KEGG   ENZYME: 3.1.3.56Help
Entry
EC 3.1.3.56                 Enzyme                                 

Name
inositol-polyphosphate 5-phosphatase;
type I inositol-polyphosphate phosphatase;
inositol trisphosphate phosphomonoesterase;
InsP3/Ins(1,3,4,5)P4 5-phosphatase;
inosine triphosphatase;
D-myo-inositol 1,4,5-triphosphate 5-phosphatase;
D-myo-inositol 1,4,5-trisphosphate 5-phosphatase;
L-myo-inositol 1,4,5-trisphosphate-monoesterase;
inositol phosphate 5-phosphomonoesterase;
inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase;
Ins(1,4,5)P3 5-phosphatase;
D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase;
inositol 1,4,5-trisphosphate phosphatase;
inositol polyphosphate-5-phosphatase;
myo-inositol-1,4,5-trisphosphate 5-phosphatase;
inositol-1,4,5-trisphosphate 5-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase
Reaction(IUBMB)
(1) D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate [RN:R03394];
(2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate [RN:R03430]
Reaction(KEGG)
Substrate
D-myo-inositol 1,4,5-trisphosphate [CPD:C01245];
H2O [CPD:C00001];
1D-myo-inositol 1,3,4,5-tetrakisphosphate [CPD:C01272]
Product
myo-inositol 1,4-bisphosphate [CPD:C01220];
phosphate [CPD:C00009];
1D-myo-inositol 1,3,4-trisphosphate [CPD:C01243]
Comment
One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids.
History
EC 3.1.3.56 created 1989, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K01106  inositol-1,4,5-trisphosphate 5-phosphatase
Genes
HSA: 27124(INPP5J) 3632(INPP5A) 51763(INPP5K)
PTR: 454410(INPP5K) 458767(INPP5J) 747128(INPP5A)
PPS: 100976910(INPP5K) 100980932(INPP5J) 100995871(INPP5A)
GGO: 101124081(INPP5K) 101127025(INPP5J) 101137047(INPP5A)
PON: 100440857(INPP5A) 100457320(INPP5J)
NLE: 100585101(INPP5J) 100587560(INPP5A) 100601583(INPP5K)
MCC: 718308(INPP5J) 719508(INPP5A) 721222(INPP5K)
MCF: 101867263(INPP5K) 102124549(INPP5A) 102139212(INPP5J)
CSAB: 103216744(INPP5A) 103223181(INPP5J) 103242115(INPP5K)
RRO: 104660350(INPP5J) 104670313(INPP5K) 104677635(INPP5A)
RBB: 108524657(INPP5K) 108527617(INPP5J) 108543386(INPP5A)
CJC: 100387531(INPP5A) 100395276(INPP5J) 100399558(INPP5K)
SBQ: 101034783(INPP5J) 101037105(INPP5A) 101041430(INPP5K)
MMU: 170835(Inpp5j) 19062(Inpp5k) 212111(Inpp5a)
RNO: 171088(Inpp5j) 287533(Inpp5k) 365382(Inpp5a)
CGE: 100760037(Inpp5a) 100761777(Inpp5j) 100764873(Inpp5k)
NGI: 103725829(Inpp5a) 103730507(Inpp5k) 103740431(Inpp5j)
HGL: 101704617(Inpp5a) 101719531(Inpp5k) 101726724(Inpp5j)
CCAN: 109682597(Inpp5k) 109696904(Inpp5j) 109698635(Inpp5a)
OCU: 100338012(INPP5J) 100358289(INPP5K) 103346991(INPP5A) 103347071
TUP: 102474778(INPP5J) 102485414(INPP5A) 102490192(INPP5K)
CFA: 403937(INPP5A) 480647(INPP5K) 486360(INPP5J)
