KEGG   ENZYME: 3.1.2.4Help
Entry
EC 3.1.2.4                  Enzyme                                 

Name
3-hydroxyisobutyryl-CoA hydrolase;
3-hydroxy-isobutyryl CoA hydrolase;
HIB CoA deacylase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
3-hydroxy-2-methylpropanoyl-CoA hydrolase
Reaction(IUBMB)
3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate [RN:R03352]
Reaction(KEGG)
R03352;
(other) R03158 R05064
Show
Substrate
3-hydroxy-2-methylpropanoyl-CoA [CPD:C04047];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
3-hydroxy-2-methylpropanoate [CPD:C01188]
Comment
Also hydrolyses 3-hydroxypropanoyl-CoA.
History
EC 3.1.2.4 created 1961
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec00410  beta-Alanine metabolism
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
Orthology
K05605  3-hydroxyisobutyryl-CoA hydrolase
Genes
HSA: 26275(HIBCH)
PTR: 459828(HIBCH)
PPS: 100967492(HIBCH)
GGO: 101128664(HIBCH)
PON: 100174446(HIBCH)
NLE: 100593596(HIBCH)
MCC: 713951(HIBCH)
MCF: 101865465(HIBCH)
CSAB: 103217520(HIBCH)
RRO: 104675275(HIBCH)
RBB: 108515772(HIBCH)
CJC: 100395583(HIBCH)
SBQ: 101033866(HIBCH)
MMU: 227095(Hibch)
RNO: 301384(Hibch)
CGE: 100759780(Hibch)
NGI: 103736163(Hibch)
HGL: 101725904(Hibch)
CCAN: 109696726(Hibch)
OCU: 100342287(HIBCH)
TUP: 102482347(HIBCH)
CFA: 607040(HIBCH)
AML: 100474001(HIBCH) 100480395
UMR: 103659676(HIBCH)
ORO: 101376263(HIBCH)
FCA: 101081824(HIBCH)
PTG: 102950534(HIBCH)
AJU: 106979732(HIBCH)
BTA: 535883(HIBCH)
BOM: 102277831(HIBCH)
BIU: 109565513(HIBCH)
PHD: 102329900(HIBCH)
CHX: 102177103(HIBCH)
OAS: 101111161(HIBCH)
SSC: 100514687(HIBCH)
CFR: 102520918(HIBCH)
CDK: 105099182(HIBCH)
BACU: 103016387(HIBCH)
LVE: 103071603(HIBCH)
OOR: 101270727(HIBCH)
ECB: 100069399(HIBCH)
EPZ: 103548646(HIBCH)
EAI: 106828808(HIBCH)
MYB: 102245541(HIBCH)
MYD: 102766652(HIBCH)
HAI: 109372954(HIBCH)
PALE: 102885205(HIBCH)
LAV: 100669824(HIBCH)
TMU: 101358694
MDO: 100028760(HIBCH)
SHR: 100932348(HIBCH)
OAA: 100084964(HIBCH)
GGA: 423979(HIBCH)
MGP: 100544087(HIBCH)
CJO: 107316427(HIBCH)
APLA: 101803354(HIBCH)
ACYG: 106034492(HIBCH)
TGU: 100227137(HIBCH)
GFR: 102036231(HIBCH)
FAB: 101813041(HIBCH)
PHI: 102099651(HIBCH)
PMAJ: 107207317(HIBCH)
CCW: 104693733(HIBCH)
FPG: 101912934(HIBCH)
FCH: 102059864(HIBCH)
CLV: 102093555(HIBCH)
EGZ: 104130495(HIBCH)
AAM: 106492362(HIBCH)
ASN: 102376984(HIBCH)
AMJ: 102568673(HIBCH)
PSS: 102448296(HIBCH)
CMY: 102935857(HIBCH)
CPIC: 101943533(HIBCH)
ACS: 100557019(hibch)
PVT: 110083949(HIBCH)
PBI: 103058600(HIBCH)
GJA: 107107486(HIBCH)
XLA: 100037216(hibch.L) 108702296(hibch.S)
XTR: 548942(hibch)
NPR: 108786721(HIBCH)
DRE: 798364(hibch)
SANH: 107657541(hibch) 107660603
SGH: 107565011(hibch) 107602132
CCAR: 109091641(hibch)
IPU: 108266808(hibch)
AMEX: 103032275(hibch)
