KEGG   ENZYME: 3.1.3.62Help
Entry
EC 3.1.3.62                 Enzyme                                 

Name
multiple inositol-polyphosphate phosphatase;
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase;
inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase;
inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase;
inositol tetrakisphosphate phosphomonoesterase;
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase;
MIPP
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1D-myo-inositol-hexakisphosphate 5-phosphohydrolase
Reaction(IUBMB)
myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate [RN:R07584]
Reaction(KEGG)
Substrate
myo-inositol hexakisphosphate [CPD:C01204];
H2O [CPD:C00001]
Product
myo-inositol pentakisphosphate [CPD:C15991];
phosphate [CPD:C00009]
Comment
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
History
EC 3.1.3.62 created 1992, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
Orthology
K03103  multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase
Genes
HSA: 9562(MINPP1)
PTR: 450579(MINPP1)
PPS: 100980933(MINPP1)
GGO: 101144263(MINPP1)
PON: 100173135(MINPP1)
NLE: 100602225(MINPP1)
MCC: 704362(MINPP1)
MCF: 101925472(MINPP1)
CSAB: 103216204(MINPP1)
RRO: 104675164(MINPP1)
RBB: 108527546(MINPP1)
CJC: 100391750(MINPP1)
MMU: 17330(Minpp1)
RNO: 29688(Minpp1)
CGE: 100766430(Minpp1)
NGI: 103738050(Minpp1)
HGL: 101711589(Minpp1)
CCAN: 109681827(Minpp1)
OCU: 100350561 100358192(MINPP1)
TUP: 102484201(MINPP1)
CFA: 486462(MINPP1)
AML: 100468979(MINPP1)
UMR: 103661917(MINPP1)
ORO: 101367977(MINPP1)
FCA: 101091150(MINPP1)
PTG: 102971475(MINPP1)
AJU: 106980974(MINPP1)
BTA: 541067(MINPP1)
BOM: 102266889(MINPP1)
BIU: 109553098(MINPP1)
PHD: 102338873(MINPP1)
CHX: 102187288(MINPP1)
OAS: 101118833(MINPP1)
SSC: 100152243(MINPP1)
CFR: 102522901(MINPP1)
CDK: 105088961(MINPP1)
BACU: 103015775(MINPP1)
LVE: 103073572(MINPP1)
OOR: 101278048(MINPP1)
ECB: 100062448(MINPP1)
EPZ: 103549844(MINPP1)
EAI: 106845893(MINPP1)
MYB: 102256717(MINPP1)
MYD: 102754386(MINPP1)
HAI: 109387537(MINPP1)
RSS: 109441335 109450963(MINPP1)
PALE: 102882782(MINPP1)
LAV: 100661711(MINPP1)
TMU: 101353457
MDO: 100022488(MINPP1)
SHR: 100924973(MINPP1)
GGA: 395356(MINPP1)
MGP: 100540797(MINPP1)
CJO: 107315617(MINPP1)
APLA: 101798501(MINPP1)
ACYG: 106030215(MINPP1)
TGU: 100225117(MINPP1)
GFR: 102040581(MINPP1)
FAB: 101807959(MINPP1)
PHI: 102106327(MINPP1)
PMAJ: 107207068(MINPP1)
CCAE: 111931623(MINPP1)
CCW: 104695103(MINPP1)
FPG: 101912524(MINPP1)
FCH: 102050541(MINPP1)
CLV: 102099022(MINPP1)
EGZ: 104125133(MINPP1)
AAM: 106489037(MINPP1)
ASN: 102370369(MINPP1)
PSS: 102458605(MINPP1)
CMY: 102941827(MINPP1)
CPIC: 101932598(MINPP1)
ACS: 100555619(minpp1)
PVT: 110083113(MINPP1) 110083124
PBI: 103064022(MINPP1)
GJA: 107120017(MINPP1)
XLA: 108696047(minpp1.L) 108697356(minpp1.S)
XTR: 100493648(minpp1)
NPR: 108794027(MINPP1)
DRE: 394075(minpp1b) 561891(minpp1a)
IPU: 108269684 108273659(minpp1)
