KEGG   ENZYME: 3.1.3.43Help
Entry
EC 3.1.3.43                 Enzyme                                 

Name
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase;
pyruvate dehydrogenase phosphatase;
phosphopyruvate dehydrogenase phosphatase;
[pyruvate dehydrogenase (lipoamide)]-phosphatase;
[pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
[pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase
Reaction(IUBMB)
[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate [RN:R03450]
Reaction(KEGG)
Substrate
[pyruvate dehydrogenase (acetyl-transferring)] phosphate [CPD:C01293];
H2O [CPD:C00001]
Product
[pyruvate dehydrogenase (acetyl-transferring)] [CPD:C01256];
phosphate [CPD:C00009]
Comment
A mitochondrial enzyme associated with EC 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring), in the pyruvate dehydrogenase complex.
History
EC 3.1.3.43 created 1978
Orthology
K01102  pyruvate dehydrogenase phosphatase
K19708  protein phosphatase PTC6
Genes
HSA: 54704(PDP1) 57546(PDP2)
PTR: 454147(PDP2) 472819(PDP1)
PPS: 100972380(PDP1) 100981913(PDP2)
GGO: 101139788(PDP2) 101144604(PDP1)
PON: 100172698(PDP2) 100174041(PDP1)
NLE: 100598000(PDP1) 100603637(PDP2)
MCC: 694851(PDP2) 699172(PDP1)
MCF: 101864890(PDP1) 102115490(PDP2)
CSAB: 103233132(PDP2) 103237135(PDP1)
RRO: 104655665(PDP2) 104658546(PDP1)
RBB: 108512193(PDP1) 108520759(PDP2) 108525906
CJC: 100410064(PDP2) 100414108(PDP1)
SBQ: 101047403(PDP2) 101052730(PDP1)
MMU: 381511(Pdp1) 382051(Pdp2)
MCAL: 110292587(Pdp1) 110300615(Pdp2)
MPAH: 110337572(Pdp2) 110338672(Pdp1)
RNO: 246311(Pdp2) 54705(Pdp1)
MUN: 110559754(Pdp2) 110563742(Pdp1)
CGE: 100752399 100761381(Pdp1) 100762846(Pdp2)
NGI: 103744497(Pdp2) 103745821(Pdp1) 103749861
HGL: 101700253(Pdp2) 101724432(Pdp1)
CCAN: 109691997(Pdp1) 109693318(Pdp2)
OCU: 100350736(PDP2) 100355855(PDP1)
TUP: 102472878(PDP2) 102484694(PDP1)
CFA: 477941(PDP1) 489771(PDP2)
VVP: 112929393(PDP2) 112931120(PDP1)
AML: 100471099(PDP2) 100472720(PDP1)
UMR: 103661432(PDP1) 103673680(PDP2)
UAH: 113252337(PDP2) 113252931(PDP1)
ORO: 101366344(PDP1) 101371530(PDP2)
FCA: 101082975(PDP1) 101095536(PDP2)
PTG: 102951980(PDP2) 102967311(PDP1)
AJU: 106971285(PDP2) 106974892(PDP1)
BTA: 100299267(PDP2) 280891(PDP1)
BOM: 102282548(PDP1) 102287532(PDP2)
BIU: 109568472(PDP1)
BBUB: 102394000(PDP2) 102414212(PDP1)
PHD: 102330294(PDP2) 102334297(PDP1)
CHX: 102176634(PDP2) 102188063(PDP1)
OAS: 101105182(PDP2) 101111813(PDP1)
SSC: 100153002(PDP1) 100623511(PDP2)
CFR: 102515819(PDP1) 102518428(PDP2)
CDK: 105085733(PDP1) 105088472(PDP2)
BACU: 103017011(PDP1) 103019943(PDP2)
LVE: 103079949(PDP2) 103083852(PDP1)
OOR: 101274954(PDP2) 101288676(PDP1)
DLE: 111179664(PDP2) 111180424(PDP1)
ECB: 100051376(PDP1) 100065629(PDP2)
EPZ: 103542145(PDP2) 103560684(PDP1)
EAI: 106831447(PDP1) 106839503(PDP2)
MYD: 102754418(PDP1) 102759039(PDP2)
MNA: 107534134(PDP1) 107537508(PDP2)
HAI: 109375318(PDP1) 109390162(PDP2)
RSS: 109438768(PDP1) 109460178(PDP2)
