KEGG   ENZYME: 3.1.3.36Help
Entry
EC 3.1.3.36                 Enzyme                                 

Name
phosphoinositide 5-phosphatase;
type II inositol polyphosphate 5-phosphatase;
triphosphoinositide phosphatase;
IP3 phosphatase;
PtdIns(4,5)P2 phosphatase;
triphosphoinositide phosphomonoesterase;
diphosphoinositide phosphatase;
inositol 1,4,5-triphosphate 5-phosphomonoesterase;
inositol triphosphate 5-phosphomonoesterase;
phosphatidylinositol-bisphosphatase;
phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase;
phosphatidylinositol 4,5-bisphosphate phosphatase;
polyphosphoinositol lipid 5-phosphatase;
phosphatidyl-inositol-bisphosphate phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate [RN:R04404]
Reaction(KEGG)
R04404;
(other) R09827
Show
Substrate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 4-phosphate [CPD:C01277];
phosphate [CPD:C00009]
Comment
These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56, inositol-polyphosphate 5-phosphatase.
History
EC 3.1.3.36 created 1972, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K01099  inositol polyphosphate 5-phosphatase INPP5B/F
K20278  inositol polyphosphate 5-phosphatase INPP5E
K20279  synaptojanin
Genes
HSA: 3633(INPP5B) 4952(OCRL) 56623(INPP5E) 8867(SYNJ1) 8871(SYNJ2)
PTR: 456767(INPP5B) 463094(SYNJ2) 465851(OCRL) 473959(SYNJ1) 748603(INPP5E)
PPS: 100969564(SYNJ1) 100972826(INPP5B) 100973295(INPP5E) 100988033(OCRL) 103786614(SYNJ2)
GGO: 101131117(SYNJ2) 101133552(SYNJ1) 101138003(INPP5B) 101141428(OCRL) 101150746(INPP5E)
PON: 100172875(OCRL) 100437498(SYNJ1) 100445730(INPP5E) 100454307(SYNJ2) 100462526(INPP5B)
NLE: 100589613 100597231(SYNJ2) 100598449(SYNJ1) 100599622(INPP5B) 100601830(INPP5E) 100603753(OCRL)
MCC: 702345(OCRL) 705639(SYNJ2) 707829(SYNJ1) 710121(INPP5E) 716851(INPP5B)
MCF: 101864788 101926413(SYNJ2) 102140416(INPP5E) 102144048(OCRL) 102145009(SYNJ1)
CSAB: 103216970(SYNJ1) 103225081(INPP5B) 103232534(OCRL) 103239625(INPP5E) 103240794(SYNJ2)
RRO: 104653630(INPP5B) 104655368(OCRL) 104658742(SYNJ1) 104669671(INPP5E) 104676662(SYNJ2)
RBB: 108516495(OCRL) 108525133 108536847(SYNJ1) 108540517(SYNJ2) 108542199(INPP5B) 108542841(INPP5E)
CJC: 100393539(INPP5B) 100395303(SYNJ1) 100399977(INPP5E) 100400862(SYNJ2) 100415106(OCRL)
SBQ: 101031749(INPP5E) 101036249(INPP5B) 101038137(OCRL) 101038752(SYNJ1) 101047067(SYNJ2)
MMU: 104015(Synj1) 16330(Inpp5b) 20975(Synj2) 320634(Ocrl) 64436(Inpp5e)
RNO: 103689941 114089(Inpp5e) 317576(Ocrl) 362590(Inpp5b) 84018(Synj2) 85238(Synj1)
CGE: 100751850(Inpp5b) 100757174(Synj1) 100759837(Inpp5e) 100774472(Synj2) 100774848(Ocrl)
NGI: 103728746(Ocrl) 103736463(Synj1) 103739168(Synj2) 103741211(Inpp5e) 103747699(Inpp5b)
