KEGG   ENZYME: 3.1.3.80Help
Entry
EC 3.1.3.80                 Enzyme                                 

Name
2,3-bisphosphoglycerate 3-phosphatase;
MIPP1;
2,3-BPG 3-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
2,3-bisphospho-D-glycerate 3-phosphohydrolase
Reaction(IUBMB)
2,3-bisphospho-D-glycerate + H2O = 2-phospho-D-glycerate + phosphate [RN:R09532]
Reaction(KEGG)
Substrate
2,3-bisphospho-D-glycerate [CPD:C01159];
H2O [CPD:C00001]
Product
2-phospho-D-glycerate [CPD:C00631];
phosphate [CPD:C00009]
Comment
This reaction is a shortcut in the Rapoport-Luebering shunt. It bypasses the reactions of EC 5.4.2.11/EC 5.4.2.12 [phosphoglycerate mutases (2,3-diphosphoglycerate-dependent and independent)] and directly forms 2-phospho-D-glycerate by removing the 3-phospho-group of 2,3-diphospho-D-glycerate [1]. The MIPP1 protein also catalyses the reaction of EC 3.1.3.62 (multiple inositol-polyphosphate phosphatase).
History
EC 3.1.3.80 created 2010
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec01100  Metabolic pathways
Orthology
K03103  multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase
Genes
HSA: 9562(MINPP1)
PTR: 450579(MINPP1)
PPS: 100980933(MINPP1)
GGO: 101144263(MINPP1)
PON: 100173135(MINPP1)
NLE: 100602225(MINPP1)
MCC: 704362(MINPP1)
MCF: 101925472(MINPP1)
CSAB: 103216204(MINPP1)
RRO: 104675164(MINPP1)
RBB: 108527546(MINPP1)
CJC: 100391750(MINPP1)
MMU: 17330(Minpp1)
RNO: 29688(Minpp1)
CGE: 100766430(Minpp1)
NGI: 103738050(Minpp1)
HGL: 101711589(Minpp1)
CCAN: 109681827(Minpp1)
OCU: 100350561 100358192(MINPP1)
TUP: 102484201(MINPP1)
CFA: 486462(MINPP1)
AML: 100468979(MINPP1)
UMR: 103661917(MINPP1)
ORO: 101367977(MINPP1)
FCA: 101091150(MINPP1)
PTG: 102971475(MINPP1)
AJU: 106980974(MINPP1)
BTA: 541067(MINPP1)
BOM: 102266889(MINPP1)
BIU: 109553098(MINPP1)
PHD: 102338873(MINPP1)
CHX: 102187288(MINPP1)
OAS: 101118833(MINPP1)
SSC: 100152243(MINPP1)
CFR: 102522901(MINPP1)
CDK: 105088961(MINPP1)
BACU: 103015775(MINPP1)
LVE: 103073572(MINPP1)
OOR: 101278048(MINPP1)
ECB: 100062448(MINPP1)
EPZ: 103549844(MINPP1)
EAI: 106845893(MINPP1)
MYB: 102256717(MINPP1)
MYD: 102754386(MINPP1)
HAI: 109387537(MINPP1)
RSS: 109441335 109450963(MINPP1)
PALE: 102882782(MINPP1)
LAV: 100661711(MINPP1)
TMU: 101353457
MDO: 100022488(MINPP1)
SHR: 100924973(MINPP1)
GGA: 395356(MINPP1)
MGP: 100540797(MINPP1)
CJO: 107315617(MINPP1)
APLA: 101798501(MINPP1)
ACYG: 106030215(MINPP1)
TGU: 100225117(MINPP1)
GFR: 102040581(MINPP1)
FAB: 101807959(MINPP1)
PHI: 102106327(MINPP1)
PMAJ: 107207068(MINPP1)
CCW: 104695103(MINPP1)
FPG: 101912524(MINPP1)
FCH: 102050541(MINPP1)
CLV: 102099022(MINPP1)
EGZ: 104125133(MINPP1)
AAM: 106489037(MINPP1)
ASN: 102370369(MINPP1)
PSS: 102458605(MINPP1)
CMY: 102941827(MINPP1)
CPIC: 101932598(MINPP1)
ACS: 100555619(minpp1)
PVT: 110083113(MINPP1) 110083124
PBI: 103064022(MINPP1)
GJA: 107120017(MINPP1)
XLA: 108696047(minpp1.L) 108697356(minpp1.S)
XTR: 100493648(minpp1)
NPR: 108794027(MINPP1)
DRE: 394075(minpp1b) 561891(minpp1a)
IPU: 108269684 108273659(minpp1)
TRU: 101067675(minpp1)
NCC: 104956666(minpp1)
NFU: 107376031 107387490(minpp1)
ELS: 105006245(minpp1) 105010648
SFM: 108939677(minpp1)
LCM: 102349601(MINPP1) 102355063
CMK: 103180855(minpp1)
CIN: 100186130
SPU: 100891283
DME: Dmel_CG4123(Mipp1) Dmel_CG4317(Mipp2)
DSI: Dsimw501_GD12462(Dsim_GD12462) Dsimw501_GD16214(Dsim_GD16214)
PGC: 109860814
CRG: 105336484
OBI: 106879508
SHX: MS3_05089
EGL: EGR_04276
AQU: 109582726
ATH: AT1G09870
CRB: 17896695
CPAP: 110819153
CIT: 102615443
TCC: 18585803
DZI: 111298017
EGR: 104455913
GMX: 100812135(PAP02) 100815749
VRA: 106776102
VAR: 108343523
CCAJ: 109809735
CAM: 101507608
LJA: Lj0g3v0197689.1(Lj0g3v0197689.1) Lj0g3v0197689.2(Lj0g3v0197689.2) Lj0g3v0197689.3(Lj0g3v0197689.3)
ADU: 107471196
FVE: 101314222
PPER: 18785898
PMUM: 103332825
PAVI: 110749720
MDM: 103417780
PXB: 103937111
ZJU: 107413891
MCHA: 111015966
RCU: 8272082
JCU: 105645759
JRE: 108983886
CANN: 107871120
INI: 109154998
SIND: 105160857
OEU: 111390935
HAN: 110872695
DCR: 108210743
BVG: 104905971
SOE: 110781869
NNU: 104597681
OSA: 4334577
DOSA: Os03t0818100-01(Os03g0818100)
OBR: 102712072
BDI: 100831816
ATS: 109744068(LOC109744068)
SBI: 8057380
ZMA: 100282868(pco091084)
SITA: 101772807
PDA: 103708852
EGU: 105033642
MUS: 103984406
DCT: 110101297
MNG: MNEG_3694
DFA: DFA_01730
EHI: EHI_059910(101.t00003)
 » show all
Taxonomy
Reference
1  [PMID:18413611]
  Authors
Cho J, King JS, Qian X, Harwood AJ, Shears SB
  Title
Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt.
  Journal
Proc Natl Acad Sci U S A 105:5998-6003 (2008)
DOI:10.1073/pnas.0710980105
  Sequence
[ddi:DDB_G0285339] [hsa:9562]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.80
IUBMB Enzyme Nomenclature: 3.1.3.80
ExPASy - ENZYME nomenclature database: 3.1.3.80
BRENDA, the Enzyme Database: 3.1.3.80

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