DRO: 112300646(PDP2) 112315732(PDP1)
PALE: 102890859(PDP1) 102891688(PDP2)
RAY: 107502345(PDP1) 107519855(PDP2)
LAV: 100666283(PDP2) 100666913(PDP1)
MDO: 100019207(PDP2) 100029761(PDP1)
SHR: 100923400(PDP1) 100929377(PDP2)
PCW: 110198540(PDP1) 110210454(PDP2)
OAA: 100074046(PDP1) 100090454(PDP2)
GGA: 427550(PDP2) 428372(PDP1)
MGP: 100544457(PDP2) 100545056(PDP1)
CJO: 107310374(PDP1) 107319341(PDP2)
NMEL: 110393928(PDP1) 110404139(PDP2)
APLA: 101791170(PDP2) 101794102(PDP1)
ACYG: 106030512(PDP1) 106033241(PDP2)
TGU: 100222486(PDP2) 100225941(PDP1)
LSR: 110477436(PDP1) 110480654(PDP2)
SCAN: 103813531(PDP1) 103821138(PDP2)
GFR: 102041683(PDP1) 102042650(PDP2)
FAB: 101806939(PDP1) 101818130(PDP2)
PHI: 102110428(PDP2) 102113607(PDP1)
PMAJ: 107200787(PDP1) 107209817(PDP2)
CCAE: 111924542(PDP1) 111934712(PDP2)
CCW: 104687402(PDP2) 104692747(PDP1)
ETL: 114061763(PDP1) 114070970(PDP2)
FPG: 101914907(PDP1) 101920971(PDP2)
FCH: 102048165(PDP1) 102058009(PDP2)
CLV: 102097264(PDP1)
EGZ: 104123640(PDP2) 104125851(PDP1)
NNI: 104013260(PDP2) 104016416(PDP1)
ACUN: 113476347(PDP1) 113484449(PDP2)
PADL: 103913724(PDP2) 103917301(PDP1)
AAM: 106483247(PDP2) 106483874(PDP1)
ASN: 102370616(PDP1) 102384447(PDP2)
AMJ: 102562869(PDP2) 106737281(PDP1)
PSS: 102453190(PDP1) 102455495(PDP2)
CMY: 102936038(PDP2) 102937543(PDP1)
CPIC: 101932395(CA7) 101941660(PDP1)
ACS: 100553198(pdp2) 100560050(pdp1)
PVT: 110074766(PDP1) 110090666(PDP2)
PBI: 103048021(PDP1) 103067358(PDP2)
PMUR: 107288885(PDP2) 107292753(PDP1)
GJA: 107109252(PDP1) 107121356(PDP2)
XLA: 108714104(pdp2.L) 447514(pdp1.L) 779268(pdp2.S)
XTR: 100489227(pdp2) 779724(pdp1)
NPR: 108790031(PDP1) 108802188(PDP2)
DRE: 558728(pdp1) 562650(si:ch211-15p9.2) 58149(pdp2)
IPU: 108256650(pdp1) 108264162(pdp2)
PHYP: 113526479 113533031(pdp1)
AMEX: 103031800 103044684(pdp1)
EEE: 113571950(pdp1) 113580543
TRU: 101070199(pdp1) 105416886
LCO: 104918130(pdp2) 104923032(pdp1) 104939401
NCC: 104952995(pdp1) 104965111(pdp2)
PRET: 103466019 103478661(pdp1)
KMR: 108229293 108229880(pdp2) 108241150(pdp1)
AOCE: 111564884 111588678(pdp1)
CSEM: 103380112(pdp2) 103386830 103388151(pdp1)
HCQ: 109522491 109526820(pdp2) 109528999(pdp1)
MALB: 109964153(pdp1) 109967584(pdp2)
ELS: 105017457 105018915(pdp1) 105028714(pdp2)
SFM: 108934608(pdp2) 108940669(pdp1)
PKI: 111832939(pdp2) 111845357(pdp1) 111857226
LCM: 102346477(PDP1) 102351489
CMK: 103175143(pdp1) 103188634
SPU: 584018
APLC: 110987833
SKO: 100377706
DME: Dmel_CG12151(Pdp)
DER: 6551631
DSI: Dsimw501_GD27376(Dsim_GD27376)
DPE: 6597489
DWI: 6649117
DAZ: 108618921
DNV: 108657157
DHE: 111593994
MDE: 101896125
LCQ: 111688484
AME: 413080
BIM: 100740796
BTER: 100648395
SOC: 105204869
MPHA: 105832708
AEC: 105150540
ACEP: 105623897
PBAR: 105426536
VEM: 105557625
HST: 105185612
DQU: 106744053
CFO: 105259411
LHU: 105673552
PGC: 109860788
OBO: 105274637
PCF: 106792206
NVI: 100120329
MDL: 103572748
TCA: 656586
DPA: 109543276
NVL: 108569106
BMOR: 101743792
PMAC: 106719869
