KEGG   ENZYME: 3.1.3.9Help
Entry
EC 3.1.3.9                  Enzyme                                 

Name
glucose-6-phosphatase;
glucose 6-phosphate phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
D-glucose-6-phosphate phosphohydrolase
Reaction(IUBMB)
D-glucose 6-phosphate + H2O = D-glucose + phosphate [RN:R00303]
Reaction(KEGG)
Substrate
D-glucose 6-phosphate [CPD:C00092];
H2O [CPD:C00001]
Product
D-glucose [CPD:C00031];
phosphate [CPD:C00009]
Comment
Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate---hexose phosphotransferase), EC 2.7.1.79 (diphosphate---glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)].
History
EC 3.1.3.9 created 1961
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec00052  Galactose metabolism
ec00500  Starch and sucrose metabolism
ec01100  Metabolic pathways
Orthology
K01084  glucose-6-phosphatase
Genes
HSA: 2538(G6PC) 57818(G6PC2) 92579(G6PC3)
PTR: 454703(G6PC) 454720(G6PC3) 741431(G6PC2)
PPS: 100974757(G6PC) 100984489(G6PC2) 100993144(G6PC3)
GGO: 101125519(G6PC2) 101128335(G6PC3) 101141013(G6PC)
PON: 100446540(G6PC) 100453765(G6PC2) 100458617(G6PC3)
NLE: 100584622(G6PC3) 100607569(G6PC) 100607735(G6PC2)
MCC: 709062(G6PC2) 712053(G6PC) 714276(G6PC3)
MCF: 102133548(G6PC2) 102139699(G6PC3) 102144494(G6PC)
CSAB: 103217259(G6PC2) 103243337(G6PC3) 103243379(G6PC)
RRO: 104654704(G6PC3) 104655034(G6PC2) 104679987(G6PC)
RBB: 108516836(G6PC2) 108526779(G6PC) 108532178(G6PC3)
CJC: 100400025(G6PC3) 100400291(G6PC2) 100415213(G6PC)
SBQ: 101032250(G6PC2) 101033884(G6PC) 101036723(G6PC3)
MMU: 14377(G6pc) 14378(G6pc2) 68401(G6pc3)
RNO: 25634(G6pc) 303565(G6pc3) 681817(G6pc2)
CGE: 100753219(G6pc3) 100762184(G6pc2) 100763214(G6pc)
NGI: 103735922(G6pc) 103737990(G6pc2) 103738281(G6pc3)
HGL: 101708598(G6pc) 101715644(G6pc2) 101723886(G6pc3)
CCAN: 109687316(G6pc) 109689226(G6pc2) 109689545(G6pc3)
OCU: 100303766(G6PC) 100345755(G6PC2) 100358721(G6PC3)
TUP: 102482686(G6PC2) 102492187(G6PC) 102502251(G6PC3)
CFA: 403492(G6PC) 488389(G6PC2) 490942(G6PC3)
AML: 100475867(G6PC2) 100480642(G6PC) 100482095(G6PC3)
UMR: 103659532(G6PC2) 103665582(G6PC3) 103672592(G6PC)
ORO: 101372257(G6PC2) 101374429(G6PC3) 101385128(G6PC)
FCA: 101085486(G6PC2) 101097770(G6PC3) 723970(G6PC)
PTG: 102963963(G6PC) 102971546(G6PC2) 102972701(G6PC3)
AJU: 106970303(G6PC2) 106972623(G6PC) 106974277(G6PC3)
BTA: 369023(G6PC3) 505012(G6PC2) 538710(G6PC)
BOM: 102275376(G6PC2) 102276125(G6PC3) 102288249(G6PC)
BIU: 109573874(G6PC3) 109574284(G6PC) 109576447(G6PC2)
PHD: 102321107(G6PC) 102327308(G6PC2) 102344089(G6PC3)
CHX: 102170730(G6PC) 102174704(G6PC2) 102179979(G6PC3)
OAS: 100037689(G6PC) 101113421(G6PC3) 101121493(G6PC2)
SSC: 100134959(G6PC) 100512070(G6PC3) 100518871(G6PC2)
CFR: 102507692(G6PC2) 102514181(G6PC) 102514670(G6PC3)
CDK: 105090484(G6PC) 105091062(G6PC2) 105101050(G6PC3)
BACU: 103002194 103002931(G6PC2) 103004981(G6PC3) 103010774
LVE: 103070284(G6PC3) 103077238(G6PC) 103077901(G6PC2)
OOR: 101281224(G6PC3) 101283146(G6PC2) 101288353(G6PC)
ECB: 100052233(G6PC) 100062750(G6PC2) 100064862(G6PC3)
EPZ: 103550338(G6PC) 103551197(G6PC3) 103567666(G6PC2)
EAI: 106826526(G6PC) 106836447(G6PC3) 106843713(G6PC2)
MYB: 102247442(G6PC3) 102248370(G6PC2) 102253613(G6PC)
MYD: 102759248(G6PC) 102765471(G6PC3) 102774116(G6PC2)
HAI: 109390294(G6PC2) 109394967(G6PC3) 109395716(G6PC)
RSS: 109445278(G6PC2) 109455816(G6PC) 109458514(G6PC3)
PALE: 102887492(G6PC3) 102896886(G6PC2) 102898137(G6PC)
LAV: 100657260(G6PC3) 100670402(G6PC2) 100676625(G6PC)
MDO: 100011161(G6PC) 100022847(G6PC3) 100619897(G6PC2)
