KEGG   ENZYME: 3.1.2.28Help
Entry
EC 3.1.2.28                 Enzyme                                 

Name
1,4-dihydroxy-2-naphthoyl-CoA hydrolase;
menI (gene name);
ydiL (gene name)
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
1,4-dihydroxy-2-naphthoyl-CoA hydrolase
Reaction(IUBMB)
1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA [RN:R07262]
Reaction(KEGG)
Substrate
1,4-dihydroxy-2-naphthoyl-CoA [CPD:C15547];
H2O [CPD:C00001]
Product
1,4-dihydroxy-2-naphthoate [CPD:C03657];
CoA [CPD:C00010]
Comment
This enzyme participates in the synthesis of menaquinones [4], phylloquinone [3], as well as several plant pigments [1,2]. The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 does not accept benzoyl-CoA or phenylacetyl-CoA as substrates [3].
History
EC 3.1.2.28 created 2010
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12073  1,4-dihydroxy-2-naphthoyl-CoA hydrolase
K19222  1,4-dihydroxy-2-naphthoyl-CoA hydrolase
Genes
ATH: AT1G48320(DHNAT1) AT5G48950(DHNAT2)
ALY: ARALYDRAFT_473967 ARALYDRAFT_494958
CRB: 17876136 17900269
CSAT: 104723224 104725379 104758130 104760877 104777747
EUS: EUTSA_v10005061mg EUTSA_v10011838mg EUTSA_v10011840mg EUTSA_v10023991mg EUTSA_v10024062mg
BRP: 103833017 103854251 103854253 103868682 103871476 103875007
BNA: 106345174 106348827 106348888 106355856 106359448 106359526 106374261 106374604 106401948 106411331 106422399
BOE: 106293805 106297220 106304592 106309710 106325619
THJ: 104802684 104818933 104821814
CPAP: 110815696
CIT: 102630997
TCC: 18603787
GRA: 105796984
DZI: 111307549
CAM: 101497234
LJA: Lj0g3v0066299.1(Lj0g3v0066299.1) Lj0g3v0066299.2(Lj0g3v0066299.2)
ZJU: 107433311
RCU: 8262609
JCU: 105643653
HBR: 110643647
JRE: 109005666
VVI: 100259669
HAN: 110941223
CCAV: 112527779
DOSA: Os03t0691400-01(Os03g0691400) Os05t0137700-00(Os05g0137700)
OBR: 102700611
ATS: 109739334(LOC109739334) 109739581(LOC109739581) 109759559 109774910 109782834 109786370(LOC109786370) 109786371(LOC109786371)
ATR: 18430152
ECO: b1686(menI)
ECJ: JW1676(ydiI)
ECD: ECDH10B_1821(ydiI)
EBW: BWG_1500(ydiI)
ECOK: ECMDS42_1358(ydiI)
ECE: Z2714
ECS: ECs2393
ECF: ECH74115_2401(ydiL)
ETW: ECSP_2253(ydiI)
EOJ: ECO26_2414(ydiI)
EOI: ECO111_2155(ydiI)
EOH: ECO103_1829(ydiI)
ECG: E2348C_1771(ydiI)
EOK: G2583_2082(ydiI)
ESO: O3O_13830
ESM: O3M_11770
ESL: O3K_11805
ECW: EcE24377A_1902(ydiL)
ELH: ETEC_1719
ECC: c2081(ydiI)
ECP: ECP_1633
ECI: UTI89_C1878(ydiI)
ECV: APECO1_763(ydiI)
ECX: EcHS_A1767(ydiL)
ECM: EcSMS35_1510(ydiL)
ECY: ECSE_1809
ECR: ECIAI1_1738(ydiI)
ECQ: ECED1_1885(ydiI)
ECK: EC55989_1853(ydiI)
ECT: ECIAI39_1372(ydiI)
