KEGG   ENZYME: 3.1.3.75Help
Entry
EC 3.1.3.75                 Enzyme                                 

Name
phosphoethanolamine/phosphocholine phosphatase;
PHOSPHO1;
3X11A
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
phosphoethanolamine phosphohydrolase
Reaction(IUBMB)
(1) O-phosphoethanolamine + H2O = ethanolamine + phosphate [RN:R06870];
(2) phosphocholine + H2O = choline + phosphate [RN:R06871]
Reaction(KEGG)
Substrate
O-phosphoethanolamine [CPD:C00346];
H2O [CPD:C00001];
phosphocholine [CPD:C00588]
Product
ethanolamine [CPD:C00189];
phosphate [CPD:C00009];
choline [CPD:C00114]
Comment
Requires active site Mg2+ but also works, to a lesser extent, with Co2+ and Mn2+. The enzyme is highly specific for phosphoethanolamine and phosphocholine.
History
EC 3.1.3.75 created 2004
Pathway
ec00564  Glycerophospholipid metabolism
ec01100  Metabolic pathways
Orthology
K06124  phosphoethanolamine/phosphocholine phosphatase
Genes
HSA: 162466(PHOSPHO1)
PTR: 455200(PHOSPHO1)
PPS: 100995130(PHOSPHO1)
GGO: 101135403(PHOSPHO1)
PON: 100453832(PHOSPHO1)
NLE: 100595367(PHOSPHO1)
MCC: 698959(PHOSPHO1)
MCF: 102142920(PHOSPHO1)
CSAB: 103243637(PHOSPHO1)
RRO: 104659770(PHOSPHO1)
RBB: 108516490(PHOSPHO1) 108523501
CJC: 100393769(PHOSPHO1)
SBQ: 101044528(PHOSPHO1)
MMU: 237928(Phospho1)
RNO: 287644(Phospho1)
CGE: 100760987(Phospho1)
NGI: 103738361(Phospho1)
HGL: 101721548(Phospho1)
CCAN: 109691393(Phospho1)
OCU: 100344433(PHOSPHO1)
TUP: 102493382(PHOSPHO1)
CFA: 491069(PHOSPHO1)
AML: 100484341(PHOSPHO1)
ORO: 101386933(PHOSPHO1)
FCA: 101095209(PHOSPHO1)
AJU: 106985155(PHOSPHO1)
BTA: 524639(PHOSPHO1)
BOM: 102281872(PHOSPHO1)
BIU: 109574069(PHOSPHO1)
PHD: 102334987(PHOSPHO1)
CHX: 102190731(PHOSPHO1)
OAS: 101112333(PHOSPHO1)
SSC: 100621753(PHOSPHO1) 102158609
CFR: 102520575(PHOSPHO1)
CDK: 105095768(PHOSPHO1)
BACU: 103013714(PHOSPHO1)
LVE: 103077302(PHOSPHO1)
OOR: 101284285(PHOSPHO1)
ECB: 100055957(PHOSPHO1)
EPZ: 103551066(PHOSPHO1)
EAI: 106826446(PHOSPHO1)
MYB: 102253386(PHOSPHO1) 102259030 102263881
MYD: 102775093(PHOSPHO1)
HAI: 109380823(PHOSPHO1)
RSS: 109451975(PHOSPHO1)
PALE: 102882188(PHOSPHO1)
LAV: 100674633(PHOSPHO1)
TMU: 101359892
MDO: 100021539(PHOSPHO1)
SHR: 111720963(PHOSPHO1)
OAA: 100087239(PHOSPHO1)
GGA: 395650(PHOSPHO1)
MGP: 100547041(PHOSPHO1)
CJO: 107325092(PHOSPHO1)
APLA: 101795093(PHOSPHO1)
ACYG: 106048340(PHOSPHO1)
FAB: 101808298(PHOSPHO1)
PHI: 102101486(PHOSPHO1)
PMAJ: 107198660(PHOSPHO1)
FPG: 101914984(PHOSPHO1)
FCH: 102056152(PHOSPHO1)
CLV: 102086540(PHOSPHO1)
EGZ: 104131237(PHOSPHO1)
AAM: 106495963(PHOSPHO1)
ASN: 102371816(PHOSPHO1)
AMJ: 102576418(PHOSPHO1)
PSS: 102447415(PHOSPHO1)
CMY: 102936439(PHOSPHO1)
CPIC: 101942754(PHOSPHO1)
ACS: 100563935(phospho1)
PVT: 110090872(PHOSPHO1)
PBI: 103055208(PHOSPHO1)
GJA: 107108721(PHOSPHO1)
XLA: 108700823(phospho1.L) 108702531(phospho1.S)
XTR: 100492656(phospho1)
NPR: 108784014(PHOSPHO1)
DRE: 100002812(phospho1)
IPU: 108261429 108273983(phospho1)
AMEX: 103030183(phospho1) 103036134
TRU: 101070337 101076946(phospho1)
LCO: 104926289(phospho1) 104930975
MZE: 101469983 101470712(phospho1)
XMA: 102220236(phospho1) 102227979
PRET: 103469363(phospho1) 103481271
NFU: 107378570(phospho1) 107387866
KMR: 108243759(phospho1) 108249903
CSEM: 103381457 103393135(phospho1)
LCF: 108872764(phospho1) 108898750
SDU: 111217605(phospho1) 111220061
HCQ: 109519339(phospho1) 109524043
BPEC: 110154152 110161755(phospho1)
ELS: 105013313(phospho1) 105030554
SFM: 108919065(phospho1) 108941591
LCM: 102365260(PHOSPHO1)
CMK: 103183818(phospho1)
OSA: 4324704
DOSA: Os01t0720400-01(Os01g0720400)
OBR: 102716824
BDI: 100828291
ATS: 109783536(LOC109783536)
SBI: 8069806
ZMA: 100191227 100281893(TIDP3606) 100284789(pco107612)
SITA: 101772309
 » show all
Taxonomy
Reference
1  [PMID:9990301]
  Authors
Houston B, Seawright E, Jefferies D, Hoogland E, Lester D, Whitehead C, Farquharson C.
  Title
Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes.
  Journal
Biochim Biophys Acta 1448:500-6 (1999)
DOI:10.1016/S0167-4889(98)00153-0
  Sequence
[gga:395650]
Reference
2  [PMID:14983068]
  Authors
Stewart AJ, Schmid R, Blindauer CA, Paisey SJ, Farquharson C.
  Title
Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily.
  Journal
Protein Eng 16:889-95 (2003)
DOI:10.1093/protein/gzg126
  Sequence
[hsa:162466]
Reference
3  [PMID:15175005]
  Authors
Roberts SJ, Stewart AJ, Sadler PJ, Farquharson C.
  Title
Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities.
  Journal
Biochem J 382:59-65 (2004)
DOI:10.1042/BJ20040511
  Sequence
[hsa:162466]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.75
IUBMB Enzyme Nomenclature: 3.1.3.75
ExPASy - ENZYME nomenclature database: 3.1.3.75
BRENDA, the Enzyme Database: 3.1.3.75

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