HGL: 101700219(Synj2) 101701719(Inpp5e) 101704216(Inpp5b) 101718278(Synj1) 101722262(Ocrl)
OCU: 100328807(SYNJ1) 100346052(OCRL) 100350043(INPP5B) 100355301(SYNJ2)
TUP: 102475253(SYNJ1) 102476402(INPP5B) 102481520(INPP5E) 102497673(OCRL) 102502408(SYNJ2)
CFA: 100686373(INPP5B) 478403(SYNJ1) 484052(SYNJ2) 492123(OCRL) 607443(INPP5E)
AML: 100468432(INPP5E) 100476961(OCRL) 100482018(INPP5B) 100483932(SYNJ1) 100484742(SYNJ2)
UMR: 103660907(SYNJ2) 103666367(INPP5B) 103667611(OCRL) 103673106(SYNJ1) 103675239(INPP5E)
ORO: 101362942(SYNJ1) 101371002 101372290(INPP5B) 101379029(OCRL) 101384695 101386126(INPP5E)
FCA: 101087233(SYNJ2) 101090793(SYNJ1) 101092699(INPP5B) 101093901(INPP5E) 101101038(OCRL)
PTG: 102953623(SYNJ1) 102958336(SYNJ2) 102958429(INPP5E) 102964378(INPP5B) 102965696(OCRL)
AJU: 106966463(SYNJ1) 106973196(INPP5B) 106981590(OCRL) 106982681(SYNJ2) 106989561(INPP5E) 106989869
BTA: 282087(SYNJ1) 506349(INPP5E) 518435(SYNJ2) 535844(OCRL) 538291(INPP5B)
BOM: 102273891(SYNJ1) 102274367(INPP5B) 102275943(INPP5E) 102278951(OCRL) 102280878(SYNJ2)
BIU: 109555222(OCRL) 109556479(INPP5B) 109563593(SYNJ2) 109566589(INPP5E) 109576486(SYNJ1)
PHD: 102324828(SYNJ2) 102328702(INPP5B) 102329841(SYNJ1) 102331514(INPP5E) 102338669(OCRL)
CHX: 102172073(INPP5E) 102173254(INPP5B) 102173924(OCRL) 102176266(SYNJ1) 106502498(SYNJ2)
OAS: 101101853(SYNJ1) 101109366(SYNJ2) 101115530(INPP5E) 101119358(INPP5B) 101119794(OCRL) 105606046
SSC: 100512110(INPP5B) 100516167(SYNJ2) 100524726(OCRL) 100525664(SYNJ1) 110258074(INPP5E)
CFR: 102506558(INPP5B) 102512179(SYNJ2) 102513772(INPP5E) 102518942(SYNJ1) 102519568 102521852(OCRL)
CDK: 105086922(INPP5B) 105088310(SYNJ2) 105089876(SYNJ1) 105098825(OCRL) 105106024(INPP5E)
BACU: 103005365(INPP5B) 103005574(SYNJ2) 103015114(OCRL) 103017804(INPP5E) 103018952(SYNJ1)
LVE: 103071058(SYNJ1) 103081690(INPP5E) 103084395(SYNJ2) 103085051 103086884(OCRL) 103091471(INPP5B)
OOR: 101270852(INPP5B) 101272813(SYNJ2) 101279115(INPP5E) 101279498(OCRL) 101281706(SYNJ1) 101284777
ECB: 100052605(SYNJ1) 100054559(INPP5B) 100059144(OCRL) 100059716(SYNJ2) 100068731(INPP5E)
EPZ: 103549507(INPP5B) 103560448(SYNJ1) 103561753(OCRL) 103565349(INPP5E) 103566834(SYNJ2)
EAI: 106822400(SYNJ1) 106830567(INPP5B) 106834935(SYNJ2) 106845556(INPP5E) 106847107(OCRL)
MYB: 102239005(SYNJ2) 102242464(OCRL) 102244484(SYNJ1) 102247367(INPP5B) 102247617(INPP5E)
MYD: 102752783(SYNJ1) 102753741(SYNJ2) 102754754(OCRL) 102759168(INPP5B) 102762883(INPP5E)
HAI: 109378807 109382414(INPP5E) 109383603(SYNJ2) 109388879(OCRL) 109390984(INPP5B) 109393516(SYNJ1)