TRU: 101067675(minpp1)
NCC: 104956666(minpp1)
NFU: 107376031 107387490(minpp1)
ELS: 105006245(minpp1) 105010648
SFM: 108939677(minpp1)
LCM: 102349601(MINPP1) 102355063
CMK: 103180855(minpp1)
CIN: 100186130
SPU: 100891283
DME: Dmel_CG4123(Mipp1) Dmel_CG4317(Mipp2)
DER: 6544522
DPE: 6599768
DSI: Dsimw501_GD12462(Dsim_GD12462) Dsimw501_GD16214(Dsim_GD16214)
DWI: 6639228
PGC: 109860814
PCF: 106783586
CRG: 105336484
OBI: 106879508
SHX: MS3_05089
EGL: EGR_04276
AQU: 109582726
ATH: AT1G09870
CRB: 17896695
CPAP: 110819153
CIT: 102615443
TCC: 18585803
DZI: 111298017
EGR: 104455913
GMX: 100812135(PAP02) 100815749
VRA: 106776102
VAR: 108343523
CCAJ: 109809735
CAM: 101507608
LJA: Lj0g3v0197689.1(Lj0g3v0197689.1) Lj0g3v0197689.2(Lj0g3v0197689.2) Lj0g3v0197689.3(Lj0g3v0197689.3)
ADU: 107471196
FVE: 101314222
PPER: 18785898
PMUM: 103332825
PAVI: 110749720
MDM: 103417780
PXB: 103937111
ZJU: 107413891
MCHA: 111015966
RCU: 8272082
JCU: 105645759
JRE: 108983886
CANN: 107871120
INI: 109154998
SIND: 105160857
OEU: 111390935
HAN: 110872695
CCAV: 112524542
DCR: 108210743
BVG: 104905971
SOE: 110781869
NNU: 104597681
OSA: 4334577
DOSA: Os03t0818100-01(Os03g0818100)
OBR: 102712072
BDI: 100831816
ATS: 109744068(LOC109744068)
SBI: 8057380
ZMA: 100282868(pco091084)
SITA: 101772807
PDA: 103708852
EGU: 105033642
MUS: 103984406
DCT: 110101297
PEQ: 110029458
MNG: MNEG_3694
DFA: DFA_01730
EHI: EHI_059910(101.t00003)
 » show all
Taxonomy
Reference
1  [PMID:2786415]
  Authors
Cullen PJ, Irvine RF, Drobak BK, Dawson AP.
  Title
Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate.
  Journal
Biochem J 259:931-3 (1989)
Reference
2  [PMID:9359836]
  Authors
Craxton A, Caffrey JJ, Burkhart W, Safrany ST, Shears SB.
  Title
Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase.
  Journal
Biochem J 328 ( Pt 1):75-81 (1997)
  Sequence
[rno:29688]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.62
IUBMB Enzyme Nomenclature: 3.1.3.62
ExPASy - ENZYME nomenclature database: 3.1.3.62
BRENDA, the Enzyme Database: 3.1.3.62
CAS: 116958-30-6

KEGG   ENZYME: 3.1.3.80Help
Entry
EC 3.1.3.80                 Enzyme                                 

Name
2,3-bisphosphoglycerate 3-phosphatase;
MIPP1;
2,3-BPG 3-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
2,3-bisphospho-D-glycerate 3-phosphohydrolase
Reaction(IUBMB)
2,3-bisphospho-D-glycerate + H2O = 2-phospho-D-glycerate + phosphate [RN:R09532]
Reaction(KEGG)
Substrate
2,3-bisphospho-D-glycerate [CPD:C01159];
H2O [CPD:C00001]
Product
2-phospho-D-glycerate [CPD:C00631];
phosphate [CPD:C00009]
Comment
This reaction is a shortcut in the Rapoport-Luebering shunt. It bypasses the reactions of EC 5.4.2.11/EC 5.4.2.12 [phosphoglycerate mutases (2,3-diphosphoglycerate-dependent and independent)] and directly forms 2-phospho-D-glycerate by removing the 3-phospho-group of 2,3-diphospho-D-glycerate [1]. The MIPP1 protein also catalyses the reaction of EC 3.1.3.62 (multiple inositol-polyphosphate phosphatase).
