KEGG   ENZYME: 3.1.3.24Help
Entry
EC 3.1.3.24                 Enzyme                                 

Name
sucrose-phosphate phosphatase;
sucrose 6-phosphate hydrolase;
sucrose-phosphate hydrolase;
sucrose-phosphate phosphohydrolase;
sucrose-6-phosphatase;
sucrose phosphatase;
sucrose-6-phosphate phosphatase;
SPP
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
sucrose-6F-phosphate phosphohydrolase
Reaction(IUBMB)
sucrose 6F-phosphate + H2O = sucrose + phosphate [RN:R00805 R06211]
Reaction(KEGG)
Substrate
sucrose 6F-phosphate [CPD:C02591];
H2O [CPD:C00001]
Product
sucrose [CPD:C00089];
phosphate [CPD:C00009]
Comment
Requires Mg2+ for maximal activity [2]. This is the final step in the sucrose-biosynthesis pathway. The enzyme is highly specific for sucrose 6-phosphate, with fructose 6-phosphate unable to act as a substrate [2]. Belongs in the haloacid dehydrogenase (HAD) superfamily. The F of sucrose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.
History
EC 3.1.3.24 created 1972, modified 2008
Pathway
ec00500  Starch and sucrose metabolism
ec01100  Metabolic pathways
Orthology
K07024  sucrose-6-phosphatase
Genes
RSS: 109441355 109441578
ATH: AT1G51420(SPP1) AT2G35840 AT3G52340(SPP2) AT3G54270
ALY: ARALYDRAFT_485599 ARALYDRAFT_682208 ARALYDRAFT_902697 ARALYDRAFT_906833
CRB: 17885437 17885460 17888311 17897904
CSAT: 104711347 104711786 104712007 104712793 104713932 104742656 104758452 104778051 104781077 104781293 104781996 104785950 104791485 104791699 104792218 104792360
EUS: EUTSA_v10010361mg EUTSA_v10010402mg EUTSA_v10011514mg EUTSA_v10016712mg EUTSA_v10023476mg
BRP: 103832861 103841339 103857590 103863242 103863471 103865486 103868568
BNA: 106366954 106384344 106384425 106384664 106384744 106388145 106390094 106391426 106394386 106411802 106412074 106417948 106430593 106430595 106431371 106437864 106439027 106449288 106449368 111208044
BOE: 106309682 106328025 106328735 106340346 106341229 106342543
THJ: 104808403 104811340
CIT: 102613091
LJA: Lj0g3v0007959.1(Lj0g3v0007959.1) Lj0g3v0007959.2(Lj0g3v0007959.2) Lj0g3v0259839.1(Lj0g3v0259839.1) Lj0g3v0259849.1(Lj0g3v0259849.1) Lj6g3v0145980.1(Lj6g3v0145980.1) Lj6g3v0156190.1(Lj6g3v0156190.1) Lj6g3v0156190.2(Lj6g3v0156190.2) Lj6g3v0156190.3(Lj6g3v0156190.3)
RCU: 8259817
SOT: 102577786(SPP2)
NTA: 107767908(NtSPP1) 107819363(NtSPP2) 107828694 107830739
INI: 109181503
NNU: 104605199
DOSA: Os01t0376700-01(Os01g0376700) Os02t0143100-01(Os02g0143100) Os05t0144900-01(Os05g0144900)
ATS: 109757507(LOC109757507) 109762595(LOC109762595)
ZMA: 541868(spp1) 542661
PEQ: 110028814
ATR: 18421607
MNG: MNEG_4690
APRO: F751_1470
ASOC: CB4_03629(mfppA)
SYN: slr0953
SYY: SYNGTS_1845(slr0953)
SYT: SYNGTI_1845(slr0953)
SYS: SYNPCCN_1844(slr0953)
SYQ: SYNPCCP_1844(slr0953)
LET: O77CONTIG1_04515(mfppA)
AMR: AM1_2884(spp)
CYT: cce_1207(sps)
GVI: gll3839
GLJ: GKIL_4106
ANA: all0376
AVA: Ava_2821
NAZ: Aazo_2470
CALH: IJ00_04815
CTHE: Chro_0680
 » show all
Taxonomy
Reference
1  [PMID:4290548]
  Authors
Hawker JS, Hatch MD.
  Title
A specific sucrose phosphatase from plant tissues.
  Journal
Biochem J 99:102-7 (1966)
Reference
2  [PMID:11050182]
  Authors
Lunn JE, Ashton AR, Hatch MD, Heldt HW
  Title
Purification, molecular cloning, and sequence analysis of sucrose-6F-phosphate phosphohydrolase from plants.
  Journal
Proc Natl Acad Sci U S A 97:12914-9 (2000)
DOI:10.1073/pnas.230430197
  Sequence
[zma:541868] [osa:4328274] [ath:AT2G35840 AT3G54270]
Reference
3  [PMID:12753969]
  Authors
Lunn JE, MacRae E
  Title
New complexities in the synthesis of sucrose.
  Journal
Curr Opin Plant Biol 6:208-14 (2003)
DOI:10.1016/S1369-5266(03)00033-5
Reference
4  [PMID:15937230]
  Authors
Fieulaine S, Lunn JE, Borel F, Ferrer JL
  Title
The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell.
  Journal
Plant Cell 17:2049-58 (2005)
DOI:10.1105/tpc.105.031229
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.24
IUBMB Enzyme Nomenclature: 3.1.3.24
ExPASy - ENZYME nomenclature database: 3.1.3.24
BRENDA, the Enzyme Database: 3.1.3.24
CAS: 9059-33-0

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