KEGG   ENZYME: 3.1.3.86Help
Entry
EC 3.1.3.86                 Enzyme                                 

Name
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase;
SHIP1;
SHIP2;
SHIP;
p150Ship
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate [RN:R09827]
Reaction(KEGG)
Substrate
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [CPD:C05981];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [CPD:C11554];
phosphate [CPD:C00009]
Comment
This enzyme hydroylses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.
History
EC 3.1.3.86 created 2011
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K03084  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
K15909  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Genes
HSA: 3635(INPP5D) 3636(INPPL1)
PTR: 451403(INPPL1) 470683(INPP5D)
PPS: 100988546(INPP5D) 100992766(INPPL1)
GGO: 101127569(INPPL1) 101142949(INPP5D)
PON: 100446045(INPP5D) 100450015(INPPL1)
NLE: 100596562(INPPL1) 100598985(INPP5D)
MCC: 717832(INPP5D) 718421(INPPL1)
MCF: 102115401(INPPL1) 102125377 102134197(INPP5D)
CSAB: 103218100(INPP5D) 103247996(INPPL1)
RRO: 104654059(INPP5D) 104665152(INPPL1)
RBB: 108520096(INPP5D) 108543771(INPPL1)
CJC: 100396447(INPPL1) 100400043(INPP5D)
SBQ: 101029956(INPPL1) 101051962(INPP5D)
MMU: 16331(Inpp5d) 16332(Inppl1)
RNO: 54259(Inpp5d) 65038(Inppl1)
CGE: 100764735(Inpp5d) 100772102(Inppl1)
NGI: 103738235(Inpp5d) 103750804(Inppl1)
HGL: 101698814(Inppl1) 101711777(Inpp5d)
CCAN: 109693012(Inppl1) 109695964(Inpp5d)
OCU: 100339369(INPPL1) 103347299 103352489(INPP5D)
TUP: 102485077(INPPL1) 102487042(INPP5D)
CFA: 100688270(INPP5D) 485209(INPPL1)
AML: 100464150(INPP5D) 100482460(INPPL1)
UMR: 103662839(INPP5D) 103678107(INPPL1)
ORO: 101366414(INPPL1) 101378132(INPP5D)
FCA: 101095611(INPPL1) 101100500(INPP5D)
PTG: 102956183(INPPL1) 102971986(INPP5D)
AJU: 106970927(INPPL1) 106975888(INPP5D)
BTA: 507329(INPP5D) 783833(INPPL1)
BOM: 102266365(INPP5D) 102278222(INPPL1)
PHD: 102315017(INPP5D) 102326290(INPPL1)
CHX: 102170935(INPP5D) 102178924(INPPL1)
OAS: 101112941(INPP5D) 101121707(INPPL1)
SSC: 100462718(INPPL1) 100526019(INPP5D)
CFR: 102506956(INPP5D) 102509164(INPPL1)
CDK: 105096747(INPPL1) 105105239(INPP5D)
BACU: 102999607(INPPL1) 103008465(INPP5D)
LVE: 103078405(INPPL1) 103091136(INPP5D)
OOR: 101269414(INPPL1) 101279600(INPP5D)
ECB: 100064896(INPP5D) 100066037(INPPL1)
EPZ: 103549328(INPPL1) 103555980(INPP5D)
EAI: 106831625(INPPL1) 106844848(INPP5D)
MYB: 102240810(INPP5D) 102248134(INPPL1)
MYD: 102755641(INPPL1) 102769498(INPP5D)
HAI: 109372436(INPPL1) 109375054(INPP5D)
RSS: 109451485(INPP5D) 109454033(INPPL1)
PALE: 102882532(INPP5D) 102890098(INPPL1)
LAV: 100664012(INPP5D) 100673994(INPPL1)
MDO: 100015500(INPPL1) 100021361(INPP5D)
SHR: 100916136(INPP5D) 100930081(INPPL1)
OAA: 100088229 100092282(INPP5D)
GGA: 424745(INPP5D) 428692(INPPL1)
MGP: 100540799 100549631(INPP5D)
CJO: 107312645 107317932(INPP5D)
APLA: 101792254 101797866(INPP5D)
ACYG: 106040262(INPP5D) 106042953(INPPL1)
TGU: 100219581(INPP5D) 100222691
GFR: 102032471(INPPL1) 102036900 102043433(INPP5D)
FAB: 101807549(INPPL1) 101809542(INPP5D) 101820739
PHI: 102101537 102102439(INPPL1) 102105757(INPP5D)
PMAJ: 107203647 107208645(INPP5D) 107212504(INPPL1)
CCAE: 111928734 111933678(INPP5D) 111943484(INPPL1)
CCW: 104683678(INPP5D) 104687164(INPPL1) 104691345
FPG: 101918373(INPPL1) 101919963 101923853(INPP5D)
FCH: 102048151 102056843(INPP5D) 102056978(INPPL1)
CLV: 102083667(INPPL1) 102085697 102095796(INPP5D)