SHR: 100916128(G6PC) 100925165(G6PC2) 100930187(G6PC3)
OAA: 100083297(G6PC2) 100088723(G6PC3)
GGA: 100857298(G6PC) 100859356(G6PC3) 424171(G6PC2)
MGP: 100544089(G6PC2) 100548217(G6PC) 100550936(G6PC3)
CJO: 107316743(G6PC2) 107325229(G6PC3) 107325302(G6PC)
APLA: 101791867(G6PC) 101796993(G6PC2)
ACYG: 106029669 106029962(G6PC2) 106048005(G6PC)
TGU: 100219762(G6PC2) 100222678(G6PC) 101233861(G6PC)
GFR: 102033473(G6PC3) 102041145(G6PC) 102043169(G6PC2)
FAB: 101813511(G6PC) 101814845(G6PC3) 101820224(G6PC2)
PHI: 102104187(G6PC3) 102104788(G6PC) 102112343(G6PC2)
PMAJ: 107199063(G6PC3) 107207353(G6PC2) 107215190(G6PC)
CCAE: 111932120(G6PC2) 111940090(G6PC3) 111940133(G6PC)
CCW: 104693903(G6PC2) 104697772(G6PC)
FPG: 101913376(G6PC2) 101914510(G6PC3) 101915055(G6PC)
FCH: 102052041(G6PC) 102052276(G6PC2) 102056383(G6PC3)
CLV: 102088466(G6PC) 102093779(G6PC2)
EGZ: 104128036(G6PC2) 104134721(G6PC)
AAM: 106485031(G6PC3) 106491767(G6PC) 106499300(G6PC2)
AMJ: 102559917(G6PC2) 102569787(G6PC) 106737020 109280230(G6PC3)
XLA: 108700836 108702724 379290(g6pc.S) 379852(g6pc) 398854 398855(g6pc.L) 447506(g6pc2.S)
XTR: 100125173(g6pc2) 100127753(g6pc) 448183(g6pc) 779477(g6pc3.1)
NPR: 108783991(G6PC3) 108792758(G6PC)
DRE: 100000750(g6pcb) 445118(g6pca.1) 563180(g6pca.2) 790919(g6pc3)
IPU: 100528077(g6pc3) 108274326(g6pc) 108274343(g6pc)
TRU: 101061994(g6pc3) 101072756 101072977(g6pc)
MZE: 101465568(g6pc) 101465869 101467105(g6pc2) 101477484(g6pc3)
OLA: 101156928(g6pc2) 101162637(g6pc3) 101168932(g6pc) 101169348
XMA: 102218625(g6pc2) 102231471(g6pc3) 102235529(g6pc) 102235779
PRET: 103461716(g6pc2) 103481660(g6pc3) 103481693(g6pc) 103481694
NFU: 107387634 107387635(g6pc) 107387672(g6pc3) 107390053(g6pc2)
KMR: 108240742(g6pc2) 108246067 108246197(g6pc) 108246894(g6pc3)
CSEM: 103381573(g6pc3) 103381845(g6pc) 103381906
SDU: 111218458(g6pc2) 111220288(g6pc3) 111220384 111220385(g6pc)
HCQ: 109512415(g6pc) 109512421 109513332(g6pc3)
LCM: 102352326(G6PC2) 102353877(G6PC3) 102366630(G6PC)
CMK: 103174327 103176385(g6pc2) 103183778(g6pc3) 103190974(g6pc)
APLC: 110987779
SKO: 100376431
DME: Dmel_CG15400(G6P)
DER: 6542287
DPE: 6603392
DSI: Dsimw501_GD22801(Dsim_GD22801)
DWI: 6644427
MDE: 101889030
AAG: 5564502
BMOR: 101742080
PMAC: 106715232
PRAP: 111000369
HAW: 110373763
CLEC: 106664546
ZNE: 110837826
TUT: 107369671
TSP: Tsp_09960
CRG: 105320252
MYI: 110445661
LAK: 106165096
SHX: MS3_08093
EGL: EGR_06935
EPA: 110247276
ADF: 107355289
HMG: 100205966
 » show all
Taxonomy
Reference
1  [PMID:169241]
  Authors
Anchors JM, Karnovsky ML.
  Title
Purification of cerebral glucose-6-phosphatase. An enzyme involved in sleep.
  Journal
J Biol Chem 250:6408-16 (1975)
Reference
2  [PMID:164220]
  Authors
Colilla W, Jorgenson RA, Nordlie RC.
  Title
Mammalian carbamyl phosphate : glucose phosphotransferase and glucose-6-phosphate phosphohydrolase: extended tissue distribution.
  Journal
Biochim Biophys Acta 377:117-25 (1975)
DOI:10.1016/0005-2744(75)90292-2
Reference
3
  Authors
Nordlie, R.C.
  Title
Glucose-6-phosphatase, hydrolytic and synthetic activities.
  Journal
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 4, Academic Press, New York, 1971, p. 543-610.
Reference
4  [PMID:4370737]
  Authors
Nordlie RC.
  Title
Metabolic regulation by multifunctional glucose-6-phosphatase.
  Journal
Curr Top Cell Regul 8:33-117 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.9
IUBMB Enzyme Nomenclature: 3.1.3.9
ExPASy - ENZYME nomenclature database: 3.1.3.9
BRENDA, the Enzyme Database: 3.1.3.9
CAS: 9001-39-2

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