KEGG   ENZYME: 3.1.3.85Help
Entry
EC 3.1.3.85                 Enzyme                                 

Name
glucosyl-3-phosphoglycerate phosphatase;
GpgP protein
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
alpha-D-glucosyl-3-phospho-D-glycerate phosphohydrolase
Reaction(IUBMB)
2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H2O = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate [RN:R09664]
Reaction(KEGG)
Substrate
2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate [CPD:C19791];
H2O [CPD:C00001]
Product
2-O-(alpha-D-glucopyranosyl)-D-glycerate [CPD:C19792];
phosphate [CPD:C00009]
Comment
The enzyme is involved in biosynthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate via the two-step pathway in which EC 2.4.1.266 (glucosyl-3-phosphoglycerate synthase) catalyses the conversion of GDP-glucose and 3-phospho-D-glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by glucosyl-3-phosphoglycerate phosphatase. In vivo the enzyme catalyses the dephosphorylation of 2-O-(alpha-D-mannopyranosyl)-3-phospho-D-glycerate with lower efficiency [1,2]. Divalent metal ions (Mg2+, Mn2+ or Co2+) stimulate activity [1,2].
History
EC 3.1.3.85 created 2011
Orthology
K22306  glucosyl-3-phosphoglycerate phosphatase
Genes
SRR: SerAS9_4157
SRY: M621_20990
SRS: SerAS12_4158
SRA: SerAS13_4158
PVG: CRN77_07905
HSO: HS_1664(gpm)
HSM: HSM_1826
AAT: D11S_0705
AAN: D7S_00967
AAH: CF65_00942
AACN: AANUM_0700
BCEO: I35_0744
AMIH: CO731_01615(gpgP_1)
SMER: DU99_19350
EAD: OV14_a1248(gpmB)
RSU: NHU_01105
MTU: Rv2419c(gpgP)
MTC: MT2492
MRA: MRA_2445
MTUR: CFBS_2563
MTD: UDA_2419c
MTUE: J114_12960
MTUH: I917_17075
MTUL: TBHG_02358
MTUT: HKBT1_2554
MTUU: HKBT2_2557
MBO: BQ2027_MB2442C(gpgp)
MBB: BCG_2435c
MBT: JTY_2429
MBX: BCGT_2249
MAF: MAF_24340
MMIC: RN08_2682
MLE: ML1452
MLB: MLBr01452
MPA: MAP_2242c
MAO: MAP4_1582
MAVI: RC58_07880
MAVU: RE97_07880
MAV: MAV_1752
MIT: OCO_18090
MIA: OCU_18270
MID: MIP_02552
MIR: OCQ_15700
MLP: MLM_2760
MUL: MUL_3691(gpm_1)
MMC: Mmcs_3528
MKM: Mkms_3601
MJL: Mjls_3533
MMI: MMAR_3747(gpm_1)
MMAE: MMARE11_36540(gpm_1)
MMM: W7S_07700
MLI: MULP_03999(gpm_1)
MHAD: B586_09010
MVA: Mvan_3924
MGI: Mflv_2655
MPHL: MPHLCCUG_03565(gpgP)
MVQ: MYVA_3755
MAB: MAB_1623
MABB: MASS_1717
MCHE: BB28_08840
MSTE: MSTE_01623
MJD: JDM601_1489(gpm_1)
MTER: 4434518_01385(gpm_1)
ASD: AS9A_1140
CGL: NCgl2268(Cgl2350)
CGB: cg2581
CGU: WA5_2268
CGT: cgR_2233
CGM: cgp_2581
CGJ: AR0_11255