EGZ: 104126900(INPP5D) 104135987
AAM: 106484450(INPP5D) 106486171(INPPL1)
ASN: 102375443 102380530(INPP5D) 102388319(INPPL1)
AMJ: 102563685(INPPL1) 102572303(INPP5D) 102576763
PSS: 102448035(INPPL1) 102448772 102462454(INPP5D)
CMY: 102929300 102929354(INPPL1) 102935566(INPP5D)
CPIC: 101932232(INPPL1) 101950741(INPP5D) 101951468
ACS: 100556812(inppl1) 100561031(inpp5d)
PVT: 110075830(INPP5D) 110078090(INPPL1)
PBI: 103050036(INPP5D) 103051579(INPPL1) 103055569
XLA: 108698315 108708768(inppl1.L) 108718174(inpp5d.S) 399051(inpp5d.L)
XTR: 100485745(inppl1) 100497417(inpp5d)
NPR: 108785616 108796209(INPP5D) 108799086 108801007(INPPL1)
DRE: 325179(inppl1a) 559103(inpp5d)
IPU: 108261207(SHIP-2) 108268863(inppl1b) 108272096(inpp5d) 108277646(inppl1)
AMEX: 103026127 103027088(inppl1) 103032277(inpp5d) 111196212
TRU: 101065901(inppl1) 101069844 101079472(inpp5d)
LCO: 104920140(inppl1) 104923483 104925824(inpp5d)
MZE: 101476435(inpp5d) 101483507(inppl1) 101484941
OLA: 101163652(inpp5d) 101165747(inppl1) 101168299
XMA: 102221920(inpp5d) 102222770 102228371(inppl1)
PRET: 103463941(inpp5d) 103471620 103474471(inppl1)
NFU: 107378661 107380469(inppl1) 107387410(inpp5d)
KMR: 108231420 108240225(inpp5d) 108240501(inppl1)
CSEM: 103378565(inppl1) 103390762 103399950(inpp5d)
LCF: 108872540 108878870(inpp5d) 108886606(inppl1)
SDU: 111224118(inppl1) 111231975(inpp5d) 111232670
HCQ: 109516555 109525465(inppl1) 109532322(inpp5d)
BPEC: 110154735(inpp5d) 110158855 110174275(inppl1)
MALB: 109957514 109965768(inpp5d) 109970550(inppl1)
ELS: 105029104(inppl1) 105029544(inpp5d) 105029605
SFM: 108923188 108932224(inppl1) 108937425(inpp5d)
LCM: 102351582 102361839(INPPL1) 102365596(INPP5D)
SPU: 584901
APLC: 110981025
CRG: 105320686
MYI: 110463198
OBI: 106880499
LAK: 106158330
EPA: 110241032
ADF: 107355719
HMG: 100212864
AQU: 100641488
DFA: DFA_08125(Dd5P1)
SPAR: SPRG_05175
 » show all
Taxonomy
Reference
1  [PMID:8654924]
  Authors
Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold A, Rohrschneider LR
  Title
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
  Journal
Genes Dev 10:1084-95 (1996)
DOI:10.1101/gad.10.9.1084
  Sequence
[mmu:16331]
Reference
2  [PMID:8643691]
  Authors
Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G
  Title
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.
  Journal
Proc Natl Acad Sci U S A 93:1689-93 (1996)
DOI:10.1073/pnas.93.4.1689
  Sequence
[mmu:16331]
Reference
3  [PMID:9341117]
  Authors
Giuriato S, Payrastre B, Drayer AL, Plantavid M, Woscholski R, Parker P, Erneux C, Chap H
  Title
Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets.
  Journal
J Biol Chem 272:26857-63 (1997)
DOI:10.1074/jbc.272.43.26857
  Sequence
[mmu:16331]
Reference
4  [PMID:8769125]
  Authors
Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C
  Title
Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.
  Journal
Biochem Biophys Res Commun 225:243-9 (1996)
DOI:10.1006/bbrc.1996.1161
  Sequence
[hsa:3635]
Reference
5  [PMID:9824312]
  Authors
Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C
  Title
The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity.
  Journal
FEBS Lett 437:301-3 (1998)
DOI:10.1016/S0014-5793(98)01255-1
  Sequence
[hsa:3636]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.86
IUBMB Enzyme Nomenclature: 3.1.3.86
ExPASy - ENZYME nomenclature database: 3.1.3.86
BRENDA, the Enzyme Database: 3.1.3.86

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