AML: 100465896(INPP5A) 100467068(INPP5K) 100479313(INPP5J)
UMR: 103658509(INPP5A) 103667174(INPP5K) 103681118(INPP5J)
ORO: 101367060(INPP5J) 101368492(INPP5A) 101385393(INPP5K)
FCA: 101083037(INPP5A) 101085842(INPP5K) 101095688(INPP5J)
PTG: 102951376(INPP5J) 102951654(INPP5A) 102971559(INPP5K)
AJU: 106983189(INPP5K) 106983314(INPP5J)
BTA: 514123(INPP5K) 514307(INPP5J) 615232(INPP5A)
BOM: 102279605(INPP5K) 102284010(INPP5J) 102285484(INPP5A)
BIU: 109571558(INPP5J) 109574139(INPP5K) 109579046(INPP5A)
PHD: 102318041(INPP5J) 102324043 102330783(INPP5K)
CHX: 102171365(INPP5J) 102177657(INPP5K) 102181924(INPP5A)
OAS: 101103674(INPP5J) 101110014(INPP5A) 101115806(INPP5K)
SSC: 100462756(INPP5K) 100510987(INPP5J) 100512501(INPP5A)
CFR: 102510594(INPP5A) 102513746(INPP5K) 102519403 102521192 102521406(INPP5J)
CDK: 105088121(INPP5K) 105099429(INPP5J) 105104581(INPP5A)
BACU: 103000099(INPP5K) 103017049(INPP5J) 103018455(INPP5A)
LVE: 103086449(INPP5K) 103088886(INPP5A) 103089080(INPP5J)
OOR: 101274395(INPP5J) 101278141(INPP5A) 101282708(INPP5K)
ECB: 100051027(INPP5A) 100058547(INPP5J) 100072370(INPP5K)
EPZ: 103547528(INPP5K) 103554530(INPP5A) 103566939(INPP5J)
EAI: 106821965(INPP5K) 106826923(INPP5J) 106841072(INPP5A)
MYB: 102251847(INPP5K) 102256211(INPP5J) 102256550(INPP5A)
MYD: 102759392(INPP5K) 102770814(INPP5A) 102770954(INPP5J)
HAI: 109383019(INPP5J) 109383559(INPP5A) 109386898(INPP5K)
RSS: 109445706(INPP5A) 109459637(INPP5J) 109460269(INPP5K)
PALE: 102886374(INPP5K) 102886411(INPP5A) 102894864(INPP5J)
LAV: 100655016(INPP5A) 100656050(INPP5J) 100663160(INPP5K)
MDO: 100028528(INPP5J) 100619651(INPP5K)
SHR: 100914690(INPP5A) 100916010(INPP5J) 100927613(INPP5K)
OAA: 100075999(INPP5J) 100089552(INPP5K) 100093027(INPP5A)
GGA: 416996(INPP5J) 423973(INPP5A) 771549(INPP5K)
MGP: 100538550(INPP5K) 100546269(INPP5J) 104909341(INPP5A)
CJO: 107316265(INPP5A) 107321387(INPP5J) 107322425(INPP5K)
APLA: 101790657(INPP5J) 101798206(INPP5K) 101804204(INPP5A)
ACYG: 106041437(INPP5K) 106047331(INPP5A) 106047485(INPP5J)
TGU: 100218210(INPP5A) 100221510(INPP5J) 100231908(INPP5K)
GFR: 102034127(INPP5K) 102036109(INPP5A) 102040736(INPP5J)
FAB: 101806643(INPP5K) 101810436(INPP5J) 101814745(INPP5A)
PHI: 102099529(INPP5A) 102101343(INPP5K) 102114523(INPP5J)
PMAJ: 107206908(INPP5A) 107211796(INPP5J) 107212795(INPP5K)
CCAE: 111931657(INPP5A) 111936697(INPP5J) 111937741(INPP5K)
CCW: 104691071(INPP5K) 104694952(INPP5A) 104694974(INPP5J)
FPG: 101918225(INPP5K) 101918251(INPP5J) 101924782(INPP5A)
FCH: 102050343(INPP5J) 102052658(INPP5K) 102054445(INPP5A)
CLV: 102088610(INPP5K) 102090809(INPP5A) 102097794(INPP5J)
EGZ: 104128277(INPP5A) 104129956(INPP5J) 104131931(INPP5K)
AAM: 106485811(INPP5A) 106487420(INPP5J) 106487707(INPP5K)
ASN: 102367974(INPP5K) 102368100 102373735(INPP5A) 102382432(INPP5J)