RSS: 109441679 109444860(INPP5B) 109446614(SYNJ1) 109447678(OCRL) 109456843(SYNJ2) 109460934(INPP5E)
PALE: 102884156(OCRL) 102885509(SYNJ2) 102886022(INPP5E) 102890440(SYNJ1) 102894285(INPP5B)
LAV: 100654255(SYNJ2) 100655464(OCRL) 100668271(INPP5B) 100670120(INPP5E) 100674046(SYNJ1)
MDO: 100016332(SYNJ1) 100020283(INPP5E) 100021521(OCRL) 100031802(INPP5B) 100032343(SYNJ2)
SHR: 100914199(INPP5B) 100917371(OCRL) 100920906(SYNJ2) 100927587(SYNJ1) 100930476(INPP5E)
OAA: 100074182(SYNJ2) 100074269(SYNJ2) 100081303(INPP5B) 100083729(SYNJ1) 100087165(OCRL) 100092732(INPP5E)
GGA: 417135(INPP5E) 418498(SYNJ1) 419609(INPP5B) 421656(SYNJ2) 422136(OCRL)
MGP: 100540459(INPP5B) 100543286(SYNJ1) 100543414(OCRL) 100546337(SYNJ2) 100546617(INPP5E) 104914270
CJO: 107311628(SYNJ2) 107312534(OCRL) 107321710(INPP5E) 107322859(SYNJ1) 107324005(INPP5B)
APLA: 101800513(SYNJ2) 101802967(INPP5B) 101803505(OCRL) 101805183(SYNJ1) 101805278(INPP5E)
ACYG: 106034243(SYNJ2) 106037733(OCRL) 106038058(INPP5B) 106040740(INPP5E) 106043435(SYNJ1)
TGU: 100218296(INPP5E) 100219842(OCRL) 100220826(INPP5B) 100224437 100227989(SYNJ2) 100228100(SYNJ1)
GFR: 102032196(SYNJ1) 102033400(OCRL) 102041103(INPP5E) 102043869(INPP5B) 102044789(SYNJ2)
FAB: 101806093(SYNJ1) 101807630(SYNJ2) 101807806 101809360(INPP5B) 101813228(OCRL) 101814688(INPP5E) 101817124
PHI: 102100258(INPP5B) 102104956(OCRL) 102108331(SYNJ1) 102112471(SYNJ2) 102113826(INPP5E)
PMAJ: 107201794(SYNJ2) 107204051(OCRL) 107212181(INPP5E) 107213432(SYNJ1) 107214255(INPP5B)
CCAE: 111922518 111926747(SYNJ2) 111929316(OCRL) 111937067(INPP5E) 111942601(INPP5B) 111942615(SYNJ1)
CCW: 104684200(SYNJ1) 104688354(INPP5E) 104689865(SYNJ2) 104691587(OCRL) 104694716(INPP5B)
FPG: 101911635(OCRL) 101913351(SYNJ2) 101916469(SYNJ1) 101917096(INPP5B) 101924984(INPP5E)
FCH: 102047189(INPP5E) 102048578(SYNJ2) 102048833(INPP5B) 102051014(OCRL) 102055766 102055769(SYNJ1)
CLV: 102084313(INPP5E) 102088002(OCRL) 102089265(INPP5B) 102097894(SYNJ1) 102098667(SYNJ2)
EGZ: 104121748(OCRL) 104128222(SYNJ1) 104129194(INPP5B) 104129345(INPP5E) 104131176(SYNJ2)
AAM: 106484102(OCRL) 106487004(INPP5E) 106490910(INPP5B) 106494963(SYNJ1) 106498020(SYNJ2)
ASN: 102369635(SYNJ2) 102380140(INPP5E) 102382497(INPP5B) 102385377(SYNJ1) 102386023(OCRL)
AMJ: 102558549(INPP5B) 102566738(INPP5E) 102571633(OCRL) 102575458(SYNJ2) 102576848(SYNJ1)
PSS: 102446991(INPP5E) 102449725(INPP5B) 102460113(OCRL) 102461279(SYNJ2) 102463325(SYNJ1)
CMY: 102932373(INPP5E) 102936655(INPP5B) 102938143 102938192(SYNJ2) 102939662(OCRL) 102947907(SYNJ1)
CPIC: 101936637(INPP5B) 101937608(OCRL) 101940841(INPP5E) 101945887(SYNJ1) 101946228(SYNJ2)
ACS: 100555178(inpp5e) 100555494(inpp5b) 100562404(synj2) 100563751(ocrl) 100567389(synj1) 103282825