EOC: CE10_1960(ydiI)
EUM: ECUMN_1975(ydiI)
ECZ: ECS88_1736(ydiI)
ESE: ECSF_1546
EBR: ECB_01655(ydiI)
EBD: ECBD_1960
EKF: KO11_14315(ydiI)
EAB: ECABU_c19400(ydiI)
EDJ: ECDH1ME8569_1630(ydiI)
EIH: ECOK1_1806(ydiL)
ENA: ECNA114_1733(ydiI)
ELW: ECW_m1854(ydiI)
ELL: WFL_09080(ydiI)
ELC: i14_1903(ydiI)
ELD: i02_1903(ydiI)
ELP: P12B_c1397(ydiL)
EBL: ECD_01655(menI)
EBE: B21_01644(ydiI)
ELF: LF82_2874(ydiI)
ECOI: ECOPMV1_01784(ydiI)
ECOJ: P423_09005
ECOS: EC958_1906(ydiI)
EFE: EFER_1366(ydiI)
EAL: EAKF1_ch4366(ydiL)
STY: STY1757
STT: t1234
STM: STM1366
SEB: STM474_1370(ydiI)
SENI: CY43_06950
SPT: SPA1489
SEK: SSPA1382
SEI: SPC_2363
SEC: SCH_1386(ydiI)
SHB: SU5_01983
SENS: Q786_08425
SED: SeD_A1977
SEG: SG1751
SEL: SPUL_1183
SET: SEN1679
SENA: AU38_08695
SENO: AU37_08700
SENV: AU39_08705
SENQ: AU40_09700
SENL: IY59_08890
SEEP: I137_05445
SENE: IA1_06735
SBG: SBG_1206
SBZ: A464_1399
SFL: SF1716
SFX: S1848
SFV: SFV_1709
SFE: SFxv_1923(ydiI)
SFN: SFy_2459
SFS: SFyv_2514
SFT: NCTC1_01861(ydiI)
SSN: SSON_1470
SBO: SBO_1444
SBC: SbBS512_E1887(ydiL)
SDY: SDY_1674
ENC: ECL_02386
ECLO: ENC_13900
EEC: EcWSU1_01843(ydiI)
ECLX: LI66_09270
ECLY: LI62_10045
ECLZ: LI64_09335
ESA: ESA_02096
CSK: ES15_2252
CTU: CTU_18690(ydiI)
KPN: KPN_02157(ydiI)
KPU: KP1_3258
KPP: A79E_2083
KPT: VK055_0301(ybdB)
KPE: KPK_2163(ydiI)
KPR: KPR_2705(ydiI)
KPJ: N559_2127
KPX: PMK1_04524(ydiI)
KPNU: LI86_10565
KPNK: BN49_3265(ydiI)
KVA: Kvar_2034
KOX: KOX_22835
KOE: A225_3445
EAE: EAE_17095
EAR: CCG30474
CKO: CKO_01721
CRO: ROD_13641
CAMA: F384_06210
EBT: EBL_c16680(ydiI)
EBF: D782_1960
PSTS: E05_19450
YPE: YPO2406
YPK: y1933
YPH: YPC_2039(ydiI)
YPA: YPA_1750
YPN: YPN_1860
YPM: YP_2193(paaI1)
YPG: YpAngola_A2595(ydiI)
YPZ: YPZ3_1481
YPD: YPD4_1446
YPX: YPD8_1499
YPW: CH59_4240(ydiI)
YPJ: CH55_481(ydiI)
YPV: BZ15_1119(ydiI)
YPL: CH46_2699(ydiI)
YPS: YPTB2315
YPO: BZ17_139(ydiI)
YPI: YpsIP31758_1740(ydiI)
YPY: YPK_1846
YPB: YPTS_2389
YPQ: DJ40_4270(ydiI)
YPU: BZ21_1603(ydiI)
YPR: BZ20_3928(ydiI)
YPC: BZ23_1889(ydiI)
YPF: BZ19_1681
YEN: YE2173
YEY: Y11_08171
YEW: CH47_1609(ydiI)
YET: CH48_3649
YAL: AT01_278
YFR: AW19_1380(ydiI)
YIN: CH53_4117
YKR: CH54_282
YRO: CH64_719
YRU: BD65_461(ydiI)
SPE: Spro_2177
SRL: SOD_c19910(ydiI)
SPLY: Q5A_011095(menI)
SMAF: D781_2027
SMW: SMWW4_v1c22060(ydiI)
SMAR: SM39_1639
SERF: L085_17735
RAA: Q7S_13955
ECA: ECA1857
PATR: EV46_08895
PATO: GZ59_27460
PCT: PC1_2452
PEC: W5S_2736
SOD: Sant_2059
EBI: EbC_18990(ydiI)
EGE: EM595_0480(entH)
TPTY: NCTC11468_00298(ydiI)
PLU: plu2625
PAY: PAU_01905
PMR: PMI1418
XBO: XBJ1_2507
XBV: XBW1_2989(ydiI)
