KEGG   ENZYME: 3.1.3.66Help
Entry
EC 3.1.3.66                 Enzyme                                 

Name
phosphatidylinositol-3,4-bisphosphate 4-phosphatase;
inositol-3,4-bisphosphate 4-phosphatase;
D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase;
phosphoinositide 4-phosphatase;
inositol polyphosphate 4-phosphatase;
inositol polyphosphate 4-phosphatase type II
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate [RN:R07299]
Reaction(KEGG)
R07299;
(other) R04372 R10950
Show
Substrate
1-phosphatidyl-myo-inositol 3,4-bisphosphate;
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 3-phosphate [CPD:C04549];
phosphate [CPD:C00009]
Comment
Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P.
History
EC 3.1.3.66 created 1992, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K01109  inositol polyphosphate-4-phosphatase
Genes
HSA: 3631(INPP4A) 8821(INPP4B)
PTR: 461514(INPP4B) 470448(INPP4A)
PPS: 100968284(INPP4A) 100989263(INPP4B)
GGO: 101142456(INPP4A) 101144077(INPP4B)
PON: 100174369(INPP4B) 100454992(INPP4A)
NLE: 100592186(INPP4A) 100599079(INPP4B)
MCC: 699738(INPP4B) 707986(INPP4A)
MCF: 101865720(INPP4B) 102139378(INPP4A)
CSAB: 103236308(INPP4B) 103241097(INPP4A)
RRO: 104661477(INPP4A) 104670159(INPP4B)
RBB: 108526763(INPP4B) 108529486(INPP4A)
CJC: 100396234(INPP4A) 100408233(INPP4B)
SBQ: 101038514(INPP4A) 101043111(INPP4B)
MMU: 234515(Inpp4b) 269180(Inpp4a)
RNO: 116699(Inpp4b) 80849(Inpp4a)
CGE: 100767245(Inpp4a) 100771589(Inpp4b)
NGI: 103742385(Inpp4b) 103744153(Inpp4a)
HGL: 101718534(Inpp4a) 101719238(Inpp4b)
CCAN: 109687365 109687366(Inpp4b) 109694386(Inpp4a)
OCU: 100340475(INPP4A) 100348588(INPP4B)
TUP: 102471411(INPP4A) 102477229(INPP4B)
CFA: 474563(INPP4A) 476072(INPP4B)
AML: 100482175(INPP4A) 100484540(INPP4B)
UMR: 103657978(INPP4B) 103671184(INPP4A)
ORO: 101375367(INPP4A) 101380415(INPP4B)
FCA: 101088920(INPP4A) 101089005(INPP4B)
PTG: 102959803(INPP4B) 102967296(INPP4A)
BTA: 534793(INPP4B) 535487(INPP4A)
BOM: 102283345(INPP4B) 102287496(INPP4A)
BIU: 109565495(INPP4A) 109571208(INPP4B)
PHD: 102339597 102341210(INPP4A) 102343195(INPP4B)
CHX: 102180694(INPP4B) 102181043(INPP4A)
OAS: 101109605(INPP4A) 101112848(INPP4B)
SSC: 100233232(INPP4A) 100511393(INPP4B)
CFR: 102523124(INPP4A) 102524318(INPP4B)
CDK: 105087825(INPP4B) 105092115 105099796(INPP4A)
BACU: 102998108(INPP4B) 103010671(INPP4A)
LVE: 103074180(INPP4A) 103086012(INPP4B)
OOR: 101285539(INPP4A) 101286407(INPP4B)
ECB: 100051038(INPP4A) 100062978(INPP4B)
EPZ: 103549151(INPP4B) 103559003(INPP4A)
EAI: 106835458(INPP4B) 106842549(INPP4A)
MYB: 102242129(INPP4B) 102249694(INPP4A)
MYD: 102757149(INPP4B) 102763551(INPP4A)
RSS: 109446923(INPP4B) 109459404(INPP4A)
PALE: 102883721(INPP4A) 102887805(INPP4B)
LAV: 100663143(INPP4A) 100670266(INPP4B)
MDO: 100012162(INPP4A) 100026918(INPP4B)
SHR: 100918022(INPP4A) 100926247(INPP4B)
OAA: 100082415(INPP4B)
GGA: 418690(INPP4A) 422454(INPP4B)
MGP: 100543360(INPP4B) 100551349(INPP4A)
CJO: 107307314(INPP4A) 107313162(INPP4B)
APLA: 101793148(INPP4B) 101797286(INPP4A) 101802644 101803085
ACYG: 106035699(INPP4A) 106046672(INPP4B)
TGU: 100224898(INPP4B) 100225656(INPP4A)
GFR: 102039668(INPP4B) 102043062(INPP4A)
FAB: 101806527(INPP4A) 101812696(INPP4B)
PHI: 102101814(INPP4A) 102107844(INPP4B)
PMAJ: 107202431(INPP4A) 107203153(INPP4B)
CCAE: 111928895(INPP4B) 111946176(INPP4A)