PVT: 110079694(INPP5E) 110080388(SYNJ1) 110082772(INPP5B) 110084940(OCRL) 110087755(SYNJ2)
PBI: 103052147(SYNJ2) 103053023(INPP5E) 103056566(INPP5B) 103058036(OCRL) 103064194(SYNJ1)
GJA: 107106064(OCRL) 107106608(SYNJ2) 107110144(INPP5B) 107112993(INPP5E) 107114106(SYNJ1)
XLA: 100380968(synj1.S) 100381066(inpp5b.L) 100873161(ocrl.L) 108698190 108700111(ocrl.S) 108707879(synj1.L) 108716710
XTR: 100125214(ocrl) 100216051(synj2) 100486470(inpp5e) 100487517(synj1) 100497120(inpp5b)
NPR: 108789553(INPP5B) 108793001(OCRL) 108794041(SYNJ1) 108795871(SYNJ2) 108800235(INPP5E)
DRE: 337236(synj1) 563543(inpp5b) 606579(inpp5e) 777716(ocrl)
IPU: 108255662(inpp5e) 108259957 108269006(ocrl) 108269428(inpp5b) 108277096(synj1)
AMEX: 103027086(synj1) 103027958(ocrl) 103029810(inpp5b) 103038809(inpp5e)
TRU: 101070368(ocrl) 101070553(inpp5e) 101074672(inpp5b) 101077878(synj1)
LCO: 104919570(inpp5b) 104919860(ocrl) 104923663(inpp5e) 104925188(synj1)
NCC: 104941350 104941351(ocrl) 104955646(synj1) 104958594(inpp5e) 104965867(inpp5b)
MZE: 101465648(inpp5b) 101474548(inpp5e) 101480849(ocrl) 101485440(synj1)
OLA: 101161245(inpp5e) 101162611(ocrl) 101170302(inpp5b) 101172098(synj1)
XMA: 102222173(inpp5e) 102228425(inpp5b) 102228444(ocrl) 102229425(synj1)
PRET: 103469902(inpp5e) 103471562(ocrl) 103475541(synj1) 103477873(inpp5b)
NFU: 107377925(ocrl) 107379367(inpp5b) 107386282(inpp5e) 107386947(synj1)
KMR: 108231333(ocrl) 108233566(inpp5e) 108235541(inpp5b) 108236988(synj1)
LCF: 108875310 108893042 108893656(synj1) 108895406(ocrl) 108898729(inpp5b)
SDU: 111217079(synj1) 111232467(ocrl) 111235773(inpp5b) 111236487(inpp5e)
HCQ: 109513101(inpp5b) 109515772(ocrl) 109516745(synj1) 109525194(inpp5e)
BPEC: 110153533 110155831 110158622(synj1) 110158945(ocrl) 110174323(inpp5b)
MALB: 109954690(inpp5b) 109955835(ocrl) 109959114(inpp5e) 109959115 109959213(synj1)
ELS: 105006615(ocrl) 105008024(synj1) 105014130(inpp5e) 105027176(inpp5b)
SFM: 108923154(ocrl) 108927714(inpp5b) 108931048 108933635(inpp5e) 108936188(synj1)
LCM: 102349621(OCRL) 102357566(INPP5E) 102361906(SYNJ2) 102364570(INPP5B) 102367670(SYNJ1)
CMK: 103177560(ocrl) 103179631(inpp5b) 103181657(synj2) 103184698(inpp5e) 103187290(synj1)
DME: Dmel_CG10426(INPP5E) Dmel_CG3573(Ocrl) Dmel_CG6562(Synj)
DSI: Dsimw501_GD27106(Dsim_GD27106) Dsimw501_GD28984(Dsim_GD28984) Dsimw501_GD29624(Dsim_GD29624)
CEL: CELE_C16C2.3(ocrl-1) CELE_JC8.10(unc-26) CELE_T25B9.10(inpp-1)
CBR: CBG01799(Cbr-unc-26) CBG03815(Cbr-ocrl-1) CBG17633
CSAT: 104763495
CPAP: 110820300
CIT: 102623400
VAR: 108347885
CCAJ: 109790688
CAM: 101488888