XNE: XNC1_1865
XNM: XNC2_1810
XDO: XDD1_1846(ydiI)
XPO: XPG1_1570(ydiI)
PSI: S70_19485
PSX: DR96_2806(ydiI)
PRG: RB151_019400(ydiI)
PHEI: NCTC12003_02316(ydiI)
MMK: MU9_2415
ETR: ETAE_1783
ETD: ETAF_1612
ETE: ETEE_3829
LRI: NCTC12151_01725(ydiI)
PSHI: SAMEA2665130_1681(ydiI)
HIN: HI1161
HIT: NTHI1330
HIU: HIB_13190
HIE: R2846_1180(ydiI)
HIZ: R2866_1239(ydiI)
HIA: H733_1293
HDU: HD_0042
HAP: HAPS_2296
HPAZ: K756_07185
HPAS: JL26_06135
HPAK: JT17_03650
HSO: HS_1045
HSM: HSM_1529
PMU: PM0788
PMV: PMCN06_0858(ybdB)
PMP: Pmu_08660
PMUL: DR93_1624(ydiI)
MSU: MS1345(paaI)
MHQ: D650_1950
MHAT: B824_3050
MHAE: F382_08740
MHAM: J450_06235
MHAO: J451_07240
MHAL: N220_13265
MHAQ: WC39_01015
MHAY: VK67_01020
MVE: X875_1390
APL: APL_1423
APJ: APJL_1455
APA: APP7_1510
ASU: Asuc_1561
AAT: D11S_1575
AAN: D7S_00396
AACN: AANUM_1485
BTO: WQG_1930
BTRE: F542_20010
BTRH: F543_21920
BTRA: F544_1490
XCC: XCC0178
XCB: XC_0187
XCP: XCR_4353
XCV: XCV0179
XAX: XACM_0181
XAC: XAC0196
XCI: XCAW_00592(paaI)
XOO: XOO4497(PaaI)
XOM: XOO4237(XOO4237)
XOP: PXO_03576(ydiI)
XOR: XOC_0283
XAL: XALC_1531(albIII) XALC_3099
XPH: XppCFBP6546_10955(XppCFBP6546P_10955)
SML: Smlt0143
SMT: Smal_0102
SMZ: SMD_0095
PSUW: WQ53_07465
PSD: DSC_02025
LEZ: GLE_5187
LEM: LEN_0133
DKO: I596_41
VCH: VCA0580
VCS: MS6_A0630
VCI: O3Y_16258
VVU: VV2_0252
VVY: VVA0756
VPA: VPA0862
VAG: N646_4256
VSP: VS_II0770
VNI: VIBNI_B1089(ybdB)
VAN: VAA_04307
VSC: VSVS12_03912(menI)
VTA: B1648(ydiI)
VFI: VF_A0666(ydiI)
PPR: PBPRB0662(YPO2406)
PAE: PA1618
PAEV: N297_1663
PAEI: N296_1663
PAEP: PA1S_17925
PAEM: U769_17655
PAEL: T223_18985
PAEG: AI22_16055
PAEC: M802_1660
PAEO: M801_1662
PMY: Pmen_2463
PMK: MDS_2303
PPSE: BN5_1799
PCQ: PcP3B5_40210(ydiI)
PSB: Psyr_2025
PSYR: N018_09450
PFL: PFL_1745(ydiI)
PPRO: PPC_1799
PFO: Pfl01_4204(ydiI)
PFS: PFLU_1844
PFC: PflA506_1866(ydiI)
PFB: VO64_1440
PMAN: OU5_5091
PSA: PST_1897
PSTT: CH92_08885
PKC: PKB_1831
PSES: PSCI_4899
PSEM: TO66_08695
PSOS: POS17_1764
PANR: A7J50_1979
PSET: THL1_2206
PSIL: PMA3_06010
MAQ: Maqu_0328
MHC: MARHY0288
MAD: HP15_4051
PIN: Ping_1451
FBL: Fbal_0621
SAGA: M5M_11090
MICC: AUP74_00389(ydiI)
CBU: CBU_0913
CBD: CBUD_1161
CBG: CbuG_1091
CBC: CbuK_0923
LLO: LLO_1027(ydiI)
LFA: LFA_3451(ydiI)
LOK: Loa_01404
TNI: TVNIR_1666(ydiI_[C])
APAC: S7S_08055
KGE: TQ33_0145
AHA: AHA_2647
ASA: ASA_2500
AVR: B565_1553
AMED: B224_2867
ACAV: VI35_12620
TAU: Tola_0598
OCE: GU3_06730
PLG: NCTC10937_03270(ydiI)
RFR: Rfer_0061
POL: Bpro_0114
AAV: Aave_0099
AJS: Ajs_0044
AAA: Acav_0129
ACRA: BSY15_1566
VEI: Veis_0548
DAC: Daci_0084
CTES: O987_00435
RTA: Rta_00910