CEF: CE2254
CDI: DIP1773
CDP: CD241_1705(gpmB)
CDH: CDB402_1661(gpmB)
CDT: CDHC01_1707(gpmB)
CDE: CDHC02_1691(gpmB)
CDR: CDHC03_1672(gpmB)
CDA: CDHC04_1666(gpmB)
CDZ: CD31A_1776(gpmB)
CDB: CDBH8_1745(gpmB)
CDS: CDC7B_1755(gpmB)
CDD: CDCE8392_1669(gpmB)
CDW: CDPW8_1766(gpmB)
CDV: CDVA01_1632(gpmB)
CDIP: ERS451417_01789(gpmB)
CJK: jk0569(gpmB)
CUR: cu1361
CUA: CU7111_1341(gpmB)
CKP: ckrop_1352(gpmB)
CPU: cpfrc_01582(gpmB)
CPL: Cp3995_1616(gpmB)
CPG: Cp316_1614(gpmB)
CPP: CpP54B96_1603(gpmB)
CPK: Cp1002_1575(gpmB)
CPQ: CpC231_1577(gpmB)
CPX: CpI19_1582(gpmB2)
COR: Cp267_1639(gpmB)
COP: Cp31_1573(gpmB2)
COD: Cp106_1537(gpmB)
COS: Cp4202_1566(gpmB)
COI: CpCIP5297_1587(gpmB2)
COE: Cp258_1579(gpmB)
COU: Cp162_1553(gpmB2)
CPSE: CPTA_02170
CPSU: CPTB_01586
CPSF: CPTC_02170
CRD: CRES_0649(gpmB)
CUL: CULC22_01734(gpmB)
CUC: CULC809_01657(gpmB)
CUE: CULC0102_1792(gpmB)
CUN: Cul210932_1752(gpmB2)
CUS: CulFRC11_1652(gpmB2)
CUQ: Cul210931_1650(gpmB2)
CUZ: Cul05146_1736(gpmB2)
CUJ: CUL131002_1674c(gpmB2)
CVA: CVAR_0931(gpmB)
CTER: A606_03640
CGY: CGLY_11385(gpmB)
COA: DR71_1727
CSX: CSING_10300(gpgP)
CKU: UL82_03520(gpgP)
CCJ: UL81_08740(gpmB)
CMV: CMUST_12040(gpmB)
CEI: CEPID_09620(gpmB)
CTED: CTEST_09850(gpgP)
CUT: CUTER_08180(gpmB)
CSP: WM42_2089
CPHO: CPHO_03335
CGV: CGLAU_09640(gpgP)
CAQU: CAQU_09300
CAMG: CAMM_03955
NFA: NFA_13780
NCY: NOCYR_1448(gpmB)
RER: RER_37740
REY: O5Y_17415
ROP: ROP_10170
REQ: REQ_29650
RHB: NY08_439
RFA: A3L23_03762(gpgP)
RHS: A3Q41_04478(gpgP)
RHU: A3Q40_01033(gpgP_2)
GBR: Gbro_3192
GPO: GPOL_c29680(gmpB)
GOR: KTR9_3226
TPR: Tpau_2806
SRT: Srot_1008
SCO: SCO2576(pgm2)
SALB: XNR_4361
SMA: SAVERM_5481(gpmA2)
SGR: SGR_4971
SGB: WQO_10655
SCT: SCAT_1620
SFA: Sfla_4310
SBH: SBI_07140(gpm3)
SHY: SHJG_4071
SVE: SVEN_2358
SALS: SLNWT_5301
STRP: F750_2399
SFI: SFUL_2138
SALU: DC74_3105
SALL: SAZ_16575
STRE: GZL_05826
SLD: T261_5488
STRM: M444_12595
SAMB: SAM23877_2626(gpgP)
SPRI: SPRI_4947
SRW: TUE45_03181(gpgP)
SLE: sle_46590(sle_46590)
STRD: NI25_26160
SMAL: SMALA_2586
SLAU: SLA_2247
SALF: SMD44_02866(gpmB)
SALJ: SMD11_4558(gpmB)
SLX: SLAV_24675(gpgP)
SFK: KY5_2698c
KSK: KSE_25920
ARM: ART_1031
BCV: Bcav_1638
JDE: Jden_1640
LMOI: VV02_12580
XCE: Xcel_2249
IDO: I598_0164(gpgP)
CFL: Cfla_2273
CFI: Celf_2408
SERJ: SGUI_0045
BLIN: BLSMQ_1817
PAC: PPA0838
PACC: PAC1_04480
PACH: PAGK_1297
CACN: RN83_04730
PFR: PFREUD_08550(gmpB) PFREUD_11950(pgm2) PFREUD_12180(pgm)
ACIJ: JS278_01988(pspA)