CCW: 104686042(INPP4A) 104697266(INPP4B)
FPG: 101918767(INPP4A) 101920565(INPP4B)
FCH: 102045868(INPP4B) 102052619(INPP4A)
CLV: 102083531(INPP4B) 102098823(INPP4A)
EGZ: 104125227(INPP4A) 104130577(INPP4B)
AAM: 106491884(INPP4B) 106494014(INPP4A)
ASN: 102370491(INPP4B) 102374238(INPP4A)
AMJ: 102564333(INPP4A) 102575449(INPP4B)
PSS: 102454053(INPP4B) 102462079(INPP4A)
CMY: 102930596(INPP4B) 102947983
CPIC: 101948633(INPP4B) 101948721(INPP4A)
ACS: 100551799(inpp4a) 100567592(inpp4b)
PVT: 110073639(INPP4B) 110087729(INPP4A)
PBI: 103059907(INPP4A) 103061669(INPP4B)
GJA: 107110418(INPP4A) 107115930(INPP4B)
XLA: 108699497 108704365 108709723(inpp4a.S) 734645(inpp4a.L)
XTR: 100496097(inpp4b) 780177(inpp4a)
NPR: 108792572(INPP4A) 108792603(INPP4B)
DRE: 560006(inpp4b) 792527(inpp4ab)
IPU: 108263114(inpp4b) 108266600(inpp4a) 108273053
AMEX: 103021329(inpp4b) 103031647(inpp4a) 103041993
TRU: 101062964(inpp4a) 101072250 101078785(inpp4b)
OLA: 101157603 101166362 101173511(inpp4a) 105354450(inpp4b)
XMA: 102226654 102227671(inpp4a) 102230490 102230891(inpp4b)
PRET: 103471125(inpp4b) 103473821 103479950(inpp4a) 103480851
NFU: 107376814 107377187 107389437(inpp4b) 107389790(inpp4a)
KMR: 108229121 108231661(inpp4b) 108232509(inpp4a) 108249003
CSEM: 103383335(inpp4b) 103389601 103391700(inpp4a)
LCF: 108873064 108886849 108893085(inpp4b) 108900987(inpp4a)
SDU: 111216559(inpp4b) 111218669(inpp4a) 111232154 111233330
HCQ: 109511130(inpp4b) 109528509 109530600(inpp4a)
MALB: 109951897 109955537(inpp4b) 109960502 109965387(inpp4a)
LCM: 102348021(INPP4B) 102352456 102360654(INPP4A)
CMK: 103177132(inpp4a) 103181285(inpp4b)
CIN: 100180081
SPU: 579262
APLC: 110988633
SKO: 102806959
DME: Dmel_CG42271(CG42271)
DSI: Dsimw501_GD15857(Dsim_GD15857)
MDE: 101900216
AAG: 5572787
AME: 410061
BIM: 100740641
BTER: 100648942
SOC: 105202562
AEC: 105144884
ACEP: 105620322
PBAR: 105425841
HST: 105185586
DQU: 106744066
CFO: 105257670
LHU: 105674558
PGC: 109861711
PCF: 106793228
NVI: 100116145
MDL: 103573444
TCA: 655115
DPA: 109541763
NVL: 108560625
BMOR: 101743706
PMAC: 106717290
PRAP: 111000692
HAW: 110373021
PXY: 105382720
API: 100162521
DNX: 107165428
CLEC: 106672890
ZNE: 110836259
FCD: 110847053
TUT: 107360553
BMY: Bm1_46610
CRG: 105321544
MYI: 110457829
OBI: 106867758
SHX: MS3_04967
EGL: EGR_05943
EPA: 110249488
ADF: 107343560
HMG: 105845283
 » show all
Taxonomy
Reference
1  [PMID:2546770]
  Authors
Howell S, Barnaby RJ, Rowe T, Ragan CI, Gee NS.
  Title
Evidence for at least four different inositol bisphosphatases in bovine brain.
  Journal
Eur J Biochem 183:169-72 (1989)
DOI:10.1111/j.1432-1033.1989.tb14909.x
Reference
2  [PMID:7608176]
  Authors
Norris FA, Auethavekiat V, Majerus PW.
  Title
The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.
  Journal
J Biol Chem 270:16128-33 (1995)
DOI:10.1074/jbc.270.27.16128
  Sequence
[hsa:3631] [rno:80849]
Reference
3  [PMID:9295334]
  Authors
Norris FA, Atkins RC, Majerus PW.
  Title
The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.
  Journal
J Biol Chem 272:23859-64 (1997)
DOI:10.1074/jbc.272.38.23859
  Sequence
[hsa:3631 8821] [rno:116699]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.66
IUBMB Enzyme Nomenclature: 3.1.3.66
ExPASy - ENZYME nomenclature database: 3.1.3.66
BRENDA, the Enzyme Database: 3.1.3.66
CAS: 123644-80-4

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