HYB: Q5W_22220
NEU: NE0832
NET: Neut_1337
DAR: Daro_3232
ARC: ABLL_0113
PPD: Ppro_2603
DEU: DBW_3078(ydiI)
SCL: sce3016
BBAT: Bdt_0534
BBW: BDW_01930
BBAC: EP01_17120
BMX: BMS_3336
NAR: Saro_2347
SPHM: G432_02295
BLAS: BSY18_3634
ELI: ELI_09835
MAI: MICA_895
MAN: A11S_811
LSJ: LSJ_0204c(comA)
WCE: WS08_1203
WCT: WS74_1274
REQ: REQ_35040
AEQ: AEQU_0259
SYN: slr0204
SYY: SYNGTS_2465(slr0204)
SYT: SYNGTI_2464(slr0204)
SYS: SYNPCCN_2463(slr0204)
SYQ: SYNPCCP_2463(slr0204)
SYJ: D082_32600(ycf83)
SYW: SYNW2301
SYC: syc2347_c
SYG: sync_2650
SYNR: KR49_07770
SYND: KR52_03900
TEL: tll0488(ycf83)
THN: NK55_08595(dncH)
LBO: LBWT_9980
PMA: Pro_0198(fcbC)
PMM: PMM0173
PMT: PMT_2055
PMH: P9215_01911(fcbC)
PRC: EW14_0216
PRM: EW15_0262
AMR: AM1_3146
MAR: MAE_08510
MPK: VL20_1046
CYT: cce_1832
TER: Tery_4064
ANA: alr2465
AVA: Ava_0397
NAZ: Aazo_1390
CALH: IJ00_14495
CTHE: Chro_4089
PUV: PUV_02610
OTE: Oter_2808
RMR: Rmar_1468
CPI: Cpin_6229
FLN: FLA_5923
SGN: SGRA_3175
SMIZ: 4412673_00403(ydiI)
CHU: CHU_1757
DFE: Dfer_5139
SLI: Slin_2909
LBY: Lbys_3104
FAE: FAES_1269
PSEZ: HME7025_00401(menI)
HSW: Hsw_2925
FLM: MY04_0134
RAI: RA0C_1990
RAR: RIA_0490
RAG: B739_0167
RAE: G148_1892
RAT: M949_0603
EAO: BD94_3115
ELB: VO54_03444(ydiI)
CHZ: CHSO_3757
CTAK: 4412677_00883(ydiI)
FBA: FIC_01759
CTS: Ctha_2251
IAL: IALB_1315
MRO: MROS_1444
 » show all
Taxonomy
Reference
1
  Authors
Muller, W. and Leistner, E.
  Title
1,4-Naphthoquinone, an intermediate in juglone (5-hydroxy-1,4-naphthoquinone) biosynthesis.
  Journal
Phytochemistry 15:407-410 (1976)
Reference
2
  Authors
Eichinger, D., Bacher, A., Zenk, M.H. and Eisenreich, W.
  Title
Quantitative assessment of metabolic flux by 13C NMR analysis. Biosynthesis of anthraquinones in Rubia tinctorum.
  Journal
J Am Chem Soc 121:7469-7475 (1999)
Reference
3  [PMID:19321747]
  Authors
Widhalm JR, van Oostende C, Furt F, Basset GJ.
  Title
A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.
  Journal
Proc Natl Acad Sci U S A 106:5599-603 (2009)
DOI:10.1073/pnas.0900738106
  Sequence
[syn:slr0204]
Reference
4  [PMID:23564174]
  Authors
Chen M, Ma X, Chen X, Jiang M, Song H, Guo Z
  Title
Identification of a hotdog fold thioesterase involved in the biosynthesis of menaquinone in Escherichia coli.
  Journal
J Bacteriol 195:2768-75 (2013)
DOI:10.1128/JB.00141-13
  Sequence
[eco:b1686]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.28
IUBMB Enzyme Nomenclature: 3.1.2.28
ExPASy - ENZYME nomenclature database: 3.1.2.28
BRENDA, the Enzyme Database: 3.1.2.28

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