KEGG   ENZYME: 3.1.4.14Help
Entry
EC 3.1.4.14                 Enzyme                                 

Name
[acyl-carrier-protein] phosphodiesterase;
ACP hydrolyase;
ACP phosphodiesterase;
AcpH;
[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase;
holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
holo-[acyl-carrier protein] 4'-pantetheine-phosphohydrolase
Reaction(IUBMB)
holo-[acyl-carrier protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier protein] [RN:R01623]
Reaction(KEGG)
Substrate
holo-[acyl-carrier protein] [CPD:C00229];
H2O [CPD:C00001]
Product
4'-phosphopantetheine [CPD:C01134];
apo-[acyl-carrier protein]
Comment
The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl chains of 6-16 carbon atoms although it appears to demonstrate a preference for the unacylated acyl-carrier protein (ACP) and short-chain ACPs over the medium- and long-chain species [3]. Deletion of the gene encoding this enzyme abolishes ACP prosthetic-group turnover in vivo [3]. Activation of apo-ACP to form the holoenzyme is carried out by EC 2.7.8.7, holo-[acyl-carrier-protein] synthase.
History
EC 3.1.4.14 created 1972, modified 2006
Pathway
ec00770  Pantothenate and CoA biosynthesis
Orthology
K08682  acyl carrier protein phosphodiesterase
Genes
ECO: b0404(acpH)
ECJ: JW0394(yajB)
ECD: ECDH10B_0360(acpH)
EBW: BWG_0286(acpH)
ECOK: ECMDS42_0303(yajB)
ECE: Z0503(yajB)
ECS: ECs0455
ECF: ECH74115_0484(acpH)
ETW: ECSP_0469(acpH)
ELX: CDCO157_0443
EOJ: ECO26_0436(yajB)
EOI: ECO111_0434(yajB)
EOH: ECO103_0378(yajB)
ECOO: ECRM13514_0441(yajB)
ECOH: ECRM13516_0386(yajB)
ECG: E2348C_0339(acpH)
EOK: G2583_0513(acpH)
ESO: O3O_05800
ESM: O3M_19480
ESL: O3K_19495
ECW: EcE24377A_0434(acpH)
ELH: ETEC_0457
ECC: c0514(yajB)
ECP: ECP_0463
ECI: UTI89_C0426(yajB)
ECV: APECO1_1606(yajB)
ECX: EcHS_A0474(acpH)
ECM: EcSMS35_0436(acpH)
ECY: ECSE_0425
ECR: ECIAI1_0404(acpH)
ECQ: ECED1_0427(acpH)
ECK: EC55989_0413(acpH)
ECT: ECIAI39_0277(acpH)
EOC: CE10_0367(acpH)
EUM: ECUMN_0442(acpH)
ECZ: ECS88_0399(acpH)
ELO: EC042_0437(acpH)
ESE: ECSF_0364
EBD: ECBD_3257
EKF: KO11_21585(acpH)
EAB: ECABU_c04820(acpH)
EDJ: ECDH1ME8569_0389(yajB)
EIH: ECOK1_0384(acpH)
ENA: ECNA114_0381(yajB)
ELW: ECW_m0473(acpH)
ELL: WFL_02335(acpH)
ELC: i14_0496(yajB)
ELD: i02_0496(yajB)
ELP: P12B_c0416(acpH)
EBL: ECD_00352(acpH)
EBE: B21_00356(acpH)
ELF: LF82_0020(acpH)
ECOJ: P423_02055
ECOS: EC958_0542(yajB)
EFE: EFER_2621(acpH)
EAL: EAKF1_ch1035(acpH)
STY: STY0441(yajB)
STT: t2460(yajB)
STM: STM0403(yajB)
SEO: STM14_0477(yajB)
SEY: SL1344_0398(yajB)
SEM: STMDT12_C04670(acpH)
SEJ: STMUK_0409(yajB)
SEB: STM474_0422(yajB)
SENR: STMDT2_03991(yajB)
SEND: DT104_04481(yajB)
SENI: CY43_02350
SPT: SPA2320(yajB)
SEK: SSPA2163
SEI: SPC_0414(yajB)
SEC: SCH_0445(yajB)
SEH: SeHA_C0503(acpH)
SHB: SU5_01095
SEE: SNSL254_A0448(acpH)
SEW: SeSA_A0461(acpH)
SEA: SeAg_B0442(acpH)
SENS: Q786_01985
SED: SeD_A0443(acpH)
SEG: SG0415(yajB)
SEL: SPUL_2566
SET: SEN0386(yajB)
SENA: AU38_01965
SENO: AU37_01960
SENV: AU39_01965
SENQ: AU40_02185
SENL: IY59_02015
SEEP: I137_11685
SENB: BN855_4000(acpH)
SENE: IA1_02160
SBG: SBG_0359(yajB)
SBZ: A464_364
SFE: SFxv_0381(acpH)
SFT: NCTC1_00351(acpH)
SSN: SSON_0381(yajB)
SBO: SBO_0298(yajB)
SBC: SbBS512_E0323(acpH)
ENC: ECL_01161
ECLO: ENC_23560
EEC: EcWSU1_00925(acpH)
ECLX: LI66_04700
ECLY: LI62_05200
ECLZ: LI64_04890
ESA: ESA_02898
CSK: ES15_2980(acpH)
CTU: CTU_09820(acpH)
KPN: KPN_00355(yajB)
KPU: KP1_1219(yajB)
KPP: A79E_3929
KPE: KPK_4330(acpH)
KPR: KPR_4366(acpH)
KPJ: N559_4055
KPX: PMK1_02684(acpH)
KPNU: LI86_20835
KPNK: BN49_1329(acpH)
KVA: Kvar_4026
KOX: KOX_12515
KOE: A225_1232
EAE: EAE_12485
EAR: CCG31480
CKO: CKO_02757
CRO: ROD_04521(acpH)
CAMA: F384_01740
EBT: EBL_c29180(acpH)
EBF: D782_3452
PSTS: E05_38600
YPE: YPO3193
YPK: y0989
YPH: YPC_3480(acpH)
YPA: YPA_2688
YPN: YPN_0894
YPM: YP_0738
YPG: YpAngola_A3386(acpH)
YPZ: YPZ3_2811
YPD: YPD4_2800
YPX: YPD8_2791
YPW: CH59_2867
YPJ: CH55_1770
YPV: BZ15_336
YPL: CH46_1909
YPS: YPTB0926(yajB)
YPO: BZ17_1620
YPI: YpsIP31758_3125(acpH)
YPY: YPK_3266
YPB: YPTS_0967
YPQ: DJ40_1432
YPU: BZ21_171
YPR: BZ20_1120
YPC: BZ23_447
YPF: BZ19_284
YEN: YE3173
YEY: Y11_20931
YEW: CH47_2541
YET: CH48_2665
YAL: AT01_1487
YFR: AW19_2134
YIN: CH53_2830
YKR: CH54_3652
YRO: CH64_3546
YRU: BD65_2798
SPE: Spro_1059
SRL: SOD_c09040(acpH)
SPLY: Q5A_004810(acpH)
SMAF: D781_0975
SMAR: SM39_0368(acpH)
SMAC: SMDB11_0311(acpH)
SERF: L085_23515
RAA: Q7S_17050
ECA: ECA1118
PATR: EV46_05635
PATO: GZ59_11460
PCT: PC1_1017
PEC: W5S_3290
SGL: SG0644
SOD: Sant_3031
PES: SOPEG_3201(acpH1)
DDD: Dda3937_01946(acpH)
DDQ: DDI_0856
ETA: ETA_25410(acpH)
EPY: EpC_26560(acpH)
EPR: EPYR_02881(yajB)
EAM: EAMY_0948(yajB)
EAY: EAM_0956
EBI: EbC_09750(acpH)
ERJ: EJP617_20770(acpH)
EGE: EM595_0943(acpH)
PAM: PANA_0961(yajB)
PAJ: PAJ_0287(yajB)
PSTW: DSJ_05640
PLU: plu3906
PAY: PAU_03492
PMR: PMI0074
XBO: XBJ1_1681
XBV: XBW1_0982(acpH)
XNE: XNC1_0756
XNM: XNC2_0745
XDO: XDD1_0831(acpH)
XPO: XPG1_0424(acpH)
PSI: S70_06920
PSX: DR96_1871
PRG: RB151_007110(acpH)
MMK: MU9_3272
ETR: ETAE_0957
ETD: ETAF_0889
ETE: ETEE_2895(acpH)
VCH: VCA0769
VCS: MS6_A0814
VCI: O3Y_17128
VVU: VV2_0226
VVY: VVA0730
VPA: VPA0844
VAG: N646_4234
VSP: VS_II0800
VSC: VSVS12_03814(acpH)
VTA: B1157
PPR: PBPRA0739(STY0441)
PSPO: PSPO_a3178(acpH)
PIN: Ping_3540
 » show all
Taxonomy
Reference
1  [PMID:224058]
  Authors
Sobhy C.
  Title
Regulation of fatty acid synthetase activity. The 4'-phosphopantetheine hydrolase of rat liver.
  Journal
J Biol Chem 254:8561-6 (1979)
Reference
2  [PMID:4290442]
  Authors
Vagelos PR, Larrabes AR.
  Title
Acyl carrier protein. IX. Acyl carrier protein hydrolase.
  Journal
J Biol Chem 242:1776-81 (1967)
Reference
3  [PMID:16107329]
  Authors
Thomas J, Cronan JE.
  Title
The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization.
  Journal
J Biol Chem 280:34675-83 (2005)
DOI:10.1074/jbc.M505736200
  Sequence
[eco:b0404]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.14
IUBMB Enzyme Nomenclature: 3.1.4.14
ExPASy - ENZYME nomenclature database: 3.1.4.14
BRENDA, the Enzyme Database: 3.1.4.14
CAS: 37288-21-4

DBGET integrated database retrieval system