History
EC 3.1.3.80 created 2010
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec01100  Metabolic pathways
Orthology
K03103  multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase
Genes
HSA: 9562(MINPP1)
PTR: 450579(MINPP1)
PPS: 100980933(MINPP1)
GGO: 101144263(MINPP1)
PON: 100173135(MINPP1)
NLE: 100602225(MINPP1)
MCC: 704362(MINPP1)
MCF: 101925472(MINPP1)
CSAB: 103216204(MINPP1)
RRO: 104675164(MINPP1)
RBB: 108527546(MINPP1)
CJC: 100391750(MINPP1)
MMU: 17330(Minpp1)
RNO: 29688(Minpp1)
CGE: 100766430(Minpp1)
NGI: 103738050(Minpp1)
HGL: 101711589(Minpp1)
CCAN: 109681827(Minpp1)
OCU: 100350561 100358192(MINPP1)
TUP: 102484201(MINPP1)
CFA: 486462(MINPP1)
AML: 100468979(MINPP1)
UMR: 103661917(MINPP1)
ORO: 101367977(MINPP1)
FCA: 101091150(MINPP1)
PTG: 102971475(MINPP1)
AJU: 106980974(MINPP1)
BTA: 541067(MINPP1)
BOM: 102266889(MINPP1)
BIU: 109553098(MINPP1)
PHD: 102338873(MINPP1)
CHX: 102187288(MINPP1)
OAS: 101118833(MINPP1)
SSC: 100152243(MINPP1)
CFR: 102522901(MINPP1)
CDK: 105088961(MINPP1)
BACU: 103015775(MINPP1)
LVE: 103073572(MINPP1)
OOR: 101278048(MINPP1)
ECB: 100062448(MINPP1)
EPZ: 103549844(MINPP1)
EAI: 106845893(MINPP1)
MYB: 102256717(MINPP1)
MYD: 102754386(MINPP1)
HAI: 109387537(MINPP1)
RSS: 109441335 109450963(MINPP1)
PALE: 102882782(MINPP1)
LAV: 100661711(MINPP1)
TMU: 101353457
MDO: 100022488(MINPP1)
SHR: 100924973(MINPP1)
GGA: 395356(MINPP1)
MGP: 100540797(MINPP1)
CJO: 107315617(MINPP1)
APLA: 101798501(MINPP1)
ACYG: 106030215(MINPP1)
TGU: 100225117(MINPP1)
GFR: 102040581(MINPP1)
FAB: 101807959(MINPP1)
PHI: 102106327(MINPP1)
PMAJ: 107207068(MINPP1)
CCAE: 111931623(MINPP1)
CCW: 104695103(MINPP1)
FPG: 101912524(MINPP1)
FCH: 102050541(MINPP1)
CLV: 102099022(MINPP1)
EGZ: 104125133(MINPP1)
AAM: 106489037(MINPP1)
ASN: 102370369(MINPP1)
PSS: 102458605(MINPP1)
CMY: 102941827(MINPP1)
CPIC: 101932598(MINPP1)
ACS: 100555619(minpp1)
PVT: 110083113(MINPP1) 110083124
PBI: 103064022(MINPP1)
GJA: 107120017(MINPP1)
XLA: 108696047(minpp1.L) 108697356(minpp1.S)
XTR: 100493648(minpp1)
NPR: 108794027(MINPP1)
DRE: 394075(minpp1b) 561891(minpp1a)
IPU: 108269684 108273659(minpp1)
TRU: 101067675(minpp1)
NCC: 104956666(minpp1)
NFU: 107376031 107387490(minpp1)
ELS: 105006245(minpp1) 105010648
SFM: 108939677(minpp1)
LCM: 102349601(MINPP1) 102355063
CMK: 103180855(minpp1)
CIN: 100186130
SPU: 100891283
DME: Dmel_CG4123(Mipp1) Dmel_CG4317(Mipp2)
DER: 6544522
DPE: 6599768
DSI: Dsimw501_GD12462(Dsim_GD12462) Dsimw501_GD16214(Dsim_GD16214)
DWI: 6639228
PGC: 109860814
PCF: 106783586
CRG: 105336484
OBI: 106879508
SHX: MS3_05089
EGL: EGR_04276
AQU: 109582726
ATH: AT1G09870
CRB: 17896695
CPAP: 110819153
CIT: 102615443
TCC: 18585803
DZI: 111298017
EGR: 104455913
GMX: 100812135(PAP02) 100815749
VRA: 106776102
VAR: 108343523
CCAJ: 109809735
CAM: 101507608
LJA: Lj0g3v0197689.1(Lj0g3v0197689.1) Lj0g3v0197689.2(Lj0g3v0197689.2) Lj0g3v0197689.3(Lj0g3v0197689.3)
ADU: 107471196
FVE: 101314222
PPER: 18785898
PMUM: 103332825
PAVI: 110749720
MDM: 103417780
PXB: 103937111
ZJU: 107413891
MCHA: 111015966
RCU: 8272082
JCU: 105645759
JRE: 108983886
CANN: 107871120
INI: 109154998
SIND: 105160857
OEU: 111390935
HAN: 110872695
CCAV: 112524542
DCR: 108210743
BVG: 104905971
SOE: 110781869
NNU: 104597681
OSA: 4334577
DOSA: Os03t0818100-01(Os03g0818100)
OBR: 102712072
BDI: 100831816
ATS: 109744068(LOC109744068)
SBI: 8057380
ZMA: 100282868(pco091084)
SITA: 101772807
PDA: 103708852
EGU: 105033642
MUS: 103984406
DCT: 110101297
PEQ: 110029458
MNG: MNEG_3694
DFA: DFA_01730
EHI: EHI_059910(101.t00003)
 » show all
Taxonomy
Reference
1  [PMID:18413611]
  Authors
Cho J, King JS, Qian X, Harwood AJ, Shears SB
  Title
Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt.
  Journal
Proc Natl Acad Sci U S A 105:5998-6003 (2008)
DOI:10.1073/pnas.0710980105
  Sequence
[ddi:DDB_G0285339] [hsa:9562]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.80
IUBMB Enzyme Nomenclature: 3.1.3.80
ExPASy - ENZYME nomenclature database: 3.1.3.80
BRENDA, the Enzyme Database: 3.1.3.80

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