PRAP: 111000428
HAW: 110379391
TNL: 113494035
PXY: 105380491
API: 100160240
DNX: 107165367
AGS: 114126067
BTAB: 109044109
ZNE: 110841518
FCD: 110858558
TUT: 107364049
DPTE: 113797675
CEL: CELE_ZK973.3(pdp-1)
BMY: Bm1_55415
TSP: Tsp_08180
PCAN: 112576503
CRG: 105331589
MYI: 110446250
OBI: 106881099
LAK: 106171574
SHX: MS3_04029
AQU: 100636527
LJA: Lj0g3v0302609.1(Lj0g3v0302609.1) Lj1g3v3458530.1(Lj1g3v3458530.1) Lj4g3v2265160.1(Lj4g3v2265160.1) Lj4g3v2265170.1(Lj4g3v2265170.1) Lj5g3v0921300.1(Lj5g3v0921300.1) Lj5g3v2292600.1(Lj5g3v2292600.1) Lj5g3v2292600.2(Lj5g3v2292600.2) Lj6g3v1915670.1(Lj6g3v1915670.1) Lj6g3v1915690.1(Lj6g3v1915690.1)
DOSA: Os01t0976700-01(Os01g0976700) Os02t0685600-01(Os02g0685600) Os03t0832400-01(Os03g0832400) Os07t0114000-01(Os07g0114000)
ATS: 109732718(LOC109732718) 109749767(LOC109749767) 109750972(LOC109750972) 109751925(LOC109751925) 109752989(LOC109752989) 109771447(LOC109771447)
SCE: YCR079W(PTC6) YOR090C(PTC5)
KMX: KLMA_20396(PTC6) KLMA_80213(PTC5)
NCS: NCAS_0B06730(NCAS0B06730) NCAS_0D04820(NCAS0D04820)
NDI: NDAI_0B04060(NDAI0B04060) NDAI_0I00160(NDAI0I00160)
TPF: TPHA_0M01920(TPHA0M01920) TPHA_0P00960(TPHA0P00960)
TBL: TBLA_0B01830(TBLA0B01830) TBLA_0I02470(TBLA0I02470)
TDL: TDEL_0A07680(TDEL0A07680) TDEL_0C04670(TDEL0C04670)
KAF: KAFR_0F04280(KAFR0F04280) KAFR_0J01860(KAFR0J01860)
SLB: AWJ20_3923(PTC6) AWJ20_4872(PTC5)
NTE: NEUTE1DRAFT130475(NEUTE1DRAFT_130475) NEUTE1DRAFT84743(NEUTE1DRAFT_84743)
BFU: BCIN_02g02840(Bcptc6) BCIN_04g06290(Bcptc5)
ANG: ANI_1_1920014(An01g14160) ANI_1_2172024(An02g00580) ANI_1_788164(An18g05890)
ZTR: MYCGRDRAFT_50302(MgPP2CL-3) MYCGRDRAFT_52355(PP2CL2) MYCGRDRAFT_69535(MgPP2C2)
ABP: AGABI1DRAFT104972(AGABI1DRAFT_104972) AGABI1DRAFT108329(AGABI1DRAFT_108329) AGABI1DRAFT123915(AGABI1DRAFT_123915) AGABI1DRAFT125740(AGABI1DRAFT_125740) AGABI1DRAFT126912(AGABI1DRAFT_126912) AGABI1DRAFT57103(AGABI1DRAFT_57103) AGABI1DRAFT69402(AGABI1DRAFT_69402)
ABV: AGABI2DRAFT115785(AGABI2DRAFT_115785) AGABI2DRAFT117908(AGABI2DRAFT_117908) AGABI2DRAFT176112(AGABI2DRAFT_176112) AGABI2DRAFT176981(AGABI2DRAFT_176981) AGABI2DRAFT181442(AGABI2DRAFT_181442) AGABI2DRAFT188630(AGABI2DRAFT_188630) AGABI2DRAFT200439(AGABI2DRAFT_200439)
PYO: PY17X_0914900(PY01995)
PCB: PCHAS_093260(PC001398.02.0)
 » show all
Taxonomy
Reference
1  [PMID:4401694]
  Authors
Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ.
  Title
-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart.
  Journal
Arch Biochem Biophys 148:327-42 (1972)
DOI:10.1016/0003-9861(72)90151-8
Reference
2  [PMID:3004826]
  Authors
Reed LJ, Damuni Z, Merryfield ML.
  Title
Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation.
  Journal
Curr Top Cell Regul 27:41-9 (1985)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.43
IUBMB Enzyme Nomenclature: 3.1.3.43
ExPASy - ENZYME nomenclature database: 3.1.3.43
BRENDA, the Enzyme Database: 3.1.3.43
CAS: 9073-70-5

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