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Entry
EC 3.1.4.37                 Enzyme                                 

Name
2',3'-cyclic-nucleotide 3'-phosphodiesterase;
cyclic-CMP phosphodiesterase;
2',3'-cyclic AMP phosphodiesterase;
cyclic 2',3'-nucleotide 3'-phosphodiesterase;
cyclic 2',3'-nucleotide phosphodiesterase;
2',3'-cyclic nucleoside monophosphate phosphodiesterase;
2',3'-cyclic nucleotide 3'-phosphohydrolase;
CNPase;
2',3'-cyclic nucleotide phosphohydrolase;
2':3'-cyclic nucleotide 3'-phosphodiesterase;
2':3'-CNMP-3'-ase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase
Reaction(IUBMB)
nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate [RN:R03422]
Reaction(KEGG)
Substrate
nucleoside 2',3'-cyclic phosphate [CPD:C01240];
H2O [CPD:C00001]
Product
nucleoside 2'-phosphate [CPD:C03418]
Comment
The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives. An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyses the corresponding 3',5'-cyclic phosphates, but more slowly. This latter enzyme has been called cyclic-CMP phosphodiesterase.
History
EC 3.1.4.37 created 1976
Orthology
K01121  2',3'-cyclic-nucleotide 3'-phosphodiesterase
K15435  2',3'-cyclic-nucleotide 3'-phosphodiesterase
Genes
HSA: 1267(CNP)
PTR: 454673(CNP)
PPS: 100983181(CNP)
GGO: 101154558(CNP)
PON: 100171506(CNP)
NLE: 100595130(CNP)
MCC: 641337(CNP)
MCF: 101866793(CNP)
CSAB: 103243434(CNP)
RRO: 104680442(CNP)
RBB: 108518345(CNP)
CJC: 100409009(CNP)
SBQ: 101050949(CNP)
MMU: 12799(Cnp)
RNO: 25275(Cnp)
CGE: 100753220(Cnp)
NGI: 103735880(Cnp)
HGL: 101703085(Cnp)
CCAN: 109695787(Cnp)
OCU: 103351568(CNP)
TUP: 102488860(CNP)
CFA: 607694(CNP)
AML: 100467749(CNP)
UMR: 103672615(CNP)
ORO: 101368654(CNP)
FCA: 101093220(CNP)
PTG: 102971900(CNP)
AJU: 106972562(CNP)
BTA: 280752(CNP)
BOM: 102286486(CNP)
BIU: 109573868(CNP)
PHD: 102335235(CNP)
CHX: 102182826(CNP)
OAS: 101120423(CNP)
SSC: 100511587(CNP)
CFR: 102508768(CNP)
CDK: 105090447(CNP)
LVE: 103078417(CNP)
OOR: 101277548(CNP)
ECB: 100066401(CNP)
EPZ: 103550374(CNP)
EAI: 106826330(CNP)
MYB: 102246257(CNP)
MYD: 102757958(CNP)
HAI: 109395745(CNP)
RSS: 109455876(CNP)
PALE: 102887386(CNP)
LAV: 100670728(CNP)
TMU: 101346552
MDO: 100012666(CNP)
SHR: 105748993(CNP)
GGA: 395921(CNP)
MGP: 104914621(CNP)
CJO: 107325125(CNP)
APLA: 101794702(CNP)
ACYG: 106048016(CNP)
TGU: 100223675(CNP)
GFR: 102036395(CNP)
FAB: 101806325(CNP)
PHI: 102099592(CNP)
PMAJ: 107215150(CNP)
CCAE: 111939964(CNP)
CCW: 104697757(CNP)
FPG: 101923806(CNP)
FCH: 102051933(CNP)
CLV: 102094445(CNP)
EGZ: 104131388(CNP)
AAM: 106487631(CNP)
ASN: 102370911(CNP)
AMJ: 102573017(CNP)
PSS: 102444316(CNP)
CMY: 102931370(CNP)
CPIC: 101941109(CNP)
ACS: 100562366(cnp)
PVT: 110088998(CNP)
PBI: 103058614(CNP)
GJA: 107116247(CNP)
XLA: 108702467 444056(cnp.L)
XTR: 100492391(cnp)
NPR: 108792991(CNP)
DRE: 325896(cnp)
IPU: 108256586(cnp)
AMEX: 103043047(cnp)
TRU: 101073131(cnp)
LCO: 104926069(cnp)
NCC: 104949163(cnp)
MZE: 101484788(cnp)
OLA: 101161559(cnp)
XMA: 102221544(cnp)
PRET: 103469413(cnp)
NFU: 107395299(cnp)
KMR: 108243754(cnp)
CSEM: 103393138(cnp)
LCF: 108901289(cnp)
SDU: 111217693(cnp)
HCQ: 109532536(cnp)
BPEC: 110161626(cnp)
MALB: 109964255(cnp)
SASA: 100306871(cn37) 106601016
ELS: 105013339(cnp)
SFM: 108918982(cnp)
LCM: 102366632(CNP)
CMK: 103183808(cnp)
SPU: 582388
APLC: 110985385
SKO: 100373038
MYI: 110442976
OBI: 106867694
LAK: 106159031
EGL: EGR_08413
ADF: 107343453
SCE: YGR247W(CPD1)
ERC: Ecym_5571
KMX: KLMA_10332(CPD1)
NCS: NCAS_0E03850(NCAS0E03850)
NDI: NDAI_0B00960(NDAI0B00960)
TPF: TPHA_0A05230(TPHA0A05230)
TBL: TBLA_0B08020(TBLA0B08020)
TDL: TDEL_0G01030(TDEL0G01030)
KAF: KAFR_0B04390(KAFR0B04390)
CAL: CAALFM_CR06690CA(CaO19.703)
CAUR: QG37_01317
SLB: AWJ20_4080(CPD1)
NCR: NCU05539
FNU: FN1603
 » show all
Taxonomy
Reference
1
  Authors
Drummond, G.I., Iyer, N.T. and Keith, J.
  Title
Hydrolysis of ribonucleoside 2',3'-cyclic phosphates by a diesterase from brain.
  Journal
J Biol Chem 237:3535-3539 (1962)
Reference
2  [PMID:6274851]
  Authors
Helfman DM, Kuo JF.
  Title
A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides.
  Journal
J Biol Chem 257:1044-7 (1982)
Reference
3  [PMID:6263914]
  Authors
Helfman DM, Shoji M, Kuo JF.
  Title
Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP.
  Journal
J Biol Chem 256:6327-34 (1981)
Reference
4  [PMID:6272743]
  Authors
Kurihara T, Nishizawa Y, Takahashi Y, Odani S.
  Title
Chemical, immunological and catalytic properties of 2':3'-cyclic nucleotide 3'-phosphodiesterase purified from brain white matter.
  Journal
Biochem J 195:153-7 (1981)
Reference
5  [PMID:6258586]
  Authors
Nishizawa Y, Kurihara T, Takahashi Y.
  Title
Spectrophotometric assay, solubilization and purification of brain 2':3'-cyclic nucleotide 3'-phosphodiesterase.
  Journal
Biochem J 191:71-82 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.37
IUBMB Enzyme Nomenclature: 3.1.4.37
ExPASy - ENZYME nomenclature database: 3.1.4.37
BRENDA, the Enzyme Database: 3.1.4.37
CAS: 60098-35-3

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