LJA: Lj2g3v1022530.1(Lj2g3v1022530.1) Lj2g3v1022530.3(Lj2g3v1022530.3) Lj4g3v2403200.2(Lj4g3v2403200.2) Lj5g3v0614830.1(Lj5g3v0614830.1) Lj5g3v0614830.2(Lj5g3v0614830.2)
ADU: 107493305
CPEP: 111794032
JCU: 105633914
POP: 7482428
VVI: 100854877
SLY: 101247250
CANN: 107838781
SIND: 105166304
HAN: 110890653
LSV: 111891919
BVG: 104887439
SOE: 110777538
NNU: 104586498
BDI: 100831276
SBI: 8068981
SITA: 101774162
DCT: 110096594
PEQ: 110036055
APRO: F751_2752
SCE: YIL002C(INP51) YNL106C(INP52) YOR109W(INP53)
KMX: KLMA_50389(INP51) KLMA_60227(INP53)
NCS: NCAS_0A13120(NCAS0A13120) NCAS_0B06910(NCAS0B06910) NCAS_0G02600(NCAS0G02600)
NDI: NDAI_0B01090(NDAI0B01090) NDAI_0B04240(NDAI0B04240) NDAI_0F02700(NDAI0F02700)
TPF: TPHA_0B02960(TPHA0B02960) TPHA_0F01750(TPHA0F01750) TPHA_0L00740(TPHA0L00740)
TBL: TBLA_0B01340(TBLA0B01340) TBLA_0C05610(TBLA0C05610) TBLA_0J01760(TBLA0J01760)
TDL: TDEL_0F01260(TDEL0F01260) TDEL_0H03050(TDEL0H03050)
KAF: KAFR_0B04520(KAFR0B04520) KAFR_0J02020(KAFR0J02020) KAFR_0K01150(KAFR0K01150)
PIC: PICST_58872(INP51) PICST_82710(INP52)
CAL: CAALFM_C209770CA(INP51) CAALFM_C700670CA(CaO19.7052)
SLB: AWJ20_3207(INP53) AWJ20_3208(INP53) AWJ20_4283(INP51)
NTE: NEUTE1DRAFT120100(NEUTE1DRAFT_120100) NEUTE1DRAFT90897(NEUTE1DRAFT_90897)
ANG: ANI_1_1322034(An03g03860) ANI_1_510114(An13g00020)
SPO: SPBC2G2.02(syj1) SPBC577.13(syj2)
CNE: CNC06500
CNB: CNBC0700
ABP: AGABI1DRAFT121436(AGABI1DRAFT_121436) AGABI1DRAFT127695(AGABI1DRAFT_127695)
ABV: AGABI2DRAFT150338(AGABI2DRAFT_150338) AGABI2DRAFT187599(AGABI2DRAFT_187599)
MGL: MGL_3338
DDI: DDB_G0267462(Dd5P4) DDB_G0292392(Dd5P3)
DFA: DFA_03503(Dd5P2) DFA_07655(Dd5P4) DFA_08200(Dd5P3)
EHI: EHI_153490(13.t00027) EHI_159880(256.t00004)
TAN: TA16590
TPV: TP01_1149
BBO: BBOV_IV011570(23.m05939)
SMIN: v1.2.000626.t1(symbB.v1.2.000626.t1) v1.2.005687.t2(symbB.v1.2.005687.t2) v1.2.010337.t1(symbB.v1.2.010337.t1)
 » show all
Taxonomy
Reference
1  [PMID:4284485]
  Authors
Dawson RM, Thompson W.
  Title
The triphosphoinositide phosphomonoesterase of brain tissue.
  Journal
Biochem J 91:244-50 (1964)
Reference
2  [PMID:6271223]
  Authors
Roach PD, Palmer FB.
  Title
Human erythrocyte cytosol phosphatidyl-inositol-bisphosphate phosphatase.
  Journal
Biochim Biophys Acta 661:323-33 (1981)
DOI:10.1016/0005-2744(81)90021-8
Reference
3
  Authors
Woscholski, R. and Parker, P.J.
  Title
Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates.
  Journal
In: Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.36
IUBMB Enzyme Nomenclature: 3.1.3.36
ExPASy - ENZYME nomenclature database: 3.1.3.36
BRENDA, the Enzyme Database: 3.1.3.36
CAS: 9036-01-5

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