TRU: 101062000(hibch)
LCO: 104920786(hibch)
MZE: 101487479(hibch)
OLA: 101159781(hibch)
XMA: 102228701(hibch)
PRET: 103461918(hibch)
NFU: 107373713(hibch)
CSEM: 103392392(hibch)
LCF: 108897172(hibch)
HCQ: 109517563(hibch)
BPEC: 110167892(hibch)
SASA: 106586135(hibch)
ELS: 105016168(hibch)
SFM: 108924305(hibch)
LCM: 102350181(HIBCH)
CMK: 103176535(hibch)
CIN: 100177147
SPU: 586315
APLC: 110977383
SKO: 100367527
DME: Dmel_CG5044(CG5044)
DSI: Dsimw501_GD19018(Dsim_GD19018)
MDE: 101899408
AAG: 110680500
AME: 412796
BIM: 105680333
BTER: 100652056
SOC: 105200361
PBAR: 105428916
HST: 105181374
CFO: 105249032
LHU: 105671604
PGC: 109853261
NVI: 100121990
TCA: 657314
NVL: 108561023
BMOR: 101741452
PMAC: 106714316
PRAP: 111004073
API: 100165582
DNX: 107162497
ZNE: 110831737
FCD: 110845188
TUT: 107369434
CEL: CELE_F09F7.4(hach-1)
CBR: CBG24044
BMY: Bm1_41250
TSP: Tsp_02189
CRG: 105332278
MYI: 110451915
OBI: 106869583
SHX: MS3_08076
EPA: 110232109
HMG: 100212624
LJA: Lj0g3v0351029.1(Lj0g3v0351029.1) Lj3g3v0509640.1(Lj3g3v0509640.1) Lj3g3v3189750.1(Lj3g3v3189750.1) Lj4g3v3093990.1(Lj4g3v3093990.1) Lj5g3v0495890.1(Lj5g3v0495890.1) Lj6g3v0932380.1(Lj6g3v0932380.1)
DOSA: Os01t0752200-01(Os01g0752200) Os10t0552900-01(Os10g0552900) Os12t0264500-01(Os12g0264500)
ATS: 109745834(LOC109745834) 109752916(LOC109752916) 109770172(LOC109770172) 109781069(LOC109781069)
MNG: MNEG_7912
APRO: F751_6578
SCE: YDR036C(EHD3)
ERC: Ecym_2647
KMX: KLMA_40110(EHD3)
NCS: NCAS_0A10580(NCAS0A10580)
NDI: NDAI_0A05710(NDAI0A05710)
TPF: TPHA_0M01100(TPHA0M01100)
TBL: TBLA_0E02580(TBLA0E02580)
TDL: TDEL_0D03540(TDEL0D03540)
KAF: KAFR_0A01030(KAFR0A01030)
PIC: PICST_32846(EHO3)
CAL: CAALFM_C103320CA(EHD3)
CAUR: QG37_01651
SLB: AWJ20_5037(EHD3)
NCR: NCU03777
NTE: NEUTE1DRAFT76941(NEUTE1DRAFT_76941)
MGR: MGG_04012
SSCK: SPSK_04045
MAW: MAC_05969
MAJ: MAA_09180
CMT: CCM_03210
BFU: BCIN_08g03170(Bcehd3)
ANI: AN6844.2
ANG: ANI_1_1594124(An14g06290)
ABE: ARB_03372
TVE: TRV_02881
PTE: PTT_16835
CNE: CNA02940
CNB: CNBA2830
ABP: AGABI1DRAFT82326(AGABI1DRAFT_82326)
ABV: AGABI2DRAFT133832(AGABI2DRAFT_133832)
MGL: MGL_0355
PYO: PY17X_1456900(PY02220)
PCB: PCHAS_145670(PC105098.00.0)
SMIN: v1.2.034303.t1(symbB.v1.2.034303.t1) v1.2.034303.t2(symbB.v1.2.034303.t2)
SPAR: SPRG_02751
PACA: ID47_07905
 » show all
Taxonomy
Reference
1  [PMID:13457352]
  Authors
RENDINA G, COON MJ.
  Title
Enzymatic hydrolysis of the coenzyme a thiol esters of beta-hydroxypropionic and beta-hydroxyisobutyric acids.
  Journal
J Biol Chem 225:523-34 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.4
IUBMB Enzyme Nomenclature: 3.1.2.4
ExPASy - ENZYME nomenclature database: 3.1.2.4
BRENDA, the Enzyme Database: 3.1.2.4
CAS: 9025-88-1

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