLV: 102088484(ACOT8)
EGZ: 104127963(ACOT8)
AAM: 106497599(ACOT8)
ASN: 102374940(ACOT8)
AMJ: 109282370(ACOT8)
PSS: 102459959(ACOT8)
CMY: 102946356(ACOT8)
CPIC: 101938495(ACOT8)
ACS: 100554009(acot8)
PVT: 110086215(ACOT8)
PBI: 103055025(ACOT8)
GJA: 107111365(ACOT8)
XLA: 108702736(acot8.S)
XTR: 100495154(acot8)
NPR: 108793375(ACOT8)
DRE: 450052(acot8)
SANH: 107670930
SGH: 107551324(acot8)
CCAR: 109081237(acot8)
IPU: 108254895(acot8)
AMEX: 103036772(acot8)
TRU: 101074147(acot8)
LCO: 104936755(acot8)
NCC: 104967028(acot8)
MZE: 101476913(acot8)
OLA: 101168035(acot8)
XMA: 102229258(acot8)
PRET: 103465408(acot8)
NFU: 107385835(acot8)
CSEM: 103386342(acot8)
LCF: 108886572(acot8)
HCQ: 109521623(acot8)
BPEC: 110154578(acot8)
SASA: 100380377(acot8)
ELS: 105010097(acot8)
SFM: 108923421(acot8)
LCM: 102353321(ACOT8)
CMK: 103191249(acot8)
SPU: 589369
SKO: 102804197
CEL: CELE_F25E2.3(F25E2.3)
CRG: 105345904
MYI: 110443770
OBI: 106884441
LAK: 106169050
ABV: AGABI2DRAFT189998(AGABI2DRAFT_189998)
TCR: 504149.55
 » show all
Taxonomy
Reference
1  [PMID:11673457]
  Authors
Hunt MC, Solaas K, Kase BF, Alexson SE.
  Title
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.
  Journal
J Biol Chem 277:1128-38 (2002)
DOI:10.1074/jbc.M106458200
  Sequence
[mmu:170789]
Reference
2  [PMID:10817395]
  Authors
Solaas K, Sletta RJ, Soreide O, Kase BF.
  Title
Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver.
  Journal
Scand J Clin Lab Invest 60:91-102 (2000)
Reference
3  [PMID:12543708]
  Authors
Russell DW.
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.27
IUBMB Enzyme Nomenclature: 3.1.2.27
ExPASy - ENZYME nomenclature database: 3.1.2.27
BRENDA, the Enzyme Database: 3.1.2.27

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