AMJ: 102559502(INPP5A) 102559762(INPP5K) 102572423(INPP5J)
PSS: 102447470(INPP5A) 102451462(INPP5J) 102464080(INPP5K)
CMY: 102929515(INPP5A) 102943056(INPP5J) 102944286(INPP5K)
CPIC: 101940311(INPP5A) 101945750(INPP5J) 101948693(INPP5K)
PVT: 110079716(INPP5A) 110082915(INPP5J) 110084312(INPP5K)
PBI: 103054766(INPP5J) 103065503(INPP5K) 103066208(INPP5A) 103066865
GJA: 107116265(INPP5J) 107119380(INPP5K) 107123620(INPP5A)
XLA: 108696106(inpp5a.1.L) 108707052 108711626 108715295(inpp5j.L) 443677(inpp5k.L) 447532(inpp5a.1.S)
XTR: 100127685(inpp5k) 100145794(inpp5a.2) 548959(inpp5a.1) 779554(inpp5j)
NPR: 108784796(INPP5A) 108786267(INPP5J) 108799554 108801652(INPP5K)
DRE: 100037338(inpp5ka) 100317089(inpp5jb) 101884388(inpp5a) 566188(inpp5kb) 569568 641571(inpp5l)
LCM: 102349479(INPP5A) 102349489(INPP5K) 102356377(INPP5J) 102366716
CMK: 103180430(inpp5a) 103180576(inpp5k) 103184062(inpp5j) 103188986
DME: Dmel_CG42283(5PtaseI) Dmel_CG6805(CG6805) Dmel_CG9784(CG9784)
DSI: Dsimw501_GD18243(Dsim_GD18243) Dsimw501_GD27508(Dsim_GD27508) Dsimw501_GD27861(Dsim_GD27861)
LHU: 105672434
CEL: CELE_C09B8.1(ipp-5)
CBR: CBG14816(Cbr-ipp-5)
SHX: MS3_00709
EGL: EGR_01551
EPA: 110234686
HMG: 101235654
AQU: 100631474
CIT: 102620998
GRA: 105767543
GHI: 107903167
DZI: 111311385
GMX: 100810977
CCAJ: 109815189
LANG: 109358089
FVE: 101310193
PXB: 103955447
CMAX: 111473705
CMOS: 111442969
CPEP: 111796861
JRE: 108991705
VVI: 100266023
SLY: 101247013
SPEN: 107017256
SOT: 102592790
CANN: 107867077
NSY: 104223662
NTO: 104107793
NNU: 104587433
AOF: 109833215
SCE: YOL065C(INP54)
CPV: cgd2_230
 » show all
Taxonomy
Reference
1  [PMID:6285891]
  Authors
Downes CP, Mussat MC, Michell RH.
  Title
The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane.
  Journal
Biochem J 203:169-77 (1982)
Reference
2  [PMID:2540972]
  Authors
Erneux C, Lemos M, Verjans B, Vanderhaeghen P, Delvaux A, Dumont JE.
  Title
Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain.
  Journal
Eur J Biochem 181:317-22 (1989)
DOI:10.1111/j.1432-1033.1989.tb14726.x
Reference
3
  Authors
Woscholski, R. and Parker, P.J.
  Title
Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates.
  Journal
In: Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
Reference
4  [PMID:8198557]
  Authors
Verjans B, De Smedt F, Lecocq R, Vanweyenberg V, Moreau C, Erneux C.
  Title
Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase.
  Journal
Biochem J 300 ( Pt 1):85-90 (1994)
  Sequence
[cfa:403937]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.56
IUBMB Enzyme Nomenclature: 3.1.3.56
ExPASy - ENZYME nomenclature database: 3.1.3.56
BRENDA, the Enzyme Database: 3.1.3.56
CAS: 106283-14-1

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