KEGG   ENZYME: 3.1.3.57Help
Entry
EC 3.1.3.57                 Enzyme                                 

Name
inositol-1,4-bisphosphate 1-phosphatase;
inositol-polyphosphate 1-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase
Reaction(IUBMB)
1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate [RN:R03393]
Reaction(KEGG)
R03393;
(other) R03427
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Substrate
1D-myo-inositol 1,4-bisphosphate [CPD:C01220];
H2O [CPD:C00001]
Product
1D-myo-inositol 4-phosphate [CPD:C03546];
phosphate [CPD:C00009]
Comment
The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.
History
EC 3.1.3.57 created 1989, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K01107  inositol polyphosphate 1-phosphatase
K15422  3'(2'), 5'-bisphosphate nucleotidase / inositol polyphosphate 1-phosphatase
Genes
HSA: 3628(INPP1)
PTR: 460106(INPP1)
PPS: 100967835(INPP1)
GGO: 101129850(INPP1)
PON: 100461697(INPP1)
NLE: 100592468(INPP1)
MCC: 703301(INPP1)
MCF: 102129084 102144664(INPP1)
CSAB: 103217521(INPP1)
RRO: 104675276(INPP1)
RBB: 108523275 108527575(INPP1)
CJC: 100399314(INPP1)
SBQ: 101034382(INPP1)
MMU: 16329(Inpp1)
RNO: 316376(Inpp1)
CGE: 100755639
NGI: 103736162(Inpp1)
HGL: 101724306(Inpp1)
CCAN: 109678690
OCU: 100357992(INPP1)
TUP: 102481098(INPP1)
CFA: 478842(INPP1)
AML: 100473008(INPP1)
UMR: 103659679(INPP1)
ORO: 101376858(INPP1)
FCA: 101082081(INPP1)
PTG: 102951036(INPP1)
AJU: 106979728(INPP1)
BTA: 281869(INPP1)
BOM: 102276134(INPP1)
BIU: 109565484(INPP1)
PHD: 102330251(INPP1)
CHX: 102176832(INPP1)
OAS: 101110908(INPP1)
SSC: 100514878(INPP1)
CFR: 102520689(INPP1)
CDK: 105099189(INPP1)
BACU: 103020750(INPP1)
LVE: 103071146(INPP1)
OOR: 101271125(INPP1)
ECB: 100054603(INPP1)
EPZ: 103548647(INPP1)
EAI: 106828805(INPP1)
MYB: 102245840(INPP1)
MYD: 102766936(INPP1)
HAI: 109372960(INPP1)
RSS: 109452054(INPP1)
PALE: 102885459(INPP1)
LAV: 100668984(INPP1)
TMU: 101352306
MDO: 100028793(INPP1)
SHR: 100914455(INPP1)
OAA: 103169187(INPP1)
GGA: 107049248(INPP1)
MGP: 104916077(INPP1)
CJO: 107325828(INPP1)
PHI: 102109751(INPP1)
FPG: 101914982(INPP1)
CLV: 102088663(INPP1)
ASN: 102386296(INPP1)
AMJ: 102571874(INPP1)
PSS: 102452926
CMY: 102940917(INPP1) 102947691
CPIC: 101953281
ACS: 100556887(inpp1)
PVT: 110074857(INPP1)
PBI: 103053524(INPP1)
GJA: 107120900(INPP1)
XLA: 398838(inpp1.L)
XTR: 100144649(inpp1)
NPR: 108786717 108786723(INPP1)
DRE: 555899(si:ch211-160o17.2)
SANH: 107683640
SGH: 107557551(inpp1) 107562242
CCAR: 109077394(inpp1) 109104896
IPU: 108255283(inpp1)
AMEX: 103037924(inpp1)
TRU: 101068265(inpp1)
NCC: 104954761(inpp1)
MZE: 101464380(inpp1)
OLA: 101154772(inpp1)
XMA: 102216503(inpp1)
PRET: 103465287(inpp1)
NFU: 107385611(inpp1)
KMR: 108235670(inpp1)
CSEM: 103386015(inpp1)
LCF: 108898919(inpp1)
SDU: 111221493(inpp1)
HCQ: 109522370(inpp1)
BPEC: 110171309(inpp1)
MALB: 109956047(inpp1)
SASA: 100306749(inpp) 106583335
OTW: 112215856(inpp1)
ELS: 105017082(inpp1)
SFM: 108918545 108927928(inpp1)
LCM: 102349777(INPP1)
CMK: 103176536(inpp1)
CIN: 100182945
SPU: 584178
APLC: 110973571
SKO: 100373112
DME: Dmel_CG3028(Ipp)
DSI: Dsimw501_GD18939(Dsim_GD18939)
MDE: 101888480
AAG: 110674709
AME: 107963968
BIM: 100748881
BTER: 100650852
SOC: 105201853
AEC: 105151247
ACEP: 105619421
PBAR: 105430157
HST: 105190691
DQU: 106749393
CFO: 105257301
LHU: 105678194
PGC: 109863506
PCF: 106784339
NVI: 100122810
MDL: 103579536
TCA: 656805
DPA: 109539053
NVL: 108570021
BMOR: 101745603
PMAC: 106718335
PRAP: 110996506
HAW: 110374210
PXY: 105392571
API: 100162683
DNX: 107164159
CLEC: 106669705
ZNE: 110831304
FCD: 110861442
CRG: 105347500
MYI: 110465129
OBI: 106872453
SHX: MS3_03198
ADF: 107348893
CPAP: 110816127
CIT: 102627477
TCC: 18611884
VRA: 106766815
VAR: 108347870
CCAJ: 109812821
CAM: 101512228
LJA: Lj4g3v0231940.1(Lj4g3v0231940.1) Lj4g3v0231940.2(Lj4g3v0231940.2)
ADU: 107481633
AIP: 107631494
LANG: 109362951
FVE: 101292053
PPER: 18779780
PMUM: 103327119
PAVI: 110751194
CSV: 101204881
CMO: 103485286
MCHA: 111005385
CMAX: 111478099
CMOS: 111453114
CPEP: 111803461
RCU: 107261021
JCU: 105632756
HBR: 110644282
JRE: 108996258
VVI: 100244767
SLY: 101267407
SPEN: 107020572
SOT: 102601366
CANN: 107851478
NSY: 104246659
NTO: 104116454
SIND: 105178071
HAN: 110878734
LSV: 111882493
CCAV: 112515300
DCR: 108204352
BVG: 104895417
SOE: 110800752
NNU: 104606715
DOSA: Os12t0183200-00(Os12g0183200) Os12t0183300-01(Os12g0183300)
BDI: 100844934
ATS: 109732486(LOC109732486) 109734469(LOC109734469) 109770883(LOC109770883)
ZMA: 100276170(cl14808_1) 542492(dnp1)
PDA: 103720532
EGU: 105051760
MUS: 103976059
DCT: 110111209
PEQ: 110039533
AOF: 109824316
ATR: 18436938
PPP: 112292558
MNG: MNEG_5969
APRO: F751_6258
DFA: DFA_01660
 » show all
Taxonomy
Reference
1  [PMID:6309146]
  Authors
Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF.
  Title
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.
  Journal
Biochem J 212:473-82 (1983)
Reference
2  [PMID:3029066]
  Authors
Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW.
  Title
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes.
  Journal
J Biol Chem 262:2146-9 (1987)
Reference
3  [PMID:2824473]
  Authors
Inhorn RC, Majerus PW.
  Title
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+.
  Journal
J Biol Chem 262:15946-52 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.57
IUBMB Enzyme Nomenclature: 3.1.3.57
ExPASy - ENZYME nomenclature database: 3.1.3.57
BRENDA, the Enzyme Database: 3.1.3.57
CAS: 111070-17-8 111694-13-4

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