MPH: MLP_35980
NCA: Noca_1822
NDK: I601_3863(gpgP)
KFL: Kfla_2335
TFU: Tfu_2169
NDA: Ndas_3358
NAL: B005_0454
TCU: Tcur_1556
SRO: Sros_7259
FAL: FRAAL1939(gpm)
NML: Namu_1510
GOB: Gobs_1608
BSD: BLASA_1566(gpm)
MMAR: MODMU_1736(gpm)
KRA: Krad_3448
SEN: SACE_1433
AMD: AMED_6693(gpm)
AMN: RAM_34335
AMM: AMES_6594(gpm)
AMZ: B737_6594(gpm)
AOI: AORI_2014(gpm)
AJA: AJAP_29460(gpgP)
AMQ: AMETH_1785(gpm)
PDX: Psed_2006
PSEA: WY02_25465
PSEE: FRP1_05965
PSEH: XF36_16890
AMI: Amir_1199
SESP: BN6_14350
KAL: KALB_1627
ACTI: UA75_08240
ACAD: UA74_08260
AHG: AHOG_07745(gpgP)
SAQ: Sare_3852
MIL: ML5_3427
ASE: ACPL_1385
ACTN: L083_1532
AFS: AFR_07730
ACTS: ACWT_1264
CAI: Caci_7256
SNA: Snas_5474
AHE: Arch_1063
TPYO: X956_04545
BLO: BL0966
BLJ: BLD_0720
BLN: Blon_1729
BLON: BLIJ_1790
BLF: BLIF_0666
BLL: BLJ_0759
BLM: BLLJ_0645
BLG: BIL_11970
BAD: BAD_0869
BADL: BADO_0924
BLA: BLA_1271
BBB: BIF_01798
BBC: BLC1_0715
BLV: BalV_0722
BLW: W7Y_0749
BLS: W91_0771
BANI: Bl12_0699
BANL: BLAC_03820
BANM: EN10_03785
BDE: BDP_1229
BDN: BBDE_1174
BBI: BBIF_1062(gpm4)
BBP: BBPR_1123
BBF: BBB_1050(gpmB)
BBRU: Bbr_0779
BBRE: B12L_0718
BBRV: B689b_0811
BBRJ: B7017_0752
BBRC: B7019_0762
BBRN: B2258_0750
BBRS: BS27_0789
BBRD: BBBR_0747
BAST: BAST_0694
BTP: D805_1732
BCOR: BCOR_0594
BKS: BBKW_0919
BPSP: AH67_04065
BANG: BBAG_0970
BCAT: BBCT_0891
BPSC: BBPC_0890
BSCA: BBSC_1109
GVG: HMPREF0421_20973(gpm)
SIJ: SCIP_0947
PDO: PSDT_0529
TBI: Tbis_2451
DGO: DGo_CA2066(gpmB)
 » show all
Taxonomy
Reference
1  [PMID:17189358]
  Authors
Costa J, Empadinhas N, da Costa MS
  Title
Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina.
  Journal
J Bacteriol 189:1648-54 (2007)
DOI:10.1128/JB.00841-06
  Sequence
Reference
2  [PMID:16428406]
  Authors
Costa J, Empadinhas N, Goncalves L, Lamosa P, Santos H, da Costa MS
  Title
Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii.
  Journal
J Bacteriol 188:1022-30 (2006)
DOI:10.1128/JB.188.3.1022-1030.2006
  Sequence
[mbu:Mbur_0736]
Reference
3  [PMID:22355692]
  Authors
Mendes V, Maranha A, Alarico S, da Costa MS, Empadinhas N
  Title
Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis.
  Journal
Sci Rep 1:177 (2011)
DOI:10.1038/srep00177
  Sequence
[mtu:Rv2419c]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.85
IUBMB Enzyme Nomenclature: 3.1.3.85
ExPASy - ENZYME nomenclature database: 3.1.3.85
BRENDA, the Enzyme Database: 3.1.3.85

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