| Entry |
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| Name |
2',3'-cyclic-nucleotide 3'-phosphodiesterase;
cyclic-CMP phosphodiesterase;
2',3'-cyclic AMP phosphodiesterase;
cyclic 2',3'-nucleotide 3'-phosphodiesterase;
cyclic 2',3'-nucleotide phosphodiesterase;
2',3'-cyclic nucleoside monophosphate phosphodiesterase;
2',3'-cyclic nucleotide 3'-phosphohydrolase;
CNPase;
2',3'-cyclic nucleotide phosphohydrolase;
2':3'-cyclic nucleotide 3'-phosphodiesterase;
2':3'-CNMP-3'-ase
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| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
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| Sysname |
nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase
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| Reaction(IUBMB) |
nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate [RN: R03422]
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| Reaction(KEGG) |
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| Substrate |
nucleoside 2',3'-cyclic phosphate [CPD: C01240];
H2O [CPD: C00001]
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| Product |
nucleoside 2'-phosphate [CPD: C03418]
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| Comment |
The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives. An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyses the corresponding 3',5'-cyclic phosphates, but more slowly. This latter enzyme has been called cyclic-CMP phosphodiesterase.
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| History |
EC 3.1.4.37 created 1976
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| Orthology |
| K01121 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
| K15435 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Drummond, G.I., Iyer, N.T. and Keith, J. |
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| Title |
Hydrolysis of ribonucleoside 2',3'-cyclic phosphates by a diesterase from brain. |
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| Journal |
J Biol Chem 237:3535-3539 (1962) |
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| Reference |
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| Authors |
Helfman DM, Kuo JF. |
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| Title |
A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides. |
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| Journal |
J Biol Chem 257:1044-7 (1982) |
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| Reference |
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| Authors |
Helfman DM, Shoji M, Kuo JF. |
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| Title |
Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP. |
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| Journal |
J Biol Chem 256:6327-34 (1981) |
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| Reference |
|
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| Authors |
Kurihara T, Nishizawa Y, Takahashi Y, Odani S. |
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| Title |
Chemical, immunological and catalytic properties of 2':3'-cyclic nucleotide 3'-phosphodiesterase purified from brain white matter. |
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| Journal |
Biochem J 195:153-7 (1981) |
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| Reference |
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| Authors |
Nishizawa Y, Kurihara T, Takahashi Y. |
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| Title |
Spectrophotometric assay, solubilization and purification of brain 2':3'-cyclic nucleotide 3'-phosphodiesterase. |
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| Journal |
Biochem J 191:71-82 (1980) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.4.37 |
| ExPASy - ENZYME nomenclature database: | 3